| Coarse-Graining the Recognition of a Glycolipid by the C-Type Lectin Mincle Receptor. | Coarse-Graining the Recognition of a Glycolipid by the C-Type Lectin Mincle Receptor.
Noriega M, Corey RA, Haanappel E, Demange P, Czaplicki G, Atkinson RA, Chavent M. | 10/28/2024 |
| CLEC4E (Mincle) genetic variation associates with pulmonary tuberculosis in Guinea-Bissau (West Africa). | CLEC4E (Mincle) genetic variation associates with pulmonary tuberculosis in Guinea-Bissau (West Africa).
Olvany JM, Sausville LN, White MJ, Tacconelli A, Tavera G, Sobota RS, Ciccacci C, Bohlbro AS, Wejse C, Williams SM, Sirugo G., Free PMC Article | 01/15/2022 |
| A case-control study on correlation between the single nucleotide polymorphism of CLEC4E and the susceptibility to tuberculosis among Han people in Western China. | A case-control study on correlation between the single nucleotide polymorphism of CLEC4E and the susceptibility to tuberculosis among Han people in Western China.
Zhou W, Wu L, Song J, Jiao L, Zhou Y, Zhou J, Wang N, Liu T, Zhao Z, Bai H, Wu T, Ying B., Free PMC Article | 10/2/2021 |
| Molecular mechanism of obesity-induced adipose tissue inflammation; the role of Mincle in adipose tissue fibrosis and ectopic lipid accumulation. | Molecular mechanism of obesity-induced adipose tissue inflammation; the role of Mincle in adipose tissue fibrosis and ectopic lipid accumulation.
Tanaka M. | 12/12/2020 |
| Spontaneous labour is associated with up-regulated Mincle expression in the myometrium and fetal membranes. Mincle expression was also increased in fetal membranes and myometrium in the presence of pro-labour mediators. | Expression and function of macrophage-inducible C-type lectin (Mincle) in inflammation driven parturition in fetal membranes and myometrium.
Lim R, Lappas M., Free PMC Article | 04/11/2020 |
| overview of the accumulated knowledge of the multi-task danger receptor Mincle from its discovery to the latest findings | Immune Recognition of Pathogen-Derived Glycolipids Through Mincle.
Miyake Y, Yamasaki S. | 03/28/2020 |
| variations at rs10841845 and rs10841847 of CLEC4E gene are associated with increased individual protection against Pulmonary tuberculosis | Association between CLEC4E gene polymorphism of mincle and pulmonary tuberculosis infection in a northern Chinese population.
Kabuye D, Chu Y, Lao W, Jin G, Kang H. | 08/24/2019 |
| Mincle has the ability to survey mycolate-derived glycolipids from actinomycetes, distinguishing non-pathogenic (e.g. Rhodococcus spp.) and pathogenic (e.g. Mycobacterium tuberculosis) species on the basis of alpha-chain length. | Lipid structure influences the ability of glucose monocorynomycolate to signal through Mincle.
van der Peet PL, Nagata M, Shah S, White JM, Yamasaki S, Williams SJ. | 03/31/2018 |
| No association was detected with any of the SNPs analysed and susceptibility to tuberculosis. | Polymorphisms in the Pattern Recognition Receptor Mincle Gene (CLEC4E) and Association with Tuberculosis.
Bowker N, Salie M, Schurz H, van Helden PD, Kinnear CJ, Hoal EG, Möller M. | 01/13/2018 |
| combination adjuvant systems demonstrate markedly different immune activation with age, with combined DC activation via Macrophage-inducible C-type lectin and TLR7/8 representing a novel approach to enhance the efficacy of early-life vaccines. | Age-Specific Adjuvant Synergy: Dual TLR7/8 and Mincle Activation of Human Newborn Dendritic Cells Enables Th1 Polarization.
van Haren SD, Dowling DJ, Foppen W, Christensen D, Andersen P, Reed SG, Hershberg RM, Baden LR, Levy O., Free PMC Article | 07/29/2017 |
| We here show that Mincle gene expression was induced in alveolar macrophages and neutrophils in bronchoalveolar lavage fluids of mice and patients with pneumococcal pneumonia | C-type Lectin Mincle Recognizes Glucosyl-diacylglycerol of Streptococcus pneumoniae and Plays a Protective Role in Pneumococcal Pneumonia.
Behler-Janbeck F, Takano T, Maus R, Stolper J, Jonigk D, Tort Tarrés M, Fuehner T, Prasse A, Welte T, Timmer MS, Stocker BL, Nakanishi Y, Miyamoto T, Yamasaki S, Maus UA., Free PMC Article | 06/3/2017 |
| a nonredundant role for Clec4e in coordinating major biological pathways involved in atherosclerosis | Necrotic Cell Sensor Clec4e Promotes a Proatherogenic Macrophage Phenotype Through Activation of the Unfolded Protein Response.
