| The human AAA-ATPase VPS4A isoform and its co-factor VTA1 have a unique function in regulating mammalian cytokinesis abscission. | The human AAA-ATPase VPS4A isoform and its co-factor VTA1 have a unique function in regulating mammalian cytokinesis abscission.
Dvilansky I, Altaras Y, Kamenetsky N, Nachmias D, Elia N., Free PMC Article | 06/6/2024 |
| CHMP4B and VSP4A reverse GSDMD-mediated pyroptosis by cell membrane remodeling in endometrial carcinoma. | CHMP4B and VSP4A reverse GSDMD-mediated pyroptosis by cell membrane remodeling in endometrial carcinoma.
Yang Y, Chen HL, Wu SF, Bao W. | 12/21/2023 |
| Analysis of individual HIV-1 budding event using fast AFM reveals a multiplexed role for VPS4. | Analysis of individual HIV-1 budding event using fast AFM reveals a multiplexed role for VPS4.
Harel S, Altaras Y, Nachmias D, Rotem-Dai N, Dvilansky I, Elia N, Rousso I., Free PMC Article | 11/12/2022 |
| The ESCRT-III protein VPS4, but not CHMP4B or CHMP2B, is pathologically increased in familial and sporadic ALS neuronal nuclei. | The ESCRT-III protein VPS4, but not CHMP4B or CHMP2B, is pathologically increased in familial and sporadic ALS neuronal nuclei.
Coyne AN, Rothstein JD., Free PMC Article | 01/29/2022 |
| Synthetic Lethal Interaction between the ESCRT Paralog Enzymes VPS4A and VPS4B in Cancers Harboring Loss of Chromosome 18q or 16q. | Synthetic Lethal Interaction between the ESCRT Paralog Enzymes VPS4A and VPS4B in Cancers Harboring Loss of Chromosome 18q or 16q.
Neggers JE, Paolella BR, Asfaw A, Rothberg MV, Skipper TA, Yang A, Kalekar RL, Krill-Burger JM, Dharia NV, Kugener G, Kalfon J, Yuan C, Dumont N, Gonzalez A, Abdusamad M, Li YY, Spurr LF, Wu WW, Durbin AD, Wolpin BM, Piccioni F, Root DE, Boehm JS, Cherniack AD, Tsherniak A, Hong AL, Hahn WC, Stegmaier K, Golub TR, Vazquez F, Aguirre AJ., Free PMC Article | 12/25/2021 |
| Vaccinia virus hijacks ESCRT-mediated multivesicular body formation for virus egress. | Vaccinia virus hijacks ESCRT-mediated multivesicular body formation for virus egress.
Huttunen M, Samolej J, Evans RJ, Yakimovich A, White IJ, Kriston-Vizi J, Martin-Serrano J, Sundquist WI, Frickel EM, Mercer J., Free PMC Article | 12/11/2021 |
| Synthetic lethality between VPS4A and VPS4B triggers an inflammatory response in colorectal cancer. | Synthetic lethality between VPS4A and VPS4B triggers an inflammatory response in colorectal cancer.
Szymańska E, Nowak P, Kolmus K, Cybulska M, Goryca K, Derezińska-Wołek E, Szumera-Ciećkiewicz A, Brewińska-Olchowik M, Grochowska A, Piwocka K, Prochorec-Sobieszek M, Mikula M, Miączyńska M., Free PMC Article | 07/31/2021 |
| VPS4A mutation in syndromic congenital hemolytic anemia without obvious signs of dyserythropoiesis. | VPS4A mutation in syndromic congenital hemolytic anemia without obvious signs of dyserythropoiesis.
Lunati A, Petit A, Lapillonne H, Gameiro C, Saillour V, Garel C, Doummar D, Qebibo L, Aissat A, Fanen P, Bartolucci P, Galactéros F, Funalot B, Burglen L, Mansour-Hendili L. | 04/24/2021 |
| De Novo VPS4A Mutations Cause Multisystem Disease with Abnormal Neurodevelopment. | De Novo VPS4A Mutations Cause Multisystem Disease with Abnormal Neurodevelopment.
