| Endothelial ARHGEF26 is an angiogenic factor promoting VEGF signalling. | Endothelial ARHGEF26 is an angiogenic factor promoting VEGF signalling.
Zhu QM, MacDonald BT, Mizoguchi T, Chaffin M, Leed A, Arduini A, Malolepsza E, Lage K, Kaushik VK, Kathiresan S, Ellinor PT., Free PMC Article | 10/29/2022 |
| ARHGEF26 enhances Salmonella invasion and inflammation in cells and mice. | ARHGEF26 enhances Salmonella invasion and inflammation in cells and mice.
Bourgeois JS, Wang L, Rabino AF, Everitt J, Alvarez MI, Awadia S, Wittchen ES, Garcia-Mata R, Ko DC., Free PMC Article | 10/23/2021 |
| SGEF plays a role in activating RhoG during invadopodia disassembly | A RhoG-mediated signaling pathway that modulates invadopodia dynamics in breast cancer cells.
Goicoechea SM, Zinn A, Awadia SS, Snyder K, Garcia-Mata R., Free PMC Article | 11/30/2018 |
| High SGEF expression is associated with lung adenocarcinoma. | SGEF is a potential prognostic and therapeutic target for lung adenocarcinoma.
Chen Q, Lu X, Liu QX, Zhou D, Qiu Y, Dai JG, Zheng H., Free PMC Article | 09/1/2018 |
| Phenome-wide association scanning showed that CCDC92 likely affects coronary artery disease through insulin resistance pathways, whereas experimental analysis suggests that ARHGEF26 influences the transendothelial migration of leukocytes. | Genetic analysis in UK Biobank links insulin resistance and transendothelial migration pathways to coronary artery disease.
Klarin D, Zhu QM, Emdin CA, Chaffin M, Horner S, McMillan BJ, Leed A, Weale ME, Spencer CCA, Aguet F, Segrè AV, Ardlie KG, Khera AV, Kaushik VK, Natarajan P, CARDIoGRAMplusC4D Consortium, Kathiresan S., Free PMC Article | 10/28/2017 |
| yrosine phosphorylation of SGEF suppresses its interaction with RhoG, the elevation of RhoG activity, and SGEF-mediated promotion of cell migration. We identified tyrosine 530 (Y530), which is located within the Dbl homology domain, as a major phosphorylation site of SGEF by Src, and Y530F mutation blocked the inhibitory effect of Src on SGEF | Tyrosine Phosphorylation of SGEF Regulates RhoG Activity and Cell Migration.
Okuyama Y, Umeda K, Negishi M, Katoh H., Free PMC Article | 07/22/2017 |
| Data support evidence for SGEF role in both the promotion of cell invasion and cell survival signaling within glioblastoma tumors and promoting chemotherapeutic resistance. | SGEF Is Regulated via TWEAK/Fn14/NF-κB Signaling and Promotes Survival by Modulation of the DNA Repair Response to Temozolomide.
Ensign SP, Roos A, Mathews IT, Dhruv HD, Tuncali S, Sarkaria JN, Symons MH, Loftus JC, Berens ME, Tran NL., Free PMC Article | 12/17/2016 |
| A novel function of SGEF that excludes GEF. | Grb2 interacts with SGEF and antagonizes the ability of SGEF to enhance EGF-induced ERK1/2 activation.
Wang H, Li S, Li H, Wang P, Huang F, Zhao Y, Yu L, Luo G, Zhang X, Wang J, Zhou J. | 11/8/2014 |
| We report for the first time an SGEF function for RhoG that excludes GEF and the ability of SGEF to enhance EGFR stability and signaling by delaying its lysosomal sorting and degradation | SGEF enhances EGFR stability through delayed EGFR trafficking from early to late endosomes.
Wang H, Li S, Li H, Li C, Guan K, Luo G, Yu L, Wu R, Zhang X, Wang J, Zhou J. | 12/21/2013 |
| Data indicate that the Src homology 3 domain-containing GEF (SGEF) promotes fibroblast growth factor-inducible 14 (Fn14) proinvasive signaling in glioblastoma via TNF receptor-associated factor 2 (TRAF2). | The Src homology 3 domain-containing guanine nucleotide exchange factor is overexpressed in high-grade gliomas and promotes tumor necrosis factor-like weak inducer of apoptosis-fibroblast growth factor-inducible 14-induced cell migration and invasion via tumor necrosis factor receptor-associated factor 2.
Fortin Ensign SP, Mathews IT, Eschbacher JM, Loftus JC, Symons MH, Tran NL., Free PMC Article | 11/16/2013 |
| SGEF is a novel promoter of human prostate cancer progression and development. | SGEF is overexpressed in prostate cancer and contributes to prostate cancer progression.
Wang H, Wu R, Yu L, Wu F, Li S, Zhao Y, Li H, Luo G, Wang J, Zhou J. | 05/11/2013 |
| The invasive capacity of HPV transformed cells requires the hDlg-dependent enhancement of SGEF/RhoG activity. | The invasive capacity of HPV transformed cells requires the hDlg-dependent enhancement of SGEF/RhoG activity.
Krishna Subbaiah V, Massimi P, Boon SS, Myers MP, Sharek L, Garcia-Mata R, Banks L., Free PMC Article | 07/14/2012 |
| SGEF gene on chromosome 3q25.2. CSGEF expression controlled by androgen-responsive promoter of SGEF gene. SGEF may be regulator of Rho guanosine triphosphatases. CSGEF may function as regulator of Rho guanosine triphosphatase in prostate | Isolation of the novel human guanine nucleotide exchange factor Src homology 3 domain-containing guanine nucleotide exchange factor (SGEF) and of C-terminal SGEF, an N-terminally truncated form of SGEF, the expression of which is regulated by androgen in prostate cancer cells.
Qi H, Fournier A, Grenier J, Fillion C, Labrie Y, Labrie C. | 01/21/2010 |