| distribution of the actin-binding protein caldesmon in spleen and lymph nodes of mice and rats | The actin-binding protein caldesmon is in spleen and lymph nodes predominately expressed by smooth-muscle cells, reticular cells, and follicular dendritic cells.
Köhler CN., Free PMC Article | 05/11/2013 |
| CaD stabilizes the F-actin dynamics in spines, thereby enlarging the spine heads, whereas CaD knockdown decreases the spine-head size via destabilization of the F-actin dynamics. | Glucocorticoid suppresses dendritic spine development mediated by down-regulation of caldesmon expression.
Tanokashira D, Morita T, Hayashi K, Mayanagi T, Fukumoto K, Kubota Y, Yamashita T, Sobue K., Free PMC Article | 01/5/2013 |
| caldesmon is an important regulator of axon development. | Caldesmon regulates axon extension through interaction with myosin II.
Morita T, Mayanagi T, Sobue K., Free PMC Article | 03/24/2012 |
| Overexpression of l-CaD suppressed cell growth and survival in VSMCs and inhibited neointimal formation after angioplasty, partly by regulating cytoskeletal tension-FAK-ERK axis. ) | l-Caldesmon regulates proliferation and migration of vascular smooth muscle cells and inhibits neointimal formation after angioplasty.
Yokouchi K, Numaguchi Y, Kubota R, Ishii M, Imai H, Murakami R, Ogawa Y, Kondo T, Okumura K, Ingber DE, Murohara T. | 10/7/2011 |
| Caldesmon binds and stabilizes actin filaments, as well as regulates actin-myosin interaction in a calcium (Ca2+)/calmodulin (CaM)- and/or phosphorylation-dependent manner. (Review) | Diversification of caldesmon-linked actin cytoskeleton in cell motility.
Mayanagi T, Sobue K., Free PMC Article | 08/13/2011 |
| Stretch activates myometrium via ERK, caldesmon and focal adhesion signaling | Stretch activates human myometrium via ERK, caldesmon and focal adhesion signaling.
Li Y, Reznichenko M, Tribe RM, Hess PE, Taggart M, Kim H, DeGnore JP, Gangopadhyay S, Morgan KG., Free PMC Article | 03/15/2010 |
| This study reports a novel molecular mechanism (caldesmon), as well as a structural basis (podosomes/rosettes), to show how p53 can act as an anti-motility/invasion/metastasis agent. | p53 suppresses Src-induced podosome and rosette formation and cellular invasiveness through the upregulation of caldesmon.
Mukhopadhyay UK, Eves R, Jia L, Mooney P, Mak AS., Free PMC Article | 01/21/2010 |
| The smaller C-terminal region contains the minimum regulatory domain responsible for the inhibition of actomyosin ATPase, and for the binding to actin, calmodulin and TM. | Role of the basic C-terminal half of caldesmon in its regulation of F-actin: comparison between caldesmon and calponin.
Takiguchi K, Matsumura F. | 01/21/2010 |
| Caldesmon suppresses cancer cell invasion by regulating podosome/invadopodium formation. | Caldesmon suppresses cancer cell invasion by regulating podosome/invadopodium formation.
Yoshio T, Morita T, Kimura Y, Tsujii M, Hayashi N, Sobue K. | 01/21/2010 |
| caldesmon was most markedly expressed in bladder smooth muscle after partial outlet obstruction | Bladder smooth muscle cell phenotypic changes and implication of expression of contractile proteins (especially caldesmon) in rats after partial outlet obstruction.
Matsumoto S, Hanai T, Ohnishi N, Yamamoto K, Kurita T. | 01/21/2010 |
| in Rous sarcoma virus-transformed cells, changes in the balance between PAK1/2-regulated caldesmon and the Arp2/3 complex govern the formation of podosomes | Changes in the balance between caldesmon regulated by p21-activated kinases and the Arp2/3 complex govern podosome formation.
Morita T, Mayanagi T, Yoshio T, Sobue K. | 01/21/2010 |
| Data suggest that caldesmon may play a role in the regulation of the dynamics of podosome assembly and that Ca2+/calmodulin may be part of a regulatory mechanism in podosome formation. | Caldesmon is an integral component of podosomes in smooth muscle cells.
Eves R, Webb BA, Zhou S, Mak AS. | 01/21/2010 |
| ERK1/2-mediated phosphorylation of myometrial caldesmon during pregnancy and labor | ERK1/2-mediated phosphorylation of myometrial caldesmon during pregnancy and labor.
Li Y, Je HD, Malek S, Morgan KG. | 01/21/2010 |