| RUNX1 and REXO2 are associated with the heterogeneity and prognosis of IDH wild type lower grade glioma. | RUNX1 and REXO2 are associated with the heterogeneity and prognosis of IDH wild type lower grade glioma.
Wang H, Wang X, Xu L, Zhang J, Cao H., Free PMC Article | 11/22/2021 |
| Germline variant in REXO2 is a novel candidate gene in familial pheochromocytoma. | Germline variant in REXO2 is a novel candidate gene in familial pheochromocytoma.
Laitman Y, Tzur S, Attai R, Tirosh A, Friedman E., Free PMC Article | 01/23/2021 |
| Human REXO2 controls short mitochondrial RNAs generated by mtRNA processing and decay machinery to prevent accumulation of double-stranded RNA. | Human REXO2 controls short mitochondrial RNAs generated by mtRNA processing and decay machinery to prevent accumulation of double-stranded RNA.
Szewczyk M, Malik D, Borowski LS, Czarnomska SD, Kotrys AV, Klosowska-Kosicka K, Nowotny M, Szczesny RJ., Free PMC Article | 08/22/2020 |
| Efficient RNA turnover by REXO2 is thus required to maintain promoter specificity and proper regulation of transcription in mammalian mitochondria. | Dinucleotide Degradation by REXO2 Maintains Promoter Specificity in Mammalian Mitochondria.
Nicholls TJ, Spåhr H, Jiang S, Siira SJ, Koolmeister C, Sharma S, Kauppila JHK, Jiang M, Kaever V, Rackham O, Chabes A, Falkenberg M, Filipovska A, Larsson NG, Gustafsson CM., Free PMC Article | 02/22/2020 |
| This study provides the molecular basis for human Rexo2, showing how it binds and degrades nanoRNA into nucleoside monophosphates and plays a crucial role in RNA salvage pathways in mammalian mitochondria. | Structural insights into nanoRNA degradation by human Rexo2.
Chu LY, Agrawal S, Chen YP, Yang WZ, Yuan HS., Free PMC Article | 06/15/2019 |
| results demonstrate that 14-3-3sigma induces cisplatin resistance in esophageal squamous cell carcinoma cells | 14-3-3σ confers cisplatin resistance in esophageal squamous cell carcinoma cells via regulating DNA repair molecules.
Lai KK, Chan KT, Choi MY, Wang HK, Fung EY, Lam HY, Tan W, Tung LN, Tong DK, Sun RW, Lee NP, Law S. | 01/28/2017 |
| CBY1 downregulation in CML arises from reduced protein stability upon binding to 14-3-3sigma adapter protein. The ubiquitin proteasome system UPS participates in reducing stability of CBY1 bound with 14-3-3sigma through enhanced SUMOylation. | 14-3-3 Binding and Sumoylation Concur to the Down-Modulation of β-catenin Antagonist chibby 1 in Chronic Myeloid Leukemia.
Mancini M, Leo E, Takemaru K, Campi V, Castagnetti F, Soverini S, De Benedittis C, Rosti G, Cavo M, Santucci MA, Martinelli G., Free PMC Article | 04/16/2016 |
| Loss of 14-3-3sigma sensitizes cells to UVB. After a transient cell cycle arrest, 14-3-3sigma-deficient cells die by undergoing mitotic catastrophe. | The epithelium specific cell cycle regulator 14-3-3sigma is required for preventing entry into mitosis following ultraviolet B.
Vogel S, Herzinger T. | 11/8/2014 |
| REXO2 is an oligoribonuclease active in human mitochondria and present both in cytosolic and mitochondrial fractions. | REXO2 is an oligoribonuclease active in human mitochondria.
Bruni F, Gramegna P, Oliveira JM, Lightowlers RN, Chrzanowska-Lightowlers ZM., Free PMC Article | 02/22/2014 |
| Observational study of gene-disease association. (HuGE Navigator) | Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ., Free PMC Article | 12/5/2010 |
| The expression in E. coli of orn and homologues from Mycobacterium smegmatis and human, and large-scale purification of the three enzymes, is reported. | Hydrolysis of the 5'-p-nitrophenyl ester of TMP by oligoribonucleases (ORN) from Escherichia coli, Mycobacterium smegmatis, and human.
Young Park A, Elvin CM, Hamdan SM, Wood RJ, Liyou NE, Hamwood TE, Jennings PA, Dixon NE. | 01/21/2010 |
| SFN expression is involved in resistance of RSa cells to UV-C-induced cell death through the roles it plays in the DNA repair process | Involvement of human small fragment nuclease in the resistance of human cells to UV-C-induced cell death.
Ito S, Kita K, Zhai L, Wano C, Suzuki T, Yamaura A, Suzuki N. | 01/21/2010 |