| The role of GCNT1 mediated O-glycosylation in aggressive prostate cancer. | The role of GCNT1 mediated O-glycosylation in aggressive prostate cancer.
Hodgson K, Orozco-Moreno M, Scott E, Garnham R, Livermore K, Thomas H, Zhou Y, He J, Bermudez A, Garcia Marques FJ, Bastian K, Hysenaj G, Archer Goode E, Heer R, Pitteri S, Wang N, Elliott DJ, Munkley J., Free PMC Article | 10/11/2023 |
| GCNT1 expression in prostate biopsy specimen is a significant and independent predictor of recurrence after radical prostatectomy, which can be used in pre-treatment decision making for the patient. | Core 2 β-1, 6-N-acetylglucosaminyltransferase-1 expression in prostate biopsy specimen is an indicator of prostate cancer aggressiveness.
Sato T, Yoneyama T, Tobisawa Y, Hatakeyama S, Yamamoto H, Kojima Y, Mikami J, Mori K, Hashimoto Y, Koie T, Ohyama C. | 06/11/2016 |
| GCNT1 expression in prostate cancer positively correlates with cancer progression and prostate-specific antigen recurrence. | Detection of Core2 β-1,6-N-Acetylglucosaminyltransferase in Post-Digital Rectal Examination Urine Is a Reliable Indicator for Extracapsular Extension of Prostate Cancer.
Kojima Y, Yoneyama T, Hatakeyama S, Mikami J, Sato T, Mori K, Hashimoto Y, Koie T, Ohyama C, Fukuda M, Tobisawa Y., Free PMC Article | 06/4/2016 |
| Results show that ST3Gal1 uses GM130-GRASP65 and giantin, whereas C2GnT-L uses only giantin for Golgi targeting and defective giantin dimerization in PC-3 and DU145 prostate cancer cells causes fragmentation of the Golgi and prevents its targeting. | Restoration of compact Golgi morphology in advanced prostate cancer enhances susceptibility to galectin-1-induced apoptosis by modifying mucin O-glycan synthesis.
Petrosyan A, Holzapfel MS, Muirhead DE, Cheng PW., Free PMC Article | 08/15/2015 |
| NMIIA is the master regulator of Golgi fragmentation induced by heat shock or inhibition/depletion of HSP70/90 through interaction with gylosyltransferases. | Golgi fragmentation induced by heat shock or inhibition of heat shock proteins is mediated by non-muscle myosin IIA via its interaction with glycosyltransferases.
Petrosyan A, Cheng PW., Free PMC Article | 10/18/2014 |
| GCNT1 is over-expressed in prostate cancer and is associated with higher levels of core 2 O-sLe(x) in PSA, PAP and MUC1 proteins. | Increased expression of GCNT1 is associated with altered O-glycosylation of PSA, PAP, and MUC1 in human prostate cancers.
Chen Z, Gulzar ZG, St Hill CA, Walcheck B, Brooks JD., Free PMC Article | 08/9/2014 |
| Immunohistochemical expression of core 2 beta1,6-N-acetylglucosaminyl transferase 1 (C2GnT1) in endometrioid-type endometrial carcinoma may be a novel potential prognostic factor. | Immunohistochemical expression of core 2 β1,6-N-acetylglucosaminyl transferase 1 (C2GnT1) in endometrioid-type endometrial carcinoma: a novel potential prognostic factor.
Miyamoto T, Suzuki A, Asaka R, Ishikawa K, Yamada Y, Kobara H, Nakayama J, Shiozawa T. | 12/21/2013 |
| C2GnT-expressing prostate cancer cells evade NK cell immunity and survive longer in the host blood circulation, thereby resulting in the promotion of prostate cancer metastasis. | Core2 O-glycan-expressing prostate cancer cells are resistant to NK cell immunity.
