| The Alzheimer's disease-linked protease BACE2 cleaves VEGFR3 and modulates its signaling. | The Alzheimer's disease-linked protease BACE2 cleaves VEGFR3 and modulates its signaling.
Schmidt A, Hrupka B, van Bebber F, Sunil Kumar S, Feng X, Tschirner SK, Aßfalg M, Müller SA, Hilger LS, Hofmann LI, Pigoni M, Jocher G, Voytyuk I, Self EL, Ito M, Hyakkoku K, Yoshimura A, Horiguchi N, Feederle R, De Strooper B, Schulte-Merker S, Lammert E, Moechars D, Schmid B, Lichtenthaler SF., Free PMC Article | 08/21/2024 |
| BACE2 deficiency impairs expression and function of endothelial nitric oxide synthase in brain endothelial cells. | BACE2 deficiency impairs expression and function of endothelial nitric oxide synthase in brain endothelial cells.
He T, d'Uscio LV, Katusic ZS., Free PMC Article | 09/19/2023 |
| m(6)A RNA hypermethylation-induced BACE2 boosts intracellular calcium release and accelerates tumorigenesis of ocular melanoma. | m(6)A RNA hypermethylation-induced BACE2 boosts intracellular calcium release and accelerates tumorigenesis of ocular melanoma.
He F, Yu J, Yang J, Wang S, Zhuang A, Shi H, Gu X, Xu X, Chai P, Jia R., Free PMC Article | 04/2/2022 |
| Patient-specific Alzheimer-like pathology in trisomy 21 cerebral organoids reveals BACE2 as a gene dose-sensitive AD suppressor in human brain. | Patient-specific Alzheimer-like pathology in trisomy 21 cerebral organoids reveals BACE2 as a gene dose-sensitive AD suppressor in human brain.
Alić I, Goh PA, Murray A, Portelius E, Gkanatsiou E, Gough G, Mok KY, Koschut D, Brunmeir R, Yeap YJ, O'Brien NL, Groet J, Shao X, Havlicek S, Dunn NR, Kvartsberg H, Brinkmalm G, Hithersay R, Startin C, Hamburg S, Phillips M, Pervushin K, Turmaine M, Wallon D, Rovelet-Lecrux A, Soininen H, Volpi E, Martin JE, Foo JN, Becker DL, Rostagno A, Ghiso J, Krsnik Ž, Šimić G, Kostović I, Mitrečić D, LonDownS Consortium, Francis PT, Blennow K, Strydom A, Hardy J, Zetterberg H, Nižetić D., Free PMC Article | 02/5/2022 |
| Cell surface GRP78 regulates BACE2 via lysosome-dependent manner to maintain mesenchymal phenotype of glioma stem cells. | Cell surface GRP78 regulates BACE2 via lysosome-dependent manner to maintain mesenchymal phenotype of glioma stem cells.
Chen Z, Wang H, Zhang Z, Xu J, Qi Y, Xue H, Gao Z, Zhao R, Wang S, Zhang S, Qiu W, Guo X, Li G., Free PMC Article | 08/28/2021 |
| RCAN1 Inhibits BACE2 Turnover by Attenuating Proteasome-Mediated BACE2 Degradation. | RCAN1 Inhibits BACE2 Turnover by Attenuating Proteasome-Mediated BACE2 Degradation.
Qiu K, Wang S, Wang X, Wang F, Wu Y., Free PMC Article | 03/27/2021 |
| TGFbeta1-induced beta-site APP-cleaving enzyme 2 upregulation promotes tumorigenesis through the NF-kappaB signalling pathway in human gliomas. | TGFβ1-induced beta-site APP-cleaving enzyme 2 upregulation promotes tumorigenesis through the NF-κB signalling pathway in human gliomas.
Wang H, Chen Z, Wang S, Gao X, Qian M, Qiu W, Zhang Z, Zhang S, Qi Y, Sun X, Xue H, Guo X, Zhao R, Li G., Free PMC Article | 02/6/2021 |
| BACE2 degradation is mediated by both the proteasome and lysosome pathways. | BACE2 degradation is mediated by both the proteasome and lysosome pathways.
Qiu K, Liang W, Wang S, Kong T, Wang X, Li C, Wang Z, Wu Y., Free PMC Article | 11/21/2020 |
| Common BACE2 Polymorphisms are Associated with Altered Risk for Alzheimer's Disease and CSF Amyloid Biomarkers in APOE epsilon4 Non-Carriers. | Common BACE2 Polymorphisms are Associated with Altered Risk for Alzheimer's Disease and CSF Amyloid Biomarkers in APOE ε4 Non-Carriers.
Huentelman M, De Both M, Jepsen W, Piras IS, Talboom JS, Willeman M, Reiman EM, Hardy J, Myers AJ., Free PMC Article | 10/24/2020 |
| the behavior of the flap tips during simulations is different between BACE1 and BACE2. The BACE1 active site cavity is more spacious as compared to that of BACE2. The analysis of 10S loop and 113S loop showed a similar trend to that of flaps, with the BACE1 loops being more flexible and less stable than those of BACE2 | A comparative molecular dynamics study on BACE1 and BACE2 flap flexibility.
Kumalo HM, Soliman ME. | 04/8/2017 |
| RNA-seq evidence of biallelic expression of BACE2 and 10 neighboring genes in at least one primary human tissue tested indicates that the expression of BACE2 is uncoupled from the control of the maternally inherited 5mCpG imprints at the WRB differentially methylated region (DMR) in disomic controls or trisomy (Down syndrome) individuals. | Trisomy 21 Alters DNA Methylation in Parent-of-Origin-Dependent and -Independent Manners.
