| Molecular mechanism of the endothelin receptor type B interactions with Gs, Gi, and Gq. | Molecular mechanism of the endothelin receptor type B interactions with Gs, Gi, and Gq.
Ham D, Shihoya W, Nureki O, Inoue A, Chung KY. | 10/10/2024 |
| Overexpressed Galphai1 exerts pro-tumorigenic activity in nasopharyngeal carcinoma. | Overexpressed Gαi1 exerts pro-tumorigenic activity in nasopharyngeal carcinoma.
Yin DP, Zhang H, Teng H, Zhang D, Chen P, Xie L, Liu JS., Free PMC Article | 04/3/2024 |
| Candidate Gene of NOS3, MMP3, AGT, and AGT1R and Pathway Analyses for Platelet Reactivity and Clinical Outcomes of Repeat Revascularization After First PCI in Chinese Patients. | Candidate Gene of NOS3, MMP3, AGT, and AGT1R and Pathway Analyses for Platelet Reactivity and Clinical Outcomes of Repeat Revascularization After First PCI in Chinese Patients.
Zhou S, Wang Z, Liu Z, Mu G, Xie Q, Wang Z, Xiang Q, Gong Y, Cui Y. | 05/22/2023 |
| Galphai1/3 mediate Netrin-1-CD146-activated signaling and angiogenesis. | Gαi1/3 mediate Netrin-1-CD146-activated signaling and angiogenesis.
Li Y, Chai JL, Shi X, Feng Y, Li JJ, Zhou LN, Cao C, Li KR., Free PMC Article | 05/12/2023 |
| LncRNA PINK1-AS promotes Galphai1-driven gastric cancer tumorigenesis by sponging microRNA-200a. | LncRNA PINK1-AS promotes Gαi1-driven gastric cancer tumorigenesis by sponging microRNA-200a.
Lv Y, Wang Y, Song Y, Wang SS, Cheng KW, Zhang ZQ, Yao J, Zhou LN, Ling ZY, Cao C. | 01/15/2022 |
| The Galphai protein subclass selectivity to the dopamine D2 receptor is also decided by their location at the cell membrane. | The Gαi protein subclass selectivity to the dopamine D(2) receptor is also decided by their location at the cell membrane.
Polit A, Rysiewicz B, Mystek P, Błasiak E, Dziedzicka-Wasylewska M., Free PMC Article | 08/14/2021 |
| Feeling at home: Structure of the NTSR1-Gi complex in a lipid environment. | Feeling at home: Structure of the NTSR1-G(i) complex in a lipid environment.
Maharana J, Shukla AK., Free PMC Article | 06/26/2021 |
| Galphai1 inhibition mechanism of ATP-bound adenylyl cyclase type 5. | Gαi1 inhibition mechanism of ATP-bound adenylyl cyclase type 5.
Narzi D, van Keulen SC, Röthlisberger U., Free PMC Article | 05/15/2021 |
| Structures of Galpha Proteins in Complex with Their Chaperone Reveal Quality Control Mechanisms. | Structures of Gα Proteins in Complex with Their Chaperone Reveal Quality Control Mechanisms.
Seven AB, Hilger D, Papasergi-Scott MM, Zhang L, Qu Q, Kobilka BK, Tall GG, Skiniotis G., Free PMC Article | 03/27/2021 |
| Preferential Coupling of Dopamine D2S and D2L Receptor Isoforms with Gi1 and Gi2 Proteins-In Silico Study. | Preferential Coupling of Dopamine D(2S) and D(2L) Receptor Isoforms with G(i1) and G(i2) Proteins-In Silico Study.
Żuk J, Bartuzi D, Matosiuk D, Kaczor AA., Free PMC Article | 10/3/2020 |
| Orexin-A protects against oxygen-glucose deprivation/reoxygenation-induced cell damage by inhibiting endoplasmic reticulum stress-mediated apoptosis via the Gi and PI3K signaling pathways. | Orexin-A protects against oxygen-glucose deprivation/reoxygenation-induced cell damage by inhibiting endoplasmic reticulum stress-mediated apoptosis via the Gi and PI3K signaling pathways.
