| EphB1 causes retinal damage through inflammatory pathways in the retina and retinal Muller cells. | EphB1 causes retinal damage through inflammatory pathways in the retina and retinal Müller cells.
Liu L, Jiang Y, Al-Shabrawey M, Ren X, Wang S, Steinle JJ., Free PMC Article | 04/18/2024 |
| EphB1 controls long-range cortical axon guidance through a cell non-autonomous role in GABAergic cells. | EphB1 controls long-range cortical axon guidance through a cell non-autonomous role in GABAergic cells.
Assali A, Chenaux G, Cho JY, Berto S, Ehrlich NA, Cowan CW., Free PMC Article | 02/29/2024 |
| EphB1 promotes the differentiation and maturation of dendritic cells in non-small cell lung cancer. | EphB1 promotes the differentiation and maturation of dendritic cells in non-small cell lung cancer.
Xie Y, Zhang L, Wang L, Chen B, Guo X, Yang Y, Shi W, Chen A, Yi J, Tang J, Xiang J. | 01/16/2024 |
| Investigating the effects of compound paralogous EPHB receptor mutations on mouse facial development. | Investigating the effects of compound paralogous EPHB receptor mutations on mouse facial development.
Mincer ST, Niethamer TK, Teng T, Bush JO, Percival CJ., Free PMC Article | 07/9/2022 |
| Identification of tetracycline combinations as EphB1 tyrosine kinase inhibitors for treatment of neuropathic pain. | Identification of tetracycline combinations as EphB1 tyrosine kinase inhibitors for treatment of neuropathic pain.
Ahmed MS, Wang P, Nguyen NUN, Nakada Y, Menendez-Montes I, Ismail M, Bachoo R, Henkemeyer M, Sadek HA, Kandil ES., Free PMC Article | 08/21/2021 |
| EphB1 interaction with caveolin-1 in endothelial cells modulates caveolae biogenesis. | EphB1 interaction with caveolin-1 in endothelial cells modulates caveolae biogenesis.
Tiruppathi C, Regmi SC, Wang DM, Mo GCH, Toth PT, Vogel SM, Stan RV, Henkemeyer M, Minshall RD, Rehman J, Malik AB., Free PMC Article | 05/15/2021 |
| Porf-2 is capable of binding to the EphB1 receptor, causing the outgrowth of axons to stop and retract upon EphB forward signal transduction within the axon growth cone. | Neuronal GAP-Porf-2 transduces EphB1 signaling to brake axon growth.
Huang GH, Guo L, Zhu L, Liu XD, Sun ZL, Li HJ, Xu NJ, Feng DF., Free PMC Article | 03/16/2019 |
| EphA2 mAb treatment could partially inhibit LPSinduced inactivation of EphBEphrin B3 signalling, while Ephrin B3 overexpression could abrogate LPSinduced activation of EphA2Ephrin A1 signalling. EphB1/Ephrin B3 signalling may antagonise the EphA2/Ephrin A1dependent pathway following LPS treatment | Eph/ephrin signalling serves a bidirectional role in lipopolysaccharide‑induced intestinal injury.
Xiong Y, Li KX, Wei H, Jiao L, Yu SY, Zeng L., Free PMC Article | 10/20/2018 |
| ephrin type-B receptor 1 (EphB1) is upregulated in injured motor neurons, which in turn can activate astrocytes through ephrin-B1-mediated stimulation of signal transducer and activator of transcription-3 (STAT3) | A neuroprotective astrocyte state is induced by neuronal signal EphB1 but fails in ALS models.
Tyzack GE, Hall CE, Sibley CR, Cymes T, Forostyak S, Carlino G, Meyer IF, Schiavo G, Zhang SC, Gibbons GM, Newcombe J, Patani R, Lakatos A., Free PMC Article | 10/6/2018 |
| SUMOylation of EphB1 repressed activation of its downstream signaling molecule PKC-gamma, and consequently inhibited neuroblastoma tumorigenesis. | Sumoylation of EphB1 Suppresses Neuroblastoma Tumorigenesis via Inhibiting PKCγ Activation.
Chen Q, Deng R, Zhao X, Yuan H, Zhang H, Dou J, Chen R, Jin H, Wang Y, Huang J, Yu J. | 06/23/2018 |
| Findings suggest that a combination of forward and reverse EphB1/2 receptor-mediated signaling contribute to posterior branch of the anterior commissure and corpus callosum axon guidance | EphB1 and EphB2 intracellular domains regulate the formation of the corpus callosum and anterior commissure.
Robichaux MA, Chenaux G, Ho HY, Soskis MJ, Greenberg ME, Henkemeyer M, Cowan CW., Free PMC Article | 12/17/2016 |
| During re-epithelialization ephrin-B1 and its receptor EphB2 are both upregulated in vivo, just for the duration of repair. | Ephrin-Bs Drive Junctional Downregulation and Actin Stress Fiber Disassembly to Enable Wound Re-epithelialization.
