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    AOC1 amine oxidase copper containing 1 [ Homo sapiens (human) ]

    Gene ID: 26, updated on 20-Apr-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    m6A-enriched lncRNA LINC00839 promotes tumor progression by enhancing TAF15-mediated transcription of amine oxidase AOC1 in nasopharyngeal carcinoma.

    m6A-enriched lncRNA LINC00839 promotes tumor progression by enhancing TAF15-mediated transcription of amine oxidase AOC1 in nasopharyngeal carcinoma.
    Zheng WH, Long ZQ, Zheng ZQ, Zhang LL, Liang YL, Li ZX, Lv JW, Kou J, Hong XH, He SW, Xu R, Zhou GQ, Liu N, Ma J, Sun Y, Lin L, Wei D., Free PMC Article

    08/1/2023
    DAO levels were higher in atopic asthma and allergic rhinitis patients compared to controls. DAO had a high sensitivity and negative predictive value. There was a positive correlation between severity of diseases and DAO. DAO may be helpful in the assessment of severity and in ruling out respiratory allergy.

    Diamine oxidase enzyme: a novel biomarker in respiratory allergy.
    Refaat MM, Abdel-Rehim AS, Elmahdi AR, Mohamed NA, Ghonaim SS.

    06/6/2020
    Plasma diamine oxidase level > 19.7 ng/mL predicts high rate of 6-month readmission in patients with HBV-related decompensated cirrhosis.

    Plasma diamine oxidase level predicts 6-month readmission for patients with hepatitis B virus-related decompensated cirrhosis.
    Li FC, Fan YC, Li YK, Wang K., Free PMC Article

    12/21/2019
    this study shows that single nucleotide polymorphism is associated with the severity of allergic rhinitis in a group of Mexican children

    Association between two polymorphisms of histamine-metabolising enzymes and the severity of allergic rhinitis in a group of Mexican children.
    Meza-Velázquez R, López-Márquez F, Espinosa-Padilla S, Rivera-Guillen M, Gutíerrez-Díaz N, Pérez-Armendáriz L, Rosales-González M.

    06/20/2018
    The T allele of rs3787429 exhibited protective effect against CHF under the dominant and additive models , while, for SNPs in HRH2, DAO, and HNMT, no significant associations were observed in the present study

    Associations of Polymorphisms in HRH2, HRH3, DAO, and HNMT Genes with Risk of Chronic Heart Failure.
    He GH, Cai WK, Zhang JB, Ma CY, Yan F, Lu J, Xu GL., Free PMC Article

    06/20/2018
    HRH1-17 TT and HNMT-1639 TT genotypes were associated with the allergic asthma phenotype among African-American children and that the ABP 4107 GG genotype was associated with nonallergic asthma among white children.

    Genetic Variation along the Histamine Pathway in Children with Allergic versus Nonallergic Asthma.
    Anvari S, Vyhlidal CA, Dai H, Jones BL., Free PMC Article

    04/9/2016
    This study findings suggest that DAO genotypes and allelic variants are associated with the risk for migraine in Caucasian Spanish people, especially in women.

    Diamine oxidase rs10156191 and rs2052129 variants are associated with the risk for migraine.
    García-Martín E, Martínez C, Serrador M, Alonso-Navarro H, Ayuso P, Navacerrada F, Agúndez JA, Jiménez-Jiménez FJ.

    09/12/2015
    Serum diamine oxidase levels were influenced by the menstrual cycle.

    Effect of the menstrual cycle on serum diamine oxidase levels in healthy women.
    Hamada Y, Shinohara Y, Yano M, Yamamoto M, Yoshio M, Satake K, Toda A, Hirai M, Usami M.

    06/8/2013
    Low diamine oxidase activity is associated with gastrointestinal tract toxicities during chemotherapy with oral fluorouracil anti-cancer drugs in patients with gastric cancer.(

    Plasma diamine oxidase activity is a useful biomarker for evaluating gastrointestinal tract toxicities during chemotherapy with oral fluorouracil anti-cancer drugs in patients with gastric cancer.
    Namikawa T, Fukudome I, Kitagawa H, Okabayashi T, Kobayashi M, Hanazaki K.

    06/23/2012
    Diamine oxidase (DAO) variants were not associated with the histamine intolerance (HIT) phenotype per se, only with DAO activity alone and the subgroup of HIT patients displaying a reduced DAO activity.

    Association of single nucleotide polymorphisms in the diamine oxidase gene with diamine oxidase serum activities.
    Maintz L, Yu CF, Rodríguez E, Baurecht H, Bieber T, Illig T, Weidinger S, Novak N.

    10/1/2011
    Low serum diamine oxidase activity in inflammatory bowel disease.

    Clinical significance of serum diamine oxidase activity in inflammatory bowel disease: Importance of evaluation of small intestinal permeability.
    Honzawa Y, Nakase H, Matsuura M, Chiba T.

    05/14/2011
    structure of human DAO refined to 2.1 A resolution in space group C222(1) with one molecule in the asymmetric unit is reported.

