| Suppression of lysosome metabolism-meditated GARP/TGF-beta1 complexes specifically depletes regulatory T cells to inhibit breast cancer metastasis. | Suppression of lysosome metabolism-meditated GARP/TGF-β1 complexes specifically depletes regulatory T cells to inhibit breast cancer metastasis.
Ma J, Chen Y, Li T, Cao Y, Hu B, Liu Y, Zhang Y, Li X, Liu J, Zhang W, Niu H, Gao J, Zhang Z, Yue K, Wang J, Bao G, Wang C, Wang PG, Zou T, Xie S. | 06/27/2024 |
| Analysis of LAP[+] and GARP[+] Treg subsets in peripheral blood of patients with neuromyelitis optica spectrum disorders. | Analysis of LAP(+) and GARP(+) Treg subsets in peripheral blood of patients with neuromyelitis optica spectrum disorders.
Cai H, Liu Y, Dong X, Jiang F, Li H, Ouyang S, Yin W, He T, Zeng Q, Yang H. | 10/26/2023 |
| New insight into GARP striking role in cancer progression: application for cancer therapy. | New insight into GARP striking role in cancer progression: application for cancer therapy.
Lahimchi MR, Eslami M, Yousefi B. | 12/17/2022 |
| Dysregulated immunity in PID patients with low GARP expression on Tregs due to mutations in LRRC32. | Dysregulated immunity in PID patients with low GARP expression on Tregs due to mutations in LRRC32.
Lehmkuhl P, Gentz M, Garcia de Otezya AC, Grimbacher B, Schulze-Koops H, Skapenko A., Free PMC Article | 04/9/2022 |
| Novel anti-GARP antibody DS-1055a augments anti-tumor immunity by depleting highly suppressive GARP+ regulatory T cells. | Novel anti-GARP antibody DS-1055a augments anti-tumor immunity by depleting highly suppressive GARP+ regulatory T cells.
Satoh K, Kobayashi Y, Fujimaki K, Hayashi S, Ishida S, Sugiyama D, Sato T, Lim K, Miyamoto M, Kozuma S, Kadokura M, Wakita K, Hata M, Hirahara K, Amano M, Watanabe I, Okamoto A, Tuettenberg A, Jonuleit H, Tanemura A, Maruyama S, Agatsuma T, Wada T, Nishikawa H. | 02/5/2022 |
| Expression of Leucine-rich Repeat-containing Protein 32 Following Lymphocyte Stimulation in Patients with Non-IgE-mediated Gastrointestinal Food Allergies. | Expression of Leucine-rich Repeat-containing Protein 32 Following Lymphocyte Stimulation in Patients with Non-IgE-mediated Gastrointestinal Food Allergies.
Yagi H, Sato K, Arakawa N, Inoue T, Nishida Y, Yamada S, Ishige T, Yamada Y, Arakawa H, Takizawa T., Free PMC Article | 12/18/2021 |
| GARP Correlates With Tumor-Infiltrating T-Cells and Predicts the Outcome of Gastric Cancer. | GARP Correlates With Tumor-Infiltrating T-Cells and Predicts the Outcome of Gastric Cancer.
Jiang S, Zhang Y, Zhang X, Lu B, Sun P, Wu Q, Ding X, Huang J., Free PMC Article | 10/16/2021 |
| The Parkinson's Disease Protein LRRK2 Interacts with the GARP Complex to Promote Retrograde Transport to the trans-Golgi Network. | The Parkinson's Disease Protein LRRK2 Interacts with the GARP Complex to Promote Retrograde Transport to the trans-Golgi Network.
Beilina A, Bonet-Ponce L, Kumaran R, Kordich JJ, Ishida M, Mamais A, Kaganovich A, Saez-Atienzar S, Gershlick DC, Roosen DA, Pellegrini L, Malkov V, Fell MJ, Harvey K, Bonifacino JS, Moore DJ, Cookson MR., Free PMC Article | 06/5/2021 |
| GARP promotes the proliferation and therapeutic resistance of bone sarcoma cancer cells through the activation of TGF-beta. | GARP promotes the proliferation and therapeutic resistance of bone sarcoma cancer cells through the activation of TGF-β.
