| Altered NCR3 Splice Variants May Result in Deficient NK Cell Function in Renal Cell Carcinoma Patients. | Altered NCR3 Splice Variants May Result in Deficient NK Cell Function in Renal Cell Carcinoma Patients.
Wang X, Huang L, Wen X, Li D, Yang G, Zheng J., Free PMC Article | 01/4/2024 |
| Human NCR3 gene variants rs2736191 and rs11575837 alter longitudinal risk for development of pediatric malaria episodes and severe malarial anemia. | Human NCR3 gene variants rs2736191 and rs11575837 alter longitudinal risk for development of pediatric malaria episodes and severe malarial anemia.
Onyango CO, Cheng Q, Munde EO, Raballah E, Anyona SB, McMahon BH, Lambert CG, Onyango PO, Schneider KA, Perkins DJ, Ouma C., Free PMC Article | 09/19/2023 |
| Multifunctional NK Cell-Engaging Antibodies Targeting EGFR and NKp30 Elicit Efficient Tumor Cell Killing and Proinflammatory Cytokine Release. | Multifunctional NK Cell-Engaging Antibodies Targeting EGFR and NKp30 Elicit Efficient Tumor Cell Killing and Proinflammatory Cytokine Release.
Klausz K, Pekar L, Boje AS, Gehlert CL, Krohn S, Gupta T, Xiao Y, Krah S, Zaynagetdinov R, Lipinski B, Toleikis L, Poetzsch S, Rabinovich B, Peipp M, Zielonka S. | 10/22/2022 |
| Oral cancer cellderived exosomes modulate natural killer cell activity by regulating the receptors on these cells. | Oral cancer cell‑derived exosomes modulate natural killer cell activity by regulating the receptors on these cells.
Zhu X, Qin X, Wang X, Wang Y, Cao W, Zhang J, Chen W., Free PMC Article | 07/10/2021 |
| Secreted Ligands of the NK Cell Receptor NKp30: B7-H6 Is in Contrast to BAG6 Only Marginally Released via Extracellular Vesicles. | Secreted Ligands of the NK Cell Receptor NKp30: B7-H6 Is in Contrast to BAG6 Only Marginally Released via Extracellular Vesicles.
Ponath V, Hoffmann N, Bergmann L, Mäder C, Alashkar Alhamwe B, Preußer C, Pogge von Strandmann E., Free PMC Article | 05/29/2021 |
| The Natural Cytotoxicity Receptors in Health and Disease. | The Natural Cytotoxicity Receptors in Health and Disease.
Barrow AD, Martin CJ, Colonna M., Free PMC Article | 10/3/2020 |
| Altogether, these data suggested that the defective expression of NKp30 may be induced by the chronic engagement of this receptor by B7-H6 expressed on HIV-2-infected target cells. This represents a novel mechanism by which the chronic ligand exposure by the viral environment may subvert NK-cell-mediated function to establish persistent HIV-2 infection. | B7-H6-mediated downregulation of NKp30 in natural killer cells contributes to HIV-2 immune escape.
Lucar O, Sadjo Diallo M, Bayard C, Samri A, Tarantino N, Debré P, Thiébaut R, Brun-Vézinet F, Matheron S, Cheynier R, Vieillard V, ANRS CO5 IMMUNOVIR-2 Study group. | 02/1/2020 |
| this study shows that NK cells lyse Th2-polarizing dendritic cells via NKp30 | Human NK Cells Lyse Th2-Polarizing Dendritic Cells via NKp30 and DNAM-1.
Walwyn-Brown K, Guldevall K, Saeed M, Pende D, Önfelt B, MacDonald AS, Davis DM., Free PMC Article | 08/10/2019 |
| Decreases in the expression of NKp30 could influence the functional capacity of natural killer cells in the tropical spastic paraparesis patients. | Functional capacity of natural killer cells in HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients.
Queiroz GAN, Mascarenhas REM, Vieillard V, Andrade RL, Galvão-Castro B, Grassi MFR., Free PMC Article | 07/13/2019 |
| this paper shows that the decreased expression of activating receptor NKp30 on peripheral blood NK cells is positively associated with gastric cancer progression | Altered NKp30, NKp46, NKG2D, and DNAM-1 Expression on Circulating NK Cells Is Associated with Tumor Progression in Human Gastric Cancer.
