| FAM3C/ILEI protein is elevated in psoriatic lesions and triggers psoriasiform hyperproliferation in mice. | FAM3C/ILEI protein is elevated in psoriatic lesions and triggers psoriasiform hyperproliferation in mice.
Malik B, Vokic I, Mohr T, Poppelaars M, Holcmann M, Novoszel P, Timelthaler G, Lendl T, Krauss D, Elling U, Mildner M, Penninger JM, Petzelbauer P, Sibilia M, Csiszar A., Free PMC Article | 07/12/2023 |
| FAM3C in circulating tumor-derived extracellular vesicles promotes non-small cell lung cancer growth in secondary sites. | FAM3C in circulating tumor-derived extracellular vesicles promotes non-small cell lung cancer growth in secondary sites.
Thuya WL, Kong LR, Syn NL, Ding LW, Cheow ESH, Wong RTX, Wang T, Goh RMW, Song H, Jayasinghe MK, Le MT, Hu JC, Yong WP, Lee SC, Wong AL, Sethi G, Hung HT, Ho PC, Thiery JP, Sze SK, Guo T, Soo RA, Yang H, Lim YC, Wang L, Goh BC., Free PMC Article | 03/8/2023 |
| ILEI contributes to melanoma cell invasiveness in vivo without affecting primary tumor growth and is transcriptionally up-regulated by USF-1. | Interleukin-like EMT inducer (ILEI) promotes melanoma invasiveness and is transcriptionally up-regulated by upstream stimulatory factor-1 (USF-1).
Noguchi K, Dincman TA, Dalton AC, Howley BV, McCall BJ, Mohanty BK, Howe PH., Free PMC Article | 02/9/2019 |
| Data suggest that Ilei does not form interleukin-like four helix-bundle structures; Ilei exists as monomers and as covalent dimers; Ilei dimer exhibits a trans-linked domain swap converting an intramolecular disulfide to an intermolecular disulfide; dimeric Ilei appears to be involved in neoplastic invasiveness. | The interleukin-like epithelial-mesenchymal transition inducer ILEI exhibits a non-interleukin-like fold and is active as a domain-swapped dimer.
Jansson AM, Csiszar A, Maier J, Nyström AC, Ax E, Johansson P, Schiavone LH., Free PMC Article | 09/30/2017 |
| overexpression of Fam3c caused reduction of Runx2 expression at both mRNA and protein levels. Fam3c was localized in the cytoplasm and it was not secreted outside the cell during osteoblast differentiation and therefore, may function intracellularly. Furthermore, Fam3c and TGF-beta1 were found to regulate each other reciprocally | Fam3c modulates osteogenic differentiation by down-regulating Runx2.
Bendre A, Büki KG, Määttä JA. | 08/19/2017 |
| In obese diabetic mice, FAM3C expression was reduced in the liver, and hepatic FAM3C restoration improved insulin resistance, hyperglycemia, and fatty liver. FAM3C overexpression increased the expression of heat shock factor 1 (HSF1), calmodulin (CaM), and phosphorylated Akt and reduced that of gluconeogenic and lipogenic genes in diabetic mouse livers with the suppression of gluconeogenesis and lipid deposition. | Hepatic Activation of the FAM3C-HSF1-CaM Pathway Attenuates Hyperglycemia of Obese Diabetic Mice.
Chen Z, Ding L, Yang W, Wang J, Chen L, Chang Y, Geng B, Cui Q, Guan Y, Yang J. | 08/19/2017 |
| Study used immunohistochemical staining and biochemical fractionation to examine the regional distribution and subcellular localization of ILEI in mouse brains and in autopsy brains of patients with Alzheimer's disease; results suggest that a decline of ILEI expression may cause accumulation of Abeta in the brain and the eventual development of Alzheimer's disease. | Neuronal expression of ILEI/FAM3C and its reduction in Alzheimer's disease.
Liu L, Watanabe N, Akatsu H, Nishimura M. | 07/15/2017 |
| TGF-beta modulates the expression of Dab2 and ILEI mRNA required for epithelial-mesenchymal transdifferentiation by inducing phosphorylation of hnRNP E1, resulting in its release from a structural, 33-nucleotide BAT element in the 3'UTR of Dab2 and ILEI. | TGF-beta-mediated phosphorylation of hnRNP E1 induces EMT via transcript-selective translational induction of Dab2 and ILEI.
Chaudhury A, Hussey GS, Ray PS, Jin G, Fox PL, Howe PH., Free PMC Article | 04/19/2010 |
| ILEI requires cooperation with oncogenic Ras to govern hepatocellular EMT through mechanisms involving PDGF-R/beta-catenin and PDGF-R/Stat3 signaling. | ILEI requires oncogenic Ras for the epithelial to mesenchymal transition of hepatocytes and liver carcinoma progression.
Lahsnig C, Mikula M, Petz M, Zulehner G, Schneller D, van Zijl F, Huber H, Csiszar A, Beug H, Mikulits W., Free PMC Article | 01/21/2010 |
| ILEI is overexpressed and/or altered in intracellular localization in multiple human tumors. | ILEI: a cytokine essential for EMT, tumor formation, and late events in metastasis in epithelial cells.
Waerner T, Alacakaptan M, Tamir I, Oberauer R, Gal A, Brabletz T, Schreiber M, Jechlinger M, Beug H. | 01/21/2010 |
| FAM3C orthologous protein, may be involved in cell differentiation and proliferation during inner ear embryogenesis | Genomic organization and expression analysis of the murine Fam3c gene.
Pilipenko VV, Reece A, Choo DI, Greinwald JH Jr. | 01/21/2010 |