| RabGEF1 functions as an oncogene in U251 glioblastoma cells and is involved in regulating AKT and Erk pathways. | RabGEF1 functions as an oncogene in U251 glioblastoma cells and is involved in regulating AKT and Erk pathways.
Fan H, Xin T, Dong X, Yang F, Zhang R, Feng S, He D, Guo H, Pang Q. | 05/1/2021 |
| The authors demonstrate that RABGEF1, the upstream factor of the endosomal Rab GTPase cascade, is recruited to damaged mitochondria via ubiquitin binding downstream of Parkin. RABGEF1 directs the downstream Rab proteins, RAB5 and RAB7A, to damaged mitochondria, whose associations are further regulated by mitochondrial Rab-GAPs. | Endosomal Rab cycles regulate Parkin-mediated mitophagy.
Yamano K, Wang C, Sarraf SA, Münch C, Kikuchi R, Noda NN, Hizukuri Y, Kanemaki MT, Harper W, Tanaka K, Matsuda N, Youle RJ., Free PMC Article | 09/1/2018 |
| RABEX-5 mRNA expression was significantly upregulated in colorectal cancer tissues. | Higher RABEX-5 mRNA predicts unfavourable survival in patients with colorectal cancer.
Zhang JS, Yang LQ, Du BR, Gao H. | 07/28/2018 |
| we identify Rabex-5 as a Immunomodulatory drugs (IMiDs) target molecule that functions to restrain TLR activated auto-immune promoting pathways. We propose that release of Rabex-5 from complex with Cereblon enables the suppression of immune responses, contributing to the antiinflammatory properties of IMiDs. | Rabex-5 is a lenalidomide target molecule that negatively regulates TLR-induced type 1 IFN production.
Millrine D, Tei M, Gemechu Y, Kishimoto T., Free PMC Article | 01/27/2018 |
| RABGEF1 mediates recycling endosome fusion with GAS-containing autophagosome-like vacuoles through the STX6-VAMP3-VTI1B complex; SNAREs are involved in autophagosome formation in response to bacterial infection | The STX6-VTI1B-VAMP3 complex facilitates xenophagy by regulating the fusion between recycling endosomes and autophagosomes.
Nozawa T, Minowa-Nozawa A, Aikawa C, Nakagawa I., Free PMC Article | 12/9/2017 |
| findings reveal a key role for RABGEF1 in dampening keratinocyte-intrinsic MYD88 signaling and sustaining epidermal barrier function | Guanine nucleotide exchange factor RABGEF1 regulates keratinocyte-intrinsic signaling to maintain skin homeostasis.
Marichal T, Gaudenzio N, El Abbas S, Sibilano R, Zurek O, Starkl P, Reber LL, Pirottin D, Kim J, Chambon P, Roers A, Antoine N, Kawakami Y, Kawakami T, Bureau F, Tam SY, Tsai M, Galli SJ., Free PMC Article | 09/2/2017 |
| The results contradict the model of feedback activation of Rab5 and instead indicate that Rbpt5 is recruited by both Rabex5 recognizing ubiquitylated cargo and by Rab4 to activate Rab5 in a feed-forward manner. | Rabaptin5 is recruited to endosomes by Rab4 and Rabex5 to regulate endosome maturation.
Kälin S, Hirschmann DT, Buser DP, Spiess M. | 10/1/2016 |
| RABEX-5 is a potential useful indicator and predicts a poor long-term prognosis for small cell lung cancer(SCLC), which should be considered in defining the prognosis with other well-known prognosticators in C-SCLC patients | Elevated RABEX-5 protein expression predicts poor prognosis in combined small cell lung cancer.
Zhang F, Zhang M, Hu G, Cai Q, Xu T. | 04/9/2016 |
| Expression of RABEX-5 is significantly higher in gastric cancer tissues and is associated with tumor size and lymph node metastasis. | RABEX-5 is upregulated and plays an oncogenic role in gastric cancer development by activating the VEGF signaling pathway.
Wang S, Lu A, Chen X, Wei L, Ding J., Free PMC Article | 12/26/2015 |
| analysis of Rabex-5 GEF activation by Rabaptin-5 | Molecular mechanism for Rabex-5 GEF activation by Rabaptin-5.
Zhang Z, Zhang T, Wang S, Gong Z, Tang C, Chen J, Ding J., Free PMC Article | 08/1/2015 |
| This implies that Rap regulates endothelial barrier function by dual control of cytoskeletal tension. The molecular details of the signaling pathways are becoming to be elucidated | Rap1 signaling in endothelial barrier control.
Pannekoek WJ, Post A, Bos JL., Free PMC Article | 05/30/2015 |
| RABEX-5 mRNA expression is a strong predictor of poor prognosis in prostate cancer patients treated by radical prostatectomy. | Expression of RABEX-5 and its clinical significance in prostate cancer.
Zhang H, Cheng S, Wang A, Ma H, Yao B, Qi C, Liu R, Qi S, Xu Y., Free PMC Article | 08/30/2014 |
| Interaction of Rabex-5 with Rab5 depends on interaction of the MIU domain with the ubiquitinated L1 to drive its internalization. | Spatiotemporal regulation of the ubiquitinated cargo-binding activity of Rabex-5 in the endocytic pathway.
Aikawa Y, Hirakawa H, Lee S., Free PMC Article | 03/2/2013 |
| KCa2.3 is localized to a caveolin-rich domain within the plasma membrane and is endocytosed in a dynamin- and Rab5-dependent manner. | Dynamin- and Rab5-dependent endocytosis of a Ca2+ -activated K+ channel, KCa2.3.
Gao Y, Bertuccio CA, Balut CM, Watkins SC, Devor DC., Free PMC Article | 02/9/2013 |
| a novel mechanistic insight into how Rabex-5 regulates internalization and postendocytic trafficking of ubiquitinated L1 destined for lysosomal degradation. | Rabex-5 protein regulates the endocytic trafficking pathway of ubiquitinated neural cell adhesion molecule L1.
Aikawa Y., Free PMC Article | 12/8/2012 |
| RABEX-5 and RAB5 may be involved in the development of breast cancer metastasis. | [The expression and clinical significance of RABEX-5 and RAB5 in breast cancer].
Wang YJ, Li HY, Li Y, Min J. | 04/14/2012 |
| functions as an E3 ligase for Ras | Feedback regulation of Ras signaling by Rabex-5-mediated ubiquitination.
Xu L, Lubkov V, Taylor LJ, Bar-Sagi D., Free PMC Article | 12/11/2010 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| Integration of TGFB and RAS signaling silences RABGEF1 and enhances growth factor-directed cell migration. | Integration of transforming growth factor beta and RAS signaling silences a RAB5 guanine nucleotide exchange factor and enhances growth factor-directed cell migration.
Hu H, Milstein M, Bliss JM, Thai M, Malhotra G, Huynh LC, Colicelli J., Free PMC Article | 01/21/2010 |
| Fc epsilon RI-mediated mast cell functional activation is dependent on RabGEF1's GEF activity | Roles of RabGEF1/Rabex-5 domains in regulating Fc epsilon RI surface expression and Fc epsilon RI-dependent responses in mast cells.
Kalesnikoff J, Rios EJ, Chen CC, Alejandro Barbieri M, Tsai M, Tam SY, Galli SJ., Free PMC Article | 01/21/2010 |
| GGAs, a family of Arf-dependent clathrin adaptors involved in selection of TGN cargo, interact with the Rabaptin-5-Rabex-5 complex, a Rab4/Rab5 effector regulating endosome fusion | Divalent interaction of the GGAs with the Rabaptin-5-Rabex-5 complex.
Mattera R, Arighi CN, Lodge R, Zerial M, Bonifacino JS., Free PMC Article | 01/21/2010 |
| crystal structure of the RABEX-5 catalytic core in complex with nucleotide-free RAB21, a key intermediate in the exchange reaction pathway | Structural basis for Rab GTPase activation by VPS9 domain exchange factors.
Delprato A, Lambright DG., Free PMC Article | 01/21/2010 |
| Here, we report that Rabex-5, a guanine nucleotide exchange factor for Rab5, binds to ubiquitin through two independent ubiquitin binding domains | Crystal structure of the ubiquitin binding domains of rabex-5 reveals two modes of interaction with ubiquitin.
Penengo L, Mapelli M, Murachelli AG, Confalonieri S, Magri L, Musacchio A, Di Fiore PP, Polo S, Schneider TR. | 01/21/2010 |