    A new crystal form of human diamine oxidase.
    McGrath AP, Hilmer KM, Collyer CA, Dooley DM, Guss JM., Free PMC Article

    03/15/2010
    The study of a non-synonymous single nucleotide polymorphisms(rs1049793) of diamine oxidase gene does not seem to be of use in assessing susceptibility to CD

    Analysis of a non-synonymous single nucleotide polymorphism of the human diamine oxidase gene (ref. SNP ID: rs1049793) in patients with Crohn's disease.
    López Palacios N, Agúndez JA, Mendoza JL, García-Martín E, Martínez C, Fuentes Ferrer ME, Ladero JM, Taxonera C, Díaz-Rubio M.

    03/15/2010
    An aspartic acid residue, conserved in all diamine oxidases, is responsible for the diamine specificity by interacting with the second amino group of preferred diamine substrates.

    Structure and inhibition of human diamine oxidase.
    McGrath AP, Hilmer KM, Collyer CA, Shepard EM, Elmore BO, Brown DE, Dooley DM, Guss JM., Free PMC Article

    01/21/2010
    Results examine the levels of serum soluble intercellular adhesion molecule-1 (sICAM-1), plasma D-lactate and diamine oxidase (DAO) in patients with inflammatory bowel disease.

    Soluble intercellular adhesion molecule-1, D-lactate and diamine oxidase in patients with inflammatory bowel disease.
    Song WB, Lv YH, Zhang ZS, Li YN, Xiao LP, Yu XP, Wang YY, Ji HL, Ma L., Free PMC Article

    01/21/2010
    An association of the HNMT Thr105Ile polymorphism, but not of the ABP1 His645Asp polymorphism, with PD was observed. Patients with PD showed a higher frequency of homozygous HNMT genotypes

    Nonsynonymous polymorphisms of histamine-metabolising enzymes in patients with Parkinson's disease.
    Agúndez JA, Luengo A, Herráez O, Martínez C, Alonso-Navarro H, Jiménez-Jiménez FJ, García-Martín E, Agúndez JA, Luengo A, Herráez O, Martínez C, Alonso-Navarro H, Jiménez-Jiménez FJ, García-Martín E.

    01/21/2010
    Observational study of gene-disease association. (HuGE Navigator)See all PubMed (5) articles

    Polymorphisms of two histamine-metabolizing enzymes genes and childhood allergic asthma: a case control study.
    Szczepankiewicz A, Bręborowicz A, Sobkowiak P, Popiel A.

    Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol?
    Ruaño G, Thompson PD, Kane JP, Pullinger CR, Windemuth A, Seip RL, Kocherla M, Holford TR, Wu AH.

    Nonsynonymous polymorphisms of histamine-metabolising enzymes in patients with Parkinson's disease.
    Agúndez JA, Luengo A, Herráez O, Martínez C, Alonso-Navarro H, Jiménez-Jiménez FJ, García-Martín E, Agúndez JA, Luengo A, Herráez O, Martínez C, Alonso-Navarro H, Jiménez-Jiménez FJ, García-Martín E.

    Genetic variability of human diamine oxidase: occurrence of three nonsynonymous polymorphisms and study of their effect on serum enzyme activity.
    Ayuso P, García-Martín E, Martínez C, Agúndez JA, Ayuso P, García-Martín E, Martínez C, Agúndez JA.

    Polymorphisms of histamine-metabolizing enzymes and clinical manifestations of asthma and allergic rhinitis.
    García-Martín E, García-Menaya J, Sánchez B, Martínez C, Rosendo R, Agúndez JA.

    03/13/2008
    Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)

    Severity of ulcerative colitis is associated with a polymorphism at diamine oxidase gene but not at histamine N-methyltransferase gene.
    García-Martin E, Mendoza JL, Martínez C, Taxonera C, Urcelay E, Ladero JM, de la Concha EG, Díaz-Rubio M, Agúndez JA., Free PMC Article

    03/13/2008
    Individuals carrying the 645Asp amino acid displayed lower serum diamine oxidase activity as compared with noncarriers (P<0.001) with a significant gene-dose effect (P<0.05).

    Genetic variability of human diamine oxidase: occurrence of three nonsynonymous polymorphisms and study of their effect on serum enzyme activity.
    Ayuso P, García-Martín E, Martínez C, Agúndez JA, Ayuso P, García-Martín E, Martínez C, Agúndez JA.

    01/21/2010
    for the diamine oxidase gene differences in allele distribution were found in patients with food allergy and sprue compared to controls

    Analysis of genetic polymorphisms of enzymes involved in histamine metabolism.
    Petersen J, Drasche A, Raithel M, Schwelberger HG.

    01/21/2010
    newly identified DAO gene polymorphisms

    Characterisation of functional polymorphisms of the human diamine oxidase gene.
    Petersen J, Raithel M, Schwelberger HG.

    01/21/2010
    could be detected at the feto-maternal interface of human

    Localisation of mRNAs for diamine oxidase and histamine receptors H1 and H2, at the feto-maternal interface of human pregnancy.
    Brew OB, Sullivan MH.

    01/21/2010
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