| Lp-PLA2 silencing ameliorates inflammation and autophagy in nonalcoholic steatohepatitis through inhibiting the JAK2/STAT3 pathway. | Lp-PLA2 silencing ameliorates inflammation and autophagy in nonalcoholic steatohepatitis through inhibiting the JAK2/STAT3 pathway.
Yao J, Zhao Y., Free PMC Article | 07/10/2023 |
| Integrated analysis of single-cell and bulk RNA sequencing reveals pro-fibrotic PLA2G7(high) macrophages in pulmonary fibrosis. | Integrated analysis of single-cell and bulk RNA sequencing reveals pro-fibrotic PLA2G7(high) macrophages in pulmonary fibrosis.
Wang J, Jiang M, Xiong A, Zhang L, Luo L, Liu Y, Liu S, Ran Q, Wu D, Xiong Y, He X, Leung EL, Li G. | 08/13/2022 |
| Caloric restriction in humans reveals immunometabolic regulators of health span. | Caloric restriction in humans reveals immunometabolic regulators of health span.
Spadaro O, Youm Y, Shchukina I, Ryu S, Sidorov S, Ravussin A, Nguyen K, Aladyeva E, Predeus AN, Smith SR, Ravussin E, Galban C, Artyomov MN, Dixit VD., Free PMC Article | 02/19/2022 |
| Association of circulating PLA2G7 levels with cancer cachexia and assessment of darapladib as a therapy. | Association of circulating PLA2G7 levels with cancer cachexia and assessment of darapladib as a therapy.
Morigny P, Kaltenecker D, Zuber J, Machado J, Mehr L, Tsokanos FF, Kuzi H, Hermann CD, Voelkl M, Monogarov G, Springfeld C, Laurent V, Engelmann B, Friess H, Zörnig I, Krüger A, Krijgsveld J, Prokopchuk O, Fisker Schmidt S, Rohm M, Herzig S, Berriel Diaz M., Free PMC Article | 12/18/2021 |
| Platelet-Activating Factor Deteriorates Lysophosphatidylcholine-Induced Demyelination Via Its Receptor-Dependent and -Independent Effects. | Platelet-Activating Factor Deteriorates Lysophosphatidylcholine-Induced Demyelination Via Its Receptor-Dependent and -Independent Effects.
Tian Z, Chu T, Shields LBE, Zhu Q, Zhang YP, Kong M, Barnes GN, Wang Y, Shields CB, Cai J. | 06/12/2021 |
| PLA2G7 silencing can improve the myocardial fibrosis in mice with coronary atherosclerosis, and PLA2G7 is expected to be a potential target for coronary atherosclerosis | Regulation of lipoprotein-associated phospholipase A2 silencing on myocardial fibrosis in mice with coronary atherosclerosis.
Pan G, Kou L, Wu Y, Hu Y, Lin X, Guo J, Ren X, Zhang Y. | 07/11/2020 |
| Resveratrol downregulates Lp-PLA2 expression by inhibiting oxidative stress via SIRT1 pathway in a mouse model of chronic inflammation. | Resveratrol suppresses lipoprotein-associated phospholipase A(2) expression by reducing oxidative stress in macrophages and animal models.
Sun S, Zhang M, Yang Q, Shen Z, Chen J, Yu B, Wang H, Qu J, Pang D, Ren W, Ouyang H, Tang X. | 07/7/2018 |
| Lp-PLA2 augments the inflammatory response after MI and antagonizes healing by disrupting the balance between inflammation and repair. | Lp-PLA2 Antagonizes Left Ventricular Healing After Myocardial Infarction by Impairing the Appearance of Reparative Macrophages.
He S, Chousterman BG, Fenn A, Anzai A, Nairz M, Brandt M, Hilgendorf I, Sun Y, Ye YX, Iwamoto Y, Tricot B, Weissleder R, Macphee C, Libby P, Nahrendorf M, Swirski FK., Free PMC Article | 12/5/2015 |
| Plg from mouse plasma contains oxPtdPC adducts that are not affected by the action of Lp-PLA(2), suggesting that linkage to Plg protects oxPtdPCs from metabolism during their transport in the plasma. | Mouse plasminogen has oxidized phosphatidylcholine adducts that are not metabolized by lipoprotein-associated phospholipase A₂under basal conditions.
Edelstein C, Pfaffinger D, Reichert EC, Stafforini DM, Scanu AM., Free PMC Article | 07/4/2015 |
| SAA up-regulates Lp-PLA2 production significantly via a FPRL1/MAPKs./PPAR-gamma signaling pathway. | Serum amyloid A stimulates lipoprotein-associated phospholipase A2 expression in vitro and in vivo.
