| LETMD1, a target of KLF4, hinders endothelial inflammation and pyroptosis: A protective mechanism in the pathogenesis of atherosclerosis. | LETMD1, a target of KLF4, hinders endothelial inflammation and pyroptosis: A protective mechanism in the pathogenesis of atherosclerosis.
Xing Z, Du M, Zhen Y, Chen J, Li D, Liu R, Zheng J. | 11/7/2023 |
| MiR-494 Inhibits the Proliferation, Migration and Invasion of Cervical Cancer Cells by Regulating LETMD1. | MiR-494 Inhibits the Proliferation, Migration and Invasion of Cervical Cancer Cells by Regulating LETMD1.
Wen N, Zhang J, Zhang Q. | 07/16/2022 |
| The regulating role of miR-494 on HCCR1 in cervical cancer cells. | The regulating role of miR-494 on HCCR1 in cervical cancer cells.
Zheng Z, Yang X, Yu Q, Li L, Qiao L. | 07/16/2022 |
| Knockdown of SNHG1 inhibits cervical cancer growth through sponging miR-194 to regulate HCCR. | Knockdown of SNHG1 inhibits cervical cancer growth through sponging miR-194 to regulate HCCR.
Zhang J, Liu B, Zhang P, Wang L, Zhu Y. | 08/28/2021 |
| LETMD1 Regulates Phagocytosis and Inflammatory Responses to Lipopolysaccharide via Reactive Oxygen Species Generation and NF-kappaB Activation in Macrophages. | LETMD1 Regulates Phagocytosis and Inflammatory Responses to Lipopolysaccharide via Reactive Oxygen Species Generation and NF-κB Activation in Macrophages.
Lim SG, Suk K, Lee WH. | 09/12/2020 |
| HCCR-1 siRNA transfection causes significant increase in the apoptosis and decreases in the proliferation of MCF-7 cellsThese effects are related to the upregulation of the Bax expression in the MCF-7 cells. | Interaction of HCCR-1 and Bax in breast cancer.
Meng K, Yuan G, Bao H, Wang L, Ma R, Yu B, Zhao S. | 03/21/2020 |
| Data show that the activation of STAT3 protein upregulated human cervical cancer oncogene (HCCR) expression in gastric cancer cells. | Targeting HCCR expression resensitizes gastric cancer cells to chemotherapy via down-regulating the activation of STAT3.
Zhang JL, Liu XZ, Wang PY, Chen GW, Jiang Y, Qiao SK, Zhu J, Wang X, Pan YS, Liu YC., Free PMC Article | 03/11/2017 |
| Demonstrate that HBx-HCCR-E-cadherin regulation pathway might play an important role in HBV-induced hepatocarcinogenesis. | Up-regulation of human cervical cancer proto-oncogene contributes to hepatitis B virus-induced malignant transformation of hepatocyte by down-regulating E-cadherin.
Li J, Dai X, Zhang H, Zhang W, Sun S, Gao T, Kou Z, Yu H, Guo Y, Du L, Jiang S, Zhang J, Zhou Y., Free PMC Article | 08/6/2016 |
| These findings suggest that HCCR gene is over-expressed in acute leukemia patients and may be a useful biomarker for monitoring minimal residual disease. | Quantitative detection of the human cervical cancer oncogene for monitoring the minimal residual disease in acute leukemia.
Qiao SK, Guo XN, Ren JH, Zhang JN, Wang Y., Free PMC Article | 03/28/2015 |
| HCCR2 gene plays an important role in the tumorigenesis of leukemia. | Silencing HCCR2 expression inhibits the proliferation of leukemia cells by inducing apoptosis and promoting cell cycle arrest.
Qiao SK, Ren HY, Shi YJ, Liu W. | 05/31/2014 |
| HCCRBP-3 induces tumorigenesis through direct interaction with HCCR-1 in human cancers. | HCCRBP-3 induces tumorigenesis through direct interaction with HCCR-1 in human cancers.
Ha SA, Kim HK, Yoo JA, Kim S, Shin SM, Gong GH, Lee YK, Kim JW. | 02/22/2014 |
| The data demonstrate that HCCR-1 may be used as a novel predictor for the prognosis of the patients with esophageal squamous cell carcinoma. | Clinical implication of elevated human cervical cancer oncogene-1 expression in esophageal squamous cell carcinoma.
Liu Y, Li K, Ren Z, Li S, Zhang H, Fan Q., Free PMC Article | 09/15/2012 |
| HCCR-1 might play a role in the breast tumourigenesis while the overexpression of HCCR-1 induces the obesity probably by inhibiting the cholesterol-lowering effect of ApoE | Dual action of apolipoprotein E-interacting HCCR-1 oncoprotein and its implication for breast cancer and obesity.
