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    LAMP3 lysosomal associated membrane protein 3 [ Homo sapiens (human) ]

    Gene ID: 27074, updated on 10-Oct-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    The subtilisin-like protease furin regulates hemin-induced CD63 surface expression on platelets.

    The subtilisin-like protease furin regulates hemin-induced CD63 surface expression on platelets.
    Dicenta V, Pelzer A, Laspa Z, Castor T, Gawaz MP, Rohlfing AK.

    02/23/2024
    LAMP3 is a potent uterine corpus endometrial carcinoma prognostic biomarker associated with immune behavior.

    LAMP3 is a potent uterine corpus endometrial carcinoma prognostic biomarker associated with immune behavior.
    Fu B, Zhou M, Geng X, Jiang Y, Zeng H, Zhou X, Yu Z, Pan J, Zhu Y, Zheng H, Huang S, Gong Y, Huang D, Zhong Y., Free PMC Article

    01/29/2024
    Inhibition of LAMP3 mediates the protective effect of vitamin D against hypoxia/reoxygenation in trophoblast cells.

    Inhibition of LAMP3 mediates the protective effect of vitamin D against hypoxia/reoxygenation in trophoblast cells.
    Tian X, Zheng L, Ma J, Xu Y, Zhang Y, Pi Y., Free PMC Article

    11/10/2023
    MiR-526b-3p enhances sensitivity of head and neck squamous cell carcinoma cells to radiotherapy via suppressing exosomal LAMP3-mediated autophagy.

    MiR-526b-3p enhances sensitivity of head and neck squamous cell carcinoma cells to radiotherapy via suppressing exosomal LAMP3-mediated autophagy.
    Lu H, Zhou J, Li X, Han X, Ma S, Feng C.

    09/26/2023
    Lysosome-Associated Membrane Protein 3 Induces Lysosome-Dependent Cell Death by Impairing Autophagic Caspase 8 Degradation in the Salivary Glands of Individuals With Sjogren's Disease.

    Lysosome-Associated Membrane Protein 3 Induces Lysosome-Dependent Cell Death by Impairing Autophagic Caspase 8 Degradation in the Salivary Glands of Individuals With Sjögren's Disease.
    Nakamura H, Tanaka T, Zheng C, Afione SA, Warner BM, Noguchi M, Atsumi T, Chiorini JA., Free PMC Article

    08/31/2023
    LAMP3 transfer via extracellular particles induces apoptosis in Sjogren's disease.

    LAMP3 transfer via extracellular particles induces apoptosis in Sjögren's disease.
    Tanaka T, Nakamura H, Tran DT, Warner BM, Wang Y, Atsumi T, Noguchi M, Chiorini JA., Free PMC Article

    02/16/2023
    LAMP3/CD63 Expression in Early and Late Endosomes in Human Vaginal Epithelial Cells Is Associated with Enhancement of HSV-2 Infection.

    LAMP3/CD63 Expression in Early and Late Endosomes in Human Vaginal Epithelial Cells Is Associated with Enhancement of HSV-2 Infection.
    Nazli A, Chow R, Zahoor MA, Workenhe ST, Dhawan T, Verschoor C, Kaushic C., Free PMC Article

    12/24/2022
    Upregulation of ATF4-LAMP3 Axis by ORF45 Facilitates Lytic Replication of Kaposi's Sarcoma-Associated Herpesvirus.

    Upregulation of ATF4-LAMP3 Axis by ORF45 Facilitates Lytic Replication of Kaposi's Sarcoma-Associated Herpesvirus.
    Sun Q, Wang F, Chen Q, Sarid R, Li X, Kuang E., Free PMC Article

    12/24/2022
    LAMP3 inhibits autophagy and contributes to cell death by lysosomal membrane permeabilization.

    LAMP3 inhibits autophagy and contributes to cell death by lysosomal membrane permeabilization.
    Tanaka T, Warner BM, Michael DG, Nakamura H, Odani T, Yin H, Atsumi T, Noguchi M, Chiorini JA., Free PMC Article

    07/23/2022
    Association study of MCCC1/LAMP3 and DGKQ variants with Parkinson's disease in patients of Malay ancestry.

    Association study of MCCC1/LAMP3 and DGKQ variants with Parkinson's disease in patients of Malay ancestry.
    Lim JL, Ng EY, Lim SY, Tan AH, Abdul-Aziz Z, Ibrahim KA, Gopalai AA, Tay YW, Vijayanathan Y, Toh TS, Lim SK, Bee PC, Puvanarajah SD, Viswanathan S, Looi I, Lim TT, Eow GB, Cheah WK, Tan EK, Ahmad-Annuar A.

    09/25/2021
    Novel Associations of BST1 and LAMP3 With REM Sleep Behavior Disorder.

    Novel Associations of BST1 and LAMP3 With REM Sleep Behavior Disorder.
    Mufti K, Yu E, Rudakou U, Krohn L, Ruskey JA, Asayesh F, Laurent SB, Spiegelman D, Arnulf I, Hu MTM, Montplaisir JY, Gagnon JF, Desautels A, Dauvilliers Y, Gigli GL, Valente M, Janes F, Bernardini A, Högl B, Stefani A, Holzknecht E, Sonka K, Kemlink D, Oertel W, Janzen A, Plazzi G, Antelmi E, Figorilli M, Puligheddu M, Mollenhauer B, Trenkwalder C, Sixel-Döring F, Cochen De Cock V, Monaca CC, Heidbreder A, Ferini-Strambi L, Dijkstra F, Viaene M, Abril B, Boeve BF, Trempe JF, Rouleau GA, Postuma RB, Gan-Or Z., Free PMC Article

    03/28/2021
    LAMP3 induces apoptosis and autoantigen release in Sjogren's syndrome patients.

