| Vacuolar-ATPase-mediated muscle acidification caused muscular mechanical nociceptive hypersensitivity after chronic stress in rats, which involved extracellular matrix proteoglycan and ASIC3. | Vacuolar-ATPase-mediated muscle acidification caused muscular mechanical nociceptive hypersensitivity after chronic stress in rats, which involved extracellular matrix proteoglycan and ASIC3.
Nasu T, Hori A, Hotta N, Kihara C, Kubo A, Katanosaka K, Suzuki M, Mizumura K., Free PMC Article | 08/28/2023 |
| Upregulation of acid sensing ion channels is associated with esophageal hypersensitivity in GERD. | Upregulation of acid sensing ion channels is associated with esophageal hypersensitivity in GERD.
Han X, Zhang Y, Lee A, Li Z, Gao J, Wu X, Zhao J, Wang H, Chen D, Zou D, Owyang C., Free PMC Article | 01/15/2022 |
| ASIC3 inhibition modulates inflammation-induced changes in the activity and sensitivity of Adelta and C fiber sensory neurons that innervate bone. | ASIC3 inhibition modulates inflammation-induced changes in the activity and sensitivity of Aδ and C fiber sensory neurons that innervate bone.
Morgan M, Thai J, Trinh P, Habib M, Effendi KN, Ivanusic JJ., Free PMC Article | 08/7/2021 |
| Retrograde nerve growth factor signaling modulates tooth mechanical hyperalgesia induced by orthodontic tooth movement via acid-sensing ion channel 3. | Retrograde nerve growth factor signaling modulates tooth mechanical hyperalgesia induced by orthodontic tooth movement via acid-sensing ion channel 3.
Gao M, Yan X, Lu Y, Ren L, Zhang S, Zhang X, Kuang Q, Liu L, Zhou J, Wang Y, Lai W, Long H., Free PMC Article | 07/17/2021 |
| The Role of Acid-sensing Ion Channel 3 in the Modulation of Tooth Mechanical Hyperalgesia Induced by Orthodontic Tooth Movement. | The Role of Acid-sensing Ion Channel 3 in the Modulation of Tooth Mechanical Hyperalgesia Induced by Orthodontic Tooth Movement.
Yang H, Shan D, Jin Y, Liang H, Liu L, Guan Y, Chen C, Luo Q, Yang Y, Lai W, Long H. | 06/26/2021 |
| Histidine Residues Are Responsible for Bidirectional Effects of Zinc on Acid-Sensing Ion Channel 1a/3 Heteromeric Channels. | Histidine Residues Are Responsible for Bidirectional Effects of Zinc on Acid-Sensing Ion Channel 1a/3 Heteromeric Channels.
Jiang Q, Peterson AM, Chu Y, Yao X, Zha XM, Chu XP., Free PMC Article | 06/26/2021 |
| Insights into the molecular mechanisms underlying the inhibition of acid-sensing ion channel 3 gating by stomatin. | Insights into the molecular mechanisms underlying the inhibition of acid-sensing ion channel 3 gating by stomatin.
Klipp RC, Cullinan MM, Bankston JR., Free PMC Article | 06/12/2021 |
| Functional involvement of acid-sensing ion channel 3 in the swallowing reflex in rats. | Functional involvement of acid-sensing ion channel 3 in the swallowing reflex in rats.
Hossain MZ, Ando H, Unno S, Nakamoto T, Kitagawa J. | 01/16/2021 |
| Not only C- but also Adelta-fibre nociceptors in the muscle are involved in mechanical hypersensitivity after lengthening contractions, and that acid-sensing ion channel (ASIC)-3 expressed in the thin-fibre nociceptors is responsible for the mechanical hypersensitivity. | Thin-fibre receptors expressing acid-sensing ion channel 3 contribute to muscular mechanical hypersensitivity after exercise.
Matsubara T, Hayashi K, Wakatsuki K, Abe M, Ozaki N, Yamanaka A, Mizumura K, Taguchi T. | 07/18/2020 |
| Exercise pressor reflex in ASIC3 KO rats was significantly lower than the exercise pressor reflex in WT. | Functional knockout of ASIC3 attenuates the exercise pressor reflex in decerebrated rats with ligated femoral arteries.
Kim JS, Ducrocq GP, Kaufman MP., Free PMC Article | 07/18/2020 |
| found both WT and ASIC3 KO rats displayed similar pressor responses to static contraction | Effect of knockout of the ASIC3 on cardiovascular reflexes arising from hindlimb muscle in decerebrated rats.
Kim JS, Harms JE, Ruiz-Velasco V, Kaufman MP., Free PMC Article | 07/11/2020 |
| found ASIC3 expression was increased in the hippocampus of pilocarpine induced seizure rats, as well as in hippocampal neuronal cultures undergoing epileptiform discharge elicited by Mg(2+)-free media | Inhibition of Acid Sensing Ion Channel 3 Aggravates Seizures by Regulating NMDAR Function.
