| Melanoma-associated glycosyltransferase GCNT2 as an emerging biomarker and therapeutic target. | Melanoma-associated glycosyltransferase GCNT2 as an emerging biomarker and therapeutic target.
Perez M, Chakraborty A, Lau LS, Mohammed NBB, Dimitroff CJ., Free PMC Article | 09/25/2021 |
| I-branched glycans catalyzed principally by the I-branching enzyme GCNT2 are now indicated in several malignancies. | I-branched carbohydrates as emerging effectors of malignant progression.
Dimitroff CJ., Free PMC Article | 03/28/2020 |
| study suggested that GCNT2 was highly expressed in patients with esophageal squamous cell carcinoma and predicted adverse outcome; overexpression of GCNT2 induces epithelial-mesenchymal transition and promotes migration and invasion in ESCC cells; therefore, GCNT2 may act as a candidate prognostic indicator of outcome and a novel target in ESCC patients | GCNT2 induces epithelial-mesenchymal transition and promotes migration and invasion in esophageal squamous cell carcinoma cells.
Peng F, He Q, Cheng C, Pan J. | 03/2/2019 |
| miR-199a/b-5p regulates GCNT2 and I antigen expression in colon cancer cells undergoing EMT | Downregulation of miR-199a/b-5p is associated with GCNT2 induction upon epithelial-mesenchymal transition in colon cancer.
Chao CC, Wu PH, Huang HC, Chung HY, Chou YC, Cai BH, Kannagi R. | 08/19/2017 |
| This study reports a novel insertion/deletion mutation at the GCNT2 locus that is responsible for congenital cataracts in a large consanguineous family. | Deletion at the GCNT2 Locus Causes Autosomal Recessive Congenital Cataracts.
Irum B, Khan SY, Ali M, Daud M, Kabir F, Rauf B, Fatima F, Iqbal H, Khan AO, Al Obaisi S, Naeem MA, Nasir IA, Khan SN, Husnain T, Riazuddin S, Akram J, Eghrari AO, Riazuddin SA., Free PMC Article | 07/8/2017 |
| GCNT2 expression is closely associated with invasive potential of prostate cancer. | I-branching N-acetylglucosaminyltransferase regulates prostate cancer invasiveness by enhancing α5β1 integrin signaling.
Mikami J, Tobisawa Y, Yoneyama T, Hatakeyama S, Mori K, Hashimoto Y, Koie T, Ohyama C, Fukuda M., Free PMC Article | 08/13/2016 |
| Hypomethylation of the GCNT2 variant 2 reflected lymph node metastasis of colorectal cancer in the tumor and normal tissues. | Aberrant methylation of GCNT2 is tightly related to lymph node metastasis of primary CRC.
Nakamura K, Yamashita K, Sawaki H, Waraya M, Katoh H, Nakayama N, Kawamata H, Nishimiya H, Ema A, Narimatsu H, Watanabe M. | 05/9/2015 |
| An Alu repeat-mediated genomic GCNT2 deletion underlies congenital cataracts and adult i blood group | An Alu repeat-mediated genomic GCNT2 deletion underlies congenital cataracts and adult i blood group.
Borck G, Kakar N, Hoch J, Friedrich K, Freudenberg J, Nürnberg G, Yilmaz R, Daud S, Baloch DM, Nürnberg P, Oldenburg J, Ahmad J, Kubisch C. | 03/17/2012 |
| Results show involvement of GCNT2 in EMT and TGF-beta signaling, and further glycosylation modification of E-cadherin by GCNT2, are the underlying integrative mechanisms for breast cancer metastasis. | Engagement of I-branching {beta}-1, 6-N-acetylglucosaminyltransferase 2 in breast cancer metastasis and TGF-{beta} signaling.
Zhang H, Meng F, Wu S, Kreike B, Sethi S, Chen W, Miller FR, Wu G., Free PMC Article | 10/22/2011 |
| In the family with the "ii" blood group a novel GCNT2 mutation was found in the cataract patients. | Hematologic biomarkers in childhood cataracts.
Wussuki-Lior O, Abu-Horowitz A, Netzer I, Almer Z, Morad Y, Goldich Y, Yahalom V, Pras E, Pras E., Free PMC Article | 09/10/2011 |
| Observational study of gene-disease association. (HuGE Navigator) | An A/G polymorphism of core 2 branching enzyme gene is associated with prostate cancer.
Wang L, Mitoma J, Tsuchiya N, Narita S, Horikawa Y, Habuchi T, Imai A, Ishimura H, Ohyama C, Fukuda M. | 03/13/2008 |
| role of C/EBPalpha in the induction of the IGnTC gene as well as in I antigen expression | I branching formation in erythroid differentiation is regulated by transcription factor C/EBPalpha.
Twu YC, Chen CP, Hsieh CY, Tzeng CH, Sun CF, Wang SH, Chang MS, Yu LC. | 01/21/2010 |
| A nonsense mutation in the GCNT2 gene isoforms is associated with autosomal recessive congenital cataract in four distantly related Arab families from Israel. | A nonsense mutation in the glucosaminyl (N-acetyl) transferase 2 gene (GCNT2): association with autosomal recessive congenital cataracts.
Pras E, Raz J, Yahalom V, Frydman M, Garzozi HJ, Pras E, Hejtmancik JF. | 01/21/2010 |
| The I carbohydrate antigen interacts simultaneously with the entire hydrophobic patch in framework region 1 and with the outside surface of Ig heavy chain complementarity-determining region 3, leaving most of the site available for binding other antigens. | Evidence for involvement of a hydrophobic patch in framework region 1 of human V4-34-encoded Igs in recognition of the red blood cell I antigen.
Potter KN, Hobby P, Klijn S, Stevenson FK, Sutton BJ. | 01/21/2010 |