| Promoter hypermethylation of GALR1 acts as an early epigenetic susceptibility event in colorectal carcinogenesis. | Promoter hypermethylation of GALR1 acts as an early epigenetic susceptibility event in colorectal carcinogenesis.
Gu S, Qian S, Lin S, Ye D, Li Q, Yang J, Ying X, Li Z, Tang M, Wang J, Chen K, Jin M. | 09/3/2022 |
| Galanin Receptors (GalR1, GalR2, and GalR3) Expression in Colorectal Cancer Tissue and Correlations to the Overall Survival and Poor Prognosis of CRC Patients. | Galanin Receptors (GalR1, GalR2, and GalR3) Expression in Colorectal Cancer Tissue and Correlations to the Overall Survival and Poor Prognosis of CRC Patients.
Kiezun J, Godlewski J, Krazinski BE, Kozielec Z, Kmiec Z., Free PMC Article | 04/23/2022 |
| Further evidence for the association of GAL, GALR1 and NPY1R variants with opioid dependence. | Further evidence for the association of GAL, GALR1 and NPY1R variants with opioid dependence.
Randesi M, Levran O, van den Brink W, Blanken P, van Ree JM, Ott J, Kreek MJ., Free PMC Article | 09/25/2021 |
| A Three Protein-Coding Gene Prognostic Model Predicts Overall Survival in Bladder Cancer Patients. | A Three Protein-Coding Gene Prognostic Model Predicts Overall Survival in Bladder Cancer Patients.
Ning XH, Qi YY, Wang FX, Li SC, Jia ZK, Yang JJ., Free PMC Article | 05/15/2021 |
| Low GALR1 expression is associated with gastric cancer. | Galanin expression is down-regulated in patients with gastric cancer.
Zhang L, Fang P, Chai C, Shao L, Mao H, Qiao D, Kong G, Dong X, Shi M, Zhang Z, Bo P., Free PMC Article | 08/1/2020 |
| High methylation of GALR1 is associated with head and neck cancer. | Prognostic value of aberrant promoter hypermethylation of tumor-related genes in early-stage head and neck cancer.
Misawa K, Mochizuki D, Imai A, Endo S, Mima M, Misawa Y, Kanazawa T, Carey TE, Mineta H., Free PMC Article | 02/24/2018 |
| Study provides evidence that GAL and GALR1/2 genes were identified as aberrantly methylated in head and neck squamous cell carcinoma. | Site-specific methylation patterns of the GAL and GALR1/2 genes in head and neck cancer: Potential utility as biomarkers for prognosis.
Misawa K, Mochizuki D, Endo S, Mima M, Misawa Y, Imai A, Shinmura K, Kanazawa T, Carey TE, Mineta H. | 09/9/2017 |
| The MOR-Gal1R heteromer can explain previous results showing antagonistic galanin-opioid interactions and offers a new therapeutic target for the treatment of opioid use disorder | Functional μ-Opioid-Galanin Receptor Heteromers in the Ventral Tegmental Area.
Moreno E, Quiroz C, Rea W, Cai NS, Mallol J, Cortés A, Lluís C, Canela EI, Casadó V, Ferré S., Free PMC Article | 07/29/2017 |
| GAL and its receptors, GALR1 and GALR2, play a role in head and neck squamous cell carcinoma tumorigenesis | Epigenetic inactivation of galanin and GALR1/2 is associated with early recurrence in head and neck cancer.
Misawa K, Misawa Y, Kanazawa T, Mochizuki D, Imai A, Endo S, Carey TE, Mineta H. | 07/30/2016 |
| Variants in genes for galanin (GAL) and its receptors (GALR1, GALR2, GALR3), despite their disparate genomic loci, conferred increased risk of depression and anxiety in people who experienced childhood adversity or recent negative life events. | Brain galanin system genes interact with life stresses in depression-related phenotypes.
Juhasz G, Hullam G, Eszlari N, Gonda X, Antal P, Anderson IM, Hökfelt TG, Deakin JF, Bagdy G., Free PMC Article | 06/21/2014 |
| GALR1 methylation is associated with endometrial cancer. | GALR1 methylation in vaginal swabs is highly accurate in identifying women with endometrial cancer.
Doufekas K, Hadwin R, Kandimalla R, Jones A, Mould T, Crowe S, Olaitan A, Macdonald N, Fiegl H, Wik E, Salvesen HB, Widschwendter M. | 02/22/2014 |
| Moreover, we have identified a novel role for the GalR1/galanin receptor-ligand axis in chemoresistance, providing evidence to support its further evaluation as a potential therapeutic target and biomarker in colorectal cancer . | Identification of galanin and its receptor GalR1 as novel determinants of resistance to chemotherapy and potential biomarkers in colorectal cancer.
Stevenson L, Allen WL, Turkington R, Jithesh PV, Proutski I, Stewart G, Lenz HJ, Van Schaeybroeck S, Longley DB, Johnston PG., Free PMC Article | 05/4/2013 |
| Genetic variants in the GALR1 gene are associated with a protective effect in nicotine dependence. | The neuropeptide galanin and variants in the GalR1 gene are associated with nicotine dependence.
Jackson KJ, Chen X, Miles MF, Harenza J, Damaj MI., Free PMC Article | 03/24/2012 |
| The results of this study suggested an association between variation at the GALR1 locus and baseline craving for tobacco in smokers seeking cessation treatment. | The galanin receptor 1 gene associates with tobacco craving in smokers seeking cessation treatment.
