| Ehf controls mammary alveolar lineage differentiation and is a putative suppressor of breast tumorigenesis. | Ehf controls mammary alveolar lineage differentiation and is a putative suppressor of breast tumorigenesis.
Nightingale R, Reehorst CM, Vukelic N, Papadopoulos N, Liao Y, Guleria S, Bell C, Vaillant F, Paul S, Luk IY, Dhillon AS, Jenkins LJ, Morrow RJ, Jackling FC, Chand AL, Chisanga D, Chen Y, Williams DS, Anderson RL, Ellis S, Meikle PJ, Shi W, Visvader JE, Pal B, Mariadason JM. | 09/13/2024 |
| ETS homologous factor, controlled by lysine-specific demethylase 5B, suppresses clear cell renal cell carcinoma by inducing Filamin-B. | ETS homologous factor, controlled by lysine-specific demethylase 5B, suppresses clear cell renal cell carcinoma by inducing Filamin-B.
Wang F, Huang J, Zeng S, Pan Y, Zhou H. | 07/25/2024 |
| Pancreatic cancer cell-derived microRNA-155-5p-containing extracellular vesicles promote immune evasion by triggering EHF-dependent activation of Akt/NF-kappaB signaling pathway. | Pancreatic cancer cell-derived microRNA-155-5p-containing extracellular vesicles promote immune evasion by triggering EHF-dependent activation of Akt/NF-κB signaling pathway.
Wang S, Gao Y. | 02/12/2022 |
| EHF enhances malignancy by modulating AKT and MAPK/ERK signaling in nonsmall cell lung cancer cells. | EHF enhances malignancy by modulating AKT and MAPK/ERK signaling in non‑small cell lung cancer cells.
Gao L, Yang T, Zhang S, Liang Y, Shi P, Ren H, Hou P, Chen M., Free PMC Article | 11/27/2021 |
| Loss of EHF facilitates the development of treatment-induced neuroendocrine prostate cancer. | Loss of EHF facilitates the development of treatment-induced neuroendocrine prostate cancer.
Long Z, Deng L, Li C, He Q, He Y, Hu X, Cai Y, Gan Y., Free PMC Article | 10/2/2021 |
| Ese-3 Inhibits the Proliferation, Migration, and Invasion of HaCaT Cells by Downregulating PSIP1 and NUCKS1. | Ese-3 Inhibits the Proliferation, Migration, and Invasion of HaCaT Cells by Downregulating PSIP1 and NUCKS1.
Zhang C, Li J, Guo Y, Wang R, Hua L, Gan D, Zhu L, Ma P, Yang J, Li H, Li S, Song Y, Su H. | 09/11/2021 |
| Activation of EHF via STAT3 phosphorylation by LMP2A in Epstein-Barr virus-positive gastric cancer. | Activation of EHF via STAT3 phosphorylation by LMP2A in Epstein-Barr virus-positive gastric cancer.
Li W, Okabe A, Usui G, Fukuyo M, Matsusaka K, Rahmutulla B, Mano Y, Hoshii T, Funata S, Hiura N, Fukayama M, Tan P, Ushiku T, Kaneda A., Free PMC Article | 08/21/2021 |
| Expression and prognostic significance of epithelial tissue-specific transcription factor ESE3 in hepatocellular carcinoma. | Expression and prognostic significance of epithelial tissue-specific transcription factor ESE3 in hepatocellular carcinoma.
Lyu Z, Ma M, Xu Y, Wang X, Zhu Y, Ren W, Li T. | 09/19/2020 |
| Coordinate regulation of ELF5 and EHF at the chr11p13 CF modifier region. | Coordinate regulation of ELF5 and EHF at the chr11p13 CF modifier region.
Swahn H, Sabith Ebron J, Lamar KM, Yin S, Kerschner JL, NandyMazumdar M, Coppola C, Mendenhall EM, Leir SH, Harris A., Free PMC Article | 09/12/2020 |
| Tumoral EHF expression associates with the immune profile in human pancreatic ductal adenocarcinoma patients.EHF suppressed the transcription of TGFB1 and CSF2 by directly binding to their promoters. | Tumoral EHF predicts the efficacy of anti-PD1 therapy in pancreatic ductal adenocarcinoma.
Liu J, Jiang W, Zhao K, Wang H, Zhou T, Bai W, Wang X, Zhao T, Huang C, Gao S, Qin T, Yu W, Yang B, Li X, Fu D, Tan W, Yang S, Ren H, Hao J., Free PMC Article | 03/28/2020 |
| Targeting a novel miR-365-3p/EHF/KRT16/beta5-integrin/c-Met signaling pathway could improve treatment efficacy in OSCC. | A novel miR-365-3p/EHF/keratin 16 axis promotes oral squamous cell carcinoma metastasis, cancer stemness and drug resistance via enhancing β5-integrin/c-met signaling pathway.
Huang WC, Jang TH, Tung SL, Yen TC, Chan SH, Wang LH., Free PMC Article | 06/15/2019 |
| Human prostate tumors with IL-6 elevation and loss of ESE3/EHF were associated with STAT3 activation and displayed upregulation of genes related to cell adhesion, cancer stem-like and metastatic spread. | The ETS factor ESE3/EHF represses IL-6 preventing STAT3 activation and expansion of the prostate cancer stem-like compartment.
