| Expression of cell surface zinc transporter LIV1 in triple negative breast cancer is an indicator of poor prognosis and therapy failure. | Expression of cell surface zinc transporter LIV1 in triple negative breast cancer is an indicator of poor prognosis and therapy failure.
Saravanan R, Balasubramanian V, Sundaram S, Dev B, Vittalraj P, Pitani RS, Shanmugasundaram G, Rayala SK, Venkatraman G. | 04/24/2024 |
| Suppression of SLC39A6-CREB1 axis in liver cancer causes PCK1-mediated mitochondrial dysfunction. | Suppression of SLC39A6-CREB1 axis in liver cancer causes PCK1-mediated mitochondrial dysfunction.
Yu Z, Chen C, Gu H, Dong J, Zhang Y, Wang J, Ma H, Zhang G., Free PMC Article | 10/4/2023 |
| Zap70 Regulates TCR-Mediated Zip6 Activation at the Immunological Synapse. | Zap70 Regulates TCR-Mediated Zip6 Activation at the Immunological Synapse.
Kim B, Kim HY, Lee WW., Free PMC Article | 10/30/2021 |
| Oestrogen-regulated protein SLC39A6: a biomarker of good prognosis in luminal breast cancer. | Oestrogen-regulated protein SLC39A6: a biomarker of good prognosis in luminal breast cancer.
Althobiti M, El-Sharawy KA, Joseph C, Aleskandarany M, Toss MS, Green AR, Rakha EA., Free PMC Article | 10/16/2021 |
| The ZIP6/ZIP10 heteromer is essential for the zinc-mediated trigger of mitosis. | The ZIP6/ZIP10 heteromer is essential for the zinc-mediated trigger of mitosis.
Nimmanon T, Ziliotto S, Ogle O, Burt A, Gee JMW, Andrews GK, Kille P, Hogstrand C, Maret W, Taylor KM., Free PMC Article | 03/6/2021 |
| ZIP10 is predominantly expressed in the interfollicular epidermis, epidermal appendages and hair follicles. ZIP10 depletion resulted in epidermal malformations in a reconstituted human skin model via downregulation of the epigenetic enzyme histone acetyltransferase (HAT). Decreased HAT activity, resulting from either ZIP10 depletion or treatment with the zinc chelator TPEN, was readily restored by zinc supplementation. | The epithelial zinc transporter ZIP10 epigenetically regulates human epidermal homeostasis by modulating histone acetyltransferase activity.
Bin BH, Lee SH, Bhin J, Irié T, Kim S, Seo J, Mishima K, Lee TR, Hwang D, Fukada T, Cho EG. | 05/9/2020 |
| SLC39A6 is involved in gastric adenocarcinoma, and genotype at SLC39A6 rs1050631 can predict post-resection prognosis of gastric adenocarcinoma patients, at least in a population in an area with high gastric adenocarcinoma incidence. | Involvement of SLC39A6 in gastric adenocarcinoma and correlation of the SLC39A6 polymorphism rs1050631 with clinical outcomes after resection.
Gao J, Ren W, Xiao C, Wang L, Huang Q, Zhang Z, Dang Y, Weng P, Wang H, Fang X, Zhuang M, Lin L, Chen S., Free PMC Article | 04/11/2020 |
| These data demonstrate that LIV-1-GRPEL1 axis dually regulates mitotic exit as well as apoptosis by interacting with PP2A B55alpha and AIF. | The LIV-1-GRPEL1 axis adjusts cell fate during anti-mitotic agent-damaged mitosis.
Chen P, Wang B, Mo Q, Wu P, Fang Y, Tian Y, Jin X, Gao Y, Wu Y, Cao Y, Zhang Y, Xi L, Wang S, Hu J, Ma D, Zhou J, Gao Q, Chen G., Free PMC Article | 04/4/2020 |
| this work shows that zinc entry into activated lymphocytes depends on Zip6 and that this transporter is essential for the correct function of the cellular activation machinery | Zip6 Transporter Is an Essential Component of the Lymphocyte Activation Machinery.
Colomar-Carando N, Meseguer A, Company-Garrido I, Jutz S, Herrera-Fernández V, Olvera A, Kiefer K, Brander C, Steinberger P, Vicente R. | 11/2/2019 |
| ZIP6 deficiency disturbs intracellular Zn2+ homeostasis, leading to increased cell survival in hypoxia and reduced E-cadherin expression, indicating that decreased ZIP6 expression is strongly associated with resistance to hypoxia. | Zinc and its transporter ZIP6 are key mediators of breast cancer cell survival under high glucose conditions.
Matsui C, Takatani-Nakase T, Hatano Y, Kawahara S, Nakase I, Takahashi K. | 11/4/2017 |
| SLC39A6 promotes aggressiveness of esophageal carcinoma cells by increasing intracellular levels of zinc, activating phosphatidylinositol 3-kinase signaling, and up-regulating genes that regulate metastasis. | Solute Carrier Family 39 Member 6 Gene Promotes Aggressiveness of Esophageal Carcinoma Cells by Increasing Intracellular Levels of Zinc, Activating Phosphatidylinositol 3-Kinase Signaling, and Up-regulating Genes That Regulate Metastasis.
Cheng X, Wei L, Huang X, Zheng J, Shao M, Feng T, Li J, Han Y, Tan W, Tan W, Lin D, Wu C. | 08/19/2017 |
| Upregulation of SLC39A6 is associated with hepatocellular carcinoma. | miR-192, a prognostic indicator, targets the SLC39A6/SNAIL pathway to reduce tumor metastasis in human hepatocellular carcinoma.
