| Loss of ORP3 induces aneuploidy and promotes bladder cancer cell invasion through deregulated microtubule and actin dynamics. | Loss of ORP3 induces aneuploidy and promotes bladder cancer cell invasion through deregulated microtubule and actin dynamics.
Wang X, Liu J, Azoitei A, Eiseler T, Meessen S, Jiang W, Zheng X, Makori AW, Eckstein M, Hartmann A, Stilgenbauer S, Elati M, Hohwieler M, Kleger A, John A, Zengerling F, Wezel F, Bolenz C, Günes C., Free PMC Article | 09/28/2023 |
| Prognostic and biological function value of OSBPL3 in colorectal cancer analyzed by multi-omic data analysis. | Prognostic and biological function value of OSBPL3 in colorectal cancer analyzed by multi-omic data analysis.
Wang C, He Y, He Y, Liang W, Zhou C, Wu M, Meng Z, Li W, Cao J., Free PMC Article | 08/9/2023 |
| Oxysterol-binding protein-like 3 is a novel target gene of peroxisome proliferator-activated receptor gamma in fatty liver disease. | Oxysterol-binding protein-like 3 is a novel target gene of peroxisome proliferator-activated receptor γ in fatty liver disease.
Aibara D, Sakaguchi A, Matsusue K. | 03/7/2023 |
| The relationships of OSBPL3 expression with KI-67 expression and KRAS mutations in CRC: implications for diagnosis and prognosis. | The relationships of OSBPL3 expression with KI-67 expression and KRAS mutations in CRC: implications for diagnosis and prognosis.
Zhang M, Meng L, Zhang Z, Wu J, Chen X, Wang Y, He J., Free PMC Article | 01/11/2023 |
| Oxysterol binding protein-like 3 (OSBPL3) is a novel driver gene that promotes tumor growth in part through R-Ras/Akt signaling in gastric cancer. | Oxysterol binding protein-like 3 (OSBPL3) is a novel driver gene that promotes tumor growth in part through R-Ras/Akt signaling in gastric cancer.
Hu Q, Masuda T, Koike K, Sato K, Tobo T, Kuramitsu S, Kitagawa A, Fujii A, Noda M, Tsuruda Y, Otsu H, Kuroda Y, Ito S, Oki E, Mimori K., Free PMC Article | 01/1/2022 |
| Structure of human ORP3 ORD reveals conservation of a key function and ligand specificity in OSBP-related proteins. | Structure of human ORP3 ORD reveals conservation of a key function and ligand specificity in OSBP-related proteins.
Tong J, Tan L, Im YJ., Free PMC Article | 09/25/2021 |
| Calcium-stimulated disassembly of focal adhesions mediated by an ORP3/IQSec1 complex. | Calcium-stimulated disassembly of focal adhesions mediated by an ORP3/IQSec1 complex.
D'Souza RS, Lim JY, Turgut A, Servage K, Zhang J, Orth K, Sosale NG, Lazzara MJ, Allegood J, Casanova JE., Free PMC Article | 04/3/2021 |
| Downregulation of ORP3 Correlates with Reduced Survival of Colon Cancer Patients with Advanced Nodal Metastasis and of Female Patients with Grade 3 Colon Cancer. | Downregulation of ORP3 Correlates with Reduced Survival of Colon Cancer Patients with Advanced Nodal Metastasis and of Female Patients with Grade 3 Colon Cancer.
Xu P, Richter J, Blatz A, Gärtner F, Alberts R, Azoitei A, Makori WA, Meessen S, Knippschild U, Günes C., Free PMC Article | 02/20/2021 |
| The crystal structure of ORP3 reveals the conservative PI4P binding pattern. | The crystal structure of ORP3 reveals the conservative PI4P binding pattern.
Dong X, Wang Z, Ye S, Zhang R. | 02/13/2021 |
| Aneuploidy-inducing gene knockdowns overlap with cancer mutations and identify Orp3 as a B-cell lymphoma suppressor. | Aneuploidy-inducing gene knockdowns overlap with cancer mutations and identify Orp3 as a B-cell lymphoma suppressor.
Njeru SN, Kraus J, Meena JK, Lechel A, Katz SF, Kumar M, Knippschild U, Azoitei A, Wezel F, Bolenz C, Leithäuser F, Gollowitzer A, Omrani O, Hoischen C, Koeberle A, Kestler HA, Günes C, Rudolph KL. | 11/28/2020 |
| The silencing of VAP-A or ORP3 abrogated the association of Rab7-positive late endosomes with nuclear envelope invaginations and, hence, the transport of endocytosed EV-derived components to the nucleoplasm of recipient cells. | VAMP-associated protein-A and oxysterol-binding protein-related protein 3 promote the entry of late endosomes into the nucleoplasmic reticulum.
Santos MF, Rappa G, Karbanová J, Kurth T, Corbeil D, Lorico A., Free PMC Article | 03/2/2019 |
| It indicates that VAPB along with ORP3 plays a central role in maintenance of the intracellular PtdIns4P gradient. | Oxysterol-binding protein ORP3 rescues the Amyotrophic Lateral Sclerosis-linked mutant VAPB phenotype.
Darbyson A, Ngsee JK. | 07/2/2016 |
| phosphorylation of ORP3 controls its association with VAPA. Furthermore, ORP3-VAPA complexes stimulate R-Ras signaling. | OSBP-related protein 3 (ORP3) coupling with VAMP-associated protein A regulates R-Ras activity.
Weber-Boyvat M, Kentala H, Lilja J, Vihervaara T, Hanninen R, Zhou Y, Peränen J, Nyman TA, Ivaska J, Olkkonen VM. | 04/25/2015 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| The present findings demonstrate a new function of ORP3 as part of the machinery that controls the actin cytoskeleton, cell polarity and cell adhesion. | The R-Ras interaction partner ORP3 regulates cell adhesion.
Lehto M, Mäyränpää MI, Pellinen T, Ihalmo P, Lehtonen S, Kovanen PT, Groop PH, Ivaska J, Olkkonen VM. | 01/21/2010 |
| The intracellular targeting determinants of oxysterol binding protein (OSBP)-related protein 3 (ORP3) were studied using a series of truncated and point mutated constructs. | Targeting of OSBP-related protein 3 (ORP3) to endoplasmic reticulum and plasma membrane is controlled by multiple determinants.
Lehto M, Hynynen R, Karjalainen K, Kuismanen E, Hyvärinen K, Olkkonen VM. | 01/21/2010 |