| The role of heat shock protein B8 in neuronal protection against oxidative stress and mitochondrial dysfunction: A literature review. | The role of heat shock protein B8 in neuronal protection against oxidative stress and mitochondrial dysfunction: A literature review.
Wu Y, Xiong F, Ling J. | 09/9/2024 |
| Identification of Alternatively Spliced Novel Isoforms of Human HSPB8 Gene. | Identification of Alternatively Spliced Novel Isoforms of Human HSPB8 Gene.
Rashid N, Juneja P, Rathi A, Sultan I, Rehman SU. | 08/30/2024 |
| Eukaryotic Elongation Factor 1Alpha-2 (EEF1A2) Participates in the Progression of Gastric Cancer via Interaction with Heat Shock Protein B8 (HSPB8). | Eukaryotic Elongation Factor 1Alpha-2 (EEF1A2) Participates in the Progression of Gastric Cancer via Interaction with Heat Shock Protein B8 (HSPB8).
Li J, Tang X, Zhang Z. | 07/17/2023 |
| Identification of HSPB8 modulators counteracting misfolded protein accumulation in neurodegenerative diseases. | Identification of HSPB8 modulators counteracting misfolded protein accumulation in neurodegenerative diseases.
Chierichetti M, Cerretani M, Ciammaichella A, Crippa V, Rusmini P, Ferrari V, Tedesco B, Casarotto E, Cozzi M, Mina F, Pramaggiore P, Galbiati M, Piccolella M, Bresciani A, Cristofani R, Poletti A. | 04/26/2023 |
| Macrophage-specific autophagy-related gene HSPB8 is involved in the macrophage polarization in atherosclerosis. | Macrophage-specific autophagy-related gene HSPB8 is involved in the macrophage polarization in atherosclerosis.
Wang J, Zhao C, Zhang B, Liu X., Free PMC Article | 03/24/2023 |
| CircAGO2 promotes colorectal cancer progression by inhibiting heat shock protein family B (small) member 8 via miR-1-3p/retinoblastoma binding protein 4 axis. | CircAGO2 promotes colorectal cancer progression by inhibiting heat shock protein family B (small) member 8 via miR-1-3p/retinoblastoma binding protein 4 axis.
Zhu X, Luo X, Long X, Jiang S, Xie X, Zhang Q, Wang H. | 03/9/2023 |
| HSPB8 facilitates prostate cancer progression via activating the JAK/STAT3 signaling pathway. | HSPB8 facilitates prostate cancer progression via activating the JAK/STAT3 signaling pathway.
Zhang K, Yin W, Ma L, Liu Z, Li Q. | 02/11/2023 |
| HSPB8 counteracts tumor activity of BRAF- and NRAS-mutant melanoma cells by modulation of RAS-prenylation and autophagy. | HSPB8 counteracts tumor activity of BRAF- and NRAS-mutant melanoma cells by modulation of RAS-prenylation and autophagy.
Cristofani R, Piccolella M, Montagnani Marelli M, Tedesco B, Poletti A, Moretti RM., Free PMC Article | 12/3/2022 |
| [Analysis of a pedigree with distal hereditary motor neuropathy type 2A caused by mutation in HSPB8 gene]. | [Analysis of a pedigree with distal hereditary motor neuropathy type 2A caused by mutation in HSPB8 gene].
Li G, Fu J, Pang M, Song J, Ma M, Zhang J. | 07/16/2022 |
| A novel deletion in the C-terminal region of HSPB8 in a family with rimmed vacuolar myopathy. | A novel deletion in the C-terminal region of HSPB8 in a family with rimmed vacuolar myopathy.
Inoue-Shibui A, Niihori T, Kobayashi M, Suzuki N, Izumi R, Warita H, Hara K, Shirota M, Funayama R, Nakayama K, Nishino I, Aoki M, Aoki Y. | 01/22/2022 |
| HSPB8 promoted intrahepatic cholangiocarcinoma progression by enhancing epithelial-mesenchymal transition and autophagy. | HSPB8 promoted intrahepatic cholangiocarcinoma progression by enhancing epithelial-mesenchymal transition and autophagy.
Shu B, Zhou Y, Liang Q, He C, Li F. | 12/25/2021 |
| Small heat shock protein 22 kDa can modulate the aggregation and liquid-liquid phase separation behavior of tau. | Small heat shock protein 22 kDa can modulate the aggregation and liquid-liquid phase separation behavior of tau.
Darling AL, Dahrendorff J, Creodore SG, Dickey CA, Blair LJ, Uversky VN., Free PMC Article | 12/25/2021 |
| Insulin receptor substrate 1 gene expression is strongly up-regulated by HSPB8 silencing in U87 glioma cells. | Insulin receptor substrate 1 gene expression is strongly up-regulated by HSPB8 silencing in U87 glioma cells.
Hnatiuk OS, Tsymbal DO, Minchenko DO, Khita OO, Viletska YM, Rundytska OV, Kozynkevych HE, Maslak HS, Minchenko OH. | 11/13/2021 |
| HspB8 prevents aberrant phase transitions of FUS by chaperoning its folded RNA-binding domain. | HspB8 prevents aberrant phase transitions of FUS by chaperoning its folded RNA-binding domain.
