| PRPF19 mRNA Encodes a Small Open Reading Frame That Is Important for Viability of Human Cells. | PRPF19 mRNA Encodes a Small Open Reading Frame That Is Important for Viability of Human Cells.
Shepelev NM, Kurochkina AO, Dontsova OA, Rubtsova MP., Free PMC Article | 05/7/2024 |
| Comprehensive analysis of PRPF19 immune infiltrates, DNA methylation, senescence-associated secretory phenotype and ceRNA network in bladder cancer. | Comprehensive analysis of PRPF19 immune infiltrates, DNA methylation, senescence-associated secretory phenotype and ceRNA network in bladder cancer.
Wang Y, Wang J, He J, Ji B, Pang Z, Wang J, Liu Y, Ren M., Free PMC Article | 12/4/2023 |
| PRPF19 promotes the proliferation, migration, and inhibits autophagy in prostate cancer by suppressing SLC40A1. | PRPF19 promotes the proliferation, migration, and inhibits autophagy in prostate cancer by suppressing SLC40A1.
Zhang G, Zhang W, Dan M, Zou F, Qiu C, Sun C. | 11/25/2023 |
| PRP19 Enhances Esophageal Squamous Cell Carcinoma Progression by Reprogramming SREBF1-Dependent Fatty Acid Metabolism. | PRP19 Enhances Esophageal Squamous Cell Carcinoma Progression by Reprogramming SREBF1-Dependent Fatty Acid Metabolism.
Zhang GC, Yu XN, Guo HY, Sun JL, Liu ZY, Zhu JM, Liu TT, Dong L, Shen XZ, Yin J. | 02/23/2023 |
| A distinct complex of PRP19-related and trypanosomatid-specific proteins is required for pre-mRNA splicing in trypanosomes. | A distinct complex of PRP19-related and trypanosomatid-specific proteins is required for pre-mRNA splicing in trypanosomes.
Srivastava A, Ambrósio DL, Tasak M, Gosavi U, Günzl A., Free PMC Article | 01/15/2022 |
| A fine balance between Prpf19 and Exoc7 in achieving degradation of aggregated protein and suppression of cell death in spinocerebellar ataxia type 3. | A fine balance between Prpf19 and Exoc7 in achieving degradation of aggregated protein and suppression of cell death in spinocerebellar ataxia type 3.
Chen ZS, Huang X, Talbot K, Chan HYE., Free PMC Article | 09/18/2021 |
| PRPF19 regulates p53-dependent cellular senescence by modulating alternative splicing of MDM4 mRNA. | PRPF19 regulates p53-dependent cellular senescence by modulating alternative splicing of MDM4 mRNA.
Yano K, Takahashi RU, Shiotani B, Abe J, Shidooka T, Sudo Y, Yamamoto Y, Kan S, Sakagami H, Tahara H., Free PMC Article | 08/28/2021 |
| PRPF19 promotes tongue cancer growth and chemoradiotherapy resistance. | PRPF19 promotes tongue cancer growth and chemoradiotherapy resistance.
He Y, Huang C, Cai K, Liu P, Chen X, Xu YI, Ming Z, Liu Q, Xie Q, Xia X, Sun Y, Luo J, Wei R. | 08/7/2021 |
| Formation of the nineteen complex core by stepwise assembly of SPF27, CDC5L, and PLRG1 onto the Prp19 tetramer enables ubiquitin ligation. | Prp19/Pso4 Is an Autoinhibited Ubiquitin Ligase Activated by Stepwise Assembly of Three Splicing Factors.
de Moura TR, Mozaffari-Jovin S, Szabó CZK, Schmitzová J, Dybkov O, Cretu C, Kachala M, Svergun D, Urlaub H, Lührmann R, Pena V. | 01/12/2019 |
| This work implies that the gain of Prp19 is a critical event during the progression of hepatocellular carcinoma | Prp19 facilitates invasion of hepatocellular carcinoma via p38 mitogen-activated protein kinase/twist1 pathway.
Yin J, Wang L, Zhu JM, Yu Q, Xue RY, Fang Y, Zhang YA, Chen YJ, Liu TT, Dong L, Shen XZ., Free PMC Article | 12/16/2017 |
| These results demonstrate that SNEV regulates adipogenesis in hASCs and indicate that DDR capacity in general might be a pre-requisite for this process. | SNEV(hPrp19/hPso4) Regulates Adipogenesis of Human Adipose Stromal Cells.
Khan A, Dellago H, Terlecki-Zaniewicz L, Karbiener M, Weilner S, Hildner F, Steininger V, Gabriel C, Mück C, Jansen-Dürr P, Hacobian A, Scheideler M, Grillari-Voglauer R, Schosserer M, Grillari J., Free PMC Article | 11/25/2017 |
| the interactome of influenza A virus NS1 in host cells was comprehensively profiled, and our findings reveal a novel regulatory role for PRP19 in viral replication | Interactome Analysis of the NS1 Protein Encoded by Influenza A H1N1 Virus Reveals a Positive Regulatory Role of Host Protein PRP19 in Viral Replication.
