| E3 ubiquitin ligase NEDD4L negatively regulates inflammation by promoting ubiquitination of MEKK2. | E3 ubiquitin ligase NEDD4L negatively regulates inflammation by promoting ubiquitination of MEKK2.
Li H, Wang N, Jiang Y, Wang H, Xin Z, An H, Pan H, Ma W, Zhang T, Wang X, Lin W., Free PMC Article | 11/19/2022 |
| MiR-20a-5p facilitates cartilage repair in osteoarthritis via suppressing mitogen-activated protein kinase kinase kinase 2. | MiR-20a-5p facilitates cartilage repair in osteoarthritis via suppressing mitogen-activated protein kinase kinase kinase 2.
Liu J, Tang G, Liu W, Zhou Y, Fan C, Zhang W., Free PMC Article | 06/25/2022 |
| Comments on 'MAP3K2-regulated intestinal stromal cells define a distinct stem cell niche'. | Comments on 'MAP3K2-regulated intestinal stromal cells define a distinct stem cell niche'.
Wu N, Sun H, Tan J, Zhang Y, Su B., Free PMC Article | 02/19/2022 |
| MAP3K2 augments Th1 cell differentiation via IL-18 to promote T cell-mediated colitis. | MAP3K2 augments Th1 cell differentiation via IL-18 to promote T cell-mediated colitis.
Wu N, Chen D, Sun H, Tan J, Zhang Y, Zhang T, Han Y, Liu H, Ouyang X, Yang XD, Niu X, Zhong J, Wang Z, Su B. | 01/1/2022 |
| MAP3K2-regulated intestinal stromal cells define a distinct stem cell niche. | MAP3K2-regulated intestinal stromal cells define a distinct stem cell niche.
Wu N, Sun H, Zhao X, Zhang Y, Tan J, Qi Y, Wang Q, Ng M, Liu Z, He L, Niu X, Chen L, Liu Z, Li HB, Zeng YA, Roulis M, Liu D, Cheng J, Zhou B, Ng LG, Zou D, Ye Y, Flavell RA, Ginhoux F, Su B. | 12/18/2021 |
| MEKK2 mediates aberrant ERK activation in neurofibromatosis type I. | MEKK2 mediates aberrant ERK activation in neurofibromatosis type I.
Bok S, Shin DY, Yallowitz AR, Eiseman M, Cung M, Xu R, Li N, Sun J, Williams AL, Scott JE, Su B, Shim JH, Greenblatt MB., Free PMC Article | 12/5/2020 |
| Erk5 MAP kinase is activated in response to PDGF-BB in the smooth muscle cell line MOVAS in a manner dependent on Mekk2, Mek1/2, Mek5, PI3-kinase and protein kinase C (PKC). | Platelet-derived growth factor (PDGF)-induced activation of Erk5 MAP-kinase is dependent on Mekk2, Mek1/2, PKC and PI3-kinase, and affects BMP signaling.
Tsioumpekou M, Papadopoulos N, Burovic F, Heldin CH, Lennartsson J. | 12/2/2017 |
| FGF2/MEKK2 pathway mediates an alternative nonclassical pathway for beta-catenin activation, and this pathway is a key regulator of bone formation by osteoblasts | MEKK2 mediates an alternative β-catenin pathway that promotes bone formation.
Greenblatt MB, Shin DY, Oh H, Lee KY, Zhai B, Gygi SP, Lotinun S, Baron R, Liu D, Su B, Glimcher LH, Shim JH., Free PMC Article | 08/6/2016 |
| Stk38 protein kinase has a role in inhibiting TLR9-activated inflammatory responses by promoting MEKK2 ubiquitination in macrophages | Stk38 protein kinase preferentially inhibits TLR9-activated inflammatory responses by promoting MEKK2 ubiquitination in macrophages.
