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    GAP43 growth associated protein 43 [ Homo sapiens (human) ]

    Gene ID: 2596, updated on 2-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Associations of Growth-Associated Protein 43 with Cerebral Microbleeds: A Longitudinal Study.

    Associations of Growth-Associated Protein 43 with Cerebral Microbleeds: A Longitudinal Study.
    Li D, Sun Y, Ding L, Fu Y, Zhou J, Yu JT, Tan L, Alzheimer’s Disease Neuroimaging Initiative.

    02/20/2024
    Association of APOE-epsilon4 and GAP-43-related presynaptic loss with beta-amyloid, tau, neurodegeneration, and cognitive decline.

    Association of APOE-ε4 and GAP-43-related presynaptic loss with β-amyloid, tau, neurodegeneration, and cognitive decline.
    Lan G, Du J, Chen X, Wang Q, Alzheimer’s Disease Neuroimaging Initiative, Han Y, Guo T.

    11/29/2023
    GAP43-dependent mitochondria transfer from astrocytes enhances glioblastoma tumorigenicity.

    GAP43-dependent mitochondria transfer from astrocytes enhances glioblastoma tumorigenicity.
    Watson DC, Bayik D, Storevik S, Moreino SS, Sprowls SA, Han J, Augustsson MT, Lauko A, Sravya P, Røsland GV, Troike K, Tronstad KJ, Wang S, Sarnow K, Kay K, Lunavat TR, Silver DJ, Dayal S, Joseph JV, Mulkearns-Hubert E, Ystaas LAR, Deshpande G, Guyon J, Zhou Y, Magaut CR, Seder J, Neises L, Williford SE, Meiser J, Scott AJ, Sajjakulnukit P, Mears JA, Bjerkvig R, Chakraborty A, Daubon T, Cheng F, Lyssiotis CA, Wahl DR, Hjelmeland AB, Hossain JA, Miletic H, Lathia JD., Free PMC Article

    06/1/2023
    Growth associated protein 43 deficiency promotes podocyte injury by activating the calmodulin/calcineurin pathway under hyperglycemia.

    Growth associated protein 43 deficiency promotes podocyte injury by activating the calmodulin/calcineurin pathway under hyperglycemia.
    Yang Y, Shi W, Li C, Li L, Li J, Chen Y, Shi Q, Xie Z, Wang M, Zhang H, Zhao X, Chen Y, Li R, Liu S, Ye Z, Zhang L, Liang X.

    04/12/2023
    Impact of GAP-43, Cx43 and actin expression on the outcome and overall survival in diffuse and anaplastic gliomas.

    Impact of GAP-43, Cx43 and actin expression on the outcome and overall survival in diffuse and anaplastic gliomas.
    Krigers A, Demetz M, Moser P, Kerschbaumer J, Brawanski KR, Fritsch H, Thomé C, Freyschlag CF., Free PMC Article

    02/11/2023
    Association of CSF GAP-43 and APOE epsilon4 with Cognition in Mild Cognitive Impairment and Alzheimer's Disease.

    Association of CSF GAP-43 and APOE ε4 with Cognition in Mild Cognitive Impairment and Alzheimer's Disease.
    Zhu Y, Guo X, Zhu F, Zhang Q, Yang Y, For The Alzheimer's Disease Neuroimaging Initiative., Free PMC Article

    01/21/2023
    Cutaneous expression of growth-associated protein 43 is not a compelling marker for human nerve regeneration in carpal tunnel syndrome.

    Cutaneous expression of growth-associated protein 43 is not a compelling marker for human nerve regeneration in carpal tunnel syndrome.
    Carroll L, Sandy-Hindmarch O, Baskozos G, Zhu GC, McCarthy J, Schmid A., Free PMC Article

    11/26/2022
    Prognostic value of cutaneous reinnervation with GAP-43 in oxaliplatin-induced neuropathy.

    Prognostic value of cutaneous reinnervation with GAP-43 in oxaliplatin-induced neuropathy.
    Albayrak M, Figueras C, Seguí E, Campolo M, Gabarrón E, Moreno R, Maurel J, Casanova-Molla J., Free PMC Article

    07/23/2022
    The advanced development of Cx43 and GAP-43 mediated intercellular networking in IDH1 wildtype diffuse and anaplastic gliomas with lower mitotic rate.

    The advanced development of Cx43 and GAP-43 mediated intercellular networking in IDH1 wildtype diffuse and anaplastic gliomas with lower mitotic rate.
    Krigers A, Moser P, Fritsch H, Demetz M, Brawanski K, Thomé C, Freyschlag CF.

    09/18/2021
    Transcriptome profiling unveils GAP43 regulates ABC transporters and EIF2 signaling in colorectal cancer cells.

    Transcriptome profiling unveils GAP43 regulates ABC transporters and EIF2 signaling in colorectal cancer cells.
    Chen X, Wu H, Feng J, Li Y, Lv J, Shi W, Fan W, Xiao L, Sun D, Jiang M, Shi M., Free PMC Article

    05/15/2021
    Cerebrospinal fluid growth-associated protein 43 in multiple sclerosis.

    Cerebrospinal fluid growth-associated protein 43 in multiple sclerosis.
    Sandelius Å, Sandgren S, Axelsson M, Malmeström C, Novakova L, Kostanjevecki V, Vandijck M, Blennow K, Zetterberg H, Lycke J., Free PMC Article

    11/21/2020
    Growth-associated protein 43 promotes thyroid cancer cell lines progression via epithelial-mesenchymal transition.

    Growth-associated protein 43 promotes thyroid cancer cell lines progression via epithelial-mesenchymal transition.
    Zheng C, Quan RD, Wu CY, Hu J, Lin BY, Dong XB, Xia EJ, Bhandari A, Zhang XH, Wang OC., Free PMC Article

    10/24/2020
    GAL, GAP43 and NRSN1 single nucleotide polymorphisms and related gene-gene interaction networks might be involved in the altered susceptibility to Hirschsprung disease in the Han Chinese population.

