| The function role of HIGD1A in nonalcoholic steatohepatitis from chronic hepatitis B. | The function role of HIGD1A in nonalcoholic steatohepatitis from chronic hepatitis B.
Li MR, Li JZ, Wang DH, Li TY, Ye LH, Liang XJ, Zhang HC, Liu ZQ, Zhang XD, Li JQ, Liu YY, Pan CQ, Dai EH. | 04/3/2024 |
| Mitochondrial HIGD1A inhibits hepatitis B virus transcription and replication through the cellular PNKD-NF-kappaB-NR2F1 nexus. | Mitochondrial HIGD1A inhibits hepatitis B virus transcription and replication through the cellular PNKD-NF-κB-NR2F1 nexus.
Xie Z, Shen S, Huang K, Wang W, Liu Z, Zhang H, Lu M, Sun J, Hou J, Liu H, Guo H, Zhang X. | 05/24/2023 |
| HIGD1A inactivated by DNA hypermethylation promotes invasion of kidney renal clear cell carcinoma. | HIGD1A inactivated by DNA hypermethylation promotes invasion of kidney renal clear cell carcinoma.
Li L, Zhao J, Zhang H, Li D, Wu S, Xu W, Pan X, Hu W, Chu J, Luo W, Li P, Zhou X. | 05/20/2023 |
| HIG1 domain family member 1A is a crucial regulator of disorders associated with hypoxia. | HIG1 domain family member 1A is a crucial regulator of disorders associated with hypoxia.
Jia YZ, Liu J, Wang GQ, Pan H, Huang TZ, Liu R, Zhang Y. | 03/15/2023 |
| HIG1 domain family member 1A disrupts proliferation, migration, and invasion of colon adenocarcinoma cells. | HIG1 domain family member 1A disrupts proliferation, migration, and invasion of colon adenocarcinoma cells.
Xu Z, Sun J, Mao Y, Chen Y, Zhang T, Qin Y, Hua D., Free PMC Article | 02/26/2022 |
| Distinct Roles of Mitochondrial HIGD1A and HIGD2A in Respiratory Complex and Supercomplex Biogenesis. | Distinct Roles of Mitochondrial HIGD1A and HIGD2A in Respiratory Complex and Supercomplex Biogenesis.
Timón-Gómez A, Garlich J, Stuart RA, Ugalde C, Barrientos A. | 06/5/2021 |
| Higd1a, or its mimic, provides therapeutic options for the treatment of mitochondrial diseases. | Higd1a improves respiratory function in the models of mitochondrial disorder.
Nagao T, Shintani Y, Hayashi T, Kioka H, Kato H, Nishida Y, Yamazaki S, Tsukamoto O, Yashirogi S, Yazawa I, Asano Y, Shinzawa-Itoh K, Imamura H, Suzuki T, Suzuki T, Goto YI, Takashima S. | 07/11/2020 |
| High Higd-1a expression is associated with proliferation of pancreatic cancer cells through a pERK/p27/pRB pathway. | Higd-1a regulates the proliferation of pancreatic cancer cells through a pERK/p27(KIP1)/pRB pathway.
An HJ, Ryu M, Jeong HJ, Kang M, Jeon HM, Lee JO, Kim YS, Lee H. | 05/30/2020 |
| Higd1a plays positive roles in protecting cells from oxidative stress, and reactive oxygen species could induce Higd1a expression by upregulating PGC-1a and HIF-1a expressions. | Higd1a Protects Cells from Lipotoxicity under High-Fat Exposure.
Li T, Xian WJ, Gao Y, Jiang S, Yu QH, Zheng QC, Zhang Y., Free PMC Article | 12/21/2019 |
| Nuclear localization of the mitochondrial factor HIGD1A during metabolic stress. | Nuclear localization of the mitochondrial factor HIGD1A during metabolic stress.
Ameri K, Rajah AM, Nguyen V, Sanders TA, Jahangiri A, Delay M, Donne M, Choi HJ, Tormos KV, Yeghiazarians Y, Jeffrey SS, Rinaudo PF, Rowitch DH, Aghi M, Maltepe E., Free PMC Article | 11/30/2013 |
| Data indicate that hypoxia-induced gene domain protein-1a (Higd-1a) inhibits Optic atrophy 1 (Opa1) cleavage and is required for mitochondrial fusion by virtue of its interaction with Opa1. | Higd-1a interacts with Opa1 and is required for the morphological and functional integrity of mitochondria.
An HJ, Cho G, Lee JO, Paik SG, Kim YS, Lee H., Free PMC Article | 11/16/2013 |
| depletion of HIG1 increased gamma-secretase activation and enhanced hypoxia-induced mitochondrial dysfunction | HIG1, a novel regulator of mitochondrial γ-secretase, maintains normal mitochondrial function.
Hayashi H, Nakagami H, Takeichi M, Shimamura M, Koibuchi N, Oiki E, Sato N, Koriyama H, Mori M, Gerardo Araujo R, Maeda A, Morishita R, Tamai K, Kaneda Y. | 08/25/2012 |
| Observational study of gene-disease association. (HuGE Navigator) | Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ., Free PMC Article | 12/5/2010 |