Li B, Dong Z, Liu H, Xia YF, Liu XM, Luo BB, Wang WK, Li B, Gao F, Zhang C, Zhang MX, Zhang Y, An FS. | 10/26/2013 |
| Deletion of Pla2g7 decreases small intestinal polyp and colon tumor incidence in ApcMin/+ mice. | Deficiency of phospholipase A2 group 7 decreases intestinal polyposis and colon tumorigenesis in Apc(Min/+) mice.
Xu C, Reichert EC, Nakano T, Lohse M, Gardner AA, Revelo MP, Topham MK, Stafforini DM., Free PMC Article | 06/29/2013 |
| Macrophage VLDL receptor promotes PAFAH secretion in mother's milk and suppresses systemic inflammation in nursing neonates. | Macrophage VLDL receptor promotes PAFAH secretion in mother's milk and suppresses systemic inflammation in nursing neonates.
Du Y, Yang M, Wei W, Huynh HD, Herz J, Saghatelian A, Wan Y., Free PMC Article | 02/9/2013 |
| Pla2g7 and Tnfrsf21 have been identified as genetic susceptibility to influenza genes in mice. | Mapping of clinical and expression quantitative trait loci in a sex-dependent effect of host susceptibility to mouse-adapted influenza H3N2/HK/1/68.
Boivin GA, Pothlichet J, Skamene E, Brown EG, Loredo-Osti JC, Sladek R, Vidal SM. | 06/23/2012 |
| Pla2g7 plays a crucial physiological role in smooth muscle cell differentiation from stem cells, and interactions between Nrf3 and Pla2g7 are essential. | Nrf3-Pla2g7 interaction plays an essential role in smooth muscle differentiation from stem cells.
Xiao Q, Pepe AE, Wang G, Luo Z, Zhang L, Zeng L, Zhang Z, Hu Y, Ye S, Xu Q. | 04/14/2012 |
| The effects of a specific lp-PLA2 inhibitor on atherosclerosis in ApoE-deficient mice and its associated mechanisms, are reported. | Inhibition of lipoprotein-associated phospholipase A2 ameliorates inflammation and decreases atherosclerotic plaque formation in ApoE-deficient mice.
Wang WY, Zhang J, Wu WY, Li J, Ma YL, Chen WH, Yan H, Wang K, Xu WW, Shen JH, Wang YP., Free PMC Article | 01/7/2012 |
| Studies designed to evaluate the ability of precursor forms of PAF-AH to mature to fully active proteins indicated that the N-terminal end of human and mouse PAF-AH played important and opposite roles in this process. | Novel mechanism for regulation of plasma platelet-activating factor acetylhydrolase expression in mammalian cells.
Gardner AA, Reichert EC, Alexander TS, Topham MK, Stafforini DM. | 05/31/2010 |
| mouse and human PAF-AHs associate with human HDL particles of different density | Identification of a domain that mediates association of platelet-activating factor acetylhydrolase with high density lipoprotein.
Gardner AA, Reichert EC, Topham MK, Stafforini DM., Free PMC Article | 01/21/2010 |
| inactivation of PAF, produced by TEC, by the overexpression of plasma PAF-AH affects survival, migration, and the angiogenic response of TEC both in vitro and in vivo | The proangiogenic phenotype of tumor-derived endothelial cells is reverted by the overexpression of platelet-activating factor acetylhydrolase.
Doublier S, Ceretto M, Lupia E, Bravo S, Bussolati B, Camussi G. | 01/21/2010 |
| over-expression of the PAF-AH (I) catalytic subunits induces centrosomal amplification and microtubule disorganization by disturbing intracellular localization of LIS1 | Type I platelet-activating factor acetylhydrolase catalytic subunits over-expression induces pleiomorphic nuclei and centrosome amplification.
Yamaguchi N, Koizumi H, Aoki J, Natori Y, Nishikawa K, Natori Y, Takanezawa Y, Arai H. | 01/21/2010 |
| PAF acetylhydrolase activity in the uterus in early pregnancy was not produced locally but probably resulted from the influx of the plasma form of the enzyme | Identification and regulation of the platelet-activating factor acetylhydrolase activity in the mouse uterus in early pregnancy.
Chami O, O'Neill C. | 01/21/2010 |
| PAF acetylhydrolases play key roles in the hydrolysis of F2-isoprostanes esterified on phospholipids in vivo | Release of free F2-isoprostanes from esterified phospholipids is catalyzed by intracellular and plasma platelet-activating factor acetylhydrolases.
Stafforini DM, Sheller JR, Blackwell TS, Sapirstein A, Yull FE, McIntyre TM, Bonventre JV, Prescott SM, Roberts LJ 2nd. | 01/21/2010 |
| deletion of both subunits induces a marked loss of germ cells at an early spermatogenic stage. | Targeted disruption of intracellular type I platelet activating factor-acetylhydrolase catalytic subunits causes severe impairment in spermatogenesis.
Koizumi H, Yamaguchi N, Hattori M, Ishikawa TO, Aoki J, Taketo MM, Inoue K, Arai H. | 01/21/2010 |