| Gene-based association study of rare variants in children of diverse ancestries implicates TNFRSF21 in the development of allergic asthma. | Gene-based association study of rare variants in children of diverse ancestries implicates TNFRSF21 in the development of allergic asthma.
Clay S, Alladina J, Smith NP, Visness CM, Wood RA, O'Connor GT, Cohen RT, Khurana Hershey GK, Kercsmar CM, Gruchalla RS, Gill MA, Liu AH, Kim H, Kattan M, Bacharier LB, Rastogi D, Rivera-Spoljaric K, Robison RG, Gergen PJ, Busse WW, Villani AC, Cho JL, Medoff BD, Gern JE, Jackson DJ, Ober C, Dapas M., Free PMC Article | 03/12/2024 |
| Long Noncoding RNAs Testis Development Related Gene 1 Aggravates Transforming Growth Factor-beta1-Induced Fibrogenesis and Inflammatory Response of Cardiac Fibroblasts Via miR-605-3p/Tumor Necrosis Factor Receptor Superfamily-21 Axis. | Long Noncoding RNAs Testis Development Related Gene 1 Aggravates Transforming Growth Factor-β1-Induced Fibrogenesis and Inflammatory Response of Cardiac Fibroblasts Via miR-605-3p/Tumor Necrosis Factor Receptor Superfamily-21 Axis.
Cheng J, Tang Y, Cai X, Gong J. | 05/7/2022 |
| Death Receptor 6 as a Prognostic Marker in Low-grade Glioma. | Death Receptor 6 as a Prognostic Marker in Low-grade Glioma.
Stegmann SK, Kuhl S, Im NG, Diem-Dinh DT, Goertz L, Goldbrunner R, Timmer M. | 03/12/2022 |
| Proapoptotic Mitochondrial Carrier Homolog Protein PSAP Mediates Death Receptor 6 Induced Apoptosis. | Proapoptotic Mitochondrial Carrier Homolog Protein PSAP Mediates Death Receptor 6 Induced Apoptosis.
Zhang J, Zhao ZJ, Fu X, Niu H, Hu C, Dong Y, Cui MZ, Zhang F, Zeng L, Xu X. | 05/8/2021 |
| circTNFRSF21, a newly identified circular RNA promotes endometrial carcinoma pathogenesis through regulating miR-1227-MAPK13/ATF2 axis. | circTNFRSF21, a newly identified circular RNA promotes endometrial carcinoma pathogenesis through regulating miR-1227-MAPK13/ATF2 axis.
Liu Y, Chang Y, Cai Y., Free PMC Article | 02/27/2021 |
| Variants in TNFRSF21 cause non-syndromic high myopia in Chinese population. | TNFRSF21 mutations cause high myopia.
Pan H, Wu S, Wang J, Zhu T, Li T, Wan B, Liu B, Luo Y, Ma X, Sui R, Wang B. | 06/20/2020 |
| Hepatitis C virus modulates DR6 signaling pathway for viral propagation.DR6 is not involved in the entry, replication, and translation steps of the HCV life cycle.Hepatitis C virus NS5A protein specifically interacts with DR6. | Hepatitis C Virus Exploits Death Receptor 6-mediated Signaling Pathway to Facilitate Viral Propagation.
Luong TTD, Tran GVQ, Shin DJ, Lim YS, Hwang SB., Free PMC Article | 02/9/2019 |
| MiR20a5p functioned as an oncogene in HNSCC by downregulating TNFRSF21. | Upregulated miR‑20a‑5p expression promotes proliferation and invasion of head and neck squamous cell carcinoma cells by targeting of TNFRSF21.
Wu H, Pang P, Liu MD, Wang S, Jin S, Liu FY, Sun CF. | 10/13/2018 |
| Knockdown death receptor 6 by shRNA in human pDCs cell line GEN2.2 significantly diminished the CpG-ODN induced IFN-regulatory factor 7 nuclear localization and IFN-I production. | Death receptor 6 is a novel plasmacytoid dendritic cell-specific receptor and modulates type I interferon production.
Li J, Du Q, Hu R, Wang Y, Yin X, Yu H, Du P, Plumas J, Chaperot L, Liu YJ, Zhang L., Free PMC Article | 12/24/2016 |
| data identify a new mechanism underlying tumour cell extravasation and metastasis, and suggest endothelial DR6-mediated necroptotic signalling pathways as targets for anti-metastatic therapies | Tumour-cell-induced endothelial cell necroptosis via death receptor 6 promotes metastasis.
Strilic B, Yang L, Albarrán-Juárez J, Wachsmuth L, Han K, Müller UC, Pasparakis M, Offermanns S. | 09/10/2016 |
| Increase in the expression levels of mRNA and protein for the death receptor 6 is associated with various types of gynaecological malignancy. | Vascular marker expression during the development of various types of gynaecological malignancy.
Urban P, Rabajdova MB, Varga J, Kruzliak P, Fialkovicova V, Durovcova E, Marekova M. | 04/18/2015 |
| Circulating levels of DR6 and Gpm6B correlate with breast cancer tumor grade. | Breast carcinoma progression and tumour vascular markers related to apoptotic mechanisms.
