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    AMY1A amylase alpha 1A [ Homo sapiens (human) ]

    Gene ID: 276, updated on 2-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Dental caries prevalence and severity positively associate with AMY1 gene copy number.

    Dental caries prevalence and severity positively associate with AMY1 gene copy number.
    Mauricio-Castillo R, Valdevit A, Gonzalez-Davalos L, Dominguez-Perez RA, Garcia-Solis P, Vazquez-Martinez O, Hernandez-Montiel HL, Solis-Sainz JC.

    02/20/2024
    Salivary amylase gene (AMY1) copy number variation has only a minor correlation with body composition in Chinese adults.

    Salivary amylase gene (AMY1) copy number variation has only a minor correlation with body composition in Chinese adults.
    Zhang X, Moran C, Wang R, Zhou Y, Brooks N.

    06/21/2023
    Associations of SLC6A4 methylation with salivary cortisol, salivary alpha-amylase, and subjective stress in everyday life.

    Associations of SLC6A4 methylation with salivary cortisol, salivary alpha-amylase, and subjective stress in everyday life.
    Stoffel M, Rahn S, Neubauer AB, Moessner M, Aguilar-Raab C, Ditzen B.

    06/1/2023
    Genetic factors associated with serum amylase in a Japanese population: combined analysis of copy-number and single-nucleotide variants.

    Genetic factors associated with serum amylase in a Japanese population: combined analysis of copy-number and single-nucleotide variants.
    Nayema Z, Sato T, Kannon T, Tsujiguchi H, Hosomichi K, Nakamura H, Tajima A., Free PMC Article

    04/28/2023
    Salivary Alpha-Amylase Activity and Mild Cognitive Impairment among Japanese Older Adults: The Toon Health Study.

    Salivary Alpha-Amylase Activity and Mild Cognitive Impairment among Japanese Older Adults: The Toon Health Study.
    Yamane N, Ikeda A, Tomooka K, Saito I, Maruyama K, Eguchi E, Suyama K, Fujii A, Shiba T, Tanaka K, Kooka A, Nakamura S, Kajita M, Kawamura R, Takata Y, Osawa H, Steptoe A, Tanigawa T.

    10/29/2022
    The independent association between salivary alpha-amylase activity and arterial stiffness in Japanese men and women: the Toon Health Study.

    The independent association between salivary alpha-amylase activity and arterial stiffness in Japanese men and women: the Toon Health Study.
    Tajima T, Ikeda A, Steptoe A, Takahashi K, Maruyama K, Tomooka K, Saito I, Tanigawa T.

    07/30/2022
    Dietary carbohydrates interacts with AMY1 polymorphisms to influence the incidence of type 2 diabetes in Korean adults.

    Dietary carbohydrates interact with AMY1 polymorphisms to influence the incidence of type 2 diabetes in Korean adults.
    Shin D, Lee KW., Free PMC Article

    11/13/2021
    Influence of AMY1A copy number variations on obesity and other cardiometabolic risk factors: A review of the evidence.

    Influence of AMY1A copy number variations on obesity and other cardiometabolic risk factors: A review of the evidence.
    Hariharan R, Mousa A, de Courten B.

    10/23/2021
    Alpha-amylase 1A copy number variants and the association with memory performance and Alzheimer's dementia.

    Alpha-amylase 1A copy number variants and the association with memory performance and Alzheimer's dementia.
    Byman E, Nägga K, Gustavsson AM, Netherlands Brain Bank, Andersson-Assarsson J, Hansson O, Sonestedt E, Wennström M., Free PMC Article

    08/21/2021
    Diagnostic Value of Serum Amylase Levels Indicating Computed Tomography-Defined Post-Endoscopic Retrograde Cholangiopancreatography Pancreatitis: A Prospective Multicenter Observational Study.

    Diagnostic Value of Serum Amylase Levels Indicating Computed Tomography-Defined Post-Endoscopic Retrograde Cholangiopancreatography Pancreatitis: A Prospective Multicenter Observational Study.
    Inatomi O, Bamba S, Nakai Y, Kusumoto K, Kawakami T, Suzuki T, Suzuki A, Endoh B, Ota S, Inoue A, Itokawa Y, Chikugo K, Andoh A, Mizumoto Y, Tanaka K.

    08/7/2021
    Amylase Alpha 1 Gene (AMY1) Copy Number Variation and Dental Caries Experience: A Pilot Study among Adults in Lithuania.

    Amylase Alpha 1 Gene (AMY1) Copy Number Variation and Dental Caries Experience: A Pilot Study among Adults in Lithuania.
    Stangvaltaite-Mouhat L, Pūrienė A, Aleksejūnienė J, Stankeviciene I, Tommeras B, Al-Haroni M.

    07/17/2021
    Diagnostic utility of amylase alpha-1A, MOC 31, and CD 82 in renal oncocytoma versus chromophobe renal cell carcinoma.

    Diagnostic utility of amylase α-1A, MOC 31, and CD 82 in renal oncocytoma versus chromophobe renal cell carcinoma.
    Abouhashem NS, Abdelbary EH, H Abdalla MM, El-Shazly M.

    06/12/2021
    Cordycepin attenuates Salivary Hypofunction through the Prevention of Oxidative Stress in Human Submandibular Gland Cells.