Han B, Mao FY, Zhao YL, Lv YP, Teng YS, Duan M, Chen W, Cheng P, Wang TT, Liang ZY, Zhang JY, Liu YG, Guo G, Zou QM, Zhuang Y, Peng LS., Free PMC Article | 12/22/2018 |
| Low NKp30 expression on NK cells is associated with Nasopharyngeal Carcinoma. | Analysis of the Expression of Surface Receptors on NK Cells and NKG2D on Immunocytes in Peripheral Blood of Patients with Nasopharyngeal Carcinoma.
Xu Y, Zhou R, Huang C, Zhang M, Li J, Zong J, Qiu S, Lin S, Chen H, Ye Y, Pan J., Free PMC Article | 09/22/2018 |
| we propose NKp30 status as a simple and early prognostic biomarker that identifies intermediate-risk patients with poor prognosis who otherwise may not be identified with existing risk stratification systems. | NKp30 expression is a prognostic immune biomarker for stratification of patients with intermediate-risk acute myeloid leukemia.
Chretien AS, Fauriat C, Orlanducci F, Rey J, Borg GB, Gautherot E, Granjeaud S, Demerle C, Hamel JF, Cerwenka A, von Strandmann EP, Ifrah N, Lacombe C, Cornillet-Lefebvre P, Delaunay J, Toubert A, Arnoulet C, Vey N, Olive D., Free PMC Article | 04/28/2018 |
| Data indicate a sequence of events driven by tumour-derived prostaglandin D2 (PGD2) associated with engagement of the natural cytotoxicity triggering receptor 3 (NKp30)-B7H6 antigen (B7H6) pathway leading to significant group 2 innate lymphoid cells (ILC2s) activation and expansion. | Tumour-derived PGD2 and NKp30-B7H6 engagement drives an immunosuppressive ILC2-MDSC axis.
Trabanelli S, Chevalier MF, Martinez-Usatorre A, Gomez-Cadena A, Salomé B, Lecciso M, Salvestrini V, Verdeil G, Racle J, Papayannidis C, Morita H, Pizzitola I, Grandclément C, Bohner P, Bruni E, Girotra M, Pallavi R, Falvo P, Leibundgut EO, Baerlocher GM, Carlo-Stella C, Taurino D, Santoro A, Spinelli O, Rambaldi A, Giarin E, Basso G, Tresoldi C, Ciceri F, Gfeller D, Akdis CA, Mazzarella L, Minucci S, Pelicci PG, Marcenaro E, McKenzie ANJ, Vanhecke D, Coukos G, Mavilio D, Curti A, Derré L, Jandus C., Free PMC Article | 03/10/2018 |
| NKp44 and NKp30 splice variants profiles are tissue/condition specific and demonstrate similarity between placenta and cancerous tissues. | NKp44 and NKp30 splice variant profiles in decidua and tumor tissues: a comparative viewpoint.
Shemesh A, Kugel A, Steiner N, Yezersky M, Tirosh D, Edri A, Teltsh O, Rosental B, Sheiner E, Rubin E, Campbell KS, Porgador A., Free PMC Article | 02/24/2018 |
| Results found that rs2736191-C NCR3 carriers had a significant increased number of mild malaria episodes compared to the non-carriers. This SNP had a significantly increased promoter activity in NCR33 gene and involves a binding site for STAT4 and RUNX3. | Beyond genome-wide scan: Association of a cis-regulatory NCR3 variant with mild malaria in a population living in the Republic of Congo.
Baaklini S, Afridi S, Nguyen TN, Koukouikila-Koussounda F, Ndounga M, Imbert J, Torres M, Pradel L, Ntoumi F, Rihet P., Free PMC Article | 12/16/2017 |
| findings show HIV reservoir size is dependent on the presence of a defined NK cell population with a specific transcriptional signature: high NCR (NKp46 and NKp30) and IFN-gamma inducibility upon NCR and cytokine receptor engagement | Control of the HIV-1 DNA Reservoir Is Associated In Vivo and In Vitro with NKp46/NKp30 (CD335 CD337) Inducibility and Interferon Gamma Production by Transcriptionally Unique NK Cells.
Marras F, Casabianca A, Bozzano F, Ascierto ML, Orlandi C, Di Biagio A, Pontali E, Dentone C, Orofino G, Nicolini L, Taramasso L, Magnani M, Marincola FM, Wang E, Moretta L, De Maria A., Free PMC Article | 12/9/2017 |
| Copy number variations of HLA-I and activation of NKp30 pathway determine the sensitivity of gastric cancer cells to the cytotoxicity of natural killer cells | Copy number variations of HLA-I and activation of NKp30 pathway determine the sensitivity of gastric cancer cells to the cytotoxicity of natural killer cells.
