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    CACYBP calcyclin binding protein [ Homo sapiens (human) ]

    Gene ID: 27101, updated on 14-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    CacyBP promotes the development of lung adenocarcinoma by regulating OTUD5.

    CacyBP promotes the development of lung adenocarcinoma by regulating OTUD5.
    Bai M, Lu K, Che Y, Fu L.

    08/13/2024
    CACYBP knockdown inhibits progression of prostate cancer via p53.

    CACYBP knockdown inhibits progression of prostate cancer via p53.
    Li Q, Liu Z, Ma L, Yin W, Zhang K., Free PMC Article

    07/27/2023
    The Effect of CacyBP/SIP on the Phosphorylation of ERK1/2 and p38 Kinases in Clear Cell Renal Cell Carcinoma.

    The Effect of CacyBP/SIP on the Phosphorylation of ERK1/2 and p38 Kinases in Clear Cell Renal Cell Carcinoma.
    Smereczańska M, Domian N, Młynarczyk G, Kasacka I., Free PMC Article

    07/7/2023
    Involvement of CacyBP/SIP in differentiation and the immune response of HaCaT keratinocytes.

    Involvement of CacyBP/SIP in differentiation and the immune response of HaCaT keratinocytes.
    Leśniak W, Bohush A, Maksymowicz M, Piwowarczyk C, Karolak NK, Jurewicz E, Filipek A.

    06/15/2023
    Heterozygous calcyclin-binding protein/Siah1-interacting protein (CACYBP/SIP) gene pathogenic variant linked to a dominant family with paucity of interlobular bile duct.

    Heterozygous calcyclin-binding protein/Siah1-interacting protein (CACYBP/SIP) gene pathogenic variant linked to a dominant family with paucity of interlobular bile duct.
    Kanno M, Suzuki M, Tanikawa K, Numakura C, Matsuzawa SI, Niihori T, Aoki Y, Matsubara Y, Makino S, Tamiya G, Nakano S, Funayama R, Shirota M, Nakayama K, Mitsui T, Hayasaka K.

    07/2/2022
    Knockout of Calcyclin Binding Protein Impedes the Growth of Breast Cancer Cells by Regulating Cell Apoptosis and beta-Catenin Signaling.

    Knockout of Calcyclin Binding Protein Impedes the Growth of Breast Cancer Cells by Regulating Cell Apoptosis and β-Catenin Signaling.
    Wang N, Wang Y, Wang H, Luo N, Yang W, Zhao Z.

    10/23/2021
    [CacyBP promotes the proliferation and invasion of non-small cell lung cancer].

    [CacyBP promotes the proliferation and invasion of non-small cell lung cancer].
    Xu YJ, Hu YM, Qin C, Wang F, Cao W, Yu YW, Zhao L, Li J, Chen WQ, Li N, He J.

    09/25/2021
    HSP90 Co-Chaperone, CacyBP/SIP, Protects alpha-Synuclein from Aggregation.

    HSP90 Co-Chaperone, CacyBP/SIP, Protects α-Synuclein from Aggregation.
    Bohush A, Filipek A., Free PMC Article

    07/3/2021
    CacyBP/SIP protein reduces p53 stability by enhancing Mdm2 activity in p53 mutant glioma cells.

    CacyBP/SIP protein reduces p53 stability by enhancing Mdm2 activity in p53 mutant glioma cells.
    Qian F, Tang T, Wang S, Wang B, Wang L, Shi H.

    02/13/2021
    promotes autophagy by regulating levels of BRUCE/Apollon, which stimulates LC3-I degradation

    SIP/CacyBP promotes autophagy by regulating levels of BRUCE/Apollon, which stimulates LC3-I degradation.
    Jiang TX, Zou JB, Zhu QQ, Liu CH, Wang GF, Du TT, Luo ZY, Guo F, Zhou LM, Liu JJ, Zhang W, Shu YS, Yu L, Li P, Ronai ZA, Matsuzawa SI, Goldberg AL, Qiu XB., Free PMC Article

    04/4/2020
    ur results show for the first time that CacyBP/SIP binds to and affects the properties of a nuclear protein, NPM1, and that it is indispensable for preserving the structure of nucleoli under oxidative stress.

    Interaction of CacyBP/SIP with NPM1 and its influence on NPM1 localization and function in oxidative stress.
    Rosińska S, Filipek A.

    09/28/2019
    REVIEW: cellular function of S100A6 and its ligands, CacyBP/SIP and Sgt1

    Current view on cellular function of S100A6 and its ligands, CacyBP/SIP and Sgt1.
    Filipek A, Leśniak W.

    06/29/2019
    Together, the data presented here indicate a close interaction between ageing and sex on the distribution and levels of cannabinoid receptors (CB1, CB2), S100A6 and CacyBP/SIP in the human heart.

