| PLEK2 activates the PI3K/AKT signaling pathway to drive lung adenocarcinoma progression by upregulating SPC25. | PLEK2 activates the PI3K/AKT signaling pathway to drive lung adenocarcinoma progression by upregulating SPC25.
Zhang W, Yu L, Xu C, Tang T, Cao J, Chen L, Pang X, Ren W. | 08/13/2024 |
| PLEK2 mediates metastasis and invasion via alpha5-nAChR activation in nicotine-induced lung adenocarcinoma. | PLEK2 mediates metastasis and invasion via α5-nAChR activation in nicotine-induced lung adenocarcinoma.
Li Q, Li J, Wang J, Wang J, Lu T, Jia Y, Sun H, Ma X. | 01/29/2024 |
| Pleckstrin-2 promotes tumour immune escape from NK cells by activating the MT1-MMP-MICA signalling axis in gastric cancer. | Pleckstrin-2 promotes tumour immune escape from NK cells by activating the MT1-MMP-MICA signalling axis in gastric cancer.
Mao D, Zhou Z, Chen H, Liu X, Li D, Chen X, He Y, Liu M, Zhang C. | 09/8/2023 |
| Pleckstrin-2-promoted PPM1B degradation plays an important role in transforming growth factor-beta-induced breast cancer cell invasion and metastasis. | Pleckstrin-2-promoted PPM1B degradation plays an important role in transforming growth factor-β-induced breast cancer cell invasion and metastasis.
Du L, Li J, Tian Y, Feng R., Free PMC Article | 06/7/2023 |
| PLEK2 promotes cancer stemness and tumorigenesis of head and neck squamous cell carcinoma via the c-Myc-mediated positive feedback loop. | PLEK2 promotes cancer stemness and tumorigenesis of head and neck squamous cell carcinoma via the c-Myc-mediated positive feedback loop.
Zhao X, Shu D, Sun W, Si S, Ran W, Guo B, Cui L., Free PMC Article | 10/22/2022 |
| The correlation between miR -34a-3p, miR -31, PLEK2 and the occurrence, development and prognosis of colorectal cancer. | The correlation between miR -34a-3p, miR -31, PLEK2 and the occurrence, development and prognosis of colorectal cancer.
Bin H, Mei H, Hui W, Bing Z. | 07/16/2022 |
| PLEK2 promotes the proliferation and migration of non-small cell lung cancer cells in a BRD4-dependent manner. | PLEK2 promotes the proliferation and migration of non-small cell lung cancer cells in a BRD4-dependent manner.
Cai T, Yao W, Qiu L, Zhu AR, Shi Z, Du Y. | 06/18/2022 |
| Expression and prognostic potential of PLEK2 in head and neck squamous cell carcinoma based on bioinformatics analysis. | Expression and prognostic potential of PLEK2 in head and neck squamous cell carcinoma based on bioinformatics analysis.
Wang J, Sun Z, Wang J, Tian Q, Huang R, Wang H, Wang X, Han F., Free PMC Article | 02/26/2022 |
| Pleckstrin 2 is a potential drug target for colorectal carcinoma with activation of APC/betacatenin. | Pleckstrin 2 is a potential drug target for colorectal carcinoma with activation of APC/β‑catenin.
Chai B, Guo Y, Zhu N, Jia J, Zhang Z, Ping M, Jia K, Cui X, Suo Y., Free PMC Article | 02/12/2022 |
| TGF-beta-induced PLEK2 promotes metastasis and chemoresistance in oesophageal squamous cell carcinoma by regulating LCN2. | TGF-β-induced PLEK2 promotes metastasis and chemoresistance in oesophageal squamous cell carcinoma by regulating LCN2.
Wang F, Zhang C, Cheng H, Liu C, Lu Z, Zheng S, Wang S, Sun N, He J., Free PMC Article | 02/5/2022 |
| PLEK2 Gene Upregulation Might Independently Predict Shorter Progression-Free Survival in Lung Adenocarcinoma. | PLEK2 Gene Upregulation Might Independently Predict Shorter Progression-Free Survival in Lung Adenocarcinoma.
Zhang W, Li T, Hu B, Li H., Free PMC Article | 11/6/2021 |
| High PLEK2 expression is associated with migration and invasion in non-small cell lung cancer. | PLEK2 mediates metastasis and vascular invasion via the ubiquitin-dependent degradation of SHIP2 in non-small cell lung cancer.
Wu DM, Deng SH, Zhou J, Han R, Liu T, Zhang T, Li J, Chen JP, Xu Y. | 07/4/2020 |
| On the basis of these collective data, we propose that PLEK2 promotes the invasion and metastasis of GBC by EGFR/CCL2 pathway and PLEK2 can serve as a potential therapeutic target for GBC treatment. | PLEK2 promotes gallbladder cancer invasion and metastasis through EGFR/CCL2 pathway.
Shen H, He M, Lin R, Zhan M, Xu S, Huang X, Xu C, Chen W, Yao Y, Mohan M, Wang J., Free PMC Article | 12/7/2019 |
| expression of PLEK2, the strongest gene to classify melanoma patients, in CD45(-) subsets illustrates the importance of analyzing whole blood cells for biomarker studies | Transcriptome profiling of whole blood cells identifies PLEK2 and C1QB in human melanoma.
Luo Y, Robinson S, Fujita J, Siconolfi L, Magidson J, Edwards CK, Wassmann K, Storm K, Norris DA, Bankaitis-Davis D, Robinson WA, Fujita M., Free PMC Article | 11/12/2011 |
| These results suggest that PLEK2 is involved in actin rearrangement in a PI 3-kinase dependent manner. | Pleckstrin-2 selectively interacts with phosphatidylinositol 3-kinase lipid products and regulates actin organization and cell spreading.
Hamaguchi N, Ihara S, Ohdaira T, Nagano H, Iwamatsu A, Tachikawa H, Fukui Y. | 01/21/2010 |
| Pleckstrin 2 was cloned; its mRNA is widely expressed in a variety of cell lines. | Cloning, expression and chromosomal assignment of human pleckstrin 2.
Inazu T, Kuroiwa A, Matsuda Y, Miyamoto K. | 01/21/2010 |
| pleckstrin-2 uses its modular domains to bind to membrane-associated phosphatidylinositols generated by PI3K, whereby it coordinates with the actin cytoskeleton in lymphocyte spreading and immune synapse formation. | PI3K regulates pleckstrin-2 in T-cell cytoskeletal reorganization.
Bach TL, Kerr WT, Wang Y, Bauman EM, Kine P, Whiteman EL, Morgan RS, Williamson EK, Ostap EM, Burkhardt JK, Koretzky GA, Birnbaum MJ, Abrams CS., Free PMC Article | 01/21/2010 |