    LAMP3 induces apoptosis and autoantigen release in Sjögren's syndrome patients.
    Tanaka T, Warner BM, Odani T, Ji Y, Mo YQ, Nakamura H, Jang SI, Yin H, Michael DG, Hirata N, Suizu F, Ishigaki S, Oliveira FR, Motta ACF, Ribeiro-Silva A, Rocha EM, Atsumi T, Noguchi M, Chiorini JA., Free PMC Article

    12/26/2020
    The gene for the lysosomal protein LAMP3 is a direct target of the transcription factor ATF4.

    The gene for the lysosomal protein LAMP3 is a direct target of the transcription factor ATF4.
    Burton TD, Fedele AO, Xie J, Sandeman LY, Proud CG., Free PMC Article

    12/26/2020
    Depletion of LAMP3 enhances PKA-mediated VASP phosphorylation to suppress invasion and metastasis in esophageal squamous cell carcinoma.

    Depletion of LAMP3 enhances PKA-mediated VASP phosphorylation to suppress invasion and metastasis in esophageal squamous cell carcinoma.
    Huang F, Ma G, Zhou X, Zhu X, Yu X, Ding F, Cao X, Liu Z.

    12/12/2020
    Lysosome-Associated Membrane Proteins Support the Furin-Mediated Processing of the Mumps Virus Fusion Protein.

    Lysosome-Associated Membrane Proteins Support the Furin-Mediated Processing of the Mumps Virus Fusion Protein.
    Ueo A, Kubota M, Shirogane Y, Ohno S, Hashiguchi T, Yanagi Y., Free PMC Article

    11/21/2020
    Elevated LAMP3 expression is associated with epithelial-mesenchymal transition and metastatic potential in esophageal cancer.

    Long noncoding RNA HAGLR acts as a microRNA-143-5p sponge to regulate epithelial-mesenchymal transition and metastatic potential in esophageal cancer by regulating LAMP3.
    Yang C, Shen S, Zheng X, Ye K, Sun Y, Lu Y, Ge H.

    05/30/2020
    LAMP3 is an important regulator of hepatic lipid metabolism.

    LAMP3 regulates hepatic lipid metabolism through activating PI3K/Akt pathway.
    Liao X, Song L, Zhang L, Wang H, Tong Q, Xu J, Yang G, Yang S, Zheng H.

    03/23/2019
    Knockdown of LAMP3 significantly inhibited OS cell viability and promoted apoptosis. TP53, which is involved in the apoptosis pathway, was found to be highly upregulated after knockdown of LAMP3.

    LAMP3 plays an oncogenic role in osteosarcoma cells partially by inhibiting TP53.
    Liu S, Yue J, Du W, Han J, Zhang W., Free PMC Article

    10/20/2018
    LAMP3 promotes the invasion of osteosarcoma cells via SPP1 signaling.

    LAMP3 promotes the invasion of osteosarcoma cells via SPP1 signaling.
    Li Y, Du W, Han J, Ge J., Free PMC Article

    06/9/2018
    mRNA and protein levels of LAMP3 were significantly higher in oral squamous carcinoma tissues than in adjacent normal tissues. High LAMP3 expression was linked to the degree of tumor differentiation and stage.

    Clinical Significance and Prognostic Value of the Expression of LAMP3 in Oral Squamous Cell Carcinoma.
    Lu J, Ma H, Lian S, Huang D, Lian M, Zhang Y, Huang J, Feng X., Free PMC Article

    03/31/2018
    LAMP3 variants found to be associated with Bipolar disorder or Schizophrenia in other populations are also associated with Bipolar disorder risk in Latinos.

    Replication of genome-wide association study (GWAS) susceptibility loci in a Latino bipolar disorder cohort.
    Gonzalez S, Gupta J, Villa E, Mallawaarachchi I, Rodriguez M, Ramirez M, Zavala J, Armas R, Dassori A, Contreras J, Flores D, Jerez A, Ontiveros A, Nicolini H, Escamilla M., Free PMC Article

    09/23/2017
    this study shows that the vitamin D3 reduce the LAMP3 expression during the dendritic cells differentiation and maturation, via NFkappaB pathways

    Vitamin D(3) regulates LAMP3 expression in monocyte derived dendritic cells.
    Malaguarnera L, Marsullo A, Zorena K, Musumeci G, Di Rosa M.

    07/1/2017
    Immunohistochemical results showed that high lysosome-associated membrane protein 3 cytoplasmic expression was significantly related to tumor grade ( p = 0.038), lymph node metastasis ( p = 0.049), metastasis ( p < 0.001), level of CA125 ( p = 0.030), and International Federation of Gynecology and Obstetrics (FIGO) ( p < 0.001).

    LAMP3 expression correlated with poor clinical outcome in human ovarian cancer.
    Wang D, Cao X, Zhang Y, Liu Y, Yao C, Ge W, Xu Y.

    04/8/2017
    study indicates that LAMP-3 is induced by Salmonella infection and recruited to the Salmonella pathogen for intracellular proliferation.

    LAMP-3 (Lysosome-Associated Membrane Protein 3) Promotes the Intracellular Proliferation of Salmonella typhimurium.
    Lee EJ, Park KS, Jeon IS, Choi JW, Lee SJ, Choy HE, Song KD, Lee HK, Choi JK., Free PMC Article

    03/11/2017
    In laryngeal squamous cell carcinoma, high LAMP3 and high TP53 protein expression was significantly associated with tumor stage and size and patients with high expression of these proteins had poor overall survival.

    LAMP3 and TP53 overexpression predicts poor outcome in laryngeal squamous cell carcinoma.
    Qiu X, You Y, Huang J, Wang X, Zhu H, Wang Z., Free PMC Article

    05/28/2016
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