Carrillo-Gálvez AB, Quintero JE, Rodríguez R, Menéndez ST, Victoria González M, Blanco-Lorenzo V, Allonca E, de Araújo Farias V, González-Correa JE, Erill-Sagalés N, Martínez-Zubiaurre I, Hellevik T, Sánchez-Hernández S, Muñoz P, Zurita F, Martín F, Rodríguez-Manzaneque JC, Anderson P., Free PMC Article | 05/1/2021 |
| Genetic variants of the C11orf30-LRRC32 region are associated with childhood asthma in the Chinese population. | Genetic variants of the C11orf30-LRRC32 region are associated with childhood asthma in the Chinese population.
Chen J, Chen Q, Wu C, Jin Y. | 04/24/2021 |
| Thrombin contributes to cancer immune evasion via proteolysis of platelet-bound GARP to activate LTGF-beta. | Thrombin contributes to cancer immune evasion via proteolysis of platelet-bound GARP to activate LTGF-β.
Metelli A, Wu BX, Riesenberg B, Guglietta S, Huck JD, Mills C, Li A, Rachidi S, Krieg C, Rubinstein MP, Gewirth DT, Sun S, Lilly MB, Wahlquist AH, Carbone DP, Yang Y, Liu B, Li Z., Free PMC Article | 01/30/2021 |
| Novel biomarkers for primary biliary cholangitis to improve diagnosis and understand underlying regulatory mechanisms. | Novel biomarkers for primary biliary cholangitis to improve diagnosis and understand underlying regulatory mechanisms.
Bombaci M, Pesce E, Torri A, Carpi D, Crosti M, Lanzafame M, Cordiglieri C, Sinisi A, Moro M, Bernuzzi F, Gerussi A, Geginat J, Muratori L, Terracciano LM, Invernizzi P, Abrignani S, Grifantini R. | 10/24/2020 |
| Data indicate homozygous stop-gain variant in leucine rich repeat containing 32 protein (LRRC32) (c.1630C>T; p.(Arg544Ter)) as a candidate disease-associated gene in two families with developmental delay, cleft palate, and proliferative retinopathy. | Homozygous stop-gain variant in LRRC32, encoding a TGFβ receptor, associated with cleft palate, proliferative retinopathy, and developmental delay.
Harel T, Levy-Lahad E, Daana M, Mechoulam H, Horowitz-Cederboim S, Gur M, Meiner V, Elpeleg O., Free PMC Article | 06/20/2020 |
| Our findings reveal that GARP, as an immunoregulatory molecule, is located on, as well as in, tumor cells of GB and low-grade glioma, inhibiting effector T cell function, and thus contributing to the immunosuppressive tumor microenvironment of primary brain tumors. | GARP as an Immune Regulatory Molecule in the Tumor Microenvironment of Glioblastoma Multiforme.
Zimmer N, Kim E, Sprang B, Leukel P, Khafaji F, Ringel F, Sommer C, Tuettenberg J, Tuettenberg A., Free PMC Article | 01/11/2020 |
| Study demonstrated that B cells are required for the induction of oral tolerance of T cell-dependent antigens via GARP and revealed for the first time that cell surface GARP-TGF-beta is an important checkpoint for regulating B cell peripheral tolerance, highlighting a mechanism of autoimmune disease pathogenesis. | B lymphocytes confer immune tolerance via cell surface GARP-TGF-β complex.
Wallace CH, Wu BX, Salem M, Ansa-Addo EA, Metelli A, Sun S, Gilkeson G, Shlomchik MJ, Liu B, Li Z., Free PMC Article | 11/30/2019 |
| This review summarizes the most important features of GARP biology described to date including gene regulation, protein expression and mechanism in activating latent TGF-beta, and the function of GARP in regulatory T cell biology and peripheral tolerance, as well as GARP's increasingly recognized roles in platelet-mediated cancer immune evasion. [review] | Immunoregulatory functions and the therapeutic implications of GARP-TGF-β in inflammation and cancer.