Lori A, Tang Y, O'Malley S, Picciotto MR, Wu R, Conneely KN, Cubells JF., Free PMC Article | 08/13/2011 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators., Free PMC Article | 09/15/2010 |
| it has been demonstrated that GalR1-5-HT1A receptors heteromerize. | Galanin receptor-1 modulates 5-hydroxtryptamine-1A signaling via heterodimerization.
Borroto-Escuela DO, Narvaez M, Marcellino D, Parrado C, Narvaez JA, Tarakanov AO, Agnati LF, Díaz-Cabiale Z, Fuxe K. | 05/3/2010 |
| Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) | Human variation in alcohol response is influenced by variation in neuronal signaling genes.
Joslyn G, Ravindranathan A, Brush G, Schuckit M, White RL. | 04/7/2010 |
| GAL, coding for the neuropeptide galanin, and GALR1, a galanin receptor, were identified as candidate genes of oncogenesis in squamous cell carcinoma using a survey of parallel chromosomal alterations and gene expression studies in 10 SCC cell lines. | The galanin signaling cascade is a candidate pathway regulating oncogenesis in human squamous cell carcinoma.
Sugimoto T, Seki N, Shimizu S, Kikkawa N, Tsukada J, Shimada H, Sasaki K, Hanazawa T, Okamoto Y, Hata A. | 01/21/2010 |
| GALR1 is a tumor suppressor gene in head and neck squamous cell carcinoma | Epigenetic inactivation of galanin receptor 1 in head and neck cancer.
Misawa K, Ueda Y, Kanazawa T, Misawa Y, Jang I, Brenner JC, Ogawa T, Takebayashi S, Grenman RA, Herman JG, Mineta H, Carey TE., Free PMC Article | 01/21/2010 |
| GalR1 is internalized via the clathrin-dependent, endocytic pathway and then, to a large extent, delivered to lysosomes for degradation through the lysosome-targeting signal YXXO | Postendocytotic traffic of the galanin R1 receptor: a lysosomal signal motif on the cytoplasmic terminus.
Xia S, Dun XP, Hu PS, Kjaer S, Zheng K, Qian Y, Solén C, Xu T, Fredholm B, Hökfelt T, Xu ZQ., Free PMC Article | 01/21/2010 |
| Data suggest that galanin stimulates cortisol secretion from human inner adrenocortical cells, acting through GAL-R1 coupled to the adenylate cyclase/PKA-dependent signaling cascade via a Ptx-sensitive Galpha protein. | Galanin stimulates cortisol secretion from human adrenocortical cells through the activation of galanin receptor subtype 1 coupled to the adenylate cyclase-dependent signaling cascade.
Belloni AS, Malendowicz LK, Rucinski M, Guidolin D, Nussdorfer GG. | 01/21/2010 |
| Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) | Alcoholism is associated with GALR3 but not two other galanin receptor genes.
Belfer I, Hipp H, Bollettino A, McKnight C, Evans C, Virkkunen M, Albaugh B, Max MB, Goldman D, Enoch MA, Belfer I, Hipp H, Bollettino A, McKnight C, Evans C, Virkkunen M, Albaugh B, Max MB, Goldman D, Enoch MA. | 03/13/2008 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (5) articlesAssociation study of 182 candidate genes in anorexia nervosa.
Pinheiro AP, Bulik CM, Thornton LM, Sullivan PF, Root TL, Bloss CS, Berrettini WH, Schork NJ, Kaye WH, Bergen AW, Magistretti P, Brandt H, Crawford S, Crow S, Fichter MM, Goldman D, Halmi KA, Johnson C, Kaplan AS, Keel PK, Klump KL, La Via M, Mitchell JE, Strober M, Rotondo A, Treasure J, Woodside DB. Comprehensive copy number variant (CNV) analysis of neuronal pathways genes in psychiatric disorders identifies rare variants within patients.
Saus E, Brunet A, Armengol L, Alonso P, Crespo JM, Fernández-Aranda F, Guitart M, Martín-Santos R, Menchón JM, Navinés R, Soria V, Torrens M, Urretavizcaya M, Vallès V, Gratacòs M, Estivill X. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.
Gratacòs M, Costas J, de Cid R, Bayés M, González JR, Baca-García E, de Diego Y, Fernández-Aranda F, Fernández-Piqueras J, Guitart M, Martín-Santos R, Martorell L, Menchón JM, Roca M, Sáiz-Ruiz J, Sanjuán J, Torrens M, Urretavizcaya M, Valero J, Vilella E, Estivill X, Carracedo A, Psychiatric Genetics Network Group. Human galanin (GAL) and galanin 1 receptor (GALR1) variations are not involved in fat intake and early onset obesity.
Schäuble N, Reichwald K, Grassl W, Bechstein H, Müller HC, Scherag A, Geller F, Utting M, Siegfried W, Goldschmidt H, Blundell J, Lawton C, Alam R, Whybrow S, Stubbs J, Platzer M, Hebebrand J, Hinney A. | 03/13/2008 |
| There was no effect of GALR1 on alcoholism risk. | Alcoholism is associated with GALR3 but not two other galanin receptor genes.
Belfer I, Hipp H, Bollettino A, McKnight C, Evans C, Virkkunen M, Albaugh B, Max MB, Goldman D, Enoch MA, Belfer I, Hipp H, Bollettino A, McKnight C, Evans C, Virkkunen M, Albaugh B, Max MB, Goldman D, Enoch MA. | 01/21/2010 |
| disregulation of galanin receptor 1 may lead to uncontrolled proliferation and neoplastic transformation | Galanin receptor 1 has anti-proliferative effects in oral squamous cell carcinoma.
Henson BS, Neubig RR, Jang I, Ogawa T, Zhang Z, Carey TE, D'Silva NJ. | 01/21/2010 |