Kong T, Qiu K, Liu M, Cheng B, Pan Y, Yang C, Chen J, Wang C. | 08/22/2020 |
| Here, we present a 2.0-A crystal structure of Galpha i in complex with the GEM motif of GIV/Girdin. Nucleotide exchange assays, molecular dynamics simulations, and hydrogen-deuterium exchange experiments demonstrate that GEM binding to the conformational switch II causes structural changes that allosterically propagate to the hydrophobic core of the Galpha i GTPase domain | Structural basis for GPCR-independent activation of heterotrimeric Gi proteins.
Kalogriopoulos NA, Rees SD, Ngo T, Kopcho NJ, Ilatovskiy AV, Sun N, Komives EA, Chang G, Ghosh P, Kufareva I., Free PMC Article | 03/28/2020 |
| the structures of the glucagon receptor (GCGR) bound to glucagon and distinct classes of heterotrimeric G proteins, Gs or Gi1 was determined using cryo-electron microscopy | Structural basis of G(s) and G(i) recognition by the human glucagon receptor.
Qiao A, Han S, Li X, Li Z, Zhao P, Dai A, Chang R, Tai L, Tan Q, Chu X, Ma L, Thorsen TS, Reedtz-Runge S, Yang D, Wang MW, Sexton PM, Wootten D, Sun F, Zhao Q, Wu B. | 03/28/2020 |
| cryoelectron structures of human NTSR1 in complex with the agonist JMV449 and the heterotrimeric Gi1 protein, at a resolution of 3 A | Conformational transitions of a neurotensin receptor 1-G(i1) complex.
Kato HE, Zhang Y, Hu H, Suomivuori CM, Kadji FMN, Aoki J, Krishna Kumar K, Fonseca R, Hilger D, Huang W, Latorraca NR, Inoue A, Dror RO, Kobilka BK, Skiniotis G., Free PMC Article | 11/30/2019 |
| The conjugated bile acids were found to be partial agonists of the muscarinic M2, but not sphingosin-1-phosphate-2, receptors, and act partially through the Gi pathway. Furthermore, the contraction slowing effect of unconjugated bile acids may also relate to cytotoxicity at higher concentrations | Bile acids and their respective conjugates elicit different responses in neonatal cardiomyocytes: role of Gi protein, muscarinic receptors and TGR5.
Ibrahim E, Diakonov I, Arunthavarajah D, Swift T, Goodwin M, McIlvride S, Nikolova V, Williamson C, Gorelik J., Free PMC Article | 10/19/2019 |
| 24,25-epoxycholesterol, an endogenous ligand of PTCH1, can stimulate Hedgehog signalling in cells and can trigger Gi-protein signalling via human SMO in vitro | Cryo-EM structure of oxysterol-bound human Smoothened coupled to a heterotrimeric G(i).
Qi X, Liu H, Thompson B, McDonald J, Zhang C, Li X., Free PMC Article | 10/5/2019 |
| These results provide mechanistic insights into the critical role played by Galphai1/3 proteins in VEGF-induced VEGFR2 endocytosis, signaling and angiogenesis. | Gαi1 and Gαi3mediate VEGF-induced VEGFR2 endocytosis, signaling and angiogenesis.
Sun J, Huang W, Yang SF, Zhang XP, Yu Q, Zhang ZQ, Yao J, Li KR, Jiang Q, Cao C., Free PMC Article | 09/7/2019 |
| Interplay between negative and positive design elements in Galpha helical domains of G proteins determines interaction specificity toward RGS2. | Interplay between negative and positive design elements in Gα helical domains of G proteins determines interaction specificity toward RGS2.
Kasom M, Gharra S, Sadiya I, Avital-Shacham M, Kosloff M. | 04/6/2019 |
| Galphai1 mRNA and protein expression were significantly upregulated in human glioma tissues and correlates with Akt hyperactivation and microRNA-200a downregulation. Galphai1 is the primary target of microRNA-200a in mediating its anti-glioma cell activity. | microRNA-200a downregulation in human glioma leads to Gαi1 over-expression, Akt activation, and cell proliferation.