Lian J, Jing Y, Dong Q, Huan L, Chen D, Bao C, Wang Q, Zhao F, Li J, Yao M, Qin L, Liang L, He X., Free PMC Article | 12/17/2016 |
| SLC39A6 may have a tumor promoting role in esophageal carcinoma | SLC39A6: a potential target for diagnosis and therapy of esophageal carcinoma.
Cui XB, Shen YY, Jin TT, Li S, Li TT, Zhang SM, Peng H, Liu CX, Li SG, Yang L, Li N, Hu JM, Jiang JF, Li M, Liang WH, Li Y, Wei YT, Sun ZZ, Wu CY, Chen YZ, Li F., Free PMC Article | 07/30/2016 |
| Knock-down of ZIP6 but not ZIP7 in MIN6 beta cells impaired the protective effects of GLP-1 on fatty acid-induced cell apoptosis, possibly via reduced activation of the p-ERK pathway | Characterization of Zinc Influx Transporters (ZIPs) in Pancreatic β Cells: ROLES IN REGULATING CYTOSOLIC ZINC HOMEOSTASIS AND INSULIN SECRETION.
Liu Y, Batchuluun B, Ho L, Zhu D, Prentice KJ, Bhattacharjee A, Zhang M, Pourasgari F, Hardy AB, Taylor KM, Gaisano H, Dai FF, Wheeler MB., Free PMC Article | 10/24/2015 |
| drug resistance of ovarian cancer cells to trichostatin A may be related to expression of the LIV1 gene | Effect of LIV1 on the sensitivity of ovarian cancer cells to trichostatin A.
Ma X, Duan H, Liu J, Mo Q, Sun C, Ma D, Wang J. | 08/15/2015 |
| Zinc and its transporters, ZIP6 and ZIP10, are required for the breast cancer cells motility stimulated with high glucose level, such as in diabetes. | High glucose level promotes migration behavior of breast cancer cells through zinc and its transporters.
Takatani-Nakase T, Matsui C, Maeda S, Kawahara S, Takahashi K., Free PMC Article | 11/8/2014 |
| a causative role for ZIP6 in cell motility and migration | A mechanism for epithelial-mesenchymal transition and anoikis resistance in breast cancer triggered by zinc channel ZIP6 and STAT3 (signal transducer and activator of transcription 3).
Hogstrand C, Kille P, Ackland ML, Hiscox S, Taylor KM., Free PMC Article | 11/23/2013 |
| Down-regulated LIV-1 cells showed significant inhibition of proliferation in vitro and reduction of tumor growth in vivo. Furthermore, E-cadherin expression increased in LIV-1 siRNA expressing Hep-G2. | Negative correlation of LIV-1 and E-cadherin expression in hepatocellular carcinoma cells.
Shen R, Xie F, Shen H, liu Q, Zheng T, Kou X, Wang D, Yang J., Free PMC Article | 09/14/2013 |
| SLC39A6 has an important role in the prognosis of esophageal squamous-cell carcinoma and may be a potential therapeutic target. | Genome-wide association study identifies common variants in SLC39A6 associated with length of survival in esophageal squamous-cell carcinoma.
Wu C, Li D, Jia W, Hu Z, Zhou Y, Yu D, Tong T, Wang M, Lin D, Qiao Y, Zhou Y, Chang J, Zhai K, Wang M, Wei L, Tan W, Shen H, Zeng Y, Lin D. | 08/3/2013 |
| Some studies correlate LIV-1 expression with a more aggressive cancer phenotype and increased likelihood for metastasis to lymph nodes. In contrast, other evidence suggests this transporter is associated with a more favorable prognosis. [review] | Zinc and cancer: implications for LIV-1 in breast cancer.
Grattan BJ, Freake HC., Free PMC Article | 12/22/2012 |
| The results of this study showed evidence for a positive correlation between LIV1 and ZnT6 insuperior temporal, occipital, and frontal gyri in patient with alzheimer disease. | Zinc transporter mRNA levels in Alzheimer's disease postmortem brain.
Beyer N, Coulson DT, Heggarty S, Ravid R, Hellemans J, Irvine GB, Johnston JA. | 08/18/2012 |
| LIV-1 is involved in prostate cancer progression as an intracellular target of growth factor receptor signaling which promoted EMT and cancer metastasis | LIV-1 promotes prostate cancer epithelial-to-mesenchymal transition and metastasis through HB-EGF shedding and EGFR-mediated ERK signaling.
Lue HW, Yang X, Wang R, Qian W, Xu RZ, Lyles R, Osunkoya AO, Zhou BP, Vessella RL, Zayzafoon M, Liu ZR, Zhau HE, Chung LW., Free PMC Article | 03/31/2012 |
| LIV-1 mRNA upregulation is associated with the progression of cervical cancer but not with the development of endometrial carcinoma. | [Expression of LIV-1 mRNA in human cervical carcinoma and endometrial carcinoma].
Zhao L, Chen W, Li X. | 06/28/2010 |
| The present study identifies LIV1 as a critical mediator responsible for HDACi-induced apoptosis. The effect of LIV1 is, at least in part, mediated by affecting intracellular zinc homeostasis. | Identification of LIV1, a putative zinc transporter gene responsible for HDACi-induced apoptosis, using a functional gene screen approach.
Ma X, Ma Q, Liu J, Tian Y, Wang B, Taylor KM, Wu P, Wang D, Xu G, Meng L, Wang S, Ma D, Zhou J. | 05/31/2010 |
| Zip6 over-expression is not an underlying mechanism initiating breast cancer, but in fact may play a "tumor-constraining" role. | Zip6-attenuation promotes epithelial-to-mesenchymal transition in ductal breast tumor (T47D) cells.
Lopez V, Kelleher SL. | 03/1/2010 |