Alves da Silva AF, Machado FB, Pavarino ÉC, Biselli-Périco JM, Zampieri BL, da Silva Francisco Junior R, Mozer Rodrigues PT, Terra Machado D, Santos-Rebouças CB, Gomes Fernandes M, Chuva de Sousa Lopes SM, Lopes Rios ÁF, Medina-Acosta E., Free PMC Article | 05/9/2016 |
| Studies suggest that beta-Secretases BACE1/2 plays an important role in retinal homeostasis and that BACE upregulation in response to stress is a protective measure. | A Non-Canonical Role for β-Secretase in the Retina.
Qian Q, Mitter SK, Pay SL, Qi X, Rickman CB, Grant MB, Boulton ME. | 04/23/2016 |
| Data suggest that the amino acid residues would be essential for selectivity of beta-amyloid precursor protein cleavage enzymes BACE1 and BACE2 functions and could be sites for the design of selective inhibitors targeting either BACE1 or BACE2. | Amino acid sequence and structural comparison of BACE1 and BACE2 using evolutionary trace method.
Mirsafian H, Mat Ripen A, Merican AF, Bin Mohamad S., Free PMC Article | 06/27/2015 |
| Data identified two novel genome-wide significant associations: 2-h plasma glucose and HKDC1, and fasting C-peptide and BACE2. | Identification of HKDC1 and BACE2 as genes influencing glycemic traits during pregnancy through genome-wide association studies.
Hayes MG, Urbanek M, Hivert MF, Armstrong LL, Morrison J, Guo C, Lowe LP, Scheftner DA, Pluzhnikov A, Levine DM, McHugh CP, Ackerman CM, Bouchard L, Brisson D, Layden BT, Mirel D, Doheny KF, Leya MV, Lown-Hecht RN, Dyer AR, Metzger BE, Reddy TE, Cox NJ, Lowe WL Jr, HAPO Study Cooperative Research Group., Free PMC Article | 11/16/2013 |
| BACE2 cleaves the integral membrane form of PMEL within the juxtamembrane domain, releasing the PMEL luminal domain into endosomal precursors for the formation of amyloid fibrils and downstream melanosome morphogenesis. | BACE2 processes PMEL to form the melanosome amyloid matrix in pigment cells.
Rochin L, Hurbain I, Serneels L, Fort C, Watt B, Leblanc P, Marks MS, De Strooper B, Raposo G, van Niel G., Free PMC Article | 09/7/2013 |
| Inhibiting Chrna7 expression markedly stimulated the production of Abeta through the mechanism of increased expression of BACE1 and inhibited expression of BACE2 in SH-SY5Y cells. | [Influence of inhibited α7 nicotinic acetylcholine receptor gene expression on the production of β-amyloid peptide in SH-SY5Y cells].
Ouyang K, Qi XL, Guan ZZ. | 06/8/2013 |
| BACE2 overexpression in cultured cells was found to lower net amyloid ss-protein levels. | Identification of BACE2 as an avid ß-amyloid-degrading protease.
Abdul-Hay SO, Sahara T, McBride M, Kang D, Leissring MA., Free PMC Article | 04/13/2013 |
| The BACE2 distal promoter contains an activating cis-regulatory element that is responsive to Trichostatin A (TSA) treatment according to promoter reporter assays in HEK 293 cells. | Functional analysis and identification of cis-regulatory elements of human chromosome 21 gene promoters.
Warnatz HJ, Querfurth R, Guerasimova A, Cheng X, Haas SA, Hufton AL, Manke T, Vanhecke D, Nietfeld W, Vingron M, Janitz M, Lehrach H, Yaspo ML., Free PMC Article | 09/14/2011 |
| All these data point to a role for BACE2 in the IRbeta trafficking and insulin signaling. In conclusion, BACE2 is hereby presented as an important enzyme in beta-cell function. | BACE2 plays a role in the insulin receptor trafficking in pancreatic ß-cells.
Casas S, Casini P, Piquer S, Altirriba J, Soty M, Cadavez L, Gomis R, Novials A. | 01/1/2011 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators., Free PMC Article | 09/15/2010 |
| Trransgenic BACE2 mice show increased anxiety-like behaviour along with increased numbers of noradrenergic neurones in the locus coeruleus. | Characterization of a mouse model overexpressing beta-site APP-cleaving enzyme 2 reveals a new role for BACE2.
Azkona G, Amador-Arjona A, Obradors-Tarragó C, Varea E, Arqué G, Pinacho R, Fillat C, de la Luna S, Estivill X, Dierssen M. | 08/16/2010 |
| BACE1 likely accounts for most of the Abeta produced in the human brain, and that BACE2 activity is not a likely contributor | BACE1 and BACE2 enzymatic activities in Alzheimer's disease.
Ahmed RR, Holler CJ, Webb RL, Li F, Beckett TL, Murphy MP., Free PMC Article | 03/15/2010 |
| study found no association between three BACE2 polymorphisms and sporadic Alzheimer's disease in the Chinese Han population even after statistical adjustment for age, gender and APOE epsilon 4 status | Lack of association between the polymorphisms of beta-site APP-cleaving enzyme 2 (BACE2) 5'-flanking region and sporadic Alzheimer's disease.
Yu Y, Jia J. | 01/21/2010 |
| The expression levels of BACE2 was comparable between DS and controls in fetal brain and in adult brain. | Protein expression of BACE1, BACE2 and APP in Down syndrome brains.
Cheon MS, Dierssen M, Kim SH, Lubec G. | 01/21/2010 |
| Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) | Chromosome 21 BACE2 haplotype associates with Alzheimer's disease: a two-stage study.
Myllykangas L, Wavrant-De Vrièze F, Polvikoski T, Notkola IL, Sulkava R, Niinistö L, Edland SD, Arepalli S, Adighibe O, Compton D, Hardy J, Haltia M, Tienari PJ. | 03/13/2008 |