| Hyaluronan biosynthesis, by way of HAS2, is required for the retention of aggrecan. | CRISPR/Cas9 knockout of HAS2 in rat chondrosarcoma chondrocytes demonstrates the requirement of hyaluronan for aggrecan retention.
Huang Y, Askew EB, Knudson CB, Knudson W., Free PMC Article | 02/10/2018 |
| Expression patterns of Has and Hyal genes differed between normal, acute-scarred, and chronic-scarred vocal folds, indicating the distinct roles of each enzyme in maintaining HA. | Homeostasis of hyaluronic acid in normal and scarred vocal folds.
Tateya I, Tateya T, Watanuki M, Bless DM., Free PMC Article | 03/5/2016 |
| Data indicate that p38 and Ca(2+)/calmodulin-dependent protein kinase II pathways were found to be involved in the UVB-induced up-regulation of Has2 and Has3 expression. | Low dose ultraviolet B irradiation increases hyaluronan synthesis in epidermal keratinocytes via sequential induction of hyaluronan synthases Has1-3 mediated by p38 and Ca2+/calmodulin-dependent protein kinase II (CaMKII) signaling.
Rauhala L, Hämäläinen L, Salonen P, Bart G, Tammi M, Pasonen-Seppänen S, Tammi R., Free PMC Article | 09/7/2013 |
| HAS-1 expression was significantly decreased on rat vocal fold postinjury days 3, 7, 14, 28, and 56; HAS-2 expression was significantly decreased on postinjury days 28 and 56; HAS-3 expression was significantly decreased on postinjury day 56. | Extracellular matrix gene expression during wound healing of the injured rat vocal fold.
Ohno T, Hirano S, Rousseau B. | 01/21/2010 |
| Results provide evidence of HGF treatment effects on procollagen type III and HAS-2 gene expression pathways. | Effect of hepatocyte growth factor on gene expression of extracellular matrix during wound healing of the injured rat vocal fold.
Ohno T, French LC, Hirano S, Ossoff RH, Rousseau B. | 01/21/2010 |
| Increased expression of Has2 and MMP-1 genes from BSCs may have a positive potential in the treatment of vocal fold scarring. | Expression of extracellular matrix proteins in the vocal folds and bone marrow derived stromal cells of rats.
Ohno T, Hirano S, Kanemaru S, Yamashita M, Umeda H, Suehiro A, Nakamura T, Ito J. | 01/21/2010 |
| Epidermal hyaluronan synthesis, controlled by epidermal growth factor and transforming growth factor beta through changes in expression of Has2 and Has3, correlates with epidermal proliferation, thickness, and differentiation. | EGF upregulates, whereas TGF-beta downregulates, the hyaluronan synthases Has2 and Has3 in organotypic keratinocyte cultures: correlations with epidermal proliferation and differentiation.
Pasonen-Seppänen S, Karvinen S, Törrönen K, Hyttinen JM, Jokela T, Lammi MJ, Tammi MI, Tammi R. | 01/21/2010 |
| protein malnutrition has a primary impact on the gene expression of Has2 and Has3, which leads to the reduction of hyaluronan content and to disfunction of the skin | Dietary protein as a potent regulator of the hyaluronan synthase gene in rat skin.
Oishi Y, Kato H, Noguchi T. | 01/21/2010 |
| belongs to the targets of keratinocyte growth factor in keratinocytes, and support the idea that enhanced hyaluronan synthesis acts an effector for the migratory response of keratinocytes in wound healing | Keratinocyte growth factor stimulates migration and hyaluronan synthesis in the epidermis by activation of keratinocyte hyaluronan synthases 2 and 3.
Karvinen S, Pasonen-Seppänen S, Hyttinen JM, Pienimäki JP, Törrönen K, Jokela TA, Tammi MI, Tammi R. | 01/21/2010 |
| Has2 gene is a potent primary EGF and all-trans-RA responding gene with a complex regulation | The human hyaluronan synthase 2 gene is a primary retinoic acid and epidermal growth factor responding gene.
Saavalainen K, Pasonen-Seppänen S, Dunlop TW, Tammi R, Tammi MI, Carlberg C. | 01/21/2010 |
| leukemia inhibitory factor inhibits osteoblast development at least in part by stimulating high molecular weight hyaluronan synthesis through HAS2 | LIF inhibits osteoblast differentiation at least in part by regulation of HAS2 and its product hyaluronan.
Falconi D, Aubin JE. | 01/21/2010 |