Ha SA, Shin SM, Kim HK, Kim S, Namkoong H, Lee YS, Kim HJ, Jung SM, Lee YS, Chung YJ, Park YG, Jung SS, Kim JW., Free PMC Article | 12/24/2011 |
| The overexpression of HCCR-2 could enhance the division and proliferation of SMMC 7721 cells. | [HCCR-2 enhances the division and proliferation of SMMC 7721 via PI3K/Akt pathway].
Yang YM, Qian JB, Hao B, Zhang GX. | 12/17/2011 |
| Observational study of gene-disease association. (HuGE Navigator) | Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ., Free PMC Article | 12/5/2010 |
| induces neoplastic cell transformation and epithelial-mesenchymal transdifferentiation | Transdifferentiation-inducing HCCR-1 oncogene.
Ha SA, Kim HK, Yoo J, Kim S, Shin SM, Lee YS, Hur SY, Kim YW, Kim TE, Chung YJ, Jeun SS, Kim DW, Park YG, Kim J, Shin SY, Lee YH, Kim JW., Free PMC Article | 11/6/2010 |
| Treatment of PANC-1 cells with epidermal growth factor increased HCCR-1 protein level via PI3K/Akt/mTOR signaling. | Epidermal growth factor induces HCCR expression via PI3K/Akt/mTOR signaling in PANC-1 pancreatic cancer cells.
Xu Z, Zhang Y, Jiang J, Yang Y, Shi R, Hao B, Zhang Z, Huang Z, Kim JW, Zhang G., Free PMC Article | 08/23/2010 |
| TCF and beta-catenin binding plays important roles in HCCR-1 oncogene expression. | TCF/beta-catenin plays an important role in HCCR-1 oncogene expression.
Cho GW, Kim MH, Kim SH, Ha SA, Kim HK, Kim S, Kim JW., Free PMC Article | 01/21/2010 |
| Data indicate that the level of HCCR-1 in breast cancer tissues is correlated with the HER2 overexpression, p53 mutation, and ER/PR status, and determination of HCCR-1 levels as options for HER2 testing is promising although it needs further evaluation. | Oncoprotein HCCR-1 expression in breast cancer is well correlated with known breast cancer prognostic factors including the HER2 overexpression, p53 mutation, and ER/PR status.
Ha SA, Lee YS, Shin SM, Kim HK, Kim S, Namkoong H, Kim HJ, Jung SM, Lee YS, Chung YJ, Jung SS, Kim JW., Free PMC Article | 01/21/2010 |
| These experiments show the biological features of HCCR-1 in the cell, and suggest that uncontrolled expression of HCCR-1 may cause mitochondrial dysfunction. | HCCR-1, a novel oncogene, encodes a mitochondrial outer membrane protein and suppresses the UVC-induced apoptosis.
Cho GW, Shin SM, Kim HK, Ha SA, Kim S, Yoon JH, Hur SY, Kim TE, Kim JW., Free PMC Article | 01/21/2010 |
| These results suggest that the HCCR-1 oncogene expression was regulated by the phosphatidylinositol 3-kinase/Akt signaling pathway. | The phosphatidylinositol 3-kinase/Akt pathway regulates the HCCR-1 oncogene expression.
Cho GW, Shin SM, Namkoong H, Kim HK, Ha SA, Hur SY, Kim TE, Chai YG, Kim JW. | 01/21/2010 |
| HCCR-2 represents an oncoprotein that is related to breast cancer development and regulation of the p53 tumor suppressor. | Transgenic mouse model for breast cancer: induction of breast cancer in novel oncogene HCCR-2 transgenic mice.
Ko J, Shin SM, Oh YM, Lee YS, Ryoo ZY, Lee YH, Na DS, Kim JW. | 01/21/2010 |
| HCCR oncoprotein has a role in development of human breast cancer | The HCCR oncoprotein as a biomarker for human breast cancer.
Jung SS, Park HS, Lee IJ, Namkoong H, Shin SM, Cho GW, Ha SA, Park YG, Lee YS, Ko J, Kim JW. | 01/21/2010 |
| HCCR-2 probably represents a new oncogene that is related to tumorigenesis, functioning as a negative regulator of the p53 tumor suppressor | Identification and differential expression of novel human cervical cancer oncogene HCCR-2 in human cancers and its involvement in p53 stabilization.
Ko J, Lee YH, Hwang SY, Lee YS, Shin SM, Hwang JH, Kim J, Kim YW, Jang SW, Ryoo ZY, Kim IK, Namkoong SE, Kim JW. | 01/21/2010 |
| Human, similar to bacterial ribosomal protein L14 and yeast L22, gene L14.22 (clone 507E08), over-expressed in gliomas. | Isolation of novel differentially expressed genes related to human glioma using cDNA microarray and characterizations of two novel full-length genes.
Qi ZY, Li Y, Ying K, Wu CQ, Tang R, Zhou ZX, Chen ZP, Hui GZ, Xie Y. | 01/21/2010 |