Albino D, Civenni G, Rossi S, Mitra A, Catapano CV, Carbone GM., Free PMC Article | 03/3/2018 |
| EHF is a novel functional oncogene in thyroid cancer by transcriptionally regulating HER2 and HER3, and may represent a potential therapeutic target for this cancer | Increased expression of EHF contributes to thyroid tumorigenesis through transcriptionally regulating HER2 and HER3.
Lv Y, Sui F, Ma J, Ren X, Yang Q, Zhang Y, Guan H, Shi B, Hou P, Ji M., Free PMC Article | 02/24/2018 |
| The role of EHF in modifying Cystic Fibrosis lung disease severity. | Regulatory dynamics of 11p13 suggest a role for EHF in modifying CF lung disease severity.
Stolzenburg LR, Yang R, Kerschner JL, Fossum S, Xu M, Hoffmann A, Lamar KM, Ghosh S, Wachtel S, Leir SH, Harris A., Free PMC Article | 11/11/2017 |
| is a novel functional oncogene in gastric cancer by regulating the human epidermal growth factor receptor (HER) family of receptor tyrosine kinases. | Increased expression of EHF via gene amplification contributes to the activation of HER family signaling and associates with poor survival in gastric cancer.
Shi J, Qu Y, Li X, Sui F, Yao D, Yang Q, Shi B, Ji M, Hou P., Free PMC Article | 09/2/2017 |
| tight control by ESE3/EHF over the Lin28/let-7 axis is a critical barrier to malignant transformation. | Activation of the Lin28/let-7 Axis by Loss of ESE3/EHF Promotes a Tumorigenic and Stem-like Phenotype in Prostate Cancer.
Albino D, Civenni G, Dallavalle C, Roos M, Jahns H, Curti L, Rossi S, Pinton S, D'Ambrosio G, Sessa F, Hall J, Catapano CV, Carbone GM. | 08/12/2017 |
| ESE3 as a negative regulator of pancreatic ductal adenocarcinomas (PDAC) progression and metastasis by enforcing E-cadherin upregulation. | ESE3 Inhibits Pancreatic Cancer Metastasis by Upregulating E-Cadherin.
Zhao T, Jiang W, Wang X, Wang H, Zheng C, Li Y, Sun Y, Huang C, Han ZB, Yang S, Jia Z, Xie K, Ren H, Hao J., Free PMC Article | 08/12/2017 |
| EHF activates expression of the SAM pointed domain-containing ETS transcription factor, which contributes to goblet cell hyperplasia. | Ets homologous factor (EHF) has critical roles in epithelial dysfunction in airway disease.
Fossum SL, Mutolo MJ, Tugores A, Ghosh S, Randell SH, Jones LC, Leir SH, Harris A., Free PMC Article | 07/8/2017 |
| Results found that EHF was elevated in ovarian cancer tissues and correlated with short survival. Its overexpression in ovarian cancer cells promoted cell growth and metastasis, and inhibited cell apoptosis. | Knockdown of EHF inhibited the proliferation, invasion and tumorigenesis of ovarian cancer cells.
Cheng Z, Guo J, Chen L, Luo N, Yang W, Qu X. | 05/27/2017 |
| This study suggests that ESE3 plays an important role in the carcinogenesis of Esophageal Squamous Cell Carcinoma through changes in subcellular localization and may act as a tumor suppressor gene in Esophageal Squamous Cell Carcinoma. | Abnormal Localization and Tumor Suppressor Function of Epithelial Tissue-Specific Transcription Factor ESE3 in Esophageal Squamous Cell Carcinoma.
Wang L, Xing J, Cheng R, Shao Y, Li P, Zhu S, Zhang S., Free PMC Article | 05/7/2016 |
| EHF modifies the CF phenotype by altering capabilities of the epithelial cell to correctly process the folding and trafficking of mutant p.Phe508del-CFTR. | The CF-modifying gene EHF promotes p.Phe508del-CFTR residual function by altering protein glycosylation and trafficking in epithelial cells.
Stanke F, van Barneveld A, Hedtfeld S, Wölfl S, Becker T, Tümmler B., Free PMC Article | 01/31/2015 |
| Results suggest PPAR-gamma to be involved in the regulation of ESE-3b expression during monocyte-derived dendritic cells (moDCs) development and that ESE-3 expression is not correlated with the immunogenicity of dendritic cells (DCs). | Activation of peroxisome proliferator-activated receptor gamma leads to upregulation of ESE-3 expression in human monocyte-derived dendritic cells.
Sprater F, Azeem W, Appel S. | 03/1/2014 |
| The SRC family tyrosine kinase HCK and the ETS family transcription factors SPIB and EHF regulate transcytosis across a human follicle-associated epithelium model. | The SRC family tyrosine kinase HCK and the ETS family transcription factors SPIB and EHF regulate transcytosis across a human follicle-associated epithelium model.
Asai T, Morrison SL., Free PMC Article | 06/8/2013 |
| ESE-3b is the functionally most important ESE-3 isoform in dendritic cells | Expression of ESE-3 isoforms in immunogenic and tolerogenic human monocyte-derived dendritic cells.
Sprater F, Hovden AO, Appel S., Free PMC Article | 05/25/2013 |
| Low ESE3/EHF expression was also associated with increased biochemical recurrence of prostate cancer and reduced overall survival after prostatectomy | ESE3/EHF controls epithelial cell differentiation and its loss leads to prostate tumors with mesenchymal and stem-like features.
Albino D, Longoni N, Curti L, Mello-Grand M, Pinton S, Civenni G, Thalmann G, D'Ambrosio G, Sarti M, Sessa F, Chiorino G, Catapano CV, Carbone GM. | 08/11/2012 |