Nunan R, Campbell J, Mori R, Pitulescu ME, Jiang WG, Harding KG, Adams RH, Nobes CD, Martin P., Free PMC Article | 09/3/2016 |
| In a genetic medulloblastoma model, EphB1 knockout resulted in a significant delay in tumor recurrence following irradiation compared to EphB1-expressing control tumors. | Knockdown of EphB1 receptor decreases medulloblastoma cell growth and migration and increases cellular radiosensitization.
Bhatia S, Baig NA, Timofeeva O, Pasquale EB, Hirsch K, MacDonald TJ, Dritschilo A, Lee YC, Henkemeyer M, Rood B, Jung M, Wang XJ, Kool M, Rodriguez O, Albanese C, Karam SD., Free PMC Article | 03/12/2016 |
| EphB1 expression is activated in the spinal cord in a bone cancer model. | EphrinB-EphB receptor signaling contributes to bone cancer pain via Toll-like receptor and proinflammatory cytokines in rat spinal cord.
Liu S, Liu YP, Song WB, Song XJ. | 07/5/2014 |
| The studies introduce EphB1 as a new venous-restricted marker in a tissue-specific and time-dependent manner. | Tissue-specific venous expression of the EPH family receptor EphB1 in the skin vasculature.
Li W, Mukouyama YS., Free PMC Article | 02/8/2014 |
| Reelin induces EphB activation. | Reelin induces EphB activation.
Bouché E, Romero-Ortega MI, Henkemeyer M, Catchpole T, Leemhuis J, Frotscher M, May P, Herz J, Bock HH., Free PMC Article | 09/14/2013 |
| role of EphB1 receptors signalling in models of inflammatory and neuropathic pain | Involvement of EphB1 receptors signalling in models of inflammatory and neuropathic pain.
Cibert-Goton V, Yuan G, Battaglia A, Fredriksson S, Henkemeyer M, Sears T, Gavazzi I., Free PMC Article | 07/6/2013 |
| ephrin B1 has a role in maintaining the structural integrity of the developing cortex and maintaining apical adhesion of neural progenitors | Ephrin B1 maintains apical adhesion of neural progenitors.
Arvanitis DN, Béhar A, Tryoen-Tóth P, Bush JO, Jungas T, Vitale N, Davy A. | 06/29/2013 |
| PI3K and PI3K crosstalk to ERK signaling contributed to modulation of spinal nociceptive information related to ephrinBs/EphBs. | PI3K contributed to modulation of spinal nociceptive information related to ephrinBs/EphBs.
Yu LN, Zhou XL, Yu J, Huang H, Jiang LS, Zhang FJ, Cao JL, Yan M., Free PMC Article | 01/12/2013 |
| Data show that EphB1, not Ephb2, is the preferred receptor of ephrin-B2 and ephrin-B1 in mediating axon guidance at the optic chiasm despite the coexpression of EphB2 in the same ipsilaterally projecting retinal axons. | Forward signaling by EphB1/EphB2 interacting with ephrin-B ligands at the optic chiasm is required to form the ipsilateral projection.
Chenaux G, Henkemeyer M., Free PMC Article | 03/24/2012 |
| Eph receptor signalling mediates the repression of spine proliferation induced by climbing fibre activity in Purkinje cell proximal dendrit | Eph receptors are involved in the activity-dependent synaptic wiring in the mouse cerebellar cortex.
Cesa R, Premoselli F, Renna A, Ethell IM, Pasquale EB, Strata P., Free PMC Article | 12/3/2011 |
| EphB2 and EphB1 signallings are key mediators of ventral-temporal retinal ganglion cell axon retinocollicular mapping. | Critical roles for EphB and ephrin-B bidirectional signalling in retinocollicular mapping.
Thakar S, Chenaux G, Henkemeyer M., Free PMC Article | 11/19/2011 |
| Result implies a NC-derived cell-specific role of EphB-ephrin-B2 interactions in the collective migration of the thymic rudiment during organogenesis. | EphB-ephrin-B2 interactions are required for thymus migration during organogenesis.
Foster KE, Gordon J, Cardenas K, Veiga-Fernandes H, Makinen T, Grigorieva E, Wilkinson DG, Blackburn CC, Richie E, Manley NR, Adams RH, Kioussis D, Coles MC., Free PMC Article | 10/4/2010 |
| These findings implicate EPHB1 for targeting of eye-specific zones that are independent of midline guidance cues and that function in concert with correlated retinal activity to sculpt retinogeniculate projections. | Switching retinogeniculate axon laterality leads to normal targeting but abnormal eye-specific segregation that is activity dependent.
Rebsam A, Petros TJ, Mason CA., Free PMC Article | 01/21/2010 |
| EphrinBs may act as a prominent contributor to peripheral sensitization, and demonstrate that activation of peripheral ephrinBs/EphBs system induces hyperalgesia through a MAPKs-mediated mechanism. | Activation of peripheral ephrinBs/EphBs signaling induces hyperalgesia through a MAPKs-mediated mechanism in mice.
Cao JL, Ruan JP, Ling DY, Guan XH, Bao Q, Yuan Y, Zhang LC, Song XJ, Zeng YM. | 01/21/2010 |