| Analysis of urinary kallikrein-related peptidase 13 for monitoring bladder cancer. | Analysis of urinary kallikrein-related peptidase 13 for monitoring bladder cancer.
Gruba N, Rachubik P, Piwkowska A, Lesner A. | 03/12/2022 |
| LncRNA WT-AS inhibits metastatic ability of non-small cell lung cancer by regulating KLK13. | LncRNA WT-AS inhibits metastatic ability of non-small cell lung cancer by regulating KLK13.
Wang Y, Tan TZ, Wang LQ, Zhang K. | 05/8/2021 |
| Kallikrein 13 serves as a priming protease during infection by the human coronavirus HKU1. | Kallikrein 13 serves as a priming protease during infection by the human coronavirus HKU1.
Milewska A, Falkowski K, Kulczycka M, Bielecka E, Naskalska A, Mak P, Lesner A, Ochman M, Urlik M, Diamandis E, Prassas I, Potempa J, Kantyka T, Pyrc K., Free PMC Article | 12/12/2020 |
| serine proteases transmembrane protein serine 11D and kallikrein-related peptidase 13 were shown as active proteases in Cervical-vaginal fluid. | Functional proteomic profiling reveals KLK13 and TMPRSS11D as active proteases in the lower female reproductive tract.
Muytjens CMJ, Yu Y, Diamandis EP., Free PMC Article | 09/14/2019 |
| Relatively high levels of KLK13 expression in ESCC were associated with cell proliferation and correlated with tumor progression, advanced cancer stage, and poor prognosis | Expression of kallikrein-related peptidase 13 is associated with poor prognosis in esophageal squamous cell carcinoma.
Nohara K, Yamada K, Yamada L, Hagiwara T, Igari T, Yokoi C, Soma D, Yamashita S, Dohi T, Kawamura YI. | 10/13/2018 |
| Decreased KLK13 mRNA levels correlate with poor survival in esophageal squamous cell carcinoma patients. | Downregulation of KLK13 promotes the invasiveness and metastasis of oesophageal squamous cell carcinoma.
Lin Q, Mao W, Wu Q, He X, Li S, Fan Y, Chen J, Feng T, Cao X. | 07/28/2018 |
| There was no significant association of KLK13 and KLK14 mRNA expression with the clinical factors ascitic fluid volume or residual tumor mass. In univariate Cox regression analysis, elevated KLK13 mRNA levels were significantly linked with shorter progression-free (PFS; hazard ratio [HR] = 1.97, P = 0.020) and overall survival (OS; HR = 1.81, P = 0.041). | Advanced high-grade serous ovarian cancer: inverse association of KLK13 and KLK14 mRNA levels in tumor tissue and patients' prognosis.
Dettmar L, Ahmed N, Kotzsch M, Diersch S, Napieralski R, Darmoul D, Schmitt M, Weichert W, Kiechle M, Dorn J, Magdolen V. | 06/16/2018 |
| This first clinical study of KLK13 in bladder cancer reveals its deregulated expression in bladder tumors and highlights KLK13 as a promising marker for improving TaT1 patients' prognosis following treatment. | Downregulated KLK13 expression in bladder cancer highlights tumor aggressiveness and unfavorable patients' prognosis.
Tokas T, Avgeris M, Alamanis C, Scorilas A, Stravodimos KG, Constantinides CA. | 02/18/2017 |
| Our results suggest that KLK13 mRNA expression constitutes a novel biomarker for the prediction of overall survival in nonsmall cell lung cancer and that its quantitative assessment in tumor tissues can aid in treatment decision making. | Kallikrein-related peptidase 13: an independent indicator of favorable prognosis for patients with nonsmall cell lung cancer.
Gueugnon F, Barascu A, Mavridis K, Petit-Courty A, Marchand-Adam S, Gissot V, Scorilas A, Guyetant S, Courty Y. | 10/31/2015 |
| KLK13 may play an important role in regulating cellular migration and invasiveness, making the loss of KLK13 a potential biomarker for early detection of lymph node metastasis in oral squamous cell carcinomas. | Decreased expression of kallikrein-related peptidase 13: possible contribution to metastasis of human oral cancer.
Ishige S, Kasamatsu A, Ogoshi K, Saito Y, Usukura K, Yokoe H, Kouzu Y, Koike H, Sakamoto Y, Ogawara K, Shiiba M, Tanzawa H, Uzawa K. | 08/23/2014 |
| The aim of this study was to monitor serum levels of two microRNAs (miR-21 and miR-141) and three kallikreins (hK3/PSA, hK11, and hK13) before and 1, 5, and 30 days after radical prostatectomy. | Circulating microRNAs and kallikreins before and after radical prostatectomy: are they really prostate cancer markers?
Egidi MG, Cochetti G, Serva MR, Guelfi G, Zampini D, Mechelli L, Mearini E., Free PMC Article | 06/14/2014 |
| Data indicate that five out of 9 SNPs in the KLK13 gene were associated with prostate cancer risk and/or aggressiveness. | Common variation in Kallikrein genes KLK5, KLK6, KLK12, and KLK13 and risk of prostate cancer and tumor aggressiveness.