Rodger C, Flex E, Allison RJ, Sanchis-Juan A, Hasenahuer MA, Cecchetti S, French CE, Edgar JR, Carpentieri G, Ciolfi A, Pantaleoni F, Bruselles A, Genomics England Research Consortium, Onesimo R, Zampino G, Marcon F, Siniscalchi E, Lees M, Krishnakumar D, McCann E, Yosifova D, Jarvis J, Kruer MC, Marks W, Campbell J, Allen LE, Gustincich S, Raymond FL, Tartaglia M, Reid E., Free PMC Article | 01/16/2021 |
| VPS4A Mutations in Humans Cause Syndromic Congenital Dyserythropoietic Anemia due to Cytokinesis and Trafficking Defects. | VPS4A Mutations in Humans Cause Syndromic Congenital Dyserythropoietic Anemia due to Cytokinesis and Trafficking Defects.
Seu KG, Trump LR, Emberesh S, Lorsbach RB, Johnson C, Meznarich J, Underhill HR, Chou ST, Sakthivel H, Nassar NN, Seu KJ, Blanc L, Zhang W, Lutzko CM, Kalfa TA., Free PMC Article | 01/16/2021 |
| Vps4A regulates the plasma membrane localization and exosome sorting of beta-catenin, consequently decreasing beta-catenin signaling, and thereby inhibiting epithelial mesenchymal transformation and metastasis in hepatocellular carcinoma. | Vps4A mediates the localization and exosome release of β-catenin to inhibit epithelial-mesenchymal transition in hepatocellular carcinoma.
Han Q, Lv L, Wei J, Lei X, Lin H, Li G, Cao J, Xie J, Yang W, Wu S, You J, Lu J, Liu P, Min J. | 05/2/2020 |
| Visualization of IST1 structures in cells lacking the microtubule-severing enzyme spastin and in cells depleted of specific ESCRT-III components or the ATPase VPS4 demonstrated the contribution of these components to the organization and function of ESCRTs in cells. | Resolving ESCRT-III Spirals at the Intercellular Bridge of Dividing Cells Using 3D STORM.
Goliand I, Adar-Levor S, Segal I, Nachmias D, Dadosh T, Kozlov MM, Elia N. | 11/30/2019 |
| These results demonstrate that the ESCRT machinery, and in particular VPS4, plays a critical role in the early stages of PV infection. | The VPS4 component of the ESCRT machinery plays an essential role in HPV infectious entry and capsid disassembly.
Broniarczyk J, Pim D, Massimi P, Bergant M, Goździcka-Józefiak A, Crump C, Banks L., Free PMC Article | 11/17/2018 |
| Continuous ESCRT-III remodelling by dynamic subunit turnover is regulated by Vps4 to mediate membrane remodelling during cytokinesis. | Dynamic subunit turnover in ESCRT-III assemblies is regulated by Vps4 to mediate membrane remodelling during cytokinesis.
Mierzwa BE, Chiaruttini N, Redondo-Morata L, von Filseck JM, König J, Larios J, Poser I, Müller-Reichert T, Scheuring S, Roux A, Gerlich DW., Free PMC Article | 09/16/2017 |
| associations were noted between the striatal node, hyperactivity, and the vacuolar protein sorting-associated protein 4A (VPS4A) gene in humans, and the causal role of Vps4 for hyperactivity was validated in Drosophila | Neural basis of reward anticipation and its genetic determinants.
Jia T, Macare C, Desrivières S, Gonzalez DA, Tao C, Ji X, Ruggeri B, Nees F, Banaschewski T, Barker GJ, Bokde AL, Bromberg U, Büchel C, Conrod PJ, Dove R, Frouin V, Gallinat J, Garavan H, Gowland PA, Heinz A, Ittermann B, Lathrop M, Lemaitre H, Martinot JL, Paus T, Pausova Z, Poline JB, Rietschel M, Robbins T, Smolka MN, Müller CP, Feng J, Rothenfluh A, Flor H, Schumann G, IMAGEN Consortium., Free PMC Article | 12/17/2016 |
| These results point to the existence of previously undetected biological functions of the FTase alpha subunit that includes control of intracellular membrane trafficking. | Mammalian farnesyltransferase α subunit regulates vacuolar protein sorting-associated protein 4A (Vps4A)--dependent intracellular trafficking through recycling endosomes.
