| Acid-sensing receptor GPR4 plays a crucial role in lymphatic cancer metastasis. | Acid-sensing receptor GPR4 plays a crucial role in lymphatic cancer metastasis.
Nakanishi M, Ibe A, Morishita K, Shinagawa K, Yamamoto Y, Takahashi H, Ikemori K, Muragaki Y, Ehata S., Free PMC Article | 06/3/2024 |
| The proton-sensing receptors TDAG8 and GPR4 are differentially expressed in human and mouse oligodendrocytes: Exploring their role in neuroinflammation and multiple sclerosis. | The proton-sensing receptors TDAG8 and GPR4 are differentially expressed in human and mouse oligodendrocytes: Exploring their role in neuroinflammation and multiple sclerosis.
Caratis F, Opiełka M, Hausmann M, Velasco-Estevez M, Rojek B, de Vallière C, Seuwen K, Rogler G, Karaszewski B, Rutkowska A., Free PMC Article | 03/31/2024 |
| GPR4 in the pH-dependent migration of melanoma cells in the tumor microenvironment. | GPR4 in the pH-dependent migration of melanoma cells in the tumor microenvironment.
Stolwijk JA, Wallner S, Heider J, Kurz B, Pütz L, Michaelis S, Goricnik B, Erl J, Frank L, Berneburg M, Haubner F, Wegener J, Schreml S. | 04/6/2023 |
| Hypoxia-induced GPR4 suppresses trophoblast cell migration and proliferation through the MAPK signaling pathway. | Hypoxia-induced GPR4 suppresses trophoblast cell migration and proliferation through the MAPK signaling pathway.
Qi H, Yao C, Xing J, Qin Y. | 11/13/2021 |
| The evolution and mechanism of GPCR proton sensing. | The evolution and mechanism of GPCR proton sensing.
Rowe JB, Kapolka NJ, Taghon GJ, Morgan WM, Isom DG., Free PMC Article | 08/28/2021 |
| Antagonism of GPR4 with NE 52-QQ57 and the Suppression of AGE-Induced Degradation of Type II Collagen in Human Chondrocytes. | Antagonism of GPR4 with NE 52-QQ57 and the Suppression of AGE-Induced Degradation of Type II Collagen in Human Chondrocytes.
Liu H, Liu Y, Chen B. | 07/10/2021 |
| Expression profiles of proton-sensing G-protein coupled receptors in common skin tumors. | Expression profiles of proton-sensing G-protein coupled receptors in common skin tumors.
Klatt W, Wallner S, Brochhausen C, Stolwijk JA, Schreml S., Free PMC Article | 01/23/2021 |
| The expression of GPR4 is upregulated in colorectal cancer and is associated with shorter overall survival time in CRC patients. These findings reveal the novel roles of GPR4 in CRC progression and suggest GPR4 might be a new therapeutic target for CRC treatment. | Increased proton-sensing receptor GPR4 signalling promotes colorectal cancer progression by activating the hippo pathway.
Yu M, Cui R, Huang Y, Luo Y, Qin S, Zhong M., Free PMC Article | 03/21/2020 |
| Results indicate that GPR4 is expressed by multiple neuronal populations and endothelium and that its pH sensitivity is affected by level of expression and l-lactic acid (LL). GPR4 antagonist NE 52-QQ57 blunts hypercapnic response to CO2 but this effect is absent under anaesthesia, possibly due to the inhibitory effect of LL on GPR4. | CNS distribution, signalling properties and central effects of G-protein coupled receptor 4.
Hosford PS, Mosienko V, Kishi K, Jurisic G, Seuwen K, Kinzel B, Ludwig MG, Wells JA, Christie IN, Koolen L, Abdala AP, Liu BH, Gourine AV, Teschemacher AG, Kasparov S., Free PMC Article | 02/16/2019 |
| Proton-sensing GPR4 signaling mediated the proton-induced inhibitory effects on the osteogenesis of BMSCs. YAP was the downstream effector of GPR4 signaling. Extracellular pH modulates the osteogenic responses of BMSCs by regulating the proton-sensing GPR4-YAP pathway. | Decreased extracellular pH inhibits osteogenesis through proton-sensing GPR4-mediated suppression of yes-associated protein.
Tao SC, Gao YS, Zhu HY, Yin JH, Chen YX, Zhang YL, Guo SC, Zhang CQ., Free PMC Article | 04/7/2018 |
| These results suggest that zOGR1, but not GPR4, is also a metal-sensing G-protein-coupled receptor in addition to a proton-sensing G-protein-coupled receptor, although not all metals that activate hOGR1 activated zOGR1. | Manganese and cobalt activate zebrafish ovarian cancer G-protein-coupled receptor 1 but not GPR4.
Negishi J, Omori Y, Shindo M, Takanashi H, Musha S, Nagayama S, Hirayama J, Nishina H, Nakakura T, Mogi C, Sato K, Okajima F, Mochimaru Y, Tomura H. | 03/10/2018 |
| GPR4 blockade attenuated renal injury after IR and reduced the cell apoptosis through the suppression of CHOP expression. | GPR4 knockout improves renal ischemia-reperfusion injury and inhibits apoptosis via suppressing the expression of CHOP.
Dong B, Zhang X, Fan Y, Cao S, Zhang X. | 12/9/2017 |
| acidosis/GPR4-induced endoplasmic reticulum stress pathways in endothelial cells may regulate vascular growth and inflammatory response in the acidic microenvironment. | Acidosis Activates Endoplasmic Reticulum Stress Pathways through GPR4 in Human Vascular Endothelial Cells.
Dong L, Krewson EA, Yang LV., Free PMC Article | 04/29/2017 |
| it was demonstrated that GPR4 affects ECs by regulating Notch1, a function that may be important for physiological and pathological angiogenesis. | Human GPR4 and the Notch signaling pathway in endothelial cell tube formation.
Ren J, Zhang Y, Cai H, Ma H, Zhao D, Zhang X, Li Z, Wang S, Wang J, Liu R, Li Y, Qian J, Wei H, Niu L, Liu Y, Xiao L, Ding M, Jiang S. | 04/8/2017 |
| GPR4 induces angiogenesis via GPR4-induced p38-mediated IL6, IL8 and VEGFA secretion at acidic extracellular pH in squamous cell carcinoma of the head and neck | The Proton-Sensing G-Protein Coupled Receptor GPR4 Promotes Angiogenesis in Head and Neck Cancer.
Jing Z, Xu H, Chen X, Zhong Q, Huang J, Zhang Y, Guo W, Yang Z, Ding S, Chen P, Huang Z., Free PMC Article | 08/27/2016 |
| The results suggested that GPR4 may play an important role in the development of epithelial ovarian carcinoma (EOC), and its overexpression might be required for the angiogenesis, tumor growth, and metastasis of EOC | Relations between GPR4 expression, microvascular density (MVD) and clinical pathological characteristics of patients with epithelial ovarian carcinoma (EOC).
Ren J, Jin W, Gao YE, Zhang Y, Zhang X, Zhao D, Ma H, Li Z, Wang J, Xiao L, Liu R, Chen Y, Qian J, Niu L, Wei H, Liu Y. | 12/20/2014 |
| acidosis/GPR4 signaling regulates endothelial cell adhesion mainly through the G(s)/cAMP/Epac pathway | Activation of GPR4 by acidosis increases endothelial cell adhesion through the cAMP/Epac pathway.
Chen A, Dong L, Leffler NR, Asch AS, Witte ON, Yang LV., Free PMC Article | 03/31/2012 |
| The mutation of histidine residue at 79, 165, or 269 from the N-terminal of GPR4 to phenylalanine shifted the half-maximal effective concentration (EC(50)) of proton-induced signaling activities to the right, including cAMP accumulation. | Each one of certain histidine residues in G-protein-coupled receptor GPR4 is critical for extracellular proton-induced stimulation of multiple G-protein-signaling pathways.
Liu JP, Nakakura T, Tomura H, Tobo M, Mogi C, Wang JQ, He XD, Takano M, Damirin A, Komachi M, Sato K, Okajima F. | 07/26/2010 |
| Previously postulated "ligand-independent" signaling of GPR4 is mediated through proton-sensing mechanisms. | Previously postulated "ligand-independent" signaling of GPR4 is mediated through proton-sensing mechanisms.
Tobo M, Tomura H, Mogi C, Wang JQ, Liu JP, Komachi M, Damirin A, Kimura T, Murata N, Kurose H, Sato K, Okajima F. | 01/21/2010 |
| Endogenous GPR4 in endothelial cells may be a potential G protein-coupled receptor by which LPC signals proinflammatory activities. | Inflammatory stress increases receptor for lysophosphatidylcholine in human microvascular endothelial cells.
Lum H, Qiao J, Walter RJ, Huang F, Subbaiah PV, Kim KS, Holian O. | 01/21/2010 |
| GPR4 in brain endothelial cells regulates monocyte transmigration. | A novel lysophospholipid- and pH-sensitive receptor, GPR4, in brain endothelial cells regulates monocyte transmigration.
Huang F, Mehta D, Predescu S, Kim KS, Lum H. | 01/21/2010 |
| GPR4, a close relative of OGR1, also responds to pH changes, but elicits cyclic AMP formation | Proton-sensing G-protein-coupled receptors.
Ludwig MG, Vanek M, Guerini D, Gasser JA, Jones CE, Junker U, Hofstetter H, Wolf RM, Seuwen K. | 01/21/2010 |
| GPR4 and TDAG8 overexpression in human tumors plays a role in driving or maintaining tumor formation | G protein-coupled receptors GPR4 and TDAG8 are oncogenic and overexpressed in human cancers.
Sin WC, Zhang Y, Zhong W, Adhikarakunnathu S, Powers S, Hoey T, An S, Yang J. | 01/21/2010 |
| lysophosphatidylcholine receptor G protein-coupled receptor 4 (GPK4) was expressed in YPEN-1 cells and triggered the cAMP/protein kinase A/cAMP response element-binding protein pathway, resulting in upregulation of adhesion molecules. | Upregulation of endothelial adhesion molecules by lysophosphatidylcholine. Involvement of G protein-coupled receptor GPR4.
Zou Y, Kim CH, Chung JH, Kim JY, Chung SW, Kim MK, Im DS, Lee J, Yu BP, Chung HY. | 01/21/2010 |
| sphingosylphosphorylcholine and lysophosphatidic acid are not the ligands for GPR4 and that this receptor may constitutively inhibit ERK1/2 activation | The G protein-coupled receptor GPR4 suppresses ERK activation in a ligand-independent manner.
Bektas M, Barak LS, Jolly PS, Liu H, Lynch KR, Lacana E, Suhr KB, Milstien S, Spiegel S. | 01/21/2010 |