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    GABRP gamma-aminobutyric acid type A receptor subunit pi [ Homo sapiens (human) ]

    Gene ID: 2568, updated on 17-Sep-2024

    GeneRIFs: Gene References Into Functions

    Submit: New GeneRIFCorrection

    GeneRIFPubMed TitleDate
    GABRP Promotes the Metastasis of Pancreatic Cancer by Activation of the MEK/ERK Signaling Pathway.

    GABRP Promotes the Metastasis of Pancreatic Cancer by Activation of the MEK/ERK Signaling Pathway.
    Meng Y, Li R, Geng S, Chen W, Jiang W, Li Z, Hao J, Xu Z.

    		03/4/2024
    GABRP promotes CD44s-mediated gemcitabine resistance in pancreatic cancer.

    GABRP promotes CD44s-mediated gemcitabine resistance in pancreatic cancer.
    Chen C, Wu B, Wang M, Chen J, Huang Z, Shi JS., Free PMC Article

    		01/21/2023
    The Emerging Roles of pi Subunit-Containing GABAA Receptors in Different Cancers.

    The Emerging Roles of π Subunit-Containing GABA(A) Receptors in Different Cancers.
    Juvale IIA, Hassan Z, Has ATC., Free PMC Article

    		03/12/2022
    GABRP sustains the stemness of triple-negative breast cancer cells through EGFR signaling.

    GABRP sustains the stemness of triple-negative breast cancer cells through EGFR signaling.
    Li X, Wang H, Yang X, Wang X, Zhao L, Zou L, Yang Q, Hou Z, Tan J, Zhang H, Nie J, Jiao B.

    		12/25/2021
    Use of a human embryonic stem cell model to discover GABRP, WFDC2, VTCN1 and ACTC1 as markers of early first trimester human trophoblast.

    Use of a human embryonic stem cell model to discover GABRP, WFDC2, VTCN1 and ACTC1 as markers of early first trimester human trophoblast.
    Karvas RM, McInturf S, Zhou J, Ezashi T, Schust DJ, Roberts RM, Schulz LC., Free PMC Article

    		08/14/2021
    rs505474, rs1398175, and rs4868029 in the GABRA2, GABRA4, and GABRP genes, respectively, allele frequencies were significantly different between patients and controls.Four haplotypes were significantly associated with Bipolar Disorder (TA and AG for rs3815762 and rs4868029 in GABRP, GG for rs11636988 and rs8024256 in GABRB3 and GAGG for rs2197414, rs4921195, rs13188991, and rs11956731 in GABRA6.

    Contribution of genes in the GABAergic pathway to bipolar disorder and its executive function deficit in the Chinese Han population.
    Ren H, Guan L, Zhao L, Lin Y, Wang Y, Yang Z, Li X, Ma X, Cheng X, Deng W, Aitchison KJ, Cao L, Li T.

    		08/11/2018
    Hypomethylation of the GABRP promoter is associated with aggressive phenotype of ovarian cancer.

    Aberrant epigenetic regulation of GABRP associates with aggressive phenotype of ovarian cancer.
    Sung HY, Yang SD, Ju W, Ahn JH., Free PMC Article

    		02/24/2018
    genetic polymorphism is associated with systemic lupus erythematosus in female patients

    The Association of the GABRP Polymorphisms with Systemic Lupus Erythematosus.
    Kim HS, Jin EH, Mo JS, Shim H, Lee SS, Chae SC., Free PMC Article

    		10/1/2016
    data reveal a GABRP-ERK1/2-cytokeratin axis that maintains the migratory phenotype of basal-like breast cancer

    GABA(A) receptor pi (GABRP) stimulates basal-like breast cancer cell migration through activation of extracellular-regulated kinase 1/2 (ERK1/2).
    Sizemore GM, Sizemore ST, Seachrist DD, Keri RA., Free PMC Article

    		01/24/2015
    HOXA10 expression leads to production of a less progestin-responsive GABA receptor subtype pi

    HOXA10 regulates endometrial GABAA {pi} receptor expression and membrane translocation.
    Sadeghi H, Taylor HS., Free PMC Article

    		04/19/2010
    Observational study of gene-disease association. (HuGE Navigator)See all PubMed (6) articles

    Variation at the GABAA receptor gene, Rho 1 (GABRR1) associated with susceptibility to bipolar schizoaffective disorder.
    Green EK, Grozeva D, Moskvina V, Hamshere ML, Jones IR, Jones L, Forty L, Caesar S, Gordon-Smith K, Fraser C, Russell E, St Clair D, Young AH, Ferrier N, Farmer A, McGuffin P, Holmans PA, Owen MJ, O'Donovan MC, Craddock N.

    Association study of 182 candidate genes in anorexia nervosa.
    Pinheiro AP, Bulik CM, Thornton LM, Sullivan PF, Root TL, Bloss CS, Berrettini WH, Schork NJ, Kaye WH, Bergen AW, Magistretti P, Brandt H, Crawford S, Crow S, Fichter MM, Goldman D, Halmi KA, Johnson C, Kaplan AS, Keel PK, Klump KL, La Via M, Mitchell JE, Strober M, Rotondo A, Treasure J, Woodside DB.

    Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging.
    Wheeler HE, Metter EJ, Tanaka T, Absher D, Higgins J, Zahn JM, Wilhelmy J, Davis RW, Singleton A, Myers RM, Ferrucci L, Kim SK.

    Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.
    Gratacòs M, Costas J, de Cid R, Bayés M, González JR, Baca-García E, de Diego Y, Fernández-Aranda F, Fernández-Piqueras J, Guitart M, Martín-Santos R, Martorell L, Menchón JM, Roca M, Sáiz-Ruiz J, Sanjuán J, Torrens M, Urretavizcaya M, Valero J, Vilella E, Estivill X, Carracedo A, Psychiatric Genetics Network Group.

    Strong genetic evidence for a selective influence of GABAA receptors on a component of the bipolar disorder phenotype.
    Craddock N, Jones L, Jones IR, Kirov G, Green EK, Grozeva D, Moskvina V, Nikolov I, Hamshere ML, Vukcevic D, Caesar S, Gordon-Smith K, Fraser C, Russell E, Norton N, Breen G, St Clair D, Collier DA, Young AH, Ferrier IN, Farmer A, McGuffin P, Holmans PA, Wellcome Trust Case Control Consortium (WTCCC), Donnelly P, Owen MJ, O'Donovan MC.

    Genetic investigation of chromosome 5q GABAA receptor subunit genes in schizophrenia.
    Petryshen TL, Middleton FA, Tahl AR, Rockwell GN, Purcell S, Aldinger KA, Kirby A, Morley CP, McGann L, Gentile KL, Waggoner SG, Medeiros HM, Carvalho C, Macedo A, Albus M, Maier W, Trixler M, Eichhammer P, Schwab SG, Wildenauer DB, Azevedo MH, Pato MT, Pato CN, Daly MJ, Sklar P.

    		03/13/2008
    Data suggest that GABRP is progressively down-regulated with tumour-progression, and that it may be useful as a prognostic marker in breast cancer.

    Systematic characterisation of GABRP expression in sporadic breast cancer and normal breast tissue.
    Zafrakas M, Chorovicer M, Klaman I, Kristiansen G, Wild PJ, Heindrichs U, Knüchel R, Dahl E.

    		01/21/2010
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