| Chloride intracellular channel 4 participates in the regulation of lipopolysaccharide-induced inflammatory responses in human bronchial epithelial cells. | Chloride intracellular channel 4 participates in the regulation of lipopolysaccharide-induced inflammatory responses in human bronchial epithelial cells.
Luo J, Wang J, Liu H, Jiang W, Pan L, Huang W, Liu C, Qu X, Liu C, Qin X, Xiang Y. | 09/12/2024 |
| CLIC4 Function in the Epithelial-Mesenchymal Transition of Epithelial Odontogenic Lesions. | CLIC4 Function in the Epithelial-Mesenchymal Transition of Epithelial Odontogenic Lesions.
Xerez MC, da Silva Barros CC, de Souto Medeiros MR, Mafra RP, de Lucena HF, da Silveira ÉJD, de Lisboa Lopes Costa A., | 05/30/2024 |
| CLIC4 Regulates Endothelial Barrier Control by Mediating PAR1 Signaling via RhoA. | CLIC4 Regulates Endothelial Barrier Control by Mediating PAR1 Signaling via RhoA.
Kleinjan ML, Mao Y, Naiche LA, Joshi JC, Gupta A, Jesse JJ, Shaye DD, Mehta D, Kitajewski J., Free PMC Article | 09/6/2023 |
| The stromal immunoexpression of CLIC4 may be related to the difference in the biological behavior between oral squamous cell carcinoma and oral verrucous carcinoma. | The stromal immunoexpression of CLIC4 may be related to the difference in the biological behavior between oral squamous cell carcinoma and oral verrucous carcinoma.
Xerez MC, Barros CC, Queiroz SI, Silveira ÉJ, Costa AD., Free PMC Article | 08/28/2023 |
| Host CLIC4 expression in the tumor microenvironment is essential for breast cancer metastatic competence. | Host CLIC4 expression in the tumor microenvironment is essential for breast cancer metastatic competence.
Sanchez VC, Yang HH, Craig-Lucas A, Dubois W, Carofino BL, Lack J, Dwyer JE, Simpson RM, Cataisson C, Lee MP, Luo J, Hunter KW, Yuspa SH., Free PMC Article | 07/16/2022 |
| Requirement of CLIC4 Expression in Human Colorectal Cancer Cells for Sensitivity to Growth Inhibition by Fucoxanthinol. | Requirement of CLIC4 Expression in Human Colorectal Cancer Cells for Sensitivity to Growth Inhibition by Fucoxanthinol.
Yokoyama R, Kushibiki A, Yamada S, Kubota A, Kojima H, Ohta T, Hamada J, Maeda H, Mutoh M, Terasaki M., Free PMC Article | 07/2/2022 |
| Induction of Pro-Fibrotic CLIC4 in Dermal Fibroblasts by TGF-beta/Wnt3a Is Mediated by GLI2 Upregulation. | Induction of Pro-Fibrotic CLIC4 in Dermal Fibroblasts by TGF-β/Wnt3a Is Mediated by GLI2 Upregulation.
Wasson CW, Caballero-Ruiz B, Gillespie J, Derrett-Smith E, Mankouri J, Denton CP, Canettieri G, Riobo-Del Galdo NA, Del Galdo F., Free PMC Article | 04/16/2022 |
| Characterization of chloride intracellular channel 4 in the regulation of human trophoblast function. | Characterization of chloride intracellular channel 4 in the regulation of human trophoblast function.
Zhou W, Menkhorst E, Dimitriadis E. | 03/12/2022 |
| Circular RNA_0033596 aggravates endothelial cell injury induced by oxidized low-density lipoprotein via microRNA-217-5p /chloride intracellular channel 4 axis. | Circular RNA_0033596 aggravates endothelial cell injury induced by oxidized low-density lipoprotein via microRNA-217-5p /chloride intracellular channel 4 axis.
Jing B, Hui Z., Free PMC Article | 02/26/2022 |
| Detection of Cells Displaying High Expression of CLIC4 in Tumor Tissue of Patients With Colorectal Cancer. | Detection of Cells Displaying High Expression of CLIC4 in Tumor Tissue of Patients With Colorectal Cancer.
Yokoyama R, Kubota A, Kojima H, Tanaka T, Mutoh M, Terasaki M., Free PMC Article | 10/30/2021 |
| The intracellular chloride channel 4 (CLIC4) activates systemic sclerosis fibroblasts. | The intracellular chloride channel 4 (CLIC4) activates systemic sclerosis fibroblasts.
Wasson CW, Ross RL, Morton R, Mankouri J, Del Galdo F. | 10/9/2021 |
| Astragaloside IV alleviates atherosclerosis through targeting circ_0000231/miR-135a-5p/CLIC4 axis in AS cell model in vitro. | Astragaloside IV alleviates atherosclerosis through targeting circ_0000231/miR-135a-5p/CLIC4 axis in AS cell model in vitro.
Shao X, Liu Z, Liu S, Lin N, Deng Y. | 07/17/2021 |
| Chloride intracellular channel 4 is dysregulated in endometrium of women with infertility and alters receptivity. | Chloride intracellular channel 4 is dysregulated in endometrium of women with infertility and alters receptivity.