Metelli A, Salem M, Wallace CH, Wu BX, Li A, Li X, Li Z., Free PMC Article | 10/26/2019 |
| Increased GARP expression in papillary thyroid cancer was positively correlated with increased expression of Foxp3, which is very important for development of Tregs. But, there is no significant association of elevated expression of GARP with lymph node metastasis in papillary thyroid cancer. | Increased Expression of GARP in Papillary Thyroid Carcinoma.
Zhang X, Guo M, Yang J, Zheng Y, Xiao Y, Liu W, Ren F. | 07/13/2019 |
| This finding reveals how GARP exploits an unusual medley of interactions, including fold complementation by the amino terminus of TGF-beta1, to chaperone and orient the cytokine for binding and activation by alphaVbeta8. | Structural basis of latent TGF-β1 presentation and activation by GARP on human regulatory T cells.
Liénart S, Merceron R, Vanderaa C, Lambert F, Colau D, Stockis J, van der Woning B, De Haard H, Saunders M, Coulie PG, Savvides SN, Lucas S. | 04/13/2019 |
| GARP is a surface molecule of regulatory T cells with roles in the regulatory function and TGF-beta releasing [review] | GARP: a surface molecule of regulatory T cells that is involved in the regulatory function and TGF-β releasing.
Sun L, Jin H, Li H., Free PMC Article | 01/20/2018 |
| Data show that the Treg activation marker GARP (glycoprotein A repetitions predominant) is expressed on primary melanoma. | A key role of GARP in the immune suppressive tumor microenvironment.
Hahn SA, Neuhoff A, Landsberg J, Schupp J, Eberts D, Leukel P, Bros M, Weilbaecher M, Schuppan D, Grabbe S, Tueting T, Lennerz V, Sommer C, Jonuleit H, Tuettenberg A., Free PMC Article | 01/13/2018 |
| High GARP expression is associated with pancreatic cancer and liver metastases from colorectal cancer. | Combining FoxP3 and Helios with GARP/LAP markers can identify expanded Treg subsets in cancer patients.
Abd Al Samid M, Chaudhary B, Khaled YS, Ammori BJ, Elkord E., Free PMC Article | 12/16/2017 |
| study showed that stimulated, human B lymphocytes produce active TGF-beta1 from surface GARP/latent TGF-beta1 complexes with isotype switching to IgA production. | Cutting Edge: Active TGF-β1 Released from GARP/TGF-β1 Complexes on the Surface of Stimulated Human B Lymphocytes Increases Class-Switch Recombination and Production of IgA.
Dedobbeleer O, Stockis J, van der Woning B, Coulie PG, Lucas S., Free PMC Article | 09/30/2017 |
| GARP plays an important role in the pathogenesis of atopic dermatitis. | Atopic Dermatitis According to GARP: New Mechanistic Insights in Disease Pathogenesis.
Nousbeck J, Irvine AD. | 09/16/2017 |
| CD4(+) CD25(+) GARP(+) Treg cells are defective in dilated cardiomyopathy patients and GARP seems to be a better molecular definition of the regulatory phenotype. | CD4(+) CD25(+) GARP(+) regulatory T cells display a compromised suppressive function in patients with dilated cardiomyopathy.
Wei Y, Yu K, Wei H, Su X, Zhu R, Shi H, Sun H, Luo Q, Xu W, Xiao J, Zhong Y, Zeng Q., Free PMC Article | 08/19/2017 |
| these results define the oncogenic effects of the GARP-TGFbeta axis in the tumor microenvironment | Surface Expression of TGFβ Docking Receptor GARP Promotes Oncogenesis and Immune Tolerance in Breast Cancer.
Metelli A, Wu BX, Fugle CW, Rachidi S, Sun S, Zhang Y, Wu J, Tomlinson S, Howe PH, Yang Y, Garrett-Mayer E, Liu B, Li Z., Free PMC Article | 07/29/2017 |