Clément M, Basatemur G, Masters L, Baker L, Bruneval P, Iwawaki T, Kneilling M, Yamasaki S, Goodall J, Mallat Z. | 04/29/2017 |
| The expression of Mincle increases significantly during the early period of Aspergillus fumigatus infection, while expression of eight corresponding cytokines changes. Mincle, as a pattern recognition receptor, may play a role in the early innate immune response of the corneal resistance against fungus. | The role of Mincle in innate immune to fungal keratitis.
Zhao G, Xu Q, Lin J, Chen W, Cui T, Hu L, Jiang N. | 03/18/2017 |
| CLEC4E expression is significantly upregulated in human masticatory mucosa during wound healing | Human gingiva transcriptome during wound healing.
Wang Y, Tatakis DN. | 03/22/2017 |
| Induction of Mincle by Helicobacter pylori and consequent anti-inflammatory signaling denote a bacterial survival strategy. | Induction of Mincle by Helicobacter pylori and consequent anti-inflammatory signaling denote a bacterial survival strategy.
Devi S, Rajakumara E, Ahmed N., Free PMC Article | 08/27/2016 |
| our findings identify mincle as a contributor to the inflammatory response after traumatic brain injury | Mincle signaling in the innate immune response after traumatic brain injury.
de Rivero Vaccari JC, Brand FJ 3rd, Berti AF, Alonso OF, Bullock MR, de Rivero Vaccari JP. | 03/19/2016 |
| results suggest that cholesterol crystals are an endogenous ligand for hMincle and that they activate innate immune responses | Human Mincle Binds to Cholesterol Crystals and Triggers Innate Immune Responses.
Kiyotake R, Oh-Hora M, Ishikawa E, Miyamoto T, Ishibashi T, Yamasaki S., Free PMC Article | 02/13/2016 |
| Data indicate that MINCLE receptor is able to mediate the response to trehalose-6,6-dimycolate (TDM) dependent on SYK kinase and CARD9 protein. | Contribution of MINCLE-SYK Signaling to Activation of Primary Human APCs by Mycobacterial Cord Factor and the Novel Adjuvant TDB.
Ostrop J, Jozefowski K, Zimmermann S, Hofmann K, Strasser E, Lepenies B, Lang R. | 12/19/2015 |
| mincle is a fungal receptor that can suppress antifungal immunity and, as such, is a potential therapeutic target. | Fungal engagement of the C-type lectin mincle suppresses dectin-1-induced antifungal immunity.
Wevers BA, Kaptein TM, Zijlstra-Willems EM, Theelen B, Boekhout T, Geijtenbeek TB, Gringhuis SI. | 01/17/2015 |
| These results demonstrated that GroMM is a unique ligand for human Mincle that is not recognized by mouse Mincle. | Glycerol monomycolate is a novel ligand for the human, but not mouse macrophage inducible C-type lectin, Mincle.
Hattori Y, Morita D, Fujiwara N, Mori D, Nakamura T, Harashima H, Yamasaki S, Sugita M., Free PMC Article | 10/11/2014 |
| Results show the molecular mechanism of glycolipid recognition through C-type lectin receptors, which may provide clues to rational design for effective adjuvants. | Structural analysis for glycolipid recognition by the C-type lectins Mincle and MCL.
Furukawa A, Kamishikiryo J, Mori D, Toyonaga K, Okabe Y, Toji A, Kanda R, Miyake Y, Ose T, Yamasaki S, Maenaka K., Free PMC Article | 01/4/2014 |
| Macrophage-inducible C-type lectin is associated with anti-cyclic citrullinated peptide antibodies-positive rheumatoid arthritis in men. | Macrophage-inducible C-type lectin is associated with anti-cyclic citrullinated peptide antibodies-positive rheumatoid arthritis in men.
Wu XY, Guo JP, Yin FR, Lu XL, Li R, He J, Liu X, Li ZG. | 05/18/2013 |
| Mincle is a potentially critical player in human B cell responses. | Mincle and human B cell function.
Kawata K, Illarionov P, Yang GX, Kenny TP, Zhang W, Tsuda M, Ando Y, Leung PS, Ansari AA, Gershwin ME., Free PMC Article | 04/27/2013 |
| Data indicate an unusual pattern of reciprocal expression of Mincle on peripheral blood monocytes or neutrophils. | Mincle polarizes human monocyte and neutrophil responses to Candida albicans.
Vijayan D, Radford KJ, Beckhouse AG, Ashman RB, Wells CA. | 04/13/2013 |
| silencing of renal DNaseI gene expression initiates a cascade of inflammatory signals including activation of Toll like receptors and Clec4e, leading to progression of both murine and human lupus nephritis | Silencing of renal DNaseI in murine lupus nephritis imposes exposure of large chromatin fragments and activation of Toll like receptors and the Clec4e.
Thiyagarajan D, Fismen S, Seredkina N, Jacobsen S, Elung-Jensen T, Kamper AL, Fenton CG, Rekvig OP, Mortensen ES., Free PMC Article | 11/17/2012 |