| Reduced MAGI3 level by HPV18E6 contributes to Wnt/beta-catenin signaling activation and cervical cancer progression. | Reduced MAGI3 level by HPV18E6 contributes to Wnt/β-catenin signaling activation and cervical cancer progression.
Yang Z, Liu H, Song R, Lu W, Wang H, Gu S, Cao X, Chen Y, Liang J, Qin Q, Yang X, Feng D, He J., Free PMC Article | 03/26/2022 |
| Integrated analyses identify miR-34c-3p/MAGI3 axis for the Warburg metabolism in hepatocellular carcinoma. | Integrated analyses identify miR-34c-3p/MAGI3 axis for the Warburg metabolism in hepatocellular carcinoma.
Weng Q, Chen M, Yang W, Li J, Fan K, Xu M, Weng W, Lv X, Fang S, Zheng L, Song J, Zhao Z, Fan X, Ji J. | 01/23/2021 |
| Study shows that MAGI3 undergoes premature polyadenylation (pPA) at the intron immediately downstream of its large internal exon, which is normally highly modified by N(6)-methyladenosine (m(6)A). In breast cancer cells that upregulate MAGI3 (pPA) , m(6)A levels in the large internal exon of MAGI3 are significantly reduced compared to cells that do not express MAGI3 (pPA). MAGI3 (pPA) transcripts are depleted of m(6)A. | Premature polyadenylation of MAGI3 is associated with diminished N(6)-methyladenosine in its large internal exon.
Ni TK, Elman JS, Jin DX, Gupta PB, Kuperwasser C., Free PMC Article | 12/1/2018 |
| Our findings lend support to a genetic basis for modulation of intestinal epithelial barrier in IBD, and we have identified MAGI3 as a new candidate gene for IBD. | Genetic variation and expression levels of tight junction genes identifies association between MAGI3 and inflammatory bowel disease.
Norén E, Almer S, Söderman J., Free PMC Article | 03/31/2018 |
| The altered mRNA isoform, called MAGI3(pPA), produces a truncated protein that acts in a dominant-negative manner to prevent full-length MAGI3 from interacting with the YAP oncoprotein, thereby relieving YAP inhibition and promoting malignant transformation of human mammary epithelial cells. | Premature polyadenylation of MAGI3 produces a dominantly-acting oncogene in human breast cancer.
Ni TK, Kuperwasser C., Free PMC Article | 11/11/2017 |
| Results identify MAGI3 as a novel tumor suppressor and provide insight into the pathogenesis of glioma. | MAGI3 negatively regulates Wnt/β-catenin signaling and suppresses malignant phenotypes of glioma cells.
Ma Q, Yang Y, Feng D, Zheng S, Meng R, Fa P, Zhao C, Liu H, Song R, Tao T, Yang L, Dai J, Wang S, Jiang WG, He J., Free PMC Article | 10/29/2016 |
| Expression levels of MAGI3 and PTEN were significantly downregulated in gliomas. | MAGI3 Suppresses Glioma Cell Proliferation via Upregulation of PTEN Expression.
Ma Q, Zhang Y, Meng R, Xie KM, Xiong Y, Lin S, He ZL, Tao T, Yang Y, Zhao JZ, He JQ. | 12/19/2015 |
| MAGI-3 competes with NHERF-2 to negatively regulate LPA2 receptor signaling in colon cancer cells. | MAGI-3 competes with NHERF-2 to negatively regulate LPA2 receptor signaling in colon cancer cells.
Lee SJ, Ritter SL, Zhang H, Shim H, Hall RA, Yun CC., Free PMC Article | 05/14/2011 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| All of the E6 genes from different HPV types displayed similar abilities to mediate the degradation of both p53 and MAGI-3 | Comparison of p53 and the PDZ domain containing protein MAGI-3 regulation by the E6 protein from high-risk human papillomaviruses.
Ainsworth J, Thomas M, Banks L, Coutlee F, Matlashewski G., Free PMC Article | 01/21/2010 |
| These results demonstrate that MAGI-3 interacts directly with LPA(2) and regulates the ability of LPA(2) to activate Erk and RhoA. | MAGI-3 regulates LPA-induced activation of Erk and RhoA.
Zhang H, Wang D, Sun H, Hall RA, Yun CC., Free PMC Article | 01/21/2010 |
| In epithelial cells, MAGI-3 was localized with ZO-1 and cingulin at tight junctions, whereas in primary cultured astrocytes it was found in E-cadherin-based cell-cell contacts and in focal adhesion sites. | Junctional protein MAGI-3 interacts with receptor tyrosine phosphatase beta (RPTP beta) and tyrosine-phosphorylated proteins.
Adamsky K, Arnold K, Sabanay H, Peles E. | 01/21/2010 |
| Oncogenic human papillomavirus E6 proteins target the MAGI-2 and MAGI-3 proteins for degradation [MAGI-2, MAGI-3] | Oncogenic human papillomavirus E6 proteins target the MAGI-2 and MAGI-3 proteins for degradation.
Thomas M, Laura R, Hepner K, Guccione E, Sawyers C, Lasky L, Banks L. | 01/21/2010 |