Lose F, Batra J, O'Mara T, Fahey P, Marquart L, Eeles RA, Easton DF, Al Olama AA, Kote-Jarai Z, Guy M, Muir K, Lophatananon A, Rahman AA, Neal DE, Hamdy FC, Donovan JL, Chambers S, Gardiner RA, Aitken JF, Yaxley J, Alexander K, Clements JA, Spurdle AB, Kedda MA, Australian Prostate Cancer BioResource. | 01/25/2014 |
| High KLK13 expression is associated with drug response in gastric cancer. | The kallikrein-related peptidase 13 (KLK13) gene is substantially up-regulated after exposure of gastric cancer cells to antineoplastic agents.
Florou D, Mavridis K, Scorilas A. | 02/2/2013 |
| Results indicate that KLK13 may play a role in the defense of the upper digestive apparatus and in male reproductive organs. | Substrate specificity of kallikrein-related peptidase 13 activated by salts or glycosaminoglycans and a search for natural substrate candidates.
Andrade D, Assis DM, Santos JA, Alves FM, Hirata IY, Araujo MS, Blaber SI, Blaber M, Juliano MA, Juliano L. | 02/4/2012 |
| Serine protease of Kazal-type (SPINK6) expressed in normal human skin is a potent natural inhibitor of Kallikrein-related peptidases, KLK12 and KLK13. | Inhibition of kallikrein-related peptidases by the serine protease inhibitor of Kazal-type 6.
Kantyka T, Fischer J, Wu Z, Declercq W, Reiss K, Schröder JM, Meyer-Hoffert U. | 10/1/2011 |
| these results reveal the enhancing effects of KLK13 on tumor cell invasion and migration, and that it may serve as a diagnostic/prognostic marker and a potential therapeutic target for lung cancer. | Epigenetic activation of human kallikrein 13 enhances malignancy of lung adenocarcinoma by promoting N-cadherin expression and laminin degradation.
Chou RH, Lin SC, Wen HC, Wu CW, Chang WS. | 08/20/2011 |
| This is the first study disclosing the possible clinical utility of KLK13 as a new tumor biomarker capable of predicting a favorable outcome for gastric cancer patients. | Kallikrein-related peptidase 13 (KLK13) gene expressional status contributes significantly in the prognosis of primary gastric carcinomas.
Konstantoudakis G, Florou D, Mavridis K, Papadopoulos IN, Scorilas A. | 01/8/2011 |
| Observational study of gene-disease association. (HuGE Navigator) | Blood biomarker levels to aid discovery of cancer-related single-nucleotide polymorphisms: kallikreins and prostate cancer.
Klein RJ, Halldén C, Cronin AM, Ploner A, Wiklund F, Bjartell AS, Stattin P, Xu J, Scardino PT, Offit K, Vickers AJ, Grönberg H, Lilja H., Free PMC Article | 06/30/2010 |
| Combination of KLK2, 3, 13, and 14 and KLK1, 2, 5, 6, 7, 8, 10, 13, and 14 showed very strong discriminatory potential for semen liquefaction and viscosity, respectively. | Association between kallikrein-related peptidases (KLKs) and macroscopic indicators of semen analysis: their relation to sperm motility.
Emami N, Scorilas A, Soosaipillai A, Earle T, Mullen B, Diamandis EP. | 01/21/2010 |
| KLK6 and KLK13 predict tumor recurrence in epithelial ovarian carcinoma. | KLK6 and KLK13 predict tumor recurrence in epithelial ovarian carcinoma.
White NM, Mathews M, Yousef GM, Prizada A, Popadiuk C, Doré JJ., Free PMC Article | 01/21/2010 |
| non-small-cell lung cancer patients with high KLK13 expression at the mRNA or protein level had lower overall survival | Quantitative RT-PCR analysis and immunohistochemical localization of the kallikrein-related peptidases 13 and 14 in lung.
Planque C, Bléchet C, Ayadi-Kaddour A, Heuzé-Vourc'h N, Dumont P, Guyétant S, Diamandis EP, El Mezni F, Courty Y. | 01/21/2010 |
| KLK13 expression is an independent favorable prognostic marker for breast carcinoma | Human kallikrein gene 13 (KLK13) expression by quantitative RT-PCR: an independent indicator of favourable prognosis in breast cancer.
Chang A, Yousef GM, Scorilas A, Grass L, Sismondi P, Ponzone R, Diamandis EP., Free PMC Article | 01/21/2010 |
| hK13 is expressed in several common salivary gland tumors | Human kallikrein 13 expression in salivary gland tumors.
Darling MR, Jackson-Boeters L, Daley TD, Diamandis EP. | 01/21/2010 |
| hK13 interacts and forms complexes with serum protease inhibitors, including alpha2-macroglobulin, alpha1-antichymotrypsin and alpha2-antiplasmin | Complex formation between human kallikrein 13 and serum protease inhibitors.
Kapadia C, Yousef GM, Mellati AA, Magklara A, Wasney GA, Diamandis EP. | 01/21/2010 |
| Human kallikrein13 may play a role in tissue remodeling and/or tumor invasion and metastasis. | Human kallikrein 13 involvement in extracellular matrix degradation.
Kapadia C, Ghosh MC, Grass L, Diamandis EP. | 01/21/2010 |