| Sialylated keratan sulfates on MUC5B are Siglec-8 ligands in the human esophagus. | Sialylated keratan sulfates on MUC5B are Siglec-8 ligands in the human esophagus.
Li TA, Gonzalez-Gil A, Awol AK, Ackerman SJ, Orsburn BC, Schnaar RL., | 09/5/2024 |
| Induction of the endogenous sialoglycan ligand for eosinophil death receptor Siglec-8 in chronic rhinosinusitis with hyperplastic nasal polyposis. | Induction of the endogenous sialoglycan ligand for eosinophil death receptor Siglec-8 in chronic rhinosinusitis with hyperplastic nasal polyposis.
Lee HS, Gonzalez-Gil A, Drake V, Li TA, Schnaar RL, Kim J., Free PMC Article | 04/9/2022 |
| First Evidence for a Role of Siglec-8 in Breast Cancer. | First Evidence for a Role of Siglec-8 in Breast Cancer.
Trebo A, Ditsch N, Degenhardt T, Kuhn C, Rahmeh M, Schmoeckel E, Mayr D, Czogalla B, Kolben T, Meister S, Mahner S, Jeschke U, Hester A., Free PMC Article | 04/24/2021 |
| Promoter region single nucleotide polymorphism of siglec-8 gene associates with susceptibility to allergic asthma. | Promoter region single nucleotide polymorphism of siglec-8 gene associates with susceptibility to allergic asthma.
Sajay-Asbaghi M, Sadeghi-Shabestrai M, Monfaredan A, Seyfizadeh N, Razavi A, Kazemi T. | 03/27/2021 |
| Siglec-8 is highly expressed on blood eosinophils from eosinophilic donors and normal donors and represents a potential therapeutic target for eosinophilic disorders | Sialic acid-binding immunoglobulin-like lectin (Siglec) 8 in patients with eosinophilic disorders: Receptor expression and targeting using chimeric antibodies.
Legrand F, Cao Y, Wechsler JB, Zhu X, Zimmermann N, Rampertaap S, Monsale J, Romito K, Youngblood BA, Brock EC, Makiya MA, Tomasevic N, Bebbington C, Maric I, Metcalfe DD, Bochner BS, Klion AD., Free PMC Article | 05/9/2020 |
| These data demonstrate that Siglec-8 functions uniquely as an activating receptor on IL-5-primed eosinophils through a novel pathway involving regulation of beta2-integrin-dependent adhesion, NADPH oxidase, and a subset of protein kinases | Sialic acid-binding immunoglobulin-like lectin 8 (Siglec-8) is an activating receptor mediating β(2)-integrin-dependent function in human eosinophils.
Carroll DJ, O'Sullivan JA, Nix DB, Cao Y, Tiemeyer M, Bochner BS., Free PMC Article | 08/3/2019 |
| Targeting saporin to Siglec-8 consistently caused extensive cell death. | Leveraging Siglec-8 endocytic mechanisms to kill human eosinophils and malignant mast cells.
O'Sullivan JA, Carroll DJ, Cao Y, Salicru AN, Bochner BS., Free PMC Article | 08/3/2019 |
| In differentiating ,eosinophils, SIGLEC-8 messenger RNA and protein were markedly down-regulated in parallel with OLIG2 by an OLIG2 small interfering RNA or a short hairpin RNA. An E-box in the first intron was found to stimulate SIGLEC-8 gene transcription and to bind OLIG2. | Olig2 is expressed late in human eosinophil development and controls Siglec-8 expression.
Hwang SM, Uhm TG, Lee SK, Kong SK, Jung KH, Binas B, Chai YG, Park SW, Chung IY. | 09/16/2017 |
| miR-215 acts in concert with the host gene IARS2 to affect neuron migration and proliferation through the target gene SIGLEC-8. | Role of MiR-215 in Hirschsprung's Disease Pathogenesis by Targeting SIGLEC-8.
Lei H, Li H, Xie H, Du C, Xia Y, Tang W. | 02/18/2017 |
| Our study suggested that intratumoral Siglec-8 expression was an independent prognostic factor for overall survival of patients with gastric cancer | Decreased expression of Siglec-8 associates with poor prognosis in patients with gastric cancer after surgical resection.
Cao Y, Liu H, Zhang H, Lin C, Li R, Zhang W, Shen Z, Xu J. | 02/18/2017 |
| Ligands for Siglec-8 and Siglec-9 may regulate the function of eosinophils, mast cells, neutrophils, and other cells in sinus mucosa. | Regulation of airway inflammation by Siglec-8 and Siglec-9 sialoglycan ligand expression.
Schleimer RP, Schnaar RL, Bochner BS., Free PMC Article | 09/24/2016 |
| Inflammation results in up-regulation of immuneinhibitory Siglec-8 and Siglec-9 sialoglycan ligands on human airways. | Expression of ligands for Siglec-8 and Siglec-9 in human airways and airway cells.
Jia Y, Yu H, Fernandes SM, Wei Y, Gonzalez-Gil A, Motari MG, Vajn K, Stevens WW, Peters AT, Bochner BS, Kern RC, Schleimer RP, Schnaar RL., Free PMC Article | 05/2/2015 |
| Siglec-8 expression is sensitive to tiotropium and formoterol, indicating that it may be involved in COPD pathogenesis and may influence COPD phenotyping | Siglec-8 in induced sputum of COPD patients.
Mroz RM, Holownia A, Wielgat P, Sitko A, Skopinski T, Chyczewska E, Braszko JJ. | 01/11/2014 |
| In activated eosinophils ligation of Siglec-8 leads to ROS-dependent enhancement of IL-5-induced ERK phosphorylation, which results in a novel mode of biochemically regulated eosinophil cell death. | Mechanism of Siglec-8-mediated cell death in IL-5-activated eosinophils: role for reactive oxygen species-enhanced MEK/ERK activation.