Liu YY, Chen MB, Cheng L, Zhang ZQ, Yu ZQ, Jiang Q, Chen G, Cao C. | 03/2/2019 |
| 3.5 A resolution cryo-electron microscopy structure of the mu-opioid receptor (muOR) bound to the agonist peptide DAMGO and nucleotide-free Gi; these results shed light on the structural features that contribute to the Gi protein-coupling specificity of the microOR | Structure of the µ-opioid receptor-G(i) protein complex.
Koehl A, Hu H, Maeda S, Zhang Y, Qu Q, Paggi JM, Latorraca NR, Hilger D, Dawson R, Matile H, Schertler GFX, Granier S, Weis WI, Dror RO, Manglik A, Skiniotis G, Kobilka BK., Free PMC Article | 12/22/2018 |
| using cryo-electron microscopy, it is shown that the major interactions between activated rhodopsin and Gi are mediated by the C-terminal helix of the Gi alpha-subunit, which is wedged into the cytoplasmic cavity of the transmembrane helix bundle and directly contacts the amino terminus of helix 8 of rhodopsin | Cryo-EM structure of human rhodopsin bound to an inhibitory G protein.
Kang Y, Kuybeda O, de Waal PW, Mukherjee S, Van Eps N, Dutka P, Zhou XE, Bartesaghi A, Erramilli S, Morizumi T, Gu X, Yin Y, Liu P, Jiang Y, Meng X, Zhao G, Melcher K, Ernst OP, Kossiakoff AA, Subramaniam S, Xu HE., Free PMC Article | 12/22/2018 |
| HL-60 neutrophil-like cells expressing Rap1a(G12V) or Radil have an elongated phenotype because of enhanced uropod adhesion as they attempt to migrate on fibronectin. This elongated phenotype driven by Rap1a(G12V) or Radil is reversed by Galphai1(Q204L), but not by WT Galphai1 expression, suggesting that Galphai-GTP also regulates adhesion in immune cells at the level of, or downstream of, Radil. | Activated heterotrimeric G protein α(i) subunits inhibit Rap-dependent cell adhesion and promote cell migration.
To JY, Smrcka AV., Free PMC Article | 12/1/2018 |
| complex between M2R and holo-Gi1 is an octamer comprising four copies of each, and that activation is accompanied by a decrease in the oligomeric size of Gi1 | Single-Molecule Analysis of the Supramolecular Organization of the M2 Muscarinic Receptor and the Gαi1 Protein.
Shivnaraine RV, Fernandes DD, Ji H, Li Y, Kelly B, Zhang Z, Han YR, Huang F, Sankar KS, Dubins DN, Rocheleau JV, Wells JW, Gradinaru CC. | 05/12/2018 |
| GIV is a bifunctional modulator of G proteins; it serves as a guanine nucleotide dissociation inhibitor (GDI) for Galphas using the same motif that allows it to serve as a guanine-nucleotide exchange factor for Galphai | GIV/Girdin activates Gαi and inhibits Gαs via the same motif.
Gupta V, Bhandari D, Leyme A, Aznar N, Midde KK, Lo IC, Ear J, Niesman I, López-Sánchez I, Blanco-Canosa JB, von Zastrow M, Garcia-Marcos M, Farquhar MG, Ghosh P., Free PMC Article | 01/27/2018 |
| The authors demonstrate that Glu53, Glu60, and Glu118 of human Ngb are crucial for both the neuroprotective activity and interaction with Gi. Moreover, they show that Lys46, Lys70, Arg208, Lys209, and Lys210 residues of Gi are important for binding to human Ngb. | Identification of residues crucial for the interaction between human neuroglobin and the α-subunit of heterotrimeric Gi protein.
Takahashi N, Wakasugi K., Free PMC Article | 01/20/2018 |