| Deciphering the role of SAMHD1 in endometrial cancer progression. | Deciphering the role of SAMHD1 in endometrial cancer progression.
Qiang P, Chen Y, Shao Y, Deng Q, Xu S, Zhu W., Free PMC Article | 10/17/2024 |
| Acetylation of SAMHD1 at lysine 580 is crucial for blocking HIV-1 infection. | Acetylation of SAMHD1 at lysine 580 is crucial for blocking HIV-1 infection.
Bulnes-Ramos A, Schott K, Rabinowitz J, Luchsinger C, Bertelli C, Miyagi E, Yu CH, Persaud M, Shepard C, König R, Kim B, Ivanov DN, Strebel K, Diaz-Griffero F., Free PMC Article | 09/17/2024 |
| SAMHD1 dysfunction induces IL-34 expression via NF-kappaB p65 in neuronal SH-SY5Y cells. | SAMHD1 dysfunction induces IL-34 expression via NF-κB p65 in neuronal SH-SY5Y cells.
Zhang L, Wang W, Chen T, Cui J, Li X, Liu A, Liu R, Fang L, Jiang J, Yang L, Wu D, Ying S. | 03/29/2024 |
| SAMHD1 compound heterozygous rare variants associated with moyamoya and mitral valve disease in the absence of other features of Aicardi-Goutieres syndrome. | SAMHD1 compound heterozygous rare variants associated with moyamoya and mitral valve disease in the absence of other features of Aicardi-Goutières syndrome.
Karla AR, Pinard A, Boerio ML, Hemelsoet D, Tavernier SJ, De Pauw M, Vereecke E, Fraser S, Bamshad MJ, Guo D, Callewaert B, Milewicz DM. | 03/11/2024 |
| Gene editing of SAMHD1 in macrophage-like cells reveals complex relationships between SAMHD1 phospho-regulation, HIV-1 restriction, and cellular dNTP levels. | Gene editing of SAMHD1 in macrophage-like cells reveals complex relationships between SAMHD1 phospho-regulation, HIV-1 restriction, and cellular dNTP levels.
Schüssler M, Schott K, Fuchs NV, Oo A, Zahadi M, Rauch P, Kim B, König R., Free PMC Article | 01/3/2024 |
| Guanine-containing ssDNA and RNA induce dimeric and tetrameric structural forms of SAMHD1. | Guanine-containing ssDNA and RNA induce dimeric and tetrameric structural forms of SAMHD1.
Orris B, Sung MW, Bhat S, Xu Y, Huynh KW, Han S, Johnson DC, Bosbach B, Shields DJ, Stivers JT., Free PMC Article | 12/20/2023 |
| Activation of STING by SAMHD1 Deficiency Promotes PANoptosis and Enhances Efficacy of PD-L1 Blockade in Diffuse Large B-cell Lymphoma. | Activation of STING by SAMHD1 Deficiency Promotes PANoptosis and Enhances Efficacy of PD-L1 Blockade in Diffuse Large B-cell Lymphoma.
Cai Y, Chen X, Lu T, Fang X, Ding M, Yu Z, Hu S, Liu J, Zhou X, Wang X., Free PMC Article | 10/4/2023 |
| SAMHD1-induced endosomal FAK signaling promotes human renal clear cell carcinoma metastasis by activating Rac1-mediated lamellipodia protrusion. | SAMHD1-induced endosomal FAK signaling promotes human renal clear cell carcinoma metastasis by activating Rac1-mediated lamellipodia protrusion.
An S, Vo TTL, Son T, Choi H, Kim J, Lee J, Kim BH, Choe M, Ha E, Surh YJ, Kim KW, Seo JH., Free PMC Article | 08/25/2023 |
| SAMHD1 single nucleotide polymorphisms impact outcome in children with newly diagnosed acute myeloid leukemia. | SAMHD1 single nucleotide polymorphisms impact outcome in children with newly diagnosed acute myeloid leukemia.
Marrero RJ, Cao X, Wu H, Elsayed AH, Klco JM, Ribeiro RC, Rubnitz JE, Ma X, Meshinchi S, Aplenc R, Kolb EA, Ries RE, Alonzo TA, Pounds SB, Lamba JK., Free PMC Article | 08/24/2023 |
| SAMHD1 impairs type I interferon induction through the MAVS, IKKepsilon, and IRF7 signaling axis during viral infection. | SAMHD1 impairs type I interferon induction through the MAVS, IKKε, and IRF7 signaling axis during viral infection.
Espada CE, Sari L, Cahill MP, Yang H, Phillips S, Martinez N, Kenney AD, Yount JS, Xiong Y, Lin MM, Wu L., Free PMC Article | 08/3/2023 |
| Protein oxidation increases SAMHD1 binding ssDNA via its regulatory site. | Protein oxidation increases SAMHD1 binding ssDNA via its regulatory site.
Simermeyer TL, Batalis S, Rogers LC, Zalesak OJ, Hollis T., Free PMC Article | 07/27/2023 |
| The host antiviral protein SAMHD1 suppresses NF-kappaB activation by interacting with the IKK complex during inflammatory responses and viral infection. | The host antiviral protein SAMHD1 suppresses NF-κB activation by interacting with the IKK complex during inflammatory responses and viral infection.
Yang H, Espada CE, Phillips S, Martinez N, Kenney AD, Yount JS, Xiong Y, Wu L., Free PMC Article | 07/3/2023 |
| Recombinant Klotho attenuates IFNgamma receptor signaling and SAMHD1 expression through blocking NF-kappaB translocation in glomerular mesangial cells. | Recombinant Klotho attenuates IFNγ receptor signaling and SAMHD1 expression through blocking NF-κB translocation in glomerular mesangial cells.