Kubala MH, Norwood SJ, Gomez GA, Jones A, Johnston W, Yap AS, Mureev S, Alexandrov K. | 04/23/2016 |
| these experiments suggest that miR-16 and VPS4a expression are altered in end-stage heart failure and in response to unloading with a left ventricular assist device | Identification of a new target of miR-16, Vacuolar Protein Sorting 4a.
Adhikari N, Guan W, Capaldo B, Mackey AJ, Carlson M, Ramakrishnan S, Walek D, Gupta M, Mitchell A, Eckman P, John R, Ashley E, Barton PJ, Hall JL., Free PMC Article | 12/19/2015 |
| Ca2+-dependent accumulation of ESCRT III-Vps4 complex following large focal injury to the cell membrane and identify the role of ALG-2 as the initiator of sequential ESCRT III-Vps4A/B complex assembly. | Mechanism of Ca²⁺-triggered ESCRT assembly and regulation of cell membrane repair.
Scheffer LL, Sreetama SC, Sharma N, Medikayala S, Brown KJ, Defour A, Jaiswal JK., Free PMC Article | 11/21/2015 |
| Vps4A may function as a tumor suppressor, which utilizes exosomes as mediators to regulate the secretion and uptake of miRNAs in hepatoma cells; these observations provide new insights into the development of HCC. | Vps4A functions as a tumor suppressor by regulating the secretion and uptake of exosomal microRNAs in human hepatoma cells.
Wei JX, Lv LH, Wan YL, Cao Y, Li GL, Lin HM, Zhou R, Shang CZ, Cao J, He H, Han QF, Liu PQ, Zhou G, Min J., Free PMC Article | 06/6/2015 |
| Vps4 stimulatory element of the cofactor Vta1 contacts the ATPase Vps4 alpha7 and alpha9 subunits to stimulate ATP hydrolysis. | Vps4 stimulatory element of the cofactor Vta1 contacts the ATPase Vps4 α7 and α9 to stimulate ATP hydrolysis.
Davies BA, Norgan AP, Payne JA, Schulz ME, Nichols MD, Tan JA, Xu Z, Katzmann DJ., Free PMC Article | 02/7/2015 |
| Propose that the abscission checkpoint is mediated by ANCHR and CHMP4C through retention of VPS4 at the midbody ring. | ANCHR mediates Aurora-B-dependent abscission checkpoint control through retention of VPS4.
Thoresen SB, Campsteijn C, Vietri M, Schink KO, Liestøl K, Andersen JS, Raiborg C, Stenmark H. | 08/9/2014 |
| VPS4 is required for endosomal transport of LDL cholesterol in HeLa cells. | The AAA ATPase VPS4/SKD1 regulates endosomal cholesterol trafficking independently of ESCRT-III.
Du X, Kazim AS, Dawes IW, Brown AJ, Yang H. | 06/22/2013 |
| silencing CHMP6 and VPS4A also blocked epidermal growth factor receptor (EGFR) recycling | CHMP6 and VPS4A mediate the recycling of Ras to the plasma membrane to promote growth factor signaling.
Zheng ZY, Cheng CM, Fu XR, Chen LY, Xu L, Terrillon S, Wong ST, Bar-Sagi D, Songyang Z, Chang EC., Free PMC Article | 01/5/2013 |
| VPS4, a master regulator of MVB sorting, may serve as a determinant of lysosomal targeting or extracellular secretion of alphaSYN and thereby contribute to the intercellular propagation of Lewy pathology in PD | The AAA-ATPase VPS4 regulates extracellular secretion and lysosomal targeting of α-synuclein.
Hasegawa T, Konno M, Baba T, Sugeno N, Kikuchi A, Kobayashi M, Miura E, Tanaka N, Tamai K, Furukawa K, Arai H, Mori F, Wakabayashi K, Aoki M, Itoyama Y, Takeda A., Free PMC Article | 05/26/2012 |
| These results indicate that VPS4A has a direct role in membrane scission leading to HIV-1 release. | Live-cell visualization of dynamics of HIV budding site interactions with an ESCRT component.
Baumgärtel V, Ivanchenko S, Dupont A, Sergeev M, Wiseman PW, Kräusslich HG, Bräuchle C, Müller B, Lamb DC. | 06/4/2011 |