| The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer. | The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer.
Vervoort SJ, Welsh SA, Devlin JR, Barbieri E, Knight DA, Offley S, Bjelosevic S, Costacurta M, Todorovski I, Kearney CJ, Sandow JJ, Fan Z, Blyth B, McLeod V, Vissers JHA, Pavic K, Martin BP, Gregory G, Demosthenous E, Zethoven M, Kong IY, Hawkins ED, Hogg SJ, Kelly MJ, Newbold A, Simpson KJ, Kauko O, Harvey KF, Ohlmeyer M, Westermarck J, Gray N, Gardini A, Johnstone RW., Free PMC Article | 01/8/2022 |
| INTS6 promotes colorectal cancer progression by activating of AKT and ERK signaling. | INTS6 promotes colorectal cancer progression by activating of AKT and ERK signaling.
Ding X, Chen T, Shi Q, Nan P, Wang X, Xie D, Li J. | 11/27/2021 |
| Downregulation of Wnt/beta-catenin signaling was observed during the activation period, and the impairment of beta-catenin degradation reversed the tumor suppressor effects of INTS6. | Small RNA-induced INTS6 gene up-regulation suppresses castration-resistant prostate cancer cells by regulating β-catenin signaling.
Chen H, Shen HX, Lin YW, Mao YQ, Liu B, Xie LP., Free PMC Article | 11/9/2019 |
| the results of our study show that down-regulated INTS6 expression is associated with a poorer prognosis in hepatocellular carcinoma (HCC) patients. This newly identified INTS6/WIF-1 axis indicates the molecular mechanism of HCC and may represent a therapeutic target in HCC patients. | Integrator complex subunit 6 (INTS6) inhibits hepatocellular carcinoma growth by Wnt pathway and serve as a prognostic marker.
Lui KY, Zhao H, Qiu C, Li C, Zhang Z, Peng H, Fu R, Chen HA, Lu MQ., Free PMC Article | 05/19/2018 |
| DICE1 appears to be involved in prostate cancer progression rather than in the initiation of prostate cancer. | Genetic Variants of DICE1/INTS6 in German Prostate Cancer Families with Linkage to 13q14.
Böhm M, Maier C, Küfer R, Röpke A, Vogel W, Wieland I. | 09/24/2016 |
| Findings demonstrate INTS6P1 and INTS6 exert the tumor suppressive roles through competing for oncomiR-17-5p. | Pseudogene INTS6P1 regulates its cognate gene INTS6 through competitive binding of miR-17-5p in hepatocellular carcinoma.
Peng H, Ishida M, Li L, Saito A, Kamiya A, Hamilton JP, Fu R, Olaru AV, An F, Popescu I, Iacob R, Dima S, Alexandrescu ST, Grigorie R, Nastase A, Berindan-Neagoe I, Tomuleasa C, Graur F, Zaharia F, Torbenson MS, Mezey E, Lu M, Selaru FM., Free PMC Article | 03/5/2016 |
| In response to the DNA damage response, INTS3-hSSB1-INTS6 complex relocates to the DNA damage sites. | A core hSSB1-INTS complex participates in the DNA damage response.
Zhang F, Ma T, Yu X., Free PMC Article | 06/7/2014 |
| Findings suggest that EBV encoded miR-BART3* miRNA targets DICE1 tumor suppressor to promote cellular growth and transformation in nasopharyngeal cancer(NPC). | Targeting of DICE1 tumor suppressor by Epstein-Barr virus-encoded miR-BART3* microRNA in nasopharyngeal carcinoma.
Lei T, Yuen KS, Xu R, Tsao SW, Chen H, Li M, Kok KH, Jin DY. | 06/15/2013 |
| A protein encoded by this locus was found to be differentially expressed in postmortem brains from patients with atypical frontotemporal lobar degeneration. | Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration.
Martins-de-Souza D, Guest PC, Mann DM, Roeber S, Rahmoune H, Bauder C, Kretzschmar H, Volk B, Baborie A, Bahn S. | 04/26/2012 |
| Molecular characterization of the tumor suppressor gene in lung carcinoma cells | Molecular characterization of the DICE1 (DDX26) tumor suppressor gene in lung carcinoma cells.
Wieland I, Röpke A, Stumm M, Sell C, Weidle UH, Wieacker PF. | 01/21/2010 |
| DICE1 has a growth-suppressing activity and interferes with anchorage-independent growth of IGF-IR transformed tumor cells dependent upon IGF-I signaling | Ectopic expression of DICE1 suppresses tumor cell growth.
Wieland I, Sell C, Weidle UH, Wieacker P. | 01/21/2010 |
| Not mutated in human cancer cell lines which demonstratse 13q14 deletions. | Absence of mutations in DICE1/DDX26 gene in human cancer cell lines with frequent 13q14 deletions.
Hernández M, Papadopoulos N, Almeida TA. | 01/21/2010 |
| Somatic mutations were identified in three patients (3/56, 5%), and one novel polymorphism was identified in 3% of ESCC patients (4/136) and 3% of healthy individuals (6/232). We conclude that DICE1 mutations occur in ESCC but are infrequent. | Allelic loss on chromosome 13q14 and mutation in deleted in cancer 1 gene in esophageal squamous cell carcinoma.
Li WJ, Hu N, Su H, Wang C, Goldstein AM, Wang Y, Emmert-Buck MR, Roth MJ, Guo WJ, Taylor PR. | 01/21/2010 |