| The Epigenetic Legacy of Maternal Protein Restriction: Renal Ptger1 DNA Methylation Changes in Hypertensive Rat Offspring. | The Epigenetic Legacy of Maternal Protein Restriction: Renal Ptger1 DNA Methylation Changes in Hypertensive Rat Offspring.
Jia H, Miyoshi M, Li X, Furukawa K, Otani L, Shirahige K, Miura F, Ito T, Kato H., Free PMC Article | 04/24/2024 |
| Alcohol reinstatement after prolonged abstinence from alcohol drinking by female adolescent rats: Roles of cyclooxygenase-2 and the prostaglandin E2 receptor 1. | Alcohol reinstatement after prolonged abstinence from alcohol drinking by female adolescent rats: Roles of cyclooxygenase-2 and the prostaglandin E(2) receptor 1.
Kline HL, Yamamoto BK. | 06/25/2022 |
| Role of the PGE2 receptor in ischemia-reperfusion injury of the rat retina. | Role of the PGE2 receptor in ischemia-reperfusion injury of the rat retina.
Deng C, Chen S, Li X, Luo H, Zhang Q, Hu P, Wang F, Xiong C, Sun T, Zhang X., Free PMC Article | 02/6/2021 |
| Our study identifies the EP1 signaling pathway as an important link between neuroinflammation and MMP-mediated BBB breakdown in ischemic stroke. | Detrimental role of the EP1 prostanoid receptor in blood-brain barrier damage following experimental ischemic stroke.
Frankowski JC, DeMars KM, Ahmad AS, Hawkins KE, Yang C, Leclerc JL, Doré S, Candelario-Jalil E., Free PMC Article | 10/22/2016 |
| A transient interaction between COX-2 and EP1 constitutes a feedback loop whereby an increase in COX-2 expression elevates EP1. | Upregulation of prostaglandin receptor EP1 expression involves its association with cyclooxygenase-2.
Sood R, Flint-Ashtamker G, Borenstein D, Barki-Harrington L., Free PMC Article | 04/2/2016 |
| Results indicate that EP1 receptor activation during seizures, through a protein kinase C pathway, increases probability of kainic acid induced status epilepticus, and independently promotes hippocampal neurodegeneration and a broad inflammatory response | The prostaglandin EP1 receptor potentiates kainate receptor activation via a protein kinase C pathway and exacerbates status epilepticus.
Rojas A, Gueorguieva P, Lelutiu N, Quan Y, Shaw R, Dingledine R., Free PMC Article | 04/25/2015 |
| EP1 deletion exacerbates neuro-behavioral impairments following intracerebral hemorrhage, potentially by slowing down/impairing microglial phagocytosis. | Role of PGE₂ EP1 receptor in intracerebral hemorrhage-induced brain injury.
Singh N, Ma B, Leonardo CC, Ahmad AS, Narumiya S, Doré S., Free PMC Article | 05/3/2014 |
| PGE2 appears to act both as a primary mediator of antigen-induced airway contraction via the EP4 receptor and as a downstream modulator of serotonin-induced bronchoconstriction via the EP1 receptor | Modulation of antigen-induced responses by serotonin and prostaglandin E2 via EP1 and EP4 receptors in the peripheral rat lung.
Larsson-Callerfelt AK, Dahlén SE, Kühl AR, Lex D, Uhlig S, Martin C. | 09/7/2013 |
| Results suggest that prostanoid EP(1) receptors are involved in positive regulation of the beating rate. | Prostanoid receptors involved in regulation of the beating rate of neonatal rat cardiomyocytes.
Mechiche H, Grassin-Delyle S, Robinet A, Nazeyrollas P, Devillier P., Free PMC Article | 03/9/2013 |
| The blockade of EP1 receptor in the ventrolateral periaqueductal grey leads to antinociception in neuropathic pain conditions, despite its down-regulation. | EP1 receptor within the ventrolateral periaqueductal grey controls thermonociception and rostral ventromedial medulla cell activity in healthy and neuropathic rat.
Palazzo E, Guida F, Gatta L, Luongo L, Boccella S, Bellini G, Marabese I, de Novellis V, Rossi F, Maione S., Free PMC Article | 01/12/2013 |
| In the trigeminal-vascular system (TVS) we found highest expression of EP(1) and EP(2) protein in the trigeminal nucleus caudalis. | Prostaglandin E2 receptor expression in the rat trigeminal-vascular system and other brain structures involved in pain.
Myren M, Olesen J, Gupta S. | 04/28/2012 |
| EP1 receptors were expressed in forebrain neurons & were induced in endothelial cells after hypoxic-ischemic injury in the neonatal rat. Its inhibition by SC-51089 reduced the injury. | Function of prostaglandin E2 EP receptors in the acute outcome of rodent hypoxic ischemic encephalopathy.
Taniguchi H, Anacker C, Suarez-Mier GB, Wang Q, Andreasson K., Free PMC Article | 03/17/2012 |
| An EP1 receptor antagonist improves pain-related behavior in the rat model and might be a potential agent to improve pain-related behavior in patients with lumbar disc herniation. | Analgesic effects of prostaglandin E2 receptor subtype EP1 receptor antagonist: experimental study of application of nucleus pulposus.