Wen M, Ma X, Cheng H, Jiang W, Xu X, Zhang Y, Zhang Y, Guo Z, Yu Y, Xu H, Qian C, Cao X, An H. | 03/26/2016 |
| methylation of MAP3K2 by SMYD3 increases MAP kinase signalling and promotes the formation of Ras-driven carcinomas | SMYD3 links lysine methylation of MAP3K2 to Ras-driven cancer.
Mazur PK, Reynoird N, Khatri P, Jansen PW, Wilkinson AW, Liu S, Barbash O, Van Aller GS, Huddleston M, Dhanak D, Tummino PJ, Kruger RG, Garcia BA, Butte AJ, Vermeulen M, Sage J, Gozani O., Free PMC Article | 07/19/2014 |
| MEKK2 is regulated through a phosphorylation-dependent association with 14-3-3, a group of adapters that modulate dimerization and association between proteins | MEKK2 kinase association with 14-3-3 protein regulates activation of c-Jun N-terminal kinase.
Matitau AE, Gabor TV, Gill RM, Scheid MP., Free PMC Article | 12/28/2013 |
| MEKK2 signaling contributes to right ventricular hypertrophy and altered myocardial inflammatory gene expression in response to hypoxia-induced pulmonary hypertension. | MAP kinase kinase kinase-2 (MEKK2) regulates hypertrophic remodeling of the right ventricle in hypoxia-induced pulmonary hypertension.
Brown RD, Ambler SK, Li M, Sullivan TM, Henry LN, Crossno JT Jr, Long CS, Garrington TP, Stenmark KR., Free PMC Article | 03/9/2013 |
| MEKK2 alone can suppress T-cell TGF-beta responses. MEKK2 or MEKK3 can cause ERK1/2 to phosphorylate SMAD2/3 and suppress R-SMAD-dependent transcription. MEKK2 and MEKK3 play overlapping roles in regulating Th-cell differentiation via TGF-beta | The kinases MEKK2 and MEKK3 regulate transforming growth factor-β-mediated helper T cell differentiation.
Chang X, Liu F, Wang X, Lin A, Zhao H, Su B., Free PMC Article | 11/30/2012 |
| Data show that HDAC4 binds and promotes the deacetylation and activation of a key MAP3 kinase, MEKK2. | A direct HDAC4-MAP kinase crosstalk activates muscle atrophy program.
Choi MC, Cohen TJ, Barrientos T, Wang B, Li M, Simmons BJ, Yang JS, Cox GA, Zhao Y, Yao TP., Free PMC Article | 10/27/2012 |
| Data from experiments with Mekk2(-/-) mice show that MEKK2 may be required for controlling the strength of T cell receptor/CD3 signaling. | Disruption of Mekk2 in mice reveals an unexpected role for MEKK2 in modulating T-cell receptor signal transduction.
Guo Z, Clydesdale G, Cheng J, Kim K, Gan L, McConkey DJ, Ullrich SE, Zhuang Y, Su B., Free PMC Article | 01/21/2010 |
| Rap1 and MEKK2 are critical upstream signaling molecules mediating BDNF stimulation of ERK5 in central nervous system neurons | Brain-derived neurotrophic factor activates ERK5 in cortical neurons via a Rap1-MEKK2 signaling cascade.
Wang Y, Su B, Xia Z. | 01/21/2010 |
| PB1 domain mediates the association of MEKK2 and MEKK3 with MEK5 and that the respective PB1 domains of these kinases are critical for regulation of the ERK5 pathway. | PB1 domains of MEKK2 and MEKK3 interact with the MEK5 PB1 domain for activation of the ERK5 pathway.
Nakamura K, Johnson GL. | 01/21/2010 |
| A noncanonical function of Map3k2 domain is described for coordinated erk5 kinase and map2k7 signaling. | Noncanonical function of MEKK2 and MEK5 PB1 domains for coordinated extracellular signal-regulated kinase 5 and c-Jun N-terminal kinase signaling.
Nakamura K, Johnson GL., Free PMC Article | 01/21/2010 |