Okamoto T, Yoneyama MS, Hatakeyama S, Mori K, Yamamoto H, Koie T, Saitoh H, Yamaya K, Funyu T, Fukuda M, Ohyama C, Tsuboi S., Free PMC Article | 11/16/2013 |
| GOLPH3 can regulate cell-cell interaction by controlling Golgi retention of C2GnT1. | Golgi phosphoprotein 3 determines cell binding properties under dynamic flow by controlling Golgi localization of core 2 N-acetylglucosaminyltransferase 1.
Ali MF, Chachadi VB, Petrosyan A, Cheng PW., Free PMC Article | 02/23/2013 |
| Down-regulation of C2GnT1 is correlated with breast cancer | MUC1 in human and murine mammary carcinoma cells decreases the expression of core 2 β1,6-N-acetylglucosaminyltransferase and β-galactoside α2,3-sialyltransferase.
Solatycka A, Owczarek T, Piller F, Piller V, Pula B, Wojciech L, Podhorska-Okolow M, Dziegiel P, Ugorski M. | 12/8/2012 |
| The X-ray crystal structure (2.3 A resolution) of a mutant form of C2GnT-L (C217S) in complex with UDP was solved. C2GnT-L exists in an "open" conformation and a "closed" conformation. | Structural and mechanistic characterization of leukocyte-type core 2 β1,6-N-acetylglucosaminyltransferase: a metal-ion-independent GT-A glycosyltransferase.
Pak JE, Satkunarajah M, Seetharaman J, Rini JM. | 02/4/2012 |
| In C2GnT-expressing bladder tumour cells galectin-3 bound the NKG2D-binding site of MICA, reducing the affinity of MICA for NKG2D on natural killer cells and hence severely impairing natural killer cell activation. | A novel strategy for evasion of NK cell immunity by tumours expressing core2 O-glycans.
Tsuboi S, Sutoh M, Hatakeyama S, Hiraoka N, Habuchi T, Horikawa Y, Hashimoto Y, Yoneyama T, Mori K, Koie T, Nakamura T, Saitoh H, Yamaya K, Funyu T, Fukuda M, Ohyama C., Free PMC Article | 10/8/2011 |
| Data show that the reconstituted membrane system in cells expressing C2GnT-I led to the lipid vesicles exhibiting an enzyme activity 11 times higher than that found in microsomal membranes. | A glycosyltransferase-enriched reconstituted membrane system for the synthesis of branched O-linked glycans in vitro.
Susini S, Jeanneau C, Mathieu S, Carmona S, El-Battari A. | 07/30/2011 |
| Core2 O-glycan structure is essential for expression of SI and DDP-IV during intestinal cell differentiation. | Core2 O-glycan structure is essential for the cell surface expression of sucrase isomaltase and dipeptidyl peptidase-IV during intestinal cell differentiation.
Lee SH, Yu SY, Nakayama J, Khoo KH, Stone EL, Fukuda MN, Marth JD, Fukuda M., Free PMC Article | 01/1/2011 |
| Overexpression of C2GnT-1 enhances the metastatic potential of testicular germ cell tumor. | Core 2 N-acetylglucosaminyltransferase-1 expression induces aggressive potential of testicular germ cell tumor.
Hatakeyama S, Kyan A, Yamamoto H, Okamoto A, Sugiyama N, Suzuki Y, Yoneyama T, Hashimoto Y, Koie T, Yamada S, Saito H, Arai Y, Fukuda M, Ohyama C., Free PMC Article | 08/16/2010 |
| Data show that a short glycopeptide Galbeta1-3GalNAcalpha-TAGV was identified as an efficient C2GnT substrate. | Site directed processing: role of amino acid sequences and glycosylation of acceptor glycopeptides in the assembly of extended mucin type O-glycan core 2.
Brockhausen I, Dowler T, Paulsen H. | 01/21/2010 |
| 15-fold increase in C2GnT1 mRNA levels in colorectal adenocarcinomas compared to normal colorectal tissues | The high affinity selectin glycan ligand C2-O-sLex and mRNA transcripts of the core 2 beta-1,6-N-acetylglucosaminyltransferase (C2GnT1) gene are highly expressed in human colorectal adenocarcinomas.
