| Binding of the Treslin-MTBP Complex to Specific Regions of the Human Genome Promotes the Initiation of DNA Replication. | Binding of the Treslin-MTBP Complex to Specific Regions of the Human Genome Promotes the Initiation of DNA Replication.
Kumagai A, Dunphy WG., Free PMC Article | 05/8/2021 |
| data show that MTBP aggravates the invasion and metastasis of HCC by promoting the MDM2-mediated degradation of E-cadherin. | MTBP Promotes the Invasion and Metastasis of Hepatocellular Carcinoma by Enhancing the MDM2-Mediated Degradation of E-Cadherin.
Lu S, Zhou W, Wei H, He L, Li L. | 02/20/2016 |
| Overexpression of MTBP resulted in the suppression of the migratory and metastatic potential of Hepatocellular carcinoma cells, while its downregulation increased the migration. | MTBP inhibits migration and metastasis of hepatocellular carcinoma.
Bi Q, Ranjan A, Fan R, Agarwal N, Welch DR, Weinman SA, Ding J, Iwakuma T., Free PMC Article | 06/20/2015 |
| MTBP significantly contributes to breast cancer survival and is a potential novel therapeutic target in Triple-negative breast cancer . | MTBP is overexpressed in triple-negative breast cancer and contributes to its growth and survival.
Grieb BC, Chen X, Eischen CM., Free PMC Article | 06/6/2015 |
| MTBP associated with MYC at promoters and increased MYC-mediated transcription, proliferation, neoplastic transformation, and tumor development. | Oncogenic protein MTBP interacts with MYC to promote tumorigenesis.
Grieb BC, Gramling MW, Arrate MP, Chen X, Beauparlant SL, Haines DS, Xiao H, Eischen CM., Free PMC Article | 10/18/2014 |
| MTBP acts with Treslin/TICRR to integrate signals from cell cycle and DNA damage response pathways to control the initiation of DNA replication in human cells. | Identification of a heteromeric complex that promotes DNA replication origin firing in human cells.
Boos D, Yekezare M, Diffley JF. | 06/15/2013 |
| MTBP also inhibited ACTN4-mediated F-actin bundling. | MTBP suppresses cell migration and filopodia formation by inhibiting ACTN4.
Agarwal N, Adhikari AS, Iyer SV, Hekmatdoost K, Welch DR, Iwakuma T., Free PMC Article | 06/8/2013 |
| identification and characterization of mouse Mdm2 binding protein | A novel cellular protein (MTBP) binds to MDM2 and induces a G1 arrest that is suppressed by MDM2.
Boyd MT, Vlatkovic N, Haines DS. | 08/6/2012 |
| MTBP has an important role in recruiting and/or retaining the Mad1/Mad2 complex at the kinetochores during prometaphase, but its degradation is required for silencing the mitotic checkpoint. | MTBP plays a crucial role in mitotic progression and chromosome segregation.
Agarwal N, Tochigi Y, Adhikari AS, Cui S, Cui Y, Iwakuma T., Free PMC Article | 10/1/2011 |
| results represent the first examination of MTBP expression in human tissues and provide evidence for a p53 status-dependent role for MTBP in suppressing disease progression in squamous cell carcinoma of the head and neck patients | Loss of MTBP expression is associated with reduced survival in a biomarker-defined subset of patients with squamous cell carcinoma of the head and neck.
Vlatković N, El-Fert A, Devling T, Ray-Sinha A, Gore DM, Rubbi CP, Dodson A, Jones AS, Helliwell TR, Jones TM, Boyd MT. | 08/27/2011 |
| Data suggest that MTBP differentially regulates the activity of MDM2 towards two of its most critical targets (itself and p53) and in doing so significantly contributes to MDM2-dependent p53 homeostasis in unstressed cells. | Regulation of p53 and MDM2 activity by MTBP.
Brady M, Vlatkovic N, Boyd MT, Brady M, Vlatkovic N, Boyd MT., Free PMC Articles: PMC543405, PMC543405 | 01/21/2010 |
| MTBP contributes to MDM2 activity and through this to negative regulation of p53 | Regulation of p53 and MDM2 activity by MTBP.
Brady M, Vlatkovic N, Boyd MT, Brady M, Vlatkovic N, Boyd MT., Free PMC Articles: PMC543405, PMC543405 | 02/22/2005 |