Cao Q, Xiao ZM, Wang X, Weng C, Ding M, Zhu F, Lu ZN. | 04/20/2019 |
| ASIC3 expression in trigeminal caudal nucleus is elevated in a rat model of recurrent migraine. | Expression of ASIC3 in the Trigeminal Nucleus Caudalis Plays a Role in a Rat Model of Recurrent Migraine.
Wang S, Wu BX, Liu CY, Qin GC, Yan WH, Zhou JY, Chen LX. | 02/23/2019 |
| Study shows that a ring of rat ASIC3 glutamates (Glu435), located above the channel gate, modulates proton sensitivity and contributes to the formation of the elusive Ca2+ block site, enhancing understanding of ASIC gating mechanisms and provide structural and energetic insights into this unique calcium-binding site. | Identification of a unique Ca(2+)-binding site in rat acid-sensing ion channel 3.
Zuo Z, Smith RN, Chen Z, Agharkar AS, Snell HD, Huang R, Liu J, Gonzales EB., Free PMC Article | 12/22/2018 |
| The ASIC3/P2X3 cognate receptor is a pain-relevant and ligand-gated cationic channel. | The ASIC3/P2X3 cognate receptor is a pain-relevant and ligand-gated cationic channel.
Stephan G, Huang L, Tang Y, Vilotti S, Fabbretti E, Yu Y, Nörenberg W, Franke H, Gölöncsér F, Sperlágh B, Dopychai A, Hausmann R, Schmalzing G, Rubini P, Illes P., Free PMC Article | 11/24/2018 |
| these results suggested that NFkappaB and ASIC3 may serve an important role in intervertebral disc degeneration caused by nucleus pulposus. | Upregulation of nuclear factor‑κB and acid sensing ion channel 3 in dorsal root ganglion following application of nucleus pulposus onto the nerve root in rats.
Wang D, Pan H, Zhu H, Zhu L, He YJ, Wang J, Jia GY. | 05/19/2018 |
| Amiloride inhibited pilocarpine-induced seizures by deactivating ASIC1a/ASIC3 channels. | Amiloride suppresses pilocarpine-induced seizures via ASICs other than NHE in rats.
Liang JJ, Huang LF, Chen XM, Pan SQ, Lu ZN, Xiao ZM., Free PMC Article | 10/29/2016 |
| identified the expression and localization of different ASIC subunits in the rest and activated microglia and further elucidated the role of ASICs in microglia activation and inflammatory response | Acid-sensing ion channels promote the inflammation and migration of cultured rat microglia.
Yu XW, Hu ZL, Ni M, Fang P, Zhang PW, Shu Q, Fan H, Zhou HY, Ni L, Zhu LQ, Chen JG, Wang F. | 09/26/2015 |
| Upregulation of mRNA and protein levels of ASIC3 suggested its potential involvement in the development and maintenance of cancer-induced bone pain | Increased expression of acid-sensing ion channel 3 within dorsal root ganglia in a rat model of bone cancer pain.
Qiu F, Wei X, Zhang S, Yuan W, Mi W. | 02/28/2015 |
| In this study, we made a homology model of ASIC3 and used extensive protein-protein docking to predict for the first time, the probable sites of APETx2 interaction on ASIC3. | In silico assessment of interaction of sea anemone toxin APETx2 and acid sensing ion channel 3.
Rahman T, Smith ES. | 09/27/2014 |
| The predominant ASIC subtype responding to decreased meningeal pH is ASIC3. | pH-evoked dural afferent signaling is mediated by ASIC3 and is sensitized by mast cell mediators.
Yan J, Wei X, Bischoff C, Edelmayer RM, Dussor G., Free PMC Article | 07/19/2014 |
| Experiments with Asic3 inhibitors show that Asic3 inhibition leads to loss of pressure-induced vasodilation due to pressure detection failure rather than endothelial mechanisms. | Asic3 is a neuronal mechanosensor for pressure-induced vasodilation that protects against pressure ulcers.
Fromy B, Lingueglia E, Sigaudo-Roussel D, Saumet JL, Lazdunski M. | 10/26/2013 |
| Our data show that anions modulate a variety of ASIC properties and are dependent on the subunit composition, and the mechanism of modulation for ASIC2a and -3 is distinct from that of ASIC1a. | Acid-sensing ion channels (ASICs) are differentially modulated by anions dependent on their subunit composition.
Kusama N, Gautam M, Harding AM, Snyder PM, Benson CJ., Free PMC Article | 03/9/2013 |
| Dimerization of stomatin is crucial for the repression of acid-sensing ion channel 3 (ASIC3) activity. | A stomatin dimer modulates the activity of acid-sensing ion channels.
Brand J, Smith ES, Schwefel D, Lapatsina L, Poole K, Omerbašić D, Kozlenkov A, Behlke J, Lewin GR, Daumke O., Free PMC Article | 01/5/2013 |
| Nonproton ligand sensing domain is required for paradoxical stimulation of acid-sensing ion channel 3 (ASIC3) channels by amiloride | Nonproton ligand sensing domain is required for paradoxical stimulation of acid-sensing ion channel 3 (ASIC3) channels by amiloride.
Li WG, Yu Y, Huang C, Cao H, Xu TL., Free PMC Article | 02/25/2012 |