Tsai KD, Lee YC, Chen BY, Wu LS, Liang SY, Liu MY, Hung YW, Hsu HL, Chen PQ, Shieh JC, Lee YJ, Lin TH., Free PMC Article | 05/25/2023 |
| Purified recombinant lentiviral Vpx proteins maintain their SAMHD1 degradation efficiency in resting CD4[+] T cells. | Purified recombinant lentiviral Vpx proteins maintain their SAMHD1 degradation efficiency in resting CD4(+) T cells.
Nair R, Pignot Y, Salinas-Illarena A, Bärreiter VA, Wratil PR, Keppler OT, Wichmann C, Baldauf HM. | 05/8/2023 |
| SAMHD1 restricts the deoxyguanosine triphosphate pool contributing to telomere stability in telomerase-positive cells. | SAMHD1 restricts the deoxyguanosine triphosphate pool contributing to telomere stability in telomerase-positive cells.
D'Aronco G, Ferraro P, Sassano V, Dagostino C, Biancotto M, Palumbo E, Presot E, Russo A, Bianchi V, Rampazzo C. | 03/24/2023 |
| SAMHD1 expression modulates innate immune activation and correlates with ovarian cancer prognosis. | SAMHD1 expression modulates innate immune activation and correlates with ovarian cancer prognosis.
Gutiérrez-Chamorro L, Felip E, Bernat-Peguera A, Ezeonwumelu IJ, Teruel I, Martínez-Cardús A, Clotet B, Riveira-Muñoz E, Romeo M, Margelí M, Ballana E., Free PMC Article | 03/2/2023 |
| SAMHD1 silencing cooperates with radiotherapy to enhance anti-tumor immunity through IFI16-STING pathway in lung adenocarcinoma. | SAMHD1 silencing cooperates with radiotherapy to enhance anti-tumor immunity through IFI16-STING pathway in lung adenocarcinoma.
Li Y, Gao Y, Jiang X, Cheng Y, Zhang J, Xu L, Liu X, Huang Z, Xie C, Gong Y., Free PMC Article | 01/11/2023 |
| Interferon-inducible SAMHD1 restricts viral replication through downregulation of lipid synthesis. | Interferon-inducible SAMHD1 restricts viral replication through downregulation of lipid synthesis.
An N, Ge Q, Shao H, Li Q, Guo F, Liang C, Li X, Yi D, Yang L, Cen S., Free PMC Article | 12/24/2022 |
| Sulforaphane Reduces SAMHD1 Phosphorylation To Protect Macrophages from HIV-1 Infection. | Sulforaphane Reduces SAMHD1 Phosphorylation To Protect Macrophages from HIV-1 Infection.
Sharifi HJ, Paine DN, Fazzari VA, Tipple AF, Patterson E, de Noronha CMC., Free PMC Article | 12/24/2022 |
| SAMHD1 controls innate immunity by regulating condensation of immunogenic self RNA. | SAMHD1 controls innate immunity by regulating condensation of immunogenic self RNA.
Maharana S, Kretschmer S, Hunger S, Yan X, Kuster D, Traikov S, Zillinger T, Gentzel M, Elangovan S, Dasgupta P, Chappidi N, Lucas N, Maser KI, Maatz H, Rapp A, Marchand V, Chang YT, Motorin Y, Hubner N, Hartmann G, Hyman AA, Alberti S, Lee-Kirsch MA. | 10/15/2022 |
| SAMHD1 associates with inflammation and vasculitis in paediatric-onset systemic lupus erythematosus. | SAMHD1 associates with inflammation and vasculitis in paediatric-onset systemic lupus erythematosus.
Zhao X, Li C, Li S, Zhang J, Kuang W, Deng J, Tan X, Li C, Wang J. | 10/8/2022 |
| SAMHD1, positively regulated by KLF4, suppresses the proliferation of gastric cancer cells through MAPK p38 signaling pathway. | SAMHD1, positively regulated by KLF4, suppresses the proliferation of gastric cancer cells through MAPK p38 signaling pathway.
Chen Z, Jiang Z, Meng L, Wang Y, Lin M, Wei Z, Han W, Ying S, Xu A., Free PMC Article | 09/17/2022 |
| Mechanistic Interplay between HIV-1 Reverse Transcriptase Enzyme Kinetics and Host SAMHD1 Protein: Viral Myeloid-Cell Tropism and Genomic Mutagenesis. | Mechanistic Interplay between HIV-1 Reverse Transcriptase Enzyme Kinetics and Host SAMHD1 Protein: Viral Myeloid-Cell Tropism and Genomic Mutagenesis.
Bowen NE, Oo A, Kim B., Free PMC Article | 08/6/2022 |
| Pharmacological Targeting of Sphingosine Kinases Impedes HIV-1 Infection of CD4 T Cells through SAMHD1 Modulation. | Pharmacological Targeting of Sphingosine Kinases Impedes HIV-1 Infection of CD4 T Cells through SAMHD1 Modulation.
Resop RS, Bosque A., Free PMC Article | 05/21/2022 |
| Elimination of Aicardi-Goutieres syndrome protein SAMHD1 activates cellular innate immunity and suppresses SARS-CoV-2 replication. | Elimination of Aicardi-Goutières syndrome protein SAMHD1 activates cellular innate immunity and suppresses SARS-CoV-2 replication.
Oo A, Zandi K, Shepard C, Bassit LC, Musall K, Goh SL, Cho YJ, Kim DH, Schinazi RF, Kim B., Free PMC Article | 04/30/2022 |