    Cordycepin attenuates Salivary Hypofunction through the Prevention of Oxidative Stress in Human Submandibular Gland Cells.
    Jaiboonma A, Kaokaen P, Chaicharoenaudomrung N, Kunhorm P, Janebodin K, Noisa P, Jitprasertwong P., Free PMC Article

    06/5/2021
    AMY1 diploid copy number among end-stage renal disease patients.

    AMY1 diploid copy number among end-stage renal disease patients.
    Grammatikopoulou MG, Gkiouras K, Markaki AG, Gkouskou KK, Aivaliotis M, Stylianou K, Bogdanos DP.

    06/5/2021
    Association of AMY1A/AMY2A copy numbers and AMY1/AMY2 serum enzymatic activity with obesity in Mexican children.

    Association of AMY1A/AMY2A copy numbers and AMY1/AMY2 serum enzymatic activity with obesity in Mexican children.
    Vázquez-Moreno M, Mejía-Benítez A, Sharma T, Peralta-Romero J, Locia-Morales D, Klünder-Klünder M, National Obesity Network Mexico, Cruz M, Meyre D.

    02/27/2021
    AMY1 Gene Copy Number Correlates With Glucose Absorption and Visceral Fat Volume, but Not with Insulin Resistance.

    AMY1 Gene Copy Number Correlates With Glucose Absorption and Visceral Fat Volume, but Not with Insulin Resistance.
    Barber TM, Bhatti AA, Elder PJD, Ball SP, Calvez R, Ramsden DB, Cuthbertson DJ, Pfeiffer AF, Burnett D, Weickert MO.

    02/20/2021
    The salivary-alpha-amylase level after stroop test in anxious patients can predict the severity of anxiety.

    The salivary-α-amylase level after stroop test in anxious patients can predict the severity of anxiety.
    Liu Y, Yin H, Ma H, Yu X, Liu G, Guo L, Geng Q.

    12/12/2020
    Type 1 diabetes pancreata displayed significant reductions in the frequency of AMY(-) cell clusters.

    Temporal Analysis of Amylase Expression in Control, Autoantibody-Positive, and Type 1 Diabetes Pancreatic Tissues.
    Kusmartseva I, Beery M, Hiller H, Padilla M, Selman S, Posgai A, Nick HS, Campbell-Thompson M, Schatz DA, Haller MJ, Wasserfall CH, Atkinson MA., Free PMC Article

    07/11/2020
    At baseline, a modest association between AMY1 gene copy number and BMI (P = 0.04) was observed but AMY1 gene copy was not associated with baseline glycemic variables.

    Salivary α-amylase copy number is not associated with weight trajectories and glycemic improvements following clinical weight loss: results from a 2-phase dietary intervention study.
    Valsesia A, Kulkarni SS, Marquis J, Leone P, Mironova P, Walter O, Hjorth MF, Descombes P, Hager J, Saris WH, Astrup A, Darimont C, O'Callaghan NJ.

    02/1/2020
    High amylase expression is associated with diabetes.

    Estimation of salivary glucose, amylase, calcium, and phosphorus among non-diabetics and diabetics: Potential identification of non-invasive diagnostic markers.
    Tiongco REG, Arceo ES, Rivera NS, Flake CCD, Policarpio AR.

    01/11/2020
    A significant link between serum amylase activity and ABO blood type in Chinese subjects.

    Serum amylase activity altered by the ABO blood group system in Chinese subjects.
    Peng YF, Goyal H, Lin H, Liu DC, Li L., Free PMC Article

    12/14/2019
    High-AMY1-gene copy number subjects had higher levels of salivary Porphyromonas; their gut microbiota had increased abundance of resistant starch-degrading microbes, produced higher levels of short-chain fatty acids, and drove higher adiposity when transferred to germ-free mice. This study establishes AMY1-gene copy number as a genetic factor associated with microbiome composition and function.

    Human Salivary Amylase Gene Copy Number Impacts Oral and Gut Microbiomes.
    Poole AC, Goodrich JK, Youngblut ND, Luque GG, Ruaud A, Sutter JL, Waters JL, Shi Q, El-Hadidi M, Johnson LM, Bar HY, Huson DH, Booth JG, Ley RE.

    11/23/2019
    Diurnal patterns of salivary alpha amylase and salivary IgA exist in healthy young children and are not affected by their nutrient intake, sex, Asian ethnicity, and body mass index.

    Young Children Display Diurnal Patterns of Salivary IgA and Alpha-Amylase Expression Which Are Independent of Food Intake and Demographic Factors.
    Lim PW, Nambiar S, Muhardi L, Abdul Kader UH, Garssen J, Sandalova E., Free PMC Article

    06/1/2019
    66 proteins that interact with amylase in whole saliva were identified.

    Revealing the Amylase Interactome in Whole Saliva Using Proteomic Approaches.
    Crosara KTB, Zuanazzi D, Moffa EB, Xiao Y, Machado MAAM, Siqueira WL., Free PMC Article

    09/22/2018
    AMY1 copy number was significantly correlated with the variation observed in salivary amylase production and enzyme activity but did not explain the majority of observed variation between individuals. AMY1-odd and AMY1-even haplotypes showed a different relationship between copy number and expression levels, but the difference was not statistically significant.

    Copy number variation of human AMY1 is a minor contributor to variation in salivary amylase expression and activity.
    Carpenter D, Mitchell LM, Armour JA., Free PMC Article

    02/17/2018
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