| Glycerol 3-phosphate dehydrogenases (1 and 2) in cancer and other diseases. | Glycerol 3-phosphate dehydrogenases (1 and 2) in cancer and other diseases.
Oh S, Mai XL, Kim J, de Guzman ACV, Lee JY, Park S., Free PMC Article | 09/4/2024 |
| GPD2: The relationship with cancer and neural stemness. | GPD2: The relationship with cancer and neural stemness.
Mikeli M, Fujikawa M, Tanabe T. | 03/22/2023 |
| A ferroptosis defense mechanism mediated by glycerol-3-phosphate dehydrogenase 2 in mitochondria. | A ferroptosis defense mechanism mediated by glycerol-3-phosphate dehydrogenase 2 in mitochondria.
Wu S, Mao C, Kondiparthi L, Poyurovsky MV, Olszewski K, Gan B., Free PMC Article | 07/2/2022 |
| mGPDH Deficiency leads to melanoma metastasis via induced NRF2. | mGPDH Deficiency leads to melanoma metastasis via induced NRF2.
Li X, Zhou L, Zhang Y, He X, Lu H, Zhang L, Tian Y, Liu X, Zheng H, Shao J, Long M., Free PMC Article | 10/2/2021 |
| Deficiency of Mitochondrial Glycerol 3-Phosphate Dehydrogenase Exacerbates Podocyte Injury and the Progression of Diabetic Kidney Disease. | Deficiency of Mitochondrial Glycerol 3-Phosphate Dehydrogenase Exacerbates Podocyte Injury and the Progression of Diabetic Kidney Disease.
Qu H, Gong X, Liu X, Zhang R, Wang Y, Huang B, Zhang L, Zheng H, Zheng Y. | 09/4/2021 |
| mRNA and protein levels reduced in livers of patients with nonalcoholic fatty liver disease | Deficiency of Mitochondrial Glycerol 3-Phosphate Dehydrogenase Contributes to Hepatic Steatosis.
Zheng Y, Qu H, Xiong X, Wang Y, Liu X, Zhang L, Liao X, Liao Q, Sun Z, Ouyang Q, Yang G, Zhu Z, Xu J, Zheng H., Free PMC Article | 06/27/2020 |
| We report 3 additional patients with a de novo deletion encompassing NR4A2: 2 patients have deletions encompassing only NR4A2 gene and 1 patient has a deletion including NR4A2 and the first exon of GPD2 | NR4A2 haploinsufficiency is associated with intellectual disability and autism spectrum disorder.
Lévy J, Grotto S, Mignot C, Maruani A, Delahaye-Duriez A, Benzacken B, Keren B, Haye D, Xavier J, Heulin M, Charles E, Verloes A, Dupont C, Pipiras E, Tabet AC. | 11/16/2019 |
| Here, the authors identify mGPDH as a critical regulator of skeletal muscle regeneration. Specifically, it regulates myogenic markers and myoblast differentiation by controlling mitochondrial biogenesis via CaMKKbeta/AMPK. | Mitochondrial glycerol 3-phosphate dehydrogenase promotes skeletal muscle regeneration.
Liu X, Qu H, Zheng Y, Liao Q, Zhang L, Liao X, Xiong X, Wang Y, Zhang R, Wang H, Tong Q, Liu Z, Dong H, Yang G, Zhu Z, Xu J, Zheng H., Free PMC Article | 07/27/2019 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesGenetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ. A sequence variation in the mitochondrial glycerol-3-phosphate dehydrogenase gene is associated with increased plasma glycerol and free fatty acid concentrations among French Canadians.
St-Pierre J, Vohl MC, Brisson D, Perron P, Després JP, Hudson TJ, Gaudet D. | 03/13/2008 |
| the up-regulation of mGPDH, due to a highly glycolytic environment, contributes to the overall increase in ROS generation and may result in the progression of prostate cancer | Increased expression of mitochondrial glycerophosphate dehydrogenase and antioxidant enzymes in prostate cancer cell lines/cancer.
Chowdhury SK, Raha S, Tarnopolsky MA, Singh G. | 01/21/2010 |
| testis-specific promoter of mitochondrial GPDH | Germ cell nuclear factor relieves cAMP-response element modulator tau-mediated activation of the testis-specific promoter of human mitochondrial glycerol-3-phosphate dehydrogenase.
Rajkovic M, Middendorff R, Wetzel MG, Frkovic D, Damerow S, Seitz HJ, Weitzel JM. | 01/21/2010 |
| Overall, these data demonstrate that mGPDH is involved in maintaining a high rate of glycolysis and is an important site of electron leakage leading to ROS production in prostate cancer cells. | High activity of mitochondrial glycerophosphate dehydrogenase and glycerophosphate-dependent ROS production in prostate cancer cell lines.
Chowdhury SK, Gemin A, Singh G. | 01/21/2010 |