St Hill CA, Farooqui M, Mitcheltree G, Gulbahce HE, Jessurun J, Cao Q, Walcheck B., Free PMC Article | 01/21/2010 |
| Pancreas carcinoma antigen, C2GnT, fused to invariant chain elicits T-cell response and tumor growth inhibition. | Pancreas carcinoma antigen fused to invariant chain elicits T-cell response and tumor growth inhibition.
Nagaraj S, Neumann J, Winzen B, Frank S, Ziske C, Sievers E, Koch N, Schmidt-Wolf IG. | 01/21/2010 |
| 2 beta1,6 N-acetylglucosaminyltransferase-I transcription is regulated by Sp1 in lymphocytes and epithelial cells | Control of core 2 beta1,6 N-acetylglucosaminyltransferase-I transcription by Sp1 in lymphocytes and epithelial cells.
Falkenberg VR, Fregien N. | 01/21/2010 |
| regulation of O-glycosylation controls sLe(x) expression, and also suggest that O-glycans may have a function in dendritic cells migration | Sialyl-Lewis(x) on P-selectin glycoprotein ligand-1 is regulated during differentiation and maturation of dendritic cells: a mechanism involving the glycosyltransferases C2GnT1 and ST3Gal I.
Julien S, Grimshaw MJ, Sutton-Smith M, Coleman J, Morris HR, Dell A, Taylor-Papadimitriou J, Burchell JM. | 01/21/2010 |
| A/G polymorphism in enzyme is associated with the susceptibility to prostate cancer in a Japanese population | An A/G polymorphism of core 2 branching enzyme gene is associated with prostate cancer.
Wang L, Mitoma J, Tsuchiya N, Narita S, Horikawa Y, Habuchi T, Imai A, Ishimura H, Ohyama C, Fukuda M. | 01/21/2010 |
| A differential functional impact of N-glycosylation on C2GnT-1 and FucT-VII and disclose that a strongly reduced FucT-VII activity retains the ability to fucosylate PSGL-1 on the core2-based binding site(s) for the three selectins. | N-glycans of core2 beta(1,6)-N-acetylglucosaminyltransferase-I (C2GnT-I) but not those of alpha(1,3)-fucosyltransferase-VII (FucT-VII) are required for the synthesis of functional P-selectin glycoprotein ligand-1 (PSGL-1): effects on P-, L- and E-selectin binding.
Prorok-Hamon M, Notel F, Mathieu S, Langlet C, Fukuda M, El-Battari A., Free PMC Article | 01/21/2010 |
| glycosyltransferase haploinsufficiency results in altered cellular glycosylation and resistance to cell death, identifying a new survival mechanism for T-lymphoma cells | Haploinsufficiency of C2GnT-I glycosyltransferase renders T lymphoma cells resistant to cell death.
Cabrera PV, Amano M, Mitoma J, Chan J, Said J, Fukuda M, Baum LG., Free PMC Article | 01/21/2010 |
| upregulated by all-trans retinoic acid (RA) and by IL-4 and IL-13 in the H292 airway epithelial cell line | Mucin biosynthesis: upregulation of core 2 beta 1,6 N-acetylglucosaminyltransferase by retinoic acid and Th2 cytokines in a human airway epithelial cell line.
Beum PV, Basma H, Bastola DR, Cheng PW. | 01/21/2010 |
| EGF suppressed C2GnT activity in a time- and dose-dependent fashion, and also suppressed core 4 beta1,6 N-acetylglucosaminyltransferase (C4GnT) activity | Mucin biosynthesis: epidermal growth factor downregulates core 2 enzymes in a human airway adenocarcinoma cell line.
Beum PV, Bastola DR, Cheng PW. | 01/21/2010 |