| Stratifin promotes the malignant progression of HCC via binding and hyperactivating AKT signaling. | Stratifin promotes the malignant progression of HCC via binding and hyperactivating AKT signaling.
Li R, Yan X, Zhong W, Zheng J, Li X, Liang J, Hu Z, Liu H, Chen G, Yang Y, Zhang J, Qu E, Liu W. | 06/8/2024 |
| Stratifin as a novel diagnostic biomarker in serum for diffuse alveolar damage. | Stratifin as a novel diagnostic biomarker in serum for diffuse alveolar damage.
Arakawa N, Ushiki A, Abe M, Matsuyama S, Saito Y, Kashiwada T, Horimasu Y, Gemma A, Tatsumi K, Hattori N, Tsushima K, Miyashita K, Saito K, Nakamura R, Toyoda T, Ogawa K, Sato M, Takamatsu K, Mori K, Nishiya T, Izumi T, Ohno Y, Saito Y, Hanaoka M., Free PMC Article | 10/8/2022 |
| Long non-coding RNA titin-antisense RNA1 contributes to growth and metastasis of cholangiocarcinoma by suppressing microRNA-513a-5p to upregulate stratifin. | Long non-coding RNA titin-antisense RNA1 contributes to growth and metastasis of cholangiocarcinoma by suppressing microRNA-513a-5p to upregulate stratifin.
Liu Y, Sun J, Qi P, Liu Y., Free PMC Article | 02/19/2022 |
| Significance of stratifin in early progression of lung adenocarcinoma and its potential therapeutic relevance. | Significance of stratifin in early progression of lung adenocarcinoma and its potential therapeutic relevance.
Shiba-Ishii A. | 02/12/2022 |
| 14-3-3 Sigma Protein Contributes to Hepatocyte Growth Factor-mediated Cell Proliferation and Invasion via Matrix Metalloproteinase-1 Regulation in Human Gastric Cancer. | 14-3-3 Sigma Protein Contributes to Hepatocyte Growth Factor-mediated Cell Proliferation and Invasion via Matrix Metalloproteinase-1 Regulation in Human Gastric Cancer.
Jung JY, Koh SA, Lee KH, Kim JR. | 01/15/2022 |
| Stratifin in ocular surface squamous neoplasia and its association with p53. | Stratifin in ocular surface squamous neoplasia and its association with p53.
Chauhan S, Sen S, Chauhan SS, Pushker N, Tandon R, Kashyap S, Vanathi M, Bajaj MS. | 01/15/2022 |
| 14-3-3sigma Functions as an Intestinal Tumor Suppressor. | 14-3-3σ Functions as an Intestinal Tumor Suppressor.
Winter M, Rokavec M, Hermeking H. | 12/18/2021 |
| Phosphorylated full-length Tau interacts with 14-3-3 proteins via two short phosphorylated sequences, each occupying a binding groove of 14-3-3 dimer. | Phosphorylated full-length Tau interacts with 14-3-3 proteins via two short phosphorylated sequences, each occupying a binding groove of 14-3-3 dimer.
Neves JF, Petrvalská O, Bosica F, Cantrelle FX, Merzougui H, O'Mahony G, Hanoulle X, Obšil T, Landrieu I. | 07/31/2021 |
| Construction and validation of a bronchoalveolar lavage cell-associated gene signature for prognosis prediction in idiopathic pulmonary fibrosis. | Construction and validation of a bronchoalveolar lavage cell-associated gene signature for prognosis prediction in idiopathic pulmonary fibrosis.
Xia Y, Lei C, Yang D, Luo H. | 06/26/2021 |
| Role of stratifin (14-3-3 sigma) in adenocarcinoma of gallbladder: A novel prognostic biomarker. | Role of stratifin (14-3-3 sigma) in adenocarcinoma of gallbladder: A novel prognostic biomarker.
Sirivatanauksorn V, Dumronggittigule W, Dulnee B, Srisawat C, Sirivatanauksorn Y, Pongpaibul A, Masaratana P, Somboonyosdech C, Sripinitchai S, Kositamongkol P, Mahawithitwong P, Tovikkai C, Sangserestid P, Limsrichamrern S. | 10/31/2020 |
| Based on above results, overexpression of SFN was correlated with the prognosis in ovarian cancer. The present study might be useful for better understanding the clinical significance of SFN mRNA. | Expression profile and prognostic value of SFN in human ovarian cancer.
Hu Y, Zeng Q, Li C, Xie Y., Free PMC Article | 07/11/2020 |
| H19 and miR- 675-5p are upregulated in Nasopharyngeal Cancer (NPC), which is related to the development of NPC. The over-expression of miR- 675-5p inhibits the expression of SFN (14-3-3sigma) protein. | H19/miR-675-5p Targeting SFN Enhances the Invasion and Metastasis of Nasalpharyngeal Cancer Cells.
Zhang T, Lei F, Jiang T, Xie L, Huang P, Li P, Huang Y, Tang X, Gong J, Lin Y, Cheng A, Huang W. | 07/11/2020 |
| Quantitative methylation results indicated that the level of methylation was significantly higher (hypermethylated) for FLT3 and EPB41L3 and significantly lower (hypomethylated) for SFN in tumour tissues as compared to the adjacent paired normal tissue. | Promoter-associated DNA methylation & expression profiling of genes (FLT 3, EPB41L3 & SFN) in patients with oral squamous cell carcinoma in the Khasi & Jaintia population of Meghalaya, India.
Khongsti S, Shunyu BN, Ghosh S., Free PMC Article | 06/20/2020 |
| High SFN expression is associated with Lung Adenocarcinogenesis. | Stratifin Inhibits SCF(FBW7) Formation and Blocks Ubiquitination of Oncoproteins during the Course of Lung Adenocarcinogenesis.
Shiba-Ishii A, Hong J, Hirokawa T, Kim Y, Nakagawa T, Sakashita S, Sakamoto N, Kozuma Y, Sato Y, Noguchi M. | 06/20/2020 |
| Stratifin (SFN) is highly expressed in cervical cancer (CC) tissues and CC cell lines compared with normal tissues and normal cell line. After interfering SFN, cell proliferation, migration and invasion ability is inhibited as well as cell apoptosis ability is promoted. Long intergenic non-protein coding RNA 1128 expedites cellular process in CC by binding with miR-383-5p to release SFN. | LINC01128 expedites cervical cancer progression by regulating miR-383-5p/SFN axis.
Hu Y, Ma Y, Liu J, Cai Y, Zhang M, Fang X., Free PMC Article | 04/11/2020 |
| Proteomic analysis of tubular epithelial cells obtained from patients with renal pathologies revealed overexpressing calreticulin along with the family of 14-3-3 proteins as key proteins overexpressed as well. | The family of 14-3-3 proteins and specifically 14-3-3σ are up-regulated during the development of renal pathologies.
Rizou M, Frangou EA, Marineli F, Prakoura N, Zoidakis J, Gakiopoulou H, Liapis G, Kavvadas P, Chatziantoniou C, Makridakis M, Vlahou A, Boletis J, Vlahakos D, Goumenos D, Daphnis E, Iatrou C, Charonis AS., Free PMC Article | 11/2/2019 |
| 14-3-3sigma (also known as stratifin, encoded by SFN) interacted preferentially with S285-phosphorylated PKP3 to promote its accumulation at tricellular contact sites, leading to stable desmosomes. | 14-3-3 proteins regulate desmosomal adhesion via plakophilins.
Rietscher K, Keil R, Jordan A, Hatzfeld M. | 11/2/2019 |
| Study shows that 14-3-3 protein sigma isoform co-localizes with phosphorylated alpha-synuclein in Lewy bodies and Lewy neurites in patients with Lewy body disease. | 14-3-3 protein sigma isoform co-localizes with phosphorylated α-synuclein in Lewy bodies and Lewy neurites in patients with Lewy body disease.
Wakabayashi K, Umahara T, Hirokawa K, Hanyu H, Uchihara T. | 03/2/2019 |
| SFN enhances RTK stabilization through abnormal USP8 regulation in lung adenocarcinoma | Stratifin regulates stabilization of receptor tyrosine kinases via interaction with ubiquitin-specific protease 8 in lung adenocarcinoma.
Kim Y, Shiba-Ishii A, Nakagawa T, Iemura SI, Natsume T, Nakano N, Matsuoka R, Sakashita S, Lee S, Kawaguchi A, Sato Y, Noguchi M. | 02/23/2019 |
| we found that differential expression of BAK1, FIS1, and SFN were altered across the Barrett's disease sequence and manipulation of these genes elicited significant effects on mitochondrial membrane potential. | The Mitochondrial Genes BAK1, FIS1 and SFN are Linked with Alterations in Mitochondrial Membrane Potential in Barrett's Esophagus.
Phelan JJ, MacCarthy F, O'Toole D, Ravi N, Reynolds JV, O'Sullivan J., Free PMC Article | 02/16/2019 |
| silencing filamin A may inhibit the invasion and migration of breast cancer cells by upregulating 14-3-3sigma. | Silencing Filamin A Inhibits the Invasion and Migration of Breast Cancer Cells by Up-regulating 14-3-3σ.
Ji ZM, Yang LL, Ni J, Xu SP, Yang C, Duan P, Lou LP, Ruan QR. | 11/3/2018 |
| Over-expressed and hypo-methylated SFN gene is associated with hepatocellular carcinoma. | Genome-wide DNA methylation analysis identifies candidate epigenetic markers and drivers of hepatocellular carcinoma.
Zheng Y, Huang Q, Ding Z, Liu T, Xue C, Sang X, Gu J. | 10/27/2018 |
| Review/Meta-analysis: 14-3-3 sigma promoter methylation may be associated with the carcinogenesis of breast cancer and might represent a useful blood-based biomarker for the clinical diagnosis of breast cancer. | Detection of 14-3-3 sigma (σ) promoter methylation as a noninvasive biomarker using blood samples for breast cancer diagnosis.
Ye M, Huang T, Ying Y, Li J, Yang P, Ni C, Zhou C, Chen S., Free PMC Article | 03/3/2018 |
| 14-3-3sigma has a paracrine effect in educating stromal cells in tumor-associated microenvironment. | Paracrine regulation of matrix metalloproteinases contributes to cancer cell invasion by hepatocellular carcinoma-secreted 14-3-3σ.
Liu CC, Chang TC, Lin YT, Yu YL, Ko BS, Sung LY, Liou JY., Free PMC Article | 01/13/2018 |
| This data indicates that 14-3-3sigma contributes to P-gp overexpression through interaction with PXR with rifampin and paclitaxel treatment. | Role of 14-3-3 sigma in over-expression of P-gp by rifampin and paclitaxel stimulation through interaction with PXR.
Kim SW, Md Hasanuzzaman, Cho M, Kim NH, Choi HY, Han JW, Park HJ, Oh JW, Shin JG. | 12/2/2017 |