| TMEM97 knockdown inhibits 5-fluorouracil resistance by regulating epithelial-mesenchymal transition and ABC transporter expression via inactivating the Akt/mTOR pathway in 5-fluorouracil-resistant colorectal cancer cells. | TMEM97 knockdown inhibits 5-fluorouracil resistance by regulating epithelial-mesenchymal transition and ABC transporter expression via inactivating the Akt/mTOR pathway in 5-fluorouracil-resistant colorectal cancer cells.
Xu Y, Tang Y, Xu Q, He W. | 02/26/2024 |
| Transmembrane protein 97 is a potential synaptic amyloid beta receptor in human Alzheimer's disease. | Transmembrane protein 97 is a potential synaptic amyloid beta receptor in human Alzheimer's disease.
Colom-Cadena M, Toombs J, Simzer E, Holt K, McGeachan R, Tulloch J, Jackson RJ, Catterson JH, Spires-Jones MP, Rose J, Waybright L, Caggiano AO, King D, Gobbo F, Davies C, Hooley M, Dunnett S, Tempelaar R, Meftah S, Tzioras M, Hamby ME, Izzo NJ, Catalano SM, Durrant CS, Smith C, Dando O, Spires-Jones TL., Free PMC Article | 02/7/2024 |
| Sigma-2 Receptor Ligand Binding Modulates Association between TSPO and TMEM97. | Sigma-2 Receptor Ligand Binding Modulates Association between TSPO and TMEM97.
Thejer BM, Infantino V, Santarsiero A, Pappalardo I, Abatematteo FS, Teakel S, Van Oosterum A, Mach RH, Denora N, Lee BC, Resta N, Bagnulo R, Niso M, Contino M, Montsch B, Heffeter P, Abate C, Cahill MA., Free PMC Article | 04/14/2023 |
| TMEM97 is transcriptionally activated by YY1 and promotes colorectal cancer progression via the GSK-3beta/beta-catenin signaling pathway. | TMEM97 is transcriptionally activated by YY1 and promotes colorectal cancer progression via the GSK-3β/β-catenin signaling pathway.
Mao D, Zhang X, Wang Z, Xu G, Zhang Y. | 08/27/2022 |
| GPCR/endocytosis/ERK signaling/S2R is involved in the regulation of the internalization, mitochondria-targeting and -activating properties of human salivary histatin 1. | GPCR/endocytosis/ERK signaling/S2R is involved in the regulation of the internalization, mitochondria-targeting and -activating properties of human salivary histatin 1.
Ma D, Sun W, Fu C, Nazmi K, Veerman ECI, Jaspers RT, Bolscher JGM, Bikker FJ, Wu G., Free PMC Article | 08/20/2022 |
| Inhibition of MAC30 exerts antitumor effects in nasopharyngeal carcinoma via affecting the Akt/GSK-3beta/beta-catenin pathway. | Inhibition of MAC30 exerts antitumor effects in nasopharyngeal carcinoma via affecting the Akt/GSK-3β/β-catenin pathway.
Zhang P, Tian Q, Gao H, Zhao A, Shao Y, Yang J. | 07/23/2022 |
| Transmembrane protein 97 exhibits oncogenic properties via enhancing LRP6-mediated Wnt signaling in breast cancer. | Transmembrane protein 97 exhibits oncogenic properties via enhancing LRP6-mediated Wnt signaling in breast cancer.
Zhu H, Su Z, Ning J, Zhou L, Tan L, Sayed S, Song J, Wang Z, Li H, Sun Q, Liu S, Sha O, Leng F, Chen X, Lu D., Free PMC Article | 02/5/2022 |
| Histatin-1 is an endogenous ligand of the sigma-2 receptor. | Histatin-1 is an endogenous ligand of the sigma-2 receptor.
Son KN, Lee H, Shah D, Kalmodia S, Miller RC, Ali M, Balasubramaniam A, Cologna SM, Kong H, Shukla D, Aakalu VK., Free PMC Article | 12/25/2021 |
| TMEM97 facilitates the activation of SOCE by downregulating the association of cholesterol to Orai1 in MDA-MB-231 cells. | TMEM97 facilitates the activation of SOCE by downregulating the association of cholesterol to Orai1 in MDA-MB-231 cells.
Cantonero C, Camello PJ, Salido GM, Rosado JA, Redondo PC. | 09/18/2021 |
| The Sigma-2 Receptor/TMEM97, PGRMC1, and LDL Receptor Complex Are Responsible for the Cellular Uptake of Abeta42 and Its Protein Aggregates. | The Sigma-2 Receptor/TMEM97, PGRMC1, and LDL Receptor Complex Are Responsible for the Cellular Uptake of Aβ42 and Its Protein Aggregates.
Riad A, Lengyel-Zhand Z, Zeng C, Weng CC, Lee VM, Trojanowski JQ, Mach RH., Free PMC Article | 06/5/2021 |
| These data indicate that the formation of a ternary complex of LDLR-PGRMC1-TMEM97 is necessary for the rapid internalization of LDL by LDLR. | Sigma-2 Receptor/TMEM97 and PGRMC-1 Increase the Rate of Internalization of LDL by LDL Receptor through the Formation of a Ternary Complex.
Riad A, Zeng C, Weng CC, Winters H, Xu K, Makvandi M, Metz T, Carlin S, Mach RH., Free PMC Article | 12/7/2019 |
| TMEM97 was found to be overexpressed in prostate cancer, and identified as a novel miR-152 target gene. | A multiplatform approach identifies miR-152-3p as a common epigenetically regulated onco-suppressor in prostate cancer targeting TMEM97.
Ramalho-Carvalho J, Gonçalves CS, Graça I, Bidarra D, Pereira-Silva E, Salta S, Godinho MI, Gomez A, Esteller M, Costa BM, Henrique R, Jerónimo C., Free PMC Article | 03/2/2019 |
| we not only confirmed the elevated MAC30 mRNA, but also demonstrated that GC with overexpression of MAC30 resisted to adjuvant platinum-based chemotherapy. | The prognostic role of MAC30 in advanced gastric cancer patients receiving platinum-based chemotherapy.
Wu X, Zhou F, Ji X, Ren K, Shan Y, Mao X, Fen Y, Chen R, Ding H, Fu X. | 08/18/2018 |
| TMEM97 possesses the full suite of molecular properties that define the sigma2 receptor, and Asp29 and Asp56 are essential for ligand recognition | Identification of the gene that codes for the σ(2) receptor.
Alon A, Schmidt HR, Wood MD, Sahn JJ, Martin SF, Kruse AC., Free PMC Article | 06/16/2018 |
| MAC30 could be a useful biomarker of tumor differentiation and outcome of patients with non-small cell lung cancer. Overexpression of MAC30 predicts a worse tumor differentiated stage and prognosis in patients with non-small cell lung cancer receiving adjuvant chemotherapy. | The Prognostic Effect of MAC30 Expression on Patients With Non-Small Cell Lung Cancer Receiving Adjuvant Chemotherapy.
Ding H, Gui X, Lin X, Chen R, Ma T, Sheng Y, Cai H, Fen Y., Free PMC Article | 05/5/2018 |
| Study generated a series of sigma1R and sigma2R/Tmem97 agonists and antagonists and tested them for efficacy in the mouse spared nerve injury model. Results show robust antineuropathic pain effects of sigma1R and sigma2R/Tmem97 ligands, demonstrate that sigma2R/Tmem97 is a novel neuropathic pain target, and identify sigma2R/Tmem97 agonist UKH-1114 as a lead molecule for further development. | Sigma 2 Receptor/Tmem97 Agonists Produce Long Lasting Antineuropathic Pain Effects in Mice.
Sahn JJ, Mejia GL, Ray PR, Martin SF, Price TJ., Free PMC Article | 12/23/2017 |
| knockdown of TMEM97 also increases levels of residual NPC1 in NPC1-mutant patient fibroblasts and reduces cholesterol storage in an NPC1-dependent manner. Our findings propose TMEM97 inhibition as a novel strategy to increase residual NPC1 levels in cells and a potential therapeutic target for Niemann-Pick type C disease (NP-C). | Reduction of TMEM97 increases NPC1 protein levels and restores cholesterol trafficking in Niemann-pick type C1 disease cells.
Ebrahimi-Fakhari D, Wahlster L, Bartz F, Werenbeck-Ueding J, Praggastis M, Zhang J, Joggerst-Thomalla B, Theiss S, Grimm D, Ory DS, Runz H., Free PMC Article | 07/15/2017 |
| Overexpression of MAC30 is associated with Squamous Cell Carcinomas of the Lung. | Prognostic Value of MAC30 Expression in Human Pure Squamous Cell Carcinomas of the Lung.
Ding H, Gui XH, Lin XB, Chen RH, Cai HR, Fen Y, Sheng YL. | 02/4/2017 |
| High expression of TMEM97 is associated with glioma. | RNA interference against TMEM97 inhibits cell proliferation, migration, and invasion in glioma cells.
Qiu G, Sun W, Zou Y, Cai Z, Wang P, Lin X, Huang J, Jiang L, Ding X, Hu G. | 01/30/2016 |
| The down-regulation of MAC30 expression efficiently inhibited the proliferation of gastric cancer cells. Furthermore, the mobility of gastric cancer cells was also inhibited by down-regulation of MAC30. | Down-regulated MAC30 expression inhibits proliferation and mobility of human gastric cancer cells.
Xu XY, Zhang LJ, Yu YQ, Zhang XT, Huang WJ, Nie XC, Song GQ. | 04/18/2015 |
| MAC30 may serve as a new molecular marker to predict the lymph node metastasis and prognosis of patients with epithelial ovarian cancer | Elevated expression of MAC30 predicts lymph node metastasis and unfavorable prognosis in patients with epithelial ovarian cancer.
Yang S, Li H, Liu Y, Ning X, Meng F, Xiao M, Wang D, Lou G, Zhang Y. | 07/27/2013 |
| Overexpression of MAC30 is associated with non-small-cell lung cancer. | Overexpression of MAC30 is associated with poor clinical outcome in human non-small-cell lung cancer.
Han KY, Gu X, Wang HR, Liu D, Lv FZ, Li JN. | 05/11/2013 |
| As the tumor penetrated the wall of the colon/rectum, MAC30 mRNA expression notably increased in colorectal tumors with T3+T4 stage compared to tumors with T1+T2 stage. | Significance of mRNA and protein expression of MAC30 in progression of colorectal cancer.
Zhao ZR, Zhang LJ, He XQ, Zhang ZY, Zhang F, Li F, Pei YB, Hu YM, Wang MW, Sun XF. | 09/15/2012 |
| expression of MAC30 in the cytoplasm markedly increased from normal oral epithelial cells to primary oral squamous cell carcinoma; MAC30 expression in primary tumors with lymph node metastasis exceeded levels in those without metastasis | Overexpression of MAC30 in the cytoplasm of oral squamous cell carcinoma predicts nodal metastasis and poor differentiation.
Yan BY, Wang DW, Zhu ZL, Yang YH, Wang MW, Cui DS, Zhang H, Sun XF. | 04/2/2011 |
| The most up-regulated gene was TMEM97 which encodes a transmembrane protein of unknown function (MAC30). | Coordinate up-regulation of TMEM97 and cholesterol biosynthesis genes in normal ovarian surface epithelial cells treated with progesterone: implications for pathogenesis of ovarian cancer.
Wilcox CB, Feddes GO, Willett-Brozick JE, Hsu LC, DeLoia JA, Baysal BE., Free PMC Article | 01/21/2010 |