Xing R, Li L, Chen L, Gao Z, Wang H, Li W, Cui J, Tian G, Liang Q, Yu J, Sung JJ, Luo G, Gao H, Xu X, Yang H, Wang J, Zhang X, Wang JM, Huang J, Yu Y, Wang J, Lu Y., Free PMC Article | 09/9/2017 |
| Data suggest that NK cells and NKp30 could play a role in Antisynthetase syndrome pathogenesis. | Involvement of NK Cells and NKp30 Pathway in Antisynthetase Syndrome.
Hervier B, Perez M, Allenbach Y, Devilliers H, Cohen F, Uzunhan Y, Ouakrim H, Dorgham K, Méritet JF, Longchampt E, Stenzel W, Cremer I, Benveniste O, Vieillard V. | 08/5/2017 |
| the stalk domains of NKp30 and NKp46, another NCR employing CD3zeta for signaling, were not exchangeable without drastic deficiencies in folding, plasma membrane targeting, and/or ligand-induced receptor signaling. | The Stalk Domain of NKp30 Contributes to Ligand Binding and Signaling of a Preassembled NKp30-CD3ζ Complex.
Memmer S, Weil S, Beyer S, Zöller T, Peters E, Hartmann J, Steinle A, Koch J., Free PMC Article | 05/27/2017 |
| Age and CMV serostatus influence the expression of NKp30, NKp46 and DNAM-1 activating receptors on resting and IL-2 activated natural killer cells. | Expression of NKp30, NKp46 and DNAM-1 activating receptors on resting and IL-2 activated NK cells from healthy donors according to CMV-serostatus and age.
Campos C, López N, Pera A, Gordillo JJ, Hassouneh F, Tarazona R, Solana R. | 06/4/2016 |
| NKp30-B7-H6 interaction is a novel cell contact mechanism that mediates activation of Group 2 innate lymphoid cells and identifies a potential target for the development of novel therapeutics for atopic dermatitis and other atopic diseases. | Group 2 Innate Lymphoid Cells Express Functional NKp30 Receptor Inducing Type 2 Cytokine Production.
Salimi M, Xue L, Jolin H, Hardman C, Cousins DJ, McKenzie AN, Ogg GS., Free PMC Article | 05/28/2016 |
| Our results suggest that NKP30-B7-H6 interaction can aggravate hepatocyte damage, probably through up-regulation of IL-32 expression in hepatitis B virus-related acute-on-chronic liver failure | NKP30-B7-H6 Interaction Aggravates Hepatocyte Damage through Up-Regulation of Interleukin-32 Expression in Hepatitis B Virus-Related Acute-On-Chronic Liver Failure.
Zou Y, Bao J, Pan X, Lu Y, Liao S, Wang X, Wang G, Lin D., Free PMC Article | 05/14/2016 |
| the interaction between NKp30 and B7-H6 may contribute to the fate of neuroblastoma patients | Clinical impact of the NKp30/B7-H6 axis in high-risk neuroblastoma patients.
Semeraro M, Rusakiewicz S, Minard-Colin V, Delahaye NF, Enot D, Vély F, Marabelle A, Papoular B, Piperoglou C, Ponzoni M, Perri P, Tchirkov A, Matta J, Lapierre V, Shekarian T, Valsesia-Wittmann S, Commo F, Prada N, Poirier-Colame V, Bressac B, Cotteret S, Brugieres L, Farace F, Chaput N, Kroemer G, Valteau-Couanet D, Zitvogel L. | 01/16/2016 |
| Suggest role for NKp30 isoforms in influencing liver damage and ensuing fibrosis in chronic hepatitis C infection. | NKp30 isoforms in patients with chronic hepatitis C virus infection.
Mantovani S, Mele D, Oliviero B, Barbarini G, Varchetta S, Mondelli MU., Free PMC Article | 12/19/2015 |
| show that in addition to NKG2D, human CEACAM1 can inhibit NK-cell activation via NKp30 or 2B4 | Inhibition of NKp30- and 2B4-mediated NK cell activation by evolutionary different human and bovine CEACAM1 receptors.
Merkt W, Urlaub D, Meinke S, Kammerer R, Watzl C. | 09/26/2015 |