Kano G, Almanan M, Bochner BS, Zimmermann N., Free PMC Article | 10/19/2013 |
| Engagement of Siglec-8 on blood eosinophils results in caspase- and mitochondria-dependent apoptosis. | Siglec-8 and Siglec-F, the new therapeutic targets in asthma.
Farid SSh, Mirshafiey A, Razavi A. | 02/2/2013 |
| Report the development of a sensitive competitive ELISA to detect sSiglec-8 in human serum samples obtained from patients with various forms of eosinophilia. | Biomarkers of eosinophil involvement in allergic and eosinophilic diseases: review of phenotypic and serum markers including a novel assay to quantify levels of soluble Siglec-8.
Na HJ, Hamilton RG, Klion AD, Bochner BS., Free PMC Article | 10/13/2012 |
| Eosinophils primed by IL-33 and/or IL-5 in vivo would be expected to display enhanced susceptibility to undergoing Siglec-8-induced apoptosis. | IL-33 enhances Siglec-8 mediated apoptosis of human eosinophils.
Na HJ, Hudson SA, Bochner BS., Free PMC Article | 07/7/2012 |
| expressed on eosinophils and basophils from subjects with chronic eosinophilic leukemia, chronic myelogenous leukemia, and on malignant and non-malignant bone marrow mast cells | Developmental, malignancy-related, and cross-species analysis of eosinophil, mast cell, and basophil siglec-8 expression.
Hudson SA, Herrmann H, Du J, Cox P, Haddad el-B, Butler B, Crocker PR, Ackerman SJ, Valent P, Bochner BS., Free PMC Article | 04/14/2012 |
| The Siglec-8 gene may be a susceptibility locus for asthma. | Polymorphisms in the sialic acid-binding immunoglobulin-like lectin-8 (Siglec-8) gene are associated with susceptibility to asthma.
Gao PS, Shimizu K, Grant AV, Rafaels N, Zhou LF, Hudson SA, Konno S, Zimmermann N, Araujo MI, Ponte EV, Cruz AA, Nishimura M, Su SN, Hizawa N, Beaty TH, Mathias RA, Rothenberg ME, Barnes KC, Bochner BS, Gao PS, Shimizu K, Grant AV, Rafaels N, Zhou LF, Hudson SA, Konno S, Zimmermann N, Araujo MI, Ponte EV, Cruz AA, Nishimura M, Su SN, Hizawa N, Beaty TH, Mathias RA, Rothenberg ME, Barnes KC, Bochner BS., Free PMC Articles: PMC2987348, PMC2987348 | 09/13/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesNew genetic associations detected in a host response study to hepatitis B vaccine.
Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML, Seielstad M. Polymorphisms in the sialic acid-binding immunoglobulin-like lectin-8 (Siglec-8) gene are associated with susceptibility to asthma.
Gao PS, Shimizu K, Grant AV, Rafaels N, Zhou LF, Hudson SA, Konno S, Zimmermann N, Araujo MI, Ponte EV, Cruz AA, Nishimura M, Su SN, Hizawa N, Beaty TH, Mathias RA, Rothenberg ME, Barnes KC, Bochner BS, Gao PS, Shimizu K, Grant AV, Rafaels N, Zhou LF, Hudson SA, Konno S, Zimmermann N, Araujo MI, Ponte EV, Cruz AA, Nishimura M, Su SN, Hizawa N, Beaty TH, Mathias RA, Rothenberg ME, Barnes KC, Bochner BS. | 04/7/2010 |
| Selective and specific engagement and binding of Siglec-8 on eosinophils by a synthetic 6'-sulfo-sLe(x)-containing ligand could be useful for controlling eosinophilic inflammatory responses in vivo. | Eosinophil-selective binding and proapoptotic effect in vitro of a synthetic Siglec-8 ligand, polymeric 6'-sulfated sialyl Lewis x.
Hudson SA, Bovin NV, Schnaar RL, Crocker PR, Bochner BS., Free PMC Article | 01/21/2010 |
| REVIEW: Siglec-8 and Siglec-F function on human eosinophils, and Siglec-8 function on mast cells | Siglec-8 on human eosinophils and mast cells, and Siglec-F on murine eosinophils, are functionally related inhibitory receptors.
Bochner BS., Free PMC Article | 01/21/2010 |
| A review of the cytotoxic effects of natural anti-Siglec8 autoantibodies on both neutrophils and eosinophils. | Natural anti-Siglec autoantibodies mediate potential immunoregulatory mechanisms: implications for the clinical use of intravenous immunoglobulins (IVIg).
von Gunten S, Simon HU. | 01/21/2010 |
| First reported inhibitory effects of Siglec engagement on human mast cells. | Inhibition of FcepsilonRI-dependent mediator release and calcium flux from human mast cells by sialic acid-binding immunoglobulin-like lectin 8 engagement.
Yokoi H, Choi OH, Hubbard W, Lee HS, Canning BJ, Lee HH, Ryu SD, von Gunten S, Bickel CA, Hudson SA, Macglashan DW Jr, Bochner BS. | 01/21/2010 |
| IL-5 priming enhances Siglec-8-mediated mitochondrial and ROS-dependent eosinophil apoptosis and eliminates caspase dependence. | Interleukin-5 priming of human eosinophils alters siglec-8 mediated apoptosis pathways.
Nutku-Bilir E, Hudson SA, Bochner BS., Free PMC Article | 01/21/2010 |