Sekiguchi M, Otoshi K, Kikuchi S, Konno S. | 01/28/2012 |
| These results suggest that PGE(2)-EP1 signaling has crucial roles in suppression of myoelectrical activity of gastric smooth muscles and inhibition of gastric emptying | Roles of prostaglandin E2-EP1 receptor signaling in regulation of gastric motor activity and emptying.
Mizuguchi S, Ohno T, Hattori Y, Ae T, Minamino T, Satoh T, Arai K, Saeki T, Hayashi I, Sugimoto Y, Narumiya S, Saigenji K, Majima M. | 11/13/2010 |
| these results provide new evidence that contributes to a better understanding of the role of EP1 and EP3 receptors in the regulation of Na+ handling and ENaC expression in the setting of renin-angiotensin-aldosterone-system activation. | E Prostanoid-1 receptor regulates renal medullary alphaENaC in rats infused with angiotensin II.
González AA, Céspedes C, Villanueva S, Michea L, Vio CP. | 01/21/2010 |
| Examine the role of prostaglandin E and thromboxane-prostanoid receptors in the response to prostaglandin E2 in the aorta of Wistar Kyoto rats and spontaneously hypertensive rats. | The role of prostaglandin E and thromboxane-prostanoid receptors in the response to prostaglandin E2 in the aorta of Wistar Kyoto rats and spontaneously hypertensive rats.
Tang EH, Jensen BL, Skott O, Leung GP, Feletou M, Man RY, Vanhoutte PM. | 01/21/2010 |
| support the possibility of targeting the EP1 receptor for antihypertensive therapy | Antihypertensive effects of selective prostaglandin E2 receptor subtype 1 targeting.
Guan Y, Zhang Y, Wu J, Qi Z, Yang G, Dou D, Gao Y, Chen L, Zhang X, Davis LS, Wei M, Fan X, Carmosino M, Hao C, Imig JD, Breyer RM, Breyer MD., Free PMC Article | 01/21/2010 |
| role of E prostanoid receptors EP1, EP2, & EP3 and F prostanoid receptors in enhancing the growth-stimulatory effect of epidermal growth factor in cultured hepatocytes | Prostaglandins enhance epidermal growth factor-induced DNA synthesis in hepatocytes by stimulation of E prostanoid 3 and F prostanoid receptors.
Meisdalen K, Dajani OF, Christoffersen T, Sandnes D. | 01/21/2010 |
| These data provide evidence of the role of prostaglandins in neuropathic pain, and suggest that not only infiltrating macrophages but also Schwann cells may be involved in the modulation of these mediators in response to nerve injury. | Localisation and modulation of prostanoid receptors EP1 and EP4 in the rat chronic constriction injury model of neuropathic pain.
Woodhams PL, MacDonald RE, Collins SD, Chessell IP, Day NC. | 01/21/2010 |
| EP1 receptor level increase in sensory neurones, and macrophage infiltration, appears to precede increased Cox-2 expression by macrophages in nerve injury | Prostanoid receptor EP1 and Cox-2 in injured human nerves and a rat model of nerve injury: a time-course study.
Durrenberger PF, Facer P, Casula MA, Yiangou Y, Gray RA, Chessell IP, Day NC, Collins SD, Bingham S, Wilson AW, Elliot D, Birch R, Anand P., Free PMC Article | 01/21/2010 |
| Results indicate that the EP1 prostanoid receptor is expressed in specific brain neuronal populations, which possibly determine the region-specific response to prostaglandin E2. | Regional distribution of the prostaglandin E2 receptor EP1 in the rat brain: accumulation in Purkinje cells of the cerebellum.
Candelario-Jalil E, Slawik H, Ridelis I, Waschbisch A, Akundi RS, Hüll M, Fiebich BL. | 01/21/2010 |
| PGE(2) increases Fn and promoted bone formation in rat osteoblasts via the EP(1)/phospholipase C/PKCalpha/c-Src signaling pathway | Prostaglandin E2 stimulates fibronectin expression through EP1 receptor, phospholipase C, protein kinase Calpha, and c-Src pathway in primary cultured rat osteoblasts.
Tang CH, Yang RS, Fu WM. | 01/21/2010 |
| Results suggest that loxoprofen or EP1 prostanoid receptor antagonists inhibit the inflammation-related neuronal activity in the bladder. | Prostaglandin facilitates afferent nerve activity via EP1 receptors during urinary bladder inflammation in rats.
Ikeda M, Kawatani M, Maruyama T, Ishihama H. | 01/21/2010 |
| Spinal PGE2 activates EP1 receptors on central terminals of primary afferents, subsequently increasing in [Ca2+]i in the spinal dorsal horn, which mediates spinal PGE2-induced nociceptive transmission. | Role of prostaglandin receptor subtype EP1 in prostaglandin E2-induced nociceptive transmission in the rat spinal dorsal horn.
Nakayama Y, Omote K, Kawamata T, Namiki A. | 01/21/2010 |
| Prostaglandin E receptor EP1 subtype has a role in the development of renal injury in hypertensive rats. | Role of prostaglandin E receptor EP1 subtype in the development of renal injury in genetically hypertensive rats.
Suganami T, Mori K, Tanaka I, Mukoyama M, Sugawara A, Makino H, Muro S, Yahata K, Ohuchida S, Maruyama T, Narumiya S, Nakao K. | 01/21/2010 |