    Common genetic variants in GAL, GAP43 and NRSN1 and interaction networks confer susceptibility to Hirschsprung disease.
    Wang Y, Yan W, Wang J, Zhou Y, Chen J, Gu B, Cai W., Free PMC Article

    12/14/2019
    GAP43 is an independent predictor of non-small cell lung cancer brain metastasis.

    GAP43, a novel metastasis promoter in non-small cell lung cancer.
    Zhang F, Ying L, Jin J, Feng J, Chen K, Huang M, Wu Y, Yu H, Su D., Free PMC Article

    07/13/2019
    We found an increased expression of Nestin and GAP43 (growth associated protein 43) in treated cells. In conclusion, Periodontal ligament mesenchymal stem cells (hPDLSCs) treated with Moringin and Cannabidiol showed an improved survival capacity and neuronal differentiation potential

    Treatment of Periodontal Ligament Stem Cells with MOR and CBD Promotes Cell Survival and Neuronal Differentiation via the PI3K/Akt/mTOR Pathway.
    Lanza Cariccio V, Scionti D, Raffa A, Iori R, Pollastro F, Diomede F, Bramanti P, Trubiani O, Mazzon E., Free PMC Article

    12/22/2018
    The expression pattern of the regeneration-associated protein GAP-43 suggested a lower regenerative capacity in nigral dopaminergic neurons of Parkinson disease patients.

    Altered Expression of Growth Associated Protein-43 and Rho Kinase in Human Patients with Parkinson's Disease.
    Saal KA, Galter D, Roeber S, Bähr M, Tönges L, Lingor P., Free PMC Article

    02/24/2018
    Findings show high level of both YKL-40 and GAP-43 in CSF of older women with suicidal ideation which suggest that a disrupted synaptic glial functioning and inflammation may be related to the aetiology of suicidal ideation in older adults.

    CSF YKL-40 and GAP-43 are related to suicidal ideation in older women.
    Rymo I, Kern S, Bjerke M, Zetterberg H, Marlow T, Blennow K, Gudmundsson P, Skoog I, Waern M.

    10/7/2017
    associations of neuromodulin and neurogranin to Alzheimer's disease

    CSF profiling of the human brain enriched proteome reveals associations of neuromodulin and neurogranin to Alzheimer's disease.
    Remnestål J, Just D, Mitsios N, Fredolini C, Mulder J, Schwenk JM, Uhlén M, Kultima K, Ingelsson M, Kilander L, Lannfelt L, Svenningsson P, Nellgård B, Zetterberg H, Blennow K, Nilsson P, Häggmark-Månberg A., Free PMC Article

    09/23/2017
    Copy-number variations are enriched for GAP43 and other neurodevelopmental genes in children with developmental coordination disorder.

    Copy-number variations are enriched for neurodevelopmental genes in children with developmental coordination disorder.
    Mosca SJ, Langevin LM, Dewey D, Innes AM, Lionel AC, Marshall CC, Scherer SW, Parboosingh JS, Bernier FP.

    08/26/2017
    Downregulation of GAP43 promotes gliomas.

    MiRNA expression profiling in human gliomas: upregulated miR-363 increases cell survival and proliferation.
    Conti A, Romeo SG, Cama A, La Torre D, Barresi V, Pezzino G, Tomasello C, Cardali S, Angileri FF, Polito F, Ferlazzo G, Di Giorgio R, Germanò A, Aguennouz M.

    02/18/2017
    The peripheral neuropathies lead to an initial increase in GAP-43 gene expression as a potential mechanism of regeneration, which is not sustained in neuropathies of long duration.

    Increased gene expression of growth associated protein-43 in skin of patients with early-stage peripheral neuropathies.
    Scheytt S, Riediger N, Braunsdorf S, Sommer C, Üçeyler N.

    04/2/2016
    Results show that PKC-dependent phosphorylation of GAP43 plays a critical role in regulating postsynaptic gephyrin aggregation in developing GABAergic synapses.

    Protein kinase C-dependent growth-associated protein 43 phosphorylation regulates gephyrin aggregation at developing GABAergic synapses.
    Wang CY, Lin HC, Song YP, Hsu YT, Lin SY, Hsu PC, Lin CH, Hung CC, Hsu MC, Kuo YM, Lee YJ, Hsu CY, Lee YH., Free PMC Article

    07/25/2015
    increased expression of TH and GAP43 might be a molecular mechanism for left atrial myoelectricity remodeling of aging atrial fibrillation patients, which might be potential therapeutic targets of atrial fibrillation.

    Expression of tyrosine hydroxylase and growth-associated protein 43 in aging atrial fibrillation patients of Xinjiang Uygur and Han nationality.
    Li YD, Li JX, Tang BP, Gan TY, Xu GJ, Zhou XH, Li H, Guo X, Mahemuti A, Sun Q, Zhang YY, Wang J.

    02/21/2015
    GAP43 is seemingly a highly sensitive marker for peripheral nerve sheath tumors

    Growth-associated protein 43 in differentiating peripheral nerve sheath tumors from other non-neural spindle cell neoplasms.
    Chen WS, Chen PL, Lu D, Lind AC, Dehner LP.

    09/27/2014
    The results showed that the decreased GAP-43 levels induced by glutamate could be partially reversed by the presence of NRG-1beta

    Effects of neuregulin-1β on growth-associated protein 43 expression in dorsal root ganglion neurons with excitotoxicity induced by glutamate in vitro.
    Li Y, Li H, Liu G, Liu Z.

    01/18/2014
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