| TOX3 regulates the proliferation and apoptosis of colorectal cancer by downregulating RhoB via the activation of the MAPK pathway. | TOX3 regulates the proliferation and apoptosis of colorectal cancer by downregulating RhoB via the activation of the MAPK pathway.
Yang W, Wu W, Liang H, Chen J, Dong X. | 07/2/2022 |
| Genetic polymorphism of fibroblast growth factor receptor 2 and trinucleotide repeat-containing 9 influence the susceptibility to HCV-induced hepatocellular carcinoma. | Genetic polymorphism of fibroblast growth factor receptor 2 and trinucleotide repeat-containing 9 influence the susceptibility to HCV-induced hepatocellular carcinoma.
Al-Khaykanee AM, Abdel-Rahman AA, Essa A, Gadallah AA, Ali BH, Al-Aqar AA, Badr EAE, Shehab-Eldeen S. | 04/23/2022 |
| Risk Association of TOX3 and MMP7 Gene Polymorphisms with Sporadic Breast Cancer in Mexican Women. | Risk Association of TOX3 and MMP7 Gene Polymorphisms with Sporadic Breast Cancer in Mexican Women.
Solis-Coronado O, Villarreal-Vela MP, Rodríguez-Gutiérrez HF, González-Guerrero JF, Cerda-Flores RM, Alcorta-Núñez F, Camarillo-Cárdenas KP, Pérez-Ibave DC, Vidal-Gutiérrez O, Ramírez-Correa GA, Garza-Rodríguez ML., Free PMC Article | 04/2/2022 |
| Association between CASC16 rs4784227 polymorphism and breast cancer susceptibility: A meta-analysis. | Association between CASC16 rs4784227 polymorphism and breast cancer susceptibility: A meta-analysis.
Liang XS, Mo JL, Hu LM, Gong CM, Liu T, Hong WX, Yin JY, Liu ZQ, Zhou HH., Free PMC Article | 07/31/2021 |
| TOX3 Promotes Ovarian Estrogen Synthesis: An RNA-Sequencing and Network Study. | TOX3 Promotes Ovarian Estrogen Synthesis: An RNA-Sequencing and Network Study.
Man Y, Zhao R, Gao X, Liu Y, Zhao S, Lu G, Chan WY, Leung PCK, Bian Y., Free PMC Article | 05/29/2021 |
| TOX3 gene variant could be associated with painful restless legs. | TOX3 gene variant could be associated with painful restless legs.
Karroum EG, Saini PS, Trotti LM, Rye DB. | 10/31/2020 |
| TOX high mobility group box family member 3 (TOX3) is one such gene, in which SNPs have been found to be associated with breast cancer. Found nine SNPs that may affect the gene regulation. | An in silico approach to characterize nonsynonymous SNPs and regulatory SNPs in human TOX3 gene.
Akhtar M, Jamal T, Din JU, Hayat C, Rauf M, Ul Haq SM, Sher Khan R, Shah AA, Jamal M, Jalil F. | 06/27/2020 |
| the TOX3 rs3803662 C>T polymorphism may not be associated with recurrent miscarriage in the southern Chinese population. | Association between the TOX3 rs3803662 C>T polymorphism and recurrent miscarriage in a southern Chinese population.
Huang W, Zhou H, Li Q, Pi L, Xu Y, Fu L, Yang Y, Lu Z, Che D, Gu X., Free PMC Article | 04/18/2020 |
| Study identified TOX3 as a novel cancer suppressor gene in clear cell renal cell carcinoma (ccRCC). Hypermethylation in the promoter region was associated with its functional loss and poor outcome in ccRCC patients. Downregulation of TOX3 could accelerate the EMT by decreasing transcriptional repression of SNAI1 and SNAI2. Its overexpression inhibited RCC cell growth, migration and invasion. | TOX3 inhibits cancer cell migration and invasion via transcriptional regulation of SNAI1 and SNAI2 in clear cell renal cell carcinoma.
Jiang B, Chen W, Qin H, Diao W, Li B, Cao W, Zhang Z, Qi W, Gao J, Chen M, Zhao X, Guo H. | 01/25/2020 |
| TOX3-rs3803662, may confer some degrees of risk of breast cancer in Iranian population. | Significant association of TOX3/LOC643714 locus-rs3803662 and breast cancer risk in a cohort of Iranian population.
Tajbakhsh A, Javan FA, Rivandi M, Moezzi A, Abedini S, Asghari M, Farjami Z, Soltanian H, Shandiz FH, Kooshyar MM, Pasdar A. | 07/13/2019 |
| The carriers of homozygous minor alleles of the TOX3 gene are not a risk factor for the development of breast cancer under conditions of exposure to ionizing radiation in the study group of the Ukrainian population. | Reserch of the gene polymorphism TOX3 / LOC643714 and the risk of breast cancer development in persons exposed to ionizing radiation after Chornobyl disaster.
Polinyk SI, Rybchenko LA, Klimyk BT. | 07/6/2019 |
| Low copy number of Tox3 is associated with nonsyndromic cleft lip and/or palate. | Two novel genes TOX3 and COL21A1 in large extended Malay families with nonsyndromic cleft lip and/or palate.
Mohamad Shah NS, Sulong S, Wan Sulaiman WA, Halim AS., Free PMC Article | 06/29/2019 |
| there was a relationship between rs2046210 and rs3803662, and the risk of developing this disease in Vietnamese women. The A allele is the risk allele for both rs2046210 (OR [95% CI] = 1.43 [1.14 - 1.78], P = 0.0015) and rs3803662 (OR [95% CI] = 1.45 [1.16 - 1.83], P = 0.001). We conclude that two polymorphisms, rs2046210 in ESR1 and rs3803662 in TNRC9, are associated with breast cancer risk in the Vietnamese population. | Two polymorphisms, rs2046210 and rs3803662, are associated with breast cancer risk in a Vietnamese case-control cohort.
Thanh NTN, Lan NTT, Phat PT, Giang NDT, Hue NT. | 12/22/2018 |
| The results confirm the association between the TOX3 SNP rs3104767 and restless legs syndrome and suggest that TOX3 variants are involved in both RLS and Parkinson's disease, but with different or even opposite effects. | TOX3 Variants Are Involved in Restless Legs Syndrome and Parkinson's Disease with Opposite Effects.
Mohtashami S, He Q, Ruskey JA, Zhou S, Dion PA, Allen RP, Earley CJ, Fon EA, Xiong L, Dupre N, Dauvilliers Y, Rouleau GA, Gan-Or Z. | 09/8/2018 |
| This meta-analysis suggested that TOX3 rs3803662 polymorphism was associated with increased breast cancer risk. | TOX high mobility group box family member 3 rs3803662 and breast cancer risk: A meta-analysis.
Li L, Guo G, Wang F, Lv P, Zhu M, Gu Y, Han M, Pei X. | 09/1/2018 |
| abnormal TOX3 methylation possibly resulting in changes in TOX3 protein expression is closely related to the occurrence of polycystic ovarian syndrome and may play a role the development of the pathology | Relationship between abnormal TOX3 gene methylation and polycystic ovarian syndrome.
Ning Z, Jiayi L, Jian R, Wanli X. | 07/7/2018 |
| Data show that three SNPs (rs9933638, rs12443621, and rs3104746) at the TOX3/LOC643714 locus contributed to lung cancer risk, suggesting that lung cancer and breast cancer are linked at the molecular and genetic level to a certain extent. | The breast cancer susceptibility-related polymorphisms at the TOX3/LOC643714 locus associated with lung cancer risk in a Han Chinese population.
Jiang C, Yu S, Qian P, Guo R, Zhang R, Ao Z, Li Q, Wu G, Chen Y, Li J, Wang C, Yao W, Xu J, Qian G, Ji F., Free PMC Article | 02/10/2018 |
| Data support a plausible molecular mechanism integrating epigenetic modifications of the TOX3 promoter and allele specific expression of SNPs in aggressive behavior of luminal breast tumors with high TOX3 expression. | Genetic and Epigenetic Regulation of TOX3 Expression in Breast Cancer.
Han YJ, Zhang J, Zheng Y, Huo D, Olopade OI., Free PMC Article | 07/1/2017 |
| Significant associations were observed between Breast Cancer risk and two Single nucleotide polymorphisms of FGFR2 [rs2981582 (P=0.005), rs1219648 (P=9.08e006)] and one Single nucleotide polymorphisms of TNRC9 [rs3803662) (P=0.012)] in Pakistani women. | Genetic variants in FGFR2 and TNRC9 genes are associated with breast cancer risk in Pakistani women.
Mazhar A, Jamil F, Bashir Q, Ahmad MS, Masood M, Tanvir I, Rashid N, Waheed A, Afzal MN, Tariq MA. | 04/22/2017 |
| The genotype of rs3803662 from TOX3 is associated with breast cancer. | Relationship between five GWAS-identified single nucleotide polymorphisms and female breast cancer in the Chinese Han population.
He Y, Liu H, Chen Q, Sun X, Liu C, Shao Y. | 03/4/2017 |
| The TNRC9 rs3803662 C>T polymorphism is greatly related to increased risk of breast cancer, in both Asian and Caucasian populations. | Increased risk of breast cancer in individuals carrying the TNRC9 rs3803662 C>T polymorphism: a meta-analysis of case-control studies.
Wang Q, Wang NY, Cao XM, Sun X, Shen D, Yuan M, Chen JF. | 02/25/2017 |
| TNRC9 GG genotype of rs3803662 is associated with increased breast cancer risk. | TNRC9 rs12443621 and FGFR2 rs2981582 polymorphisms and breast cancer risk.
Chen Y, Shi C, Guo Q., Free PMC Article | 10/22/2016 |
| The TOX3 SNPs rs3803662 C > T, rs12443621 A > G and rs8051542 C > T were all correlated with increased risk of breast cancer in the European and Asian populations, but not in the African one. | Association of three SNPs in TOX3 and breast cancer risk: Evidence from 97275 cases and 128686 controls.
Zhang L, Long X., Free PMC Article | 08/6/2016 |
| TOX3 and FGFR2 are breast cancer susceptibility genes in BRCA1/2-wild-type breast cancer patients from Sardinian population. | Genome-wide association study of susceptibility loci for breast cancer in Sardinian population.
Palomba G, Loi A, Porcu E, Cossu A, Zara I, Budroni M, Dei M, Lai S, Mulas A, Olmeo N, Ionta MT, Atzori F, Cuccuru G, Pitzalis M, Zoledziewska M, Olla N, Lovicu M, Pisano M, Abecasis GR, Uda M, Tanda F, Michailidou K, Easton DF, Chanock SJ, Hoover RN, Hunter DJ, Schlessinger D, Sanna S, Crisponi L, Palmieri G., Free PMC Article | 02/6/2016 |
| TOX3 is expressed in mammary ER(+) epithelial cells and regulates ER target genes in luminal breast cancer | TOX3 is expressed in mammary ER(+) epithelial cells and regulates ER target genes in luminal breast cancer.
Seksenyan A, Kadavallore A, Walts AE, de la Torre B, Berel D, Strom SP, Aliahmad P, Funari VA, Kaye J., Free PMC Article | 01/2/2016 |