Bilecova-Rabajdova M, Urban P, Gregova K, Varga J, Fialkovicová V, Kruzliak P, Marekova M., Free PMC Article | 01/24/2015 |
| The present findings suggested that DR6 is involved in the pathogenesis of endometriosis by creating the proliferative and anti-apoptotic characteristics of endometriosis. | Death receptor 6 is epigenetically silenced by histone deacetylation in endometriosis and promotes the pathogenesis of endometriosis.
Kai K, Nasu K, Kawano Y, Aoyagi Y, Tsukamoto Y, Hijiya N, Abe W, Okamoto M, Moriyama M, Narahara H. | 12/27/2014 |
| These results provide direct support for the model that APP and DR6 function cell autonomously and in the same pathway to control pruning | Genetic analysis reveals that amyloid precursor protein and death receptor 6 function in the same pathway to control axonal pruning independent of β-secretase.
Olsen O, Kallop DY, McLaughlin T, Huntwork-Rodriguez S, Wu Z, Duggan CD, Simon DJ, Lu Y, Easley-Neal C, Takeda K, Hass PE, Jaworski A, O'Leary DD, Weimer RM, Tessier-Lavigne M., Free PMC Article | 06/21/2014 |
| Our results support the view that DR6 functions with APP to modulate synaptic density in the adult CNS | A death receptor 6-amyloid precursor protein pathway regulates synapse density in the mature CNS but does not contribute to Alzheimer's disease-related pathophysiology in murine models.
Kallop DY, Meilandt WJ, Gogineni A, Easley-Neal C, Wu T, Jubb AM, Yaylaoglu M, Shamloo M, Tessier-Lavigne M, Scearce-Levie K, Weimer RM., Free PMC Article | 06/21/2014 |
| our findings provide new insight into a novel mechanism by which DR6 induces downstream signaling in response to an agonist antibody. | Agonist antibody activates death receptor 6 downstream signaling involving TRADD recruitment.
Hu R, Du Q, Yin X, Li J, Wang T, Zhang L. | 03/29/2014 |
| DR6 knockout mice are viable and fertile, and show hyperproliferation of T cells when stimulated. | Impaired c-Jun amino terminal kinase activity and T cell differentiation in death receptor 6-deficient mice.
Zhao H, Yan M, Wang H, Erickson S, Grewal IS, Dixit VM., Free PMC Article | 07/8/2013 |
| DR6 mediates T cell proliferation and differentiation in mice. | Enhanced CD4+ T cell proliferation and Th2 cytokine production in DR6-deficient mice.
Liu J, Na S, Glasebrook A, Fox N, Solenberg PJ, Zhang Q, Song HY, Yang DD. | 07/8/2013 |
| DR6-induced apoptosis occurs through a new pathway that is different from the type I and type II pathways through interacting with Bax. | Death receptor 6 induces apoptosis not through type I or type II pathways, but via a unique mitochondria-dependent pathway by interacting with Bax protein.
Zeng L, Li T, Xu DC, Liu J, Mao G, Cui MZ, Fu X, Xu X., Free PMC Article | 11/3/2012 |
| DR6 serum protein may be a tool to aid in the diagnosis of some sarcomatous tumors to improve treatment planning. | DR6 as a diagnostic and predictive biomarker in adult sarcoma.
Yang K, Mooney C, Spahlinger G, Schuetze S, Arias-Pulido H, Verschraegen C, Gimotty P, Buckanovich RJ., Free PMC Article | 09/22/2012 |
| SAXS measurements on the ectodomain suggested that a dimer defines the minimal physical unit of an unliganded DR6 molecule in solution. | S-SAD phasing study of death receptor 6 and its solution conformation revealed by SAXS.
Ru H, Zhao L, Ding W, Jiao L, Shaw N, Liang W, Zhang L, Hung LW, Matsugaki N, Wakatsuki S, Liu ZJ., Free PMC Article | 07/21/2012 |
| findings show that DR6 expression is significantly but transiently upregulated only in activated both CD4+ and CD8+ T cells in NF-kappaB and NF-AT dependent manner with a contribution of PI3K-dependent signaling | T-cell activation triggers death receptor-6 expression in a NF-κB and NF-AT dependent manner.
Klíma M, Broučková A, Koc M, Anděra L. | 08/13/2011 |
| The model is used to provide a satisfying structural and energetic interpretation of DR6-growth factor-like domain of NAPP binding and to suggest the possibility of and a mechanism for spontaneous apoptosis. | Computational prediction and analysis of the DR6-NAPP interaction.
Ponomarev SY, Audie J. | 08/6/2011 |
| Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) | MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer.
Zhang X, Yang H, Lee JJ, Kim E, Lippman SM, Khuri FR, Spitz MR, Lotan R, Hong WK, Wu X., Free PMC Article | 12/5/2010 |
| N-glycosylation of the extracellular part might participate in directing DR6 into lipid raft membrane microdomains. | Functional analysis of the posttranslational modifications of the death receptor 6.
Klíma M, Zájedová J, Doubravská L, Andera L. | 01/21/2010 |