Ling CK, Santos LL, Zhou W, Dimitriadis E. | 03/20/2021 |
| CLIC4 and CLIC1 bridge plasma membrane and cortical actin network for a successful cytokinesis. | CLIC4 and CLIC1 bridge plasma membrane and cortical actin network for a successful cytokinesis.
Uretmen Kagiali ZC, Saner N, Akdag M, Sanal E, Degirmenci BS, Mollaoglu G, Ozlu N., Free PMC Article | 03/13/2021 |
| CLIC4 abrogation promotes epithelial-mesenchymal transition in gastric cancer. | CLIC4 abrogation promotes epithelial-mesenchymal transition in gastric cancer.
Wang B, Zheng J, Chen Q, Wu C, Li Y, Yu XY, Liu B, Liang C, Liu SB, Ding H, Wang S, Xue T, Song D, Lei Z, Amin HM, Song YH, Zhou J. | 10/31/2020 |
| CLIC4 regulates late endosomal trafficking and matrix degradation activity of MMP14 at focal adhesions in RPE cells. | CLIC4 regulates late endosomal trafficking and matrix degradation activity of MMP14 at focal adhesions in RPE cells.
Hsu KS, Otsu W, Li Y, Wang HC, Chen S, Tsang SH, Chuang JZ, Sung CH., Free PMC Article | 10/24/2020 |
| Cellular CLIC1 and CLIC4 are required for efficient Chikungunya virus replication. | Chikungunya virus requires cellular chloride channels for efficient genome replication.
Müller M, Slivinski N, Todd EJAA, Khalid H, Li R, Karwatka M, Merits A, Mankouri J, Tuplin A., Free PMC Article | 02/1/2020 |
| These results suggest CLIC1 and CLIC4 are promising serum and tissue biomarkers as well as potential therapeutic targets for all EOC subtypes. This justifies development of high throughput serum/plasma biomarker assays to evaluate utility of a biomarker panel consisting of CLIC1, CLIC4 and CA125. | CLIC1 and CLIC4 complement CA125 as a diagnostic biomarker panel for all subtypes of epithelial ovarian cancer.
Singha B, Harper SL, Goldman AR, Bitler BG, Aird KM, Borowsky ME, Cadungog MG, Liu Q, Zhang R, Jean S, Drapkin R, Speicher DW., Free PMC Article | 11/2/2019 |
| through profilin-1 binding, CLIC4 functions in a RhoA-mDia2-regulated signaling network to integrate cortical actin assembly and membrane protrusion | Profilin binding couples chloride intracellular channel protein CLIC4 to RhoA-mDia2 signaling and filopodium formation.
Argenzio E, Klarenbeek J, Kedziora KM, Nahidiazar L, Isogai T, Perrakis A, Jalink K, Moolenaar WH, Innocenti M., Free PMC Article | 04/13/2019 |
| High CLIC4 expression is associated with Merkel cell polyomavirus positive Merkel cell carcinoma. | The cellular chloride channels CLIC1 and CLIC4 contribute to virus-mediated cell motility.
Stakaitytė G, Nwogu N, Lippiat JD, Blair GE, Poterlowicz K, Boyne JR, Macdonald A, Mankouri J, Whitehouse A., Free PMC Article | 01/19/2019 |
| Results provide evidence that the G4 structure formed in the CLIC4 promoter region may act as a regulatory element in regulating CLIC4 gene transcription. | A G-Quadruplex Structure in the Promoter Region of CLIC4 Functions as a Regulatory Element for Gene Expression.
Huang MC, Chu IT, Wang ZF, Lin S, Chang TC, Chen CT., Free PMC Article | 12/29/2018 |
| CLIC4 and Ihh could serve as biological markers for the progression, metastasis and/or invasiveness of pancreatic ductal adenocarcinoma. | Association of chloride intracellular channel 4 and Indian hedgehog proteins with survival of patients with pancreatic ductal adenocarcinoma.
Zou Q, Yang Z, Li D, Liu Z, Yuan Y., Free PMC Article | 07/8/2017 |
| in malignant pleural mesothelioma, the gene expressions of CLIC3 and CLIC4 were significantly increased compared to controls | Transcriptional over-expression of chloride intracellular channels 3 and 4 in malignant pleural mesothelioma.
Tasiopoulou V, Magouliotis D, Solenov EI, Vavougios G, Molyvdas PA, Gourgoulianis KI, Hatzoglou C, Zarogiannis SG. | 09/24/2016 |
| CLIC1 and CLIC4 are overexpressed in specific tumor types or their corresponding stroma and change localization and function from hydrophilic cytosolic to integral transmembrane proteins. (Review) | Chloride channels in cancer: Focus on chloride intracellular channel 1 and 4 (CLIC1 AND CLIC4) proteins in tumor development and as novel therapeutic targets.
Peretti M, Angelini M, Savalli N, Florio T, Yuspa SH, Mazzanti M. | 11/28/2015 |
| CLIC4 knockdown decreases cell-matrix adhesion, cell spreading and integrin signaling, whereas it increases cell motility. | CLIC4 regulates cell adhesion and β1 integrin trafficking.
Argenzio E, Margadant C, Leyton-Puig D, Janssen H, Jalink K, Sonnenberg A, Moolenaar WH. | 11/21/2015 |