Boczek EE, Fürsch J, Niedermeier ML, Jawerth L, Jahnel M, Ruer-Gruß M, Kammer KM, Heid P, Mediani L, Wang J, Yan X, Pozniakovski A, Poser I, Mateju D, Hubatsch L, Carra S, Alberti S, Hyman AA, Stengel F., Free PMC Article | 10/30/2021 |
| Heat shock protein B8 promotes proliferation and migration in lung adenocarcinoma A549 cells by maintaining mitochondrial function. | Heat shock protein B8 promotes proliferation and migration in lung adenocarcinoma A549 cells by maintaining mitochondrial function.
Yu LL, Wang Y, Xiao ZK, Chen SS. | 07/17/2021 |
| Hsp22 with an N-Terminal Domain Truncation Mediates a Reduction in Tau Protein Levels. | Hsp22 with an N-Terminal Domain Truncation Mediates a Reduction in Tau Protein Levels.
Webster JM, Darling AL, Sanders TA, Blazier DM, Vidal-Aguiar Y, Beaulieu-Abdelahad D, Plemmons DG, Hill SE, Uversky VN, Bickford PC, Dickey CA, Blair LJ., Free PMC Article | 02/20/2021 |
| HSPB8 binds BAG3 to promote spatial sequestration of ubiquitinated proteins. | HSPB8 and BAG3 cooperate to promote spatial sequestration of ubiquitinated proteins and coordinate the cellular adaptive response to proteasome insufficiency.
Guilbert SM, Lambert H, Rodrigue MA, Fuchs M, Landry J, Lavoie JN. | 02/2/2019 |
| results strongly suggest that HSP22 represses HCC progression, especially HCC cell migration, by the down-regulation of the PI3K/AKT signaling pathway. | Heat shock protein 22 (HSPB8) reduces the migration of hepatocellular carcinoma cells through the suppression of the phosphoinositide 3-kinase (PI3K)/AKT pathway.
Matsushima-Nishiwaki R, Toyoda H, Takamatsu R, Yasuda E, Okuda S, Maeda A, Kaneoka Y, Yoshimi N, Kumada T, Kozawa O. | 12/1/2018 |
| We identified impaired RNA metabolism, secondary to TDP-43 loss of function, as a possible pathological mechanism of HSPB8 toxicity, leading to muscle and nerve degeneration | Altered TDP-43-dependent splicing in HSPB8-related distal hereditary motor neuropathy and myofibrillar myopathy.
Cortese A, Laurà M, Casali C, Nishino I, Hayashi YK, Magri S, Taroni F, Stuani C, Saveri P, Moggio M, Ripolone M, Prelle A, Pisciotta C, Sagnelli A, Pichiecchio A, Reilly MM, Buratti E, Pareyson D. | 11/24/2018 |
| Data indicated that the HSPB8 expression level was strongly positively correlated with MAPK signaling pathway and CREB pathway and worse prognosis. The methylation level of its DNA was negatively associated with its expression and positively associated with overall survival. These results suggest that HSPB8 could promote the proliferation and inhibit the apoptosis of GC cells by activating ERKCREB signaling. | HSPB8 promotes cancer cell growth by activating the ERK‑CREB pathway and is indicative of a poor prognosis in gastric cancer patients.
Shen J, Li M, Min L. | 09/29/2018 |
| HSPB2 competes with HSPB8 for binding to BAG3. In contrast, HSPB3 negatively regulates HSPB2 association with BAG3. | An interaction study in mammalian cells demonstrates weak binding of HSPB2 to BAG3, which is regulated by HSPB3 and abrogated by HSPB8.
Morelli FF, Mediani L, Heldens L, Bertacchini J, Bigi I, Carrà AD, Vinet J, Carra S., Free PMC Article | 03/24/2018 |
| Silencing of HSPB8 markedly decreased the mitotic levels of BAG3 in HeLa cells, supporting its crucial role in BAG3 mitotic functions. The results support a role for the HSPB8-BAG3 chaperone complex in quality control of actin-based structure dynamics that are put under high tension, notably during cell cytokinesis. | Fine-tuning of actin dynamics by the HSPB8-BAG3 chaperone complex facilitates cytokinesis and contributes to its impact on cell division.
Varlet AA, Fuchs M, Luthold C, Lambert H, Landry J, Lavoie JN., Free PMC Article | 03/24/2018 |
| HSPB8 is involved in regulating the cell cycle and cell migration in MCF-7 cells. | The small heat shock protein B8 (HSPB8) modulates proliferation and migration of breast cancer cells.
Piccolella M, Crippa V, Cristofani R, Rusmini P, Galbiati M, Cicardi ME, Meroni M, Ferri N, Morelli FF, Carra S, Messi E, Poletti A., Free PMC Article | 02/24/2018 |
| suggest that HSPB8 may act as an intracellular factor against hepatitis C virus replication and that DNAJC5B has the same function, with more relevant results for genotype 3 | Heat shock proteins HSPB8 and DNAJC5B have HCV antiviral activity.
Braga ACS, Carneiro BM, Batista MN, Akinaga MM, Bittar C, Rahal P., Free PMC Article | 12/30/2017 |
| It has been demonstrated that HSPB8-BAG3-HSP70 ensures the functionality of stress granules and restores proteostasis by targeting defective ribosomal products for degradation. | A Surveillance Function of the HSPB8-BAG3-HSP70 Chaperone Complex Ensures Stress Granule Integrity and Dynamism.
Ganassi M, Mateju D, Bigi I, Mediani L, Poser I, Lee HO, Seguin SJ, Morelli FF, Vinet J, Leo G, Pansarasa O, Cereda C, Poletti A, Alberti S, Carra S. | 09/9/2017 |