    Sex differences in distribution of cannabinoid receptors (CB1 and CB2), S100A6 and CacyBP/SIP in human ageing hearts.
    Piotrowska Ż, Niezgoda M, Łebkowski W, Filipek A, Domian N, Kasacka I., Free PMC Article

    03/23/2019
    CacyBP expression is regulated by E2F1, EGR1, and CREB transcription factors in colorectal cancer HCT116 cells.

    Transcriptional regulation of CacyBP/SIP gene and the influence of increased CacyBP/SIP level on gene expression pattern in colorectal cancer HCT116 cells.
    Kądziołka B, Dębski KJ, Bieganowski P, Leśniak W, Filipek A.

    12/22/2018
    Results suggest that CacyBP/SIP plays an important role in inhibiting glioma cell migration and invasion through promoting the degradation of cytoplasmic p27.

    CacyBP/SIP inhibits the migration and invasion behaviors of glioblastoma cells through activating Siah1 mediated ubiquitination and degradation of cytoplasmic p27.
    Yan S, Li A, Liu Y.

    08/11/2018
    Data show that S100 calcium binding protein A6 (S100A6) is required for the Ca2+-dependent nuclear translocation of calcyclin binding protein (CacyBP/SIP) in colon cancer SW480 cells.

    The effect of S100A6 on nuclear translocation of CacyBP/SIP in colon cancer cells.
    Feng S, Zhou Q, Yang B, Li Q, Liu A, Zhao Y, Qiu C, Ge J, Zhai H., Free PMC Article

    07/7/2018
    CacyBP/SIP nuclear localization, dependent on S100 protein, suppresses gastric cancer tumorigenesis through beta-catenin degradation and the dephosphorylation of ERK1/2 during the G2 phase.

    Cell cycle-dependent translocation and regulatory mechanism of CacyBP/SIP in gastric cancer cells.
    Chen Y, Zhang K, Wang X, Li Q, Wu Q, Ning X.

    05/12/2018
    Our data have shown for the first time the regulation of CacyBP/SIP gene expression by NFAT1. Since NFAT transcription factors are involved in processes related to immune response, these results indicate potential involvement of CacyBP/SIP in the immune system.

    Regulation of CacyBP/SIP expression by NFAT1 transcription factor.
    Kądziołka B, Leśniak W, Filipek A.

    03/17/2018
    These results suggest that CacyBP/SIP may be promoting growth of colon cancer cells by enhancing ubiquitin-mediated degradation of p27kip1.

    CacyBP/SIP promotes the proliferation of colon cancer cells.
    Zhai H, Shi Y, Chen X, Wang J, Lu Y, Zhang F, Liu Z, Lei T, Fan D., Free PMC Article

    08/12/2017
    The biological characteristics and target proteins of CacyBP/SIP and its exact role in various cancers are discussed. Review.

    The potential role of CacyBP/SIP in tumorigenesis.
    Ning X, Chen Y, Wang X, Li Q, Sun S.

    02/25/2017
    CacyBP/SIP nuclear translocation contributes to the proliferation of gastric cancer cells, and CacyBP/SIP exerts this effect, at least in part, by stimulating ubiquitin-mediated degradation of p27Kip1.

    CacyBP/SIP nuclear translocation regulates p27Kip1 stability in gastric cancer cells.
    Niu YL, Li YJ, Wang JB, Lu YY, Liu ZX, Feng SS, Hu JG, Zhai HH., Free PMC Article

    01/28/2017
    CacyBP/SIP plays an important role in inhibiting apoptosis of glioma cells which might be mediated by ERK1/2 signaling pathway.

    CacyBP/SIP inhibits Doxourbicin-induced apoptosis of glioma cells due to activation of ERK1/2.
    Tang Y, Zhan W, Cao T, Tang T, Gao Y, Qiu Z, Fu C, Qian F, Yu R, Shi H.

    11/19/2016
    CacyBP/SIP is a useful indicator of dis processes in Chronic Lymphocytic Leukemia (CLL) and plays an important role in sustaining the balance of cell proliferation and apoptosis.

    Expression and regulation of CacyBP/SIP in chronic lymphocytic leukemia cell balances of cell proliferation with apoptosis.
    Fu C, Wan Y, Shi H, Gong Y, Wu Q, Yao Y, Niu M, Li Z, Xu K.

    07/30/2016
    CacyBP/SIP nuclear translocation promotes the proliferation and cell cycle progression of gastric cancer cells.

    CacyBP/SIP nuclear translocation induced by gastrin promotes gastric cancer cell proliferation.
    Zhai HH, Meng J, Wang JB, Liu ZX, Li YF, Feng SS., Free PMC Article

    05/23/2015
    Overexpression of CacyBP is associated with glioma.

    CacyBP/SIP protein is important for the proliferation of human glioma cells.
    Shi H, Gao Y, Tang Y, Wu Y, Gong H, Du J, Zheng B, Hu J, Shi Q, Yu R.

    01/17/2015
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