Kuo RL, Li ZH, Li LH, Lee KM, Tam EH, Liu HM, Liu HP, Shih SR, Wu CC. | 11/11/2017 |
| Crystal structure revealed features of the WD40 domain of human PRPF19. | Crystal structure of the WD40 domain of human PRPF19.
Zhang Y, Li Y, Liang X, Zhu Z, Sun H, He H, Min J, Liao S, Liu Y. | 10/28/2017 |
| The results suggest that RPA phosphorylation enhances the recruitment of PRP19 to RPA-ssDNA and stimulates RPA ubiquitylation through a process requiring both PRP19 and RFWD3, thereby triggering a phosphorylation-ubiquitylation circuitry that promotes ATR activation and homologous recombination. | A phosphorylation-and-ubiquitylation circuitry driving ATR activation and homologous recombination.
Dubois JC, Yates M, Gaudreau-Lapierre A, Clément G, Cappadocia L, Gaudreau L, Zou L, Maréchal A., Free PMC Article | 10/14/2017 |
| role of Pso4 in DNA repair and DNA damage | hPso4/hPrp19: a critical component of DNA repair and DNA damage checkpoint complexes.
Mahajan K. | 09/2/2017 |
| Study demonstrates that the levels of Prp19 and Cdc5L are overexpressed in hepatocellular carcinoma (HCC). Prp19 binds with Cdc5L and its downregulation results in reduction of Cdc5L. Mechanistic insights reveal that silencing Prp19 compromises translation activity of Cdc5L and facilitates lysosome-induced degradation of Cdc5L in HCC cells. | Prp19 Arrests Cell Cycle via Cdc5L in Hepatocellular Carcinoma Cells.
Huang R, Xue R, Qu D, Yin J, Shen XZ., Free PMC Article | 04/29/2017 |
| We report that PRP19 expression is elevated in lung carcinoma tissues compared to non-tumor tissues | PRP19 upregulation inhibits cell proliferation in lung adenocarcinomas by p21-mediated induction of cell cycle arrest.
Benjamin AB, Zhou X, Isaac O, Zhao H, Song Y, Chi X, Sun B, Hao L, Zhang L, Liu L, Guan H, Shao S. | 01/17/2015 |
| These findings suggest that SKAP promotes ultraviolet rays-induced cell apoptosis by negatively regulating the anti-apoptotic protein Prp19. | Small kinetochore associated protein (SKAP) promotes UV-induced cell apoptosis through negatively regulating pre-mRNA processing factor 19 (Prp19).
Lu S, Wang R, Cai C, Liang J, Xu L, Miao S, Wang L, Song W., Free PMC Article | 01/10/2015 |
| involvement of hPso4 in the recombinational repair of DSBs | The role of the human psoralen 4 (hPso4) protein complex in replication stress and homologous recombination.
Abbas M, Shanmugam I, Bsaili M, Hromas R, Shaheen M., Free PMC Article | 12/20/2014 |
| DNA damage induces down-regulation of Prp19 via impairing Prp19 stability in hepatocellular carcinoma cells. | DNA damage induces down-regulation of Prp19 via impairing Prp19 stability in hepatocellular carcinoma cells.
Yin J, Zhang YA, Liu TT, Zhu JM, Shen XZ., Free PMC Article | 11/8/2014 |
| The Prp19-CDC5L complex plays a crucial role during human pre-mRNA splicing by catalytic activation of the spliceosome. | Structural insights into the novel ARM-repeat protein CTNNBL1 and its association with the hPrp19-CDC5L complex.
Ahn JW, Kim S, Kim EJ, Kim YJ, Kim KJ. | 08/23/2014 |
| Prp19 complex as the first spliceosome subcomplex that directly contributes to mitosis in vertebrates independently of its function in interphase. | The Prp19 complex directly functions in mitotic spindle assembly.
Hofmann JC, Tegha-Dunghu J, Dräger S, Will CL, Lührmann R, Gruss OJ., Free PMC Article | 06/21/2014 |
| PRP19 directly binds RPA and localizes to DNA damage sites via RPA, promoting RPA ubiquitylation in a DNA-damage-induced manner. | PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry.
Maréchal A, Li JM, Ji XY, Wu CS, Yazinski SA, Nguyen HD, Liu S, Jiménez AE, Jin J, Zou L., Free PMC Article | 04/12/2014 |
| New insights into pre-mRNA processing factor 19 | New insights into pre-mRNA processing factor 19: A multi-faceted protein in humans.
Yin J, Zhu JM, Shen XZ. | 05/4/2013 |
| PRP19 over-expression is associated with hepatocellular carcinoma recurrence. | Ubiquitin C-terminal Hydrolase 37, a novel predictor for hepatocellular carcinoma recurrence, promotes cell migration and invasion via interacting and deubiquitinating PRP19.
Fang Y, Fu D, Tang W, Cai Y, Ma D, Wang H, Xue R, Liu T, Huang X, Dong L, Wu H, Shen X. | 03/23/2013 |