Conclusion of diagnostic odysseys due to inversions disrupting GLI3 and FBN1.
Pagnamenta AT, Yu J, Evans J, Twiss P, Genomics England Research Consortium, Musculoskeletal GeCIP MDT, Offiah AC, Wafik M, Mehta SG, Javaid MK, Smithson SF, Taylor JC., Free PMC Article

A novel mechanism of regulation of the oncogenic transcription factor GLI3 by toll-like receptor signaling.
Matissek SJ, Karbalivand M, Han W, Boutilier A, Yzar-Garcia E, Kehoe LL, Gardner DS, Hage A, Fleck K, Jeffers V, Rajsbaum R, Elsawa SF., Free PMC Article

A novel variant of GLI3, p.Asp1514Thrfs*5, is identified in a Chinese family affected by polydactyly.
Wang Y, Hao X, Jia X, Ji W, Yuan S, Gnamey EJA, Huang M, Xu L, Zhang X, Bai J, Sun W, Fu S, Liu Y, Wu J., Free PMC Article

GLI3 Is Stabilized by SPOP Mutations and Promotes Castration Resistance via Functional Cooperation with Androgen Receptor in Prostate Cancer.
Burleson M, Deng JJ, Qin T, Duong TM, Yan Y, Gu X, Das D, Easley A, Liss MA, Yew PR, Bedolla R, Kumar AP, Huang TH, Zou Y, Chen Y, Chen CL, Huang H, Sun LZ, Boyer TG., Free PMC Article

Two nonsense GLI3 variants are associated with polydactyly and syndactyly in two families by affecting the sonic hedgehog signaling pathway.
Shen X, Zhang S, Zhang X, Zhou T, Rui Y., Free PMC Article

GLI3 and androgen receptor are mutually dependent for their malignancy-promoting activity in ovarian and breast cancer cells.
Lin M, Zhu H, Shen Q, Sun LZ, Zhu X.

Homozygous GLI3 variants observed in three unrelated patients presenting with syndromic polydactyly.
El Mouatani A, Van Winckel G, Zaafrane-Khachnaoui K, Whalen S, Achaiaa A, Kaltenbach S, Superti-Furga A, Vekemans M, Fodstad H, Giuliano F, Attie-Bitach T.

GLI3 variants causing isolated polysyndactyly are not restricted to the protein's C-terminal third.
Sczakiel HL, Hülsemann W, Holtgrewe M, Abad-Perez AT, Elsner J, Schwartzmann S, Horn D, Spielmann M, Mundlos S, Mensah MA.

Coexpression of EphA10 and Gli3 promotes breast cancer cell proliferation, invasion and migration.
Peng J, Zhang D., Free PMC Article

Variant type and position predict two distinct limb phenotypes in patients with GLI3-mediated polydactyly syndromes.
Baas M, Burger EB, van den Ouweland AM, Hovius SE, de Klein A, van Nieuwenhoven CA, Galjaard RJH., Free PMC Article

Topoisomerase IIβ immunoreactivity (IR) co-localizes with neuronal marker-IR but not glial fibrillary acidic protein-IR in GLI3-positive medulloblastomas: an immunohistochemical analysis of 124 medulloblastomas from the Japan Children's Cancer Group.
Miyahara H, Natsumeda M, Kanemura Y, Yamasaki K, Riku Y, Akagi A, Oohashi W, Shofuda T, Yoshioka E, Sato Y, Taga T, Naruke Y, Ando R, Hasegawa D, Yoshida M, Sakaida T, Okada N, Watanabe H, Ozeki M, Arakawa Y, Yoshimura J, Fujii Y, Suenobu S, Ihara K, Hara J, Kakita A, Yoshida M, Iwasaki Y.

Gli activation by the estrogen receptor in breast cancer cells: Regulation of cancer cell growth by Gli3.
Massah S, Foo J, Li N, Truong S, Nouri M, Xie L, Prins GS, Buttyan R.

An intron variant of the GLI family zinc finger 3 (GLI3) gene differentiates resistance training-induced muscle fiber hypertrophy in younger men.
Vann CG, Morton RW, Mobley CB, Vechetti IJ, Ferguson BK, Haun CT, Osburn SC, Sexton CL, Fox CD, Romero MA, Roberson PA, Oikawa SY, McGlory C, Young KC, McCarthy JJ, Phillips SM, Roberts MD., Free PMC Article

Compound heterozygous GLI3 variants in siblings with thyroid hemiagenesis.
Szczepanek-Parulska E, Budny B, Borowczyk M, Zawadzka K, Sztromwasser P, Ruchała M., Free PMC Article

GLI3: a mediator of genetic diseases, development and cancer.
Matissek SJ, Elsawa SF., Free PMC Article

Novel GLI3 pathogenic variants in complex pre- and postaxial polysyndactyly and Greig cephalopolysyndactyly syndrome.
Patel R, Singh SK, Bhattacharya V, Ali A.

A GLI3 variant leading to polydactyly in heterozygotes and Pallister-Hall-like syndrome in a homozygote.
Kariminejad A, Ghaderi-Sohi S, Keshavarz E, Hashemi SA, Parsimehr E, Szenker-Ravi E, Khatoo M, Faraji Zonooz M, Reversade B, Najmabadi H, Hennekam RC.

GLI3 Promotes Invasion and Predicts Poor Prognosis in Colorectal Cancer.
Shen M, Zhang Z, Wang P., Free PMC Article

Novel frameshift mutations of ANKUB1, GLI3, and TAS2R3 associated with polysyndactyly in a Chinese family.
Zhang L, Chen X, Xu L, Guan S, Wang D, Lin Y, Wang Z., Free PMC Article

Gli3 is a novel downstream target of miR‑200a with an anti‑fibrotic role for progression of liver fibrosis in vivo and in vitro.
Li L, Ran J, Li L, Chen G, Zhang S, Wang Y., Free PMC Article

Structural basis of βTrCP1-associated GLI3 processing.
Shafique S, Rashid S., Free PMC Article

Gli3 Regulates Vomeronasal Neurogenesis, Olfactory Ensheathing Cell Formation, and GnRH-1 Neuronal Migration.
Taroc EZM, Naik AS, Lin JM, Peterson NB, Keefe DL Jr, Genis E, Fuchs G, Balasubramanian R, Forni PE., Free PMC Article

Novel GLI3 Mutations in Chinese Patients with Non-syndromic Post-axial Polydactyly.
Chen X, Yuan L, Xu H, Hu P, Yang Y, Guo Y, Guo Z, Deng H.

Targeted exome sequencing reveals a novel GLI3 mutation in a Chinese family with nonsyndromic polydactyly.
Zhao X, Xu H, Liu X, Li L.

Exome sequencing revealed a novel loss-of-function variant in the GLI3 transcriptional activator 2 domain underlies nonsyndromic postaxial polydactyly.
Umair M, Wasif N, Albalawi AM, Ramzan K, Alfadhel M, Ahmad W, Basit S., Free PMC Article