| Inhibition of USP21 leads to ovarian carcinoma cell death by suppressing MAPK signaling. | Inhibition of USP21 leads to ovarian carcinoma cell death by suppressing MAPK signaling.
Sun X, Yu J, Cui X, Tang Y, Yu Y. | 02/16/2024 |
| c-JUN-induced upregulation of LINC00174 contributes to colorectal cancer proliferation and invasion through accelerating USP21 expression. | c-JUN-induced upregulation of LINC00174 contributes to colorectal cancer proliferation and invasion through accelerating USP21 expression.
Liang W, Liu D, Wu J. | 10/25/2023 |
| Salt-like transcription factor 4 promotes laryngeal cancer progression through transcriptional activation of ubiquitin-specific protease 21 to stabilize Yin Yang 1. | Salt-like transcription factor 4 promotes laryngeal cancer progression through transcriptional activation of ubiquitin-specific protease 21 to stabilize Yin Yang 1.
Wang QD, Liu LL, Li D, Gao L, Zhang MJ. | 03/24/2023 |
| USP21 accelerates the proliferation and glycolysis of esophageal cancer cells by regulating the STAT3/FOXO1 pathway. | USP21 accelerates the proliferation and glycolysis of esophageal cancer cells by regulating the STAT3/FOXO1 pathway.
Wu Y, Guo Y, Wang Q. | 11/26/2022 |
| USP21 promotes self-renewal and tumorigenicity of mesenchymal glioblastoma stem cells by deubiquitinating and stabilizing FOXD1. | USP21 promotes self-renewal and tumorigenicity of mesenchymal glioblastoma stem cells by deubiquitinating and stabilizing FOXD1.
Zhang Q, Chen Z, Tang Q, Wang Z, Lu J, You Y, Wang H., Free PMC Article | 08/27/2022 |
| Ablation of USP21 in skeletal muscle promotes oxidative fibre phenotype, inhibiting obesity and type 2 diabetes. | Ablation of USP21 in skeletal muscle promotes oxidative fibre phenotype, inhibiting obesity and type 2 diabetes.
Kim A, Koo JH, Jin X, Kim W, Park SY, Park S, Rhee EP, Choi CS, Kim SG., Free PMC Article | 02/5/2022 |
| USP21 regulates Hippo signaling to promote radioresistance by deubiquitinating FOXM1 in cervical cancer. | USP21 regulates Hippo signaling to promote radioresistance by deubiquitinating FOXM1 in cervical cancer.
Li Z, Liu X, Yu H, Wang S, Zhao S, Jiang G. | 02/5/2022 |
| USP21 upregulation in cholangiocarcinoma promotes cell proliferation and migration in a deubiquitinase-dependent manner. | USP21 upregulation in cholangiocarcinoma promotes cell proliferation and migration in a deubiquitinase-dependent manner.
Zhou P, Song T, Sun C, He N, Cheng Q, Xiao X, Ran J, Liu M, Xie S. | 12/18/2021 |
| USP21 promotes cell proliferation by maintaining the EZH2 level in diffuse large B-cell lymphoma. | USP21 promotes cell proliferation by maintaining the EZH2 level in diffuse large B-cell lymphoma.
Ma H, Luo X, Zhou P, He N, Zhou J, Liu M, Xie W., Free PMC Article | 11/6/2021 |
| Deubiquitinating Enzyme USP21 Inhibits HIV-1 Replication by Downregulating Tat Expression. | Deubiquitinating Enzyme USP21 Inhibits HIV-1 Replication by Downregulating Tat Expression.
Gao W, Li G, Zhao S, Wang H, Huan C, Zheng B, Jiang C, Zhang W., Free PMC Article | 08/28/2021 |
| Disulfiram and 6-Thioguanine synergistically inhibit the enzymatic activities of USP2 and USP21. | Disulfiram and 6-Thioguanine synergistically inhibit the enzymatic activities of USP2 and USP21.
Lin HC, Kuan Y, Chu HF, Cheng SC, Pan HC, Chen WY, Sun CY, Lin TH. | 07/24/2021 |
| The USP21/YY1/SNHG16 axis contributes to tumor proliferation, migration, and invasion of non-small-cell lung cancer. | The USP21/YY1/SNHG16 axis contributes to tumor proliferation, migration, and invasion of non-small-cell lung cancer.
Xu P, Xiao H, Yang Q, Hu R, Jiang L, Bi R, Jiang X, Wang L, Mei J, Ding F, Huang J., Free PMC Article | 07/3/2021 |
| USP21 modulates Goosecoid function through deubiquitination. | USP21 modulates Goosecoid function through deubiquitination.
Liu F, Fu Q, Li Y, Zhang K, Tang M, Jiang W, Bo B, Cui Y, Kong L., Free PMC Article | 09/12/2020 |
| USP21 binds and deubiquitinates FOXM1 in breast cancer cells. | FOXM1 Deubiquitination by USP21 Regulates Cell Cycle Progression and Paclitaxel Sensitivity in Basal-like Breast Cancer.
Arceci A, Bonacci T, Wang X, Stewart K, Damrauer JS, Hoadley KA, Emanuele MJ., Free PMC Article | 04/18/2020 |
| USP21-mediated deubiquitination and stabilization of MEK2 plays a critical role in hepatocellular carcinoma development. | The deubiquitinase USP21 stabilizes MEK2 to promote tumor growth.
Li W, Cui K, Prochownik EV, Li Y., Free PMC Article | 04/4/2020 |
| work identifies and validates USP21 as a PDAC oncogene | USP21 deubiquitinase promotes pancreas cancer cell stemness via Wnt pathway activation.
Hou P, Ma X, Zhang Q, Wu CJ, Liao W, Li J, Wang H, Zhao J, Zhou X, Guan C, Ackroyd J, Jiang S, Zhang J, Spring DJ, Wang YA, DePinho RA., Free PMC Article | 11/23/2019 |
| Results from computational biology identified a cancer mutation that inactivates the nuclear export signals of the human deubiquitinase USP21, and leads to the aberrant accumulation of this protein in the nucleus. | Proteome-wide search for functional motifs altered in tumors: Prediction of nuclear export signals inactivated by cancer-related mutations.
Prieto G, Fullaondo A, RodrĂguez JA., Free PMC Article | 03/31/2018 |
| Data show that ubiquitin variants (Ubvs) that bind to USP2 or USP21 contain a similar core functional epitope, or "hot spot," consisting mainly of positions that are conserved as the wild type sequence, but also some positions that prefer mutant sequences. | Saturation scanning of ubiquitin variants reveals a common hot spot for binding to USP2 and USP21.
Leung I, Dekel A, Shifman JM, Sidhu SS., Free PMC Article | 02/10/2018 |
| USP21 binds to the promoter region of IL-8 and mediates transcriptional initiation, which regulates the stem-cell like property of human renal cell carcinoma | Ubiquitin specific peptidase 21 regulates interleukin-8 expression, stem-cell like property of human renal cell carcinoma.
Peng L, Hu Y, Chen D, Jiao S, Sun S., Free PMC Article | 01/20/2018 |
| USP21 interacts with, deubiquitinates and stabilizes BRCA2 to promote efficient RAD51 loading at DNA double-strand breaks. | Ubiquitin-specific protease 21 stabilizes BRCA2 to control DNA repair and tumor growth.
Liu J, Kruswick A, Dang H, Tran AD, Kwon SM, Wang XW, Oberdoerffer P., Free PMC Article | 11/18/2017 |
| a critical role of p38-mediated USP21 phosphorylation in regulating STING-mediated antiviral functions and identifies p38-USP21 axis as an important pathway that DNA virus adopts to avoid innate immunity responses. | p38 inhibition provides anti-DNA virus immunity by regulation of USP21 phosphorylation and STING activation.
Chen Y, Wang L, Jin J, Luan Y, Chen C, Li Y, Chu H, Wang X, Liao G, Yu Y, Teng H, Wang Y, Pan W, Fang L, Liao L, Jiang Z, Ge X, Li B, Wang P., Free PMC Article | 08/19/2017 |
| USP21 recruits and stabilises Gli1 at the centrosome. | The centrosomal deubiquitylase USP21 regulates Gli1 transcriptional activity and stability.
Heride C, Rigden DJ, Bertsoulaki E, Cucchi D, De Smaele E, Clague MJ, Urbé S., Free PMC Article | 08/12/2017 |
| USP21 specifically regulates the Lys48-linked polyubiquitination and stability of NANOG | Ubiquitin-specific protease 21 regulating the K48-linked polyubiquitination of NANOG.
Kwon SK, Lee DH, Kim SY, Park JH, Choi J, Baek KH. | 06/10/2017 |
| Data show that SUMOylated BANP, E5R, and Nac1 (BEN) domain 3 (BEND3) stabilizes NoRC component TTF-1-interacting protein 5 (Tip5)via association with ubiquitin specific protease 21 (USP21) debiquitinase | BEND3 represses rDNA transcription by stabilizing a NoRC component via USP21 deubiquitinase.
Khan A, Giri S, Wang Y, Chakraborty A, Ghosh AK, Anantharaman A, Aggarwal V, Sathyan KM, Ha T, Prasanth KV, Prasanth SG., Free PMC Article | 10/31/2015 |
| The protein stability of IL-33 is maintained by USP21 through deubiquitination | Deubiquitination and stabilization of IL-33 by USP21.
Tao L, Chen C, Song H, Piccioni M, Shi G, Li B., Free PMC Article | 06/20/2015 |