| Downregulation of TTF1 in the rat hypothalamic ARC or AVPV nucleus inhibits Kiss1 and GnRH expression, leading to puberty delay. | Downregulation of TTF1 in the rat hypothalamic ARC or AVPV nucleus inhibits Kiss1 and GnRH expression, leading to puberty delay.
Zang S, Yin X, Li P., Free PMC Article | 11/6/2021 |
| data indicate that TTF-1 interacts with PPFP to inhibit the pro-adipogenic response to pioglitazone, and that the ability of pioglitazone to decrease TTF-1 expression contributes to its pro-adipogenic action. | Adipogenic Differentiation of Thyroid Cancer Cells Through the Pax8-PPARγ Fusion Protein Is Regulated by Thyroid Transcription Factor 1 (TTF-1).
Xu B, O'Donnell M, O'Donnell J, Yu J, Zhang Y, Sartor MA, Koenig RJ., Free PMC Article | 05/20/2017 |
| Dual positive effects of leptin were found on protein expression and transcriptional activity of thyroid transcription factor-1 | Leptin promotes fetal lung maturity and upregulates SP-A expression in pulmonary alveoli type-II epithelial cells involving TTF-1 activation.
Chen H, Zhang JP, Huang H, Wang ZH, Cheng R, Cai WB., Free PMC Article | 03/1/2014 |
| TTF1 contributes to regulating periodic oscillations in expression of the gonadotrophin-releasing hormone (GnRH) gene expression; TTF1 transactivates GnRH transcription by binding to two sites in the GnRH promoter. | Thyroid transcription factor 1, a homeodomain containing transcription factor, contributes to regulating periodic oscillations in GnRH gene expression.
Matagne V, Kim JG, Ryu BJ, Hur MK, Kim MS, Kim K, Park BS, Damante G, Smiley G, Lee BJ, Ojeda SR., Free PMC Article | 09/29/2012 |
| The expression of Nkx2.1 mRNA in offspring of hypothyroid pregnant rat was reduced. Treatment of pregnant rats with thyroxine restored Nkx2.1 expression to nomal levels in offspring. | [Effects of supplement of thyroxine for hypothyroid pregnant rat on the expression of homeobox gene Nkx2.1 mRNA in the offspring's cerebrum tissue].
Li JH, Zhang R, Wang BL, Na R, Li Y, Zhao XJ, Liang DC, Guo G. | 09/17/2011 |
| There was a significant increase in the expression of both TTF-1 and T1alpha mRNA in the IGF-2 group, in comparison to the control group after 48 h of culture. | Effect of insulin-like growth factors on lung development in a nitrofen-induced CDH rat model.
Esumi G, Masumoto K, Teshiba R, Nagata K, Kinoshita Y, Yamaza H, Nonaka K, Taguchi T. | 05/28/2011 |
| TTF-1 transcriptionally regulates synthesis of AgRP and alpha-MSH in the ARC and affects feeding behavior via the melanocortin pathway. | Thyroid transcription factor-1 regulates feeding behavior via melanocortin pathway in the hypothalamus.
Kim JG, Park BS, Yun CH, Kim HJ, Kang SS, D'Elia AV, Damante G, Lee KU, Park JW, Kim ES, Namgoong IS, Kim YI, Lee BJ., Free PMC Article | 04/23/2011 |
| DNA methylation and chromatin modifications cooperate with Nkx2-1 to regulate Sftpb gene cell specific expression. | Epigenetic mechanisms modulate thyroid transcription factor 1-mediated transcription of the surfactant protein B gene.
Cao Y, Vo T, Millien G, Tagne JB, Kotton D, Mason RJ, Williams MC, Ramirez MI., Free PMC Article | 02/15/2010 |
| Data show that direct interaction between Foxp2 and Nkx2.1 inhibits Nkx2.1 DNA-binding and transcriptional activity and suggest a mechanism for down-regulation of SP-C during transition of AT2 cells to an AT1 cell phenotype. | Foxp2 inhibits Nkx2.1-mediated transcription of SP-C via interactions with the Nkx2.1 homeodomain.
Zhou B, Zhong Q, Minoo P, Li C, Ann DK, Frenkel B, Morrisey EE, Crandall ED, Borok Z., Free PMC Article | 01/21/2010 |
| Data suggested that a good degree of isotropy of the global molecular motion, and that the C-terminal fragment of helix III was more flexible than the preceding N-terminal portion, with slightly different limits between rigid and mobile moieties. | Helix mobility and recognition function of the rat thyroid transcription factor 1 homeodomain - hints from 15N-NMR relaxation studies.
Gümral D, Nadalin L, Corazza A, Fogolari F, Damante G, Viglino P, Esposito G. | 01/21/2010 |
| These results suggest a possible role of TTF-1 in brain fluid homeostasis in response to changes in the osmotic environment. | Thyroid transcription factor-1 exhibits osmosensitive transcription in brain-derived cell lines.
Kim JG, Bae KD, Yun CH, Im HL, Park JW, Nam-Goong IS, Kim YI, Lee BJ. | 01/21/2010 |
| structural models of two complexes, thyroid transcription factor 1 homeodomain with the target DNA sequence have been constructed by using as a template the NMR structure. | Conformational stability and DNA binding energetics of the rat thyroid transcription factor 1 homeodomain.
Del Vecchio P, Carullo P, Barone G, Pagano B, Graziano G, Iannetti A, Acquaviva R, Leonardi A, Formisano S. | 01/21/2010 |
| TTF-1 plays a regulatory role in PACAP-expressing retinal ganglion cells. | TTF-1 expression in PACAP-expressing retinal ganglion cells.
Son YJ, Park JW, Lee BJ. | 01/21/2010 |
| TTF-1 plays a regulatory role in the transcription of growth hormone and prolactin genes and may regulate transdifferentiation of cells expressing these two hormones | TTF-1 regulates growth hormone and prolactin transcription in the anterior pituitary gland.
Lee NO, Son YJ, Kim JG, Ha CM, Yun CH, Lim HL, Park JW, D'Elia AV, Damante G, Lee BJ. | 01/21/2010 |
| thyrotropin-dependent thyroglobulin gene expression is stimulated by bacterial lipopolysaccharide at the transcriptional level by involving the transcription factors thyroid transcription factor-1 and paired box domain transcription factor 8 | Bacterial lipopolysaccharide stimulates the thyrotropin-dependent thyroglobulin gene expression at the transcriptional level by involving the transcription factors thyroid transcription factor-1 and paired box domain transcription factor 8.
Vélez ML, Costamagna E, Kimura ET, Fozzatti L, Pellizas CG, Montesinos MM, Lucero AM, Coleoni AH, Santisteban P, Masini-Repiso AM. | 01/21/2010 |
| pendrin and thyroglobulin are downstream targets in vivo of TTF-1, whose action is a prime factor in controlling thyroid differentiation in vivo | Pendrin is a novel in vivo downstream target gene of the TTF-1/Nkx-2.1 homeodomain transcription factor in differentiated thyroid cells.
Dentice M, Luongo C, Elefante A, Ambrosio R, Salzano S, Zannini M, Nitsch R, Di Lauro R, Rossi G, Fenzi G, Salvatore D., Free PMC Article | 01/21/2010 |
| data suggest that TTF-1 plays an important regulatory role in the gene transcription for pituitary adenylate cyclase-activating polypeptide | Regulation of pituitary adenylate cyclase-activating polypeptide gene transcription by TTF-1, a homeodomain-containing transcription factor.
Kim MS, Hur MK, Son YJ, Park JI, Chun SY, D'Elia AV, Damante G, Cho S, Kim K, Lee BJ. | 01/21/2010 |
| the subfornical organ, an important site of angiotensinogen synthesis, is an extra-hypothalamic site of TTF-1 expression | TTF-1, a homeodomain-containing transcription factor, participates in the control of body fluid homeostasis by regulating angiotensinogen gene transcription in the rat subfornical organ.
Son YJ, Hur MK, Ryu BJ, Park SK, Damante G, D'Elia AV, Costa ME, Ojeda SR, Lee BJ. | 01/21/2010 |
| DREAM interacts with thyroid-specific transcription factor TTF-1 and regulates the expression of the thyroglobulin (Tg) gene | Transcriptional repressor DREAM interacts with thyroid transcription factor-1 and regulates thyroglobulin gene expression.
Rivas M, Mellström B, Naranjo JR, Santisteban P. | 01/21/2010 |
| suggest a novel role for TTF-1 in the regulation of feeding behavior in the rat hypothalamus | TTF-1, a homeodomain-containing transcription factor, regulates feeding behavior in the rat hypothalamus.
Kim JG, Nam-Goong IS, Yun CH, Jeong JK, Kim ES, Park JJ, Lee YC, Kim YI, Lee BJ. | 01/21/2010 |
| TTF-1 is physiologically involved in the transcriptional control of AQP-1, which is required for CSF formation. | Thyroid transcription factor-1 facilitates cerebrospinal fluid formation by regulating aquaporin-1 synthesis in the brain.
Kim JG, Son YJ, Yun CH, Kim YI, Nam-Goong IS, Park JH, Park SK, Ojeda SR, D'Elia AV, Damante G, Lee BJ. | 01/21/2010 |
| Trefoil peptide expression and goblet cell number in rat intestine: effects of KGF and fasting-refeeding | Trefoil peptide expression and goblet cell number in rat intestine: effects of KGF and fasting-refeeding.
Fernandez-Estivariz C, Gu LH, Gu L, Jonas CR, Wallace TM, Pascal RR, Devaney KL, Farrell CL, Jones DP, Podolsky DK, Ziegler TR. | 01/21/2010 |
| calcitonin gene expression could be directly activated by Nkx2.1, whereas Pax9 is not involved in transcription from the 2kbp calcitonin promoter | Functional analysis of Nkx2.1 and Pax9 for calcitonin gene transcription.
Suzuki M, Katagiri